메뉴 건너뛰기




Volumn 74, Issue 14, 2000, Pages 6278-6286

Interleukin-12 (IL-12) enhancement of the cellular immune response against human immunodeficiency virus type 1 Env antigen in a DNA prime/vaccinia virus boost vaccine regimen is time and dose dependent: Suppressive effects of IL-12 boost are mediated by nitric oxide

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VIRUS ANTIGEN; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS VECTOR;

EID: 0343517098     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.14.6278-6286.2000     Document Type: Article
Times cited : (106)

References (59)
  • 1
    • 0031569457 scopus 로고    scopus 로고
    • Cytokine in adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs
    • Ahlers, J. D., N. Dunlop, D. W. Alling, P. L. Nara, and J. A. Berzofskv. 1997. Cytokine in adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs. J. Immunol. 158:3947-3958.
    • (1997) J. Immunol. , vol.158 , pp. 3947-3958
    • Ahlers, J.D.1    Dunlop, N.2    Alling, D.W.3    Nara, P.L.4    Berzofskv, J.A.5
  • 2
    • 0031906148 scopus 로고    scopus 로고
    • Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage
    • André, S., B. Seed, J. Eberle, W. Schraut, A. Bultman, and J. Haas. 1998. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J. Virol. 72:1497-1503.
    • (1998) J. Virol. , vol.72 , pp. 1497-1503
    • André, S.1    Seed, B.2    Eberle, J.3    Schraut, W.4    Bultman, A.5    Haas, J.6
  • 3
    • 0024363970 scopus 로고
    • Humoral and cell-mediated immune responses to recombinant vaccinia viruses in mice
    • Andrew, M. E., B. E. H. Coupar, and D. B. Boyle. 1989. Humoral and cell-mediated immune responses to recombinant vaccinia viruses in mice. Immunol. Cell Biol. 67:331-337.
    • (1989) Immunol. Cell Biol. , vol.67 , pp. 331-337
    • Andrew, M.E.1    Coupar, B.E.H.2    Boyle, D.B.3
  • 4
    • 0032526629 scopus 로고    scopus 로고
    • Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signalling pathway
    • Bissinger, R. M., P. A. Tilbrook, P. G. Holt, and U. R. Kees. 1998. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signalling pathway. J. Immunol. 160:5729-5734.
    • (1998) J. Immunol. , vol.160 , pp. 5729-5734
    • Bissinger, R.M.1    Tilbrook, P.A.2    Holt, P.G.3    Kees, U.R.4
  • 7
    • 0033577255 scopus 로고    scopus 로고
    • A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentation
    • Caver, T. E., T. D. Lockey, R. V. Srinivas, R. G. Webster, and J. L. Hurwitz. 1999. A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentation. Vaccine 17:1567-1572.
    • (1999) Vaccine , vol.17 , pp. 1567-1572
    • Caver, T.E.1    Lockey, T.D.2    Srinivas, R.V.3    Webster, R.G.4    Hurwitz, J.L.5
  • 8
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow, Y. H., W. L. Huang, W. K. Chi, Y. D. Chu, and M. H. Tao. 1997. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J. Virol. 71:169-178.
    • (1997) J. Virol. , vol.71 , pp. 169-178
    • Chow, Y.H.1    Huang, W.L.2    Chi, W.K.3    Chu, Y.D.4    Tao, M.H.5
  • 9
    • 0028824039 scopus 로고
    • IL-12 deaths: Explanation and a puzzle
    • Cohen, J. 1995. IL-12 deaths: explanation and a puzzle. Science 270:908.
    • (1995) Science , vol.270 , pp. 908
    • Cohen, J.1
  • 10
    • 0030976279 scopus 로고    scopus 로고
    • The effect of interleukin-12 desensitization on the antitumor efficacy of recombinant interleukin-12
    • Coughlin, C. M., M. Wysocka, G. Trinchieri, and W. M. F. Lee. 1997. The effect of interleukin-12 desensitization on the antitumor efficacy of recombinant interleukin-12. Cancer Res. 57:2460-2467.
    • (1997) Cancer Res. , vol.57 , pp. 2460-2467
    • Coughlin, C.M.1    Wysocka, M.2    Trinchieri, G.3    Lee, W.M.F.4
  • 11
    • 0023395846 scopus 로고
    • Isolation and characterization of attenuated mutants of vaccinia virus
    • Dallo, S., and M. Esteban. 1987. Isolation and characterization of attenuated mutants of vaccinia virus. Virology 159:408-122.
    • (1987) Virology , vol.159 , pp. 408-1122
    • Dallo, S.1    Esteban, M.2
  • 17
    • 0033525799 scopus 로고    scopus 로고
    • Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants
    • Gherardi, M. M., and M. Esteban. 1999. Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants. Vaccine 17:1074-1083.
    • (1999) Vaccine , vol.17 , pp. 1074-1083
    • Gherardi, M.M.1    Esteban, M.2
  • 18
    • 0033151996 scopus 로고    scopus 로고
    • IL-12 delivery from recombinant vaccinia virus attenuates vector infectivity and enhances cellular immune response against HIV-1 gp160 protein in a dose-dependent manner
    • Gherardi, M. M., J. C. Ramírez. D. Rodriguez, J. R. Rodriguez, G. Ichio, F. Zabala, and M. Esteban. 1999. IL-12 delivery from recombinant vaccinia virus attenuates vector infectivity and enhances cellular immune response against HIV-1 gp160 protein in a dose-dependent manner. J. Immunol. 162:6724-6733.
    • (1999) J. Immunol. , vol.162 , pp. 6724-6733
    • Gherardi, M.M.1    Ramírez, J.C.2    Rodriguez, D.3    Rodriguez, J.R.4    Ichio, G.5    Zabala, F.6    Esteban, M.7
  • 21
    • 15144345621 scopus 로고    scopus 로고
    • Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for HIV-1 in mice
    • Hanke, T., T. J. Blanchard, J. Schneider, G. S. Ogg, H. Tan, M. Becker, S. C. Gilbert, A. V. S. Hill, G. L. Smith, and A. J. McMichael. 1998. Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for HIV-1 in mice. J. Gen. Virol. 79:83-90.
    • (1998) J. Gen. Virol. , vol.79 , pp. 83-90
    • Hanke, T.1    Blanchard, T.J.2    Schneider, J.3    Ogg, G.S.4    Tan, H.5    Becker, M.6    Gilbert, S.C.7    Hill, A.V.S.8    Smith, G.L.9    McMichael, A.J.10
  • 22
    • 0033016728 scopus 로고    scopus 로고
    • Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
    • Hanke, T., and A. McMichael. 1999. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS. Immunol. Lett. 66:177-181.
    • (1999) Immunol. Lett. , vol.66 , pp. 177-181
    • Hanke, T.1    McMichael, A.2
  • 23
    • 0032815843 scopus 로고    scopus 로고
    • Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen
    • Hanke, T., R. V. Samuel, T. J. Blanchard, V. C. Neumann, T. M. Allen, J. E. Boyson, S. A. Sharpe, N. Cook, G. L. Smith, D. I. Watkins, M. P. Cranage, and A. J. McMichael. 1999. Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen. J. Virol. 73:7524-7532.
    • (1999) J. Virol. , vol.73 , pp. 7524-7532
    • Hanke, T.1    Samuel, R.V.2    Blanchard, T.J.3    Neumann, V.C.4    Allen, T.M.5    Boyson, J.E.6    Sharpe, S.A.7    Cook, N.8    Smith, G.L.9    Watkins, D.I.10    Cranage, M.P.11    McMichael, A.J.12
  • 24
    • 0028852339 scopus 로고
    • Gamma interferon-induced nitric oxide-mediated inhibition of vaccinia virus replication
    • Harris, N., R. M. L. Buller, and G. Karupiah. 1995. Gamma interferon-induced nitric oxide-mediated inhibition of vaccinia virus replication. J. Virol. 69:910-915.
    • (1995) J. Virol. , vol.69 , pp. 910-915
    • Harris, N.1    Buller, R.M.L.2    Karupiah, G.3
  • 25
    • 0031795118 scopus 로고    scopus 로고
    • Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages
    • Huang, F.-P., W. Niedbala, X. Q. Wei, X. Damo, G. Feng, J. H. Robinson, C. Lam, and F. Y. Liew. 1998. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol. 28:4062-4070.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 4062-4070
    • Huang, F.-P.1    Niedbala, W.2    Wei, X.Q.3    Damo, X.4    Feng, G.5    Robinson, J.H.6    Lam, C.7    Liew, F.Y.8
  • 26
    • 0027488067 scopus 로고
    • Inhibition of viral replication by interferon-γ induced nitric oxide synthase
    • Karupiah, G., Q. W. Xie, R. M. L. Buller, C. Nathan, C. Duarte, and J. D. MacMicking. 1993. Inhibition of viral replication by Interferon-γ induced nitric oxide synthase. Science 261:1445-1448.
    • (1993) Science , vol.261 , pp. 1445-1448
    • Karupiah, G.1    Xie, Q.W.2    Buller, R.M.L.3    Nathan, C.4    Duarte, C.5    MacMicking, J.D.6
  • 27
    • 0031772993 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
    • Kent, S. J., A. Zhao, S. J. Best, J. D. Chandler, D. B. Boyle, and I. A. Ramshaw. 1998. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus. J. Virol. 72:10180-10188.
    • (1998) J. Virol. , vol.72 , pp. 10180-10188
    • Kent, S.J.1    Zhao, A.2    Best, S.J.3    Chandler, J.D.4    Boyle, D.B.5    Ramshaw, I.A.6
  • 28
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim, J. J., V. Ayavoo, M. L. Bargarazzi, M. A. Chattergoon, K. Dang, B. Wang, J. D. Boyer, and D. B. Weiner. 1997. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158:816-826.
    • (1997) J. Immunol. , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayavoo, V.2    Bargarazzi, M.L.3    Chattergoon, M.A.4    Dang, K.5    Wang, B.6    Boyer, J.D.7    Weiner, D.B.8
  • 31
    • 0033567977 scopus 로고    scopus 로고
    • In vivo immunomodulation following intradermal injection with DNA encoding IL-18
    • Kremer, L., L. Dupré, Y. Wolowczuk, and C. Locht. 1999. In vivo immunomodulation following intradermal injection with DNA encoding IL-18. J. Immunol. 163:3226-3231.
    • (1999) J. Immunol. , vol.163 , pp. 3226-3231
    • Kremer, L.1    Dupré, L.2    Wolowczuk, Y.3    Locht, C.4
  • 32
    • 0027197876 scopus 로고
    • Vaccination with two different vaccinia recombinant viruses: Long-term inhibition of secondary vaccination
    • Kündig, T. M., C. P. Kalberger, H. Hengartner, and R. M. Zinkernagel. 1993. Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination. Vaccine 111:1154-1158.
    • (1993) Vaccine , vol.111 , pp. 1154-1158
    • Kündig, T.M.1    Kalberger, C.P.2    Hengartner, H.3    Zinkernagel, R.M.4
  • 33
    • 0032476615 scopus 로고    scopus 로고
    • Immune suppression by recombinant IL-12 involves interferon γ induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant
    • Kurzawa, H., C. A. Hunter, M. Wysocka, G. Trinchieri, and W. M. F. Lee. 1998. Immune suppression by recombinant IL-12 involves interferon γ induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant. J. Exp. Med. 188:1603-1610.
    • (1998) J. Exp. Med. , vol.188 , pp. 1603-1610
    • Kurzawa, H.1    Hunter, C.A.2    Wysocka, M.3    Trinchieri, G.4    Lee, W.M.F.5
  • 34
    • 0032005134 scopus 로고    scopus 로고
    • Recombinant interleukin 12 enhances cellular immune responses to vaccination only after a period of suppression
    • Kurzawa, H., M. Wysocka, E. Aruga, A. E. Chang, G. Trinchieri, and W. M. F. Lee. 1998. Recombinant interleukin 12 enhances cellular immune responses to vaccination only after a period of suppression. Cancer Res. 58:491-499.
    • (1998) Cancer Res. , vol.58 , pp. 491-499
    • Kurzawa, H.1    Wysocka, M.2    Aruga, E.3    Chang, A.E.4    Trinchieri, G.5    Lee, W.M.F.6
  • 35
    • 0033136294 scopus 로고    scopus 로고
    • Different dose of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: The role of nitric oxide
    • Lasarte, J. J., F. J. Corrales, N. Casares, A. Lopez-Diaz de Cerio, C. Qian, X. Xie, K. Borrás-Cuesta, and J. Prieto. 1999. Different dose of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: the role of nitric oxide. J. Immunol. 162:5270-5277.
    • (1999) J. Immunol. , vol.162 , pp. 5270-5277
    • Lasarte, J.J.1    Corrales, F.J.2    Casares, N.3    Lopez-Diaz De Cerio, A.4    Qian, C.5    Xie, X.6    Borrás-Cuesta, K.7    Prieto, J.8
  • 36
    • 0028892235 scopus 로고
    • Inhibition of Vaccinia virus DNA replication by inducible expression of nitric oxid synthase
    • Melková, Z., and M. Esteban. 1995. Inhibition of Vaccinia virus DNA replication by inducible expression of nitric oxid synthase. J. Immunol. 155: 5711-5718.
    • (1995) J. Immunol. , vol.155 , pp. 5711-5718
    • Melková, Z.1    Esteban, M.2
  • 38
    • 0031252387 scopus 로고    scopus 로고
    • Intranasal immunization of a DNA vaccine with IL-12 and GM-CSF expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
    • Okada, E., S. Sasaki, N. Ishii, Y. Aoki, T. Yasuda, K. Nishioka, J. Fukushima, J. Miyazaki, B. Wahren, and K. Okuda. 1997. Intranasal immunization of a DNA vaccine with IL-12 and GM-CSF expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J. Immunol. 159:3638-3647.
    • (1997) J. Immunol. , vol.159 , pp. 3638-3647
    • Okada, E.1    Sasaki, S.2    Ishii, N.3    Aoki, Y.4    Yasuda, T.5    Nishioka, K.6    Fukushima, J.7    Miyazaki, J.8    Wahren, B.9    Okuda, K.10
  • 39
    • 0029120510 scopus 로고
    • Env-specific cytotoxic T lymphocyte responses in HIV-1 seronegative health care workers occupationally exposed to HIV-1-contaminated body fluids
    • Pinto, L. A., J. Sullivan, J. A. Berzofsky, M. Clerici, H. A. Kessler, A. L. Llanday, and G. M. Shearer. 1995. Env-specific cytotoxic T lymphocyte responses in HIV-1 seronegative health care workers occupationally exposed to HIV-1-contaminated body fluids. J. Clin. Investig. 96:867-876.
    • (1995) J. Clin. Investig. , vol.96 , pp. 867-876
    • Pinto, L.A.1    Sullivan, J.2    Berzofsky, J.A.3    Clerici, M.4    Kessler, H.A.5    Llanday, A.L.6    Shearer, G.M.7
  • 41
    • 26144456321 scopus 로고    scopus 로고
    • The biology of attenuated modified vaccinia virus Ankara (MVA) recombinant vector in mice: Fate and activation of B and T cell immune responses in comparison with the Western Reserve (WR) strain and advantages as a vaccine
    • Ramírez, J. C., M. M. Gherardi, and M. Esteban. 2000. The biology of attenuated modified vaccinia virus Ankara (MVA) recombinant vector in mice: fate and activation of B and T cell immune responses in comparison with the Western Reserve (WR) strain and advantages as a vaccine. J. Virol. 74:423-433.
    • (2000) J. Virol. , vol.74 , pp. 423-433
    • Ramírez, J.C.1    Gherardi, M.M.2    Esteban, M.3
  • 42
    • 0031903001 scopus 로고    scopus 로고
    • Does nitric oxide play a critical role in viral infections?
    • Reiss, C. S., and T. Komatsu. 1998. Does nitric oxide play a critical role in viral infections? J. Virol. 72:4547-4551.
    • (1998) J. Virol. , vol.72 , pp. 4547-4551
    • Reiss, C.S.1    Komatsu, T.2
  • 44
    • 0023968084 scopus 로고
    • Expression of the firefly luciferase gene in vaccinia virus: A highly sensitive gene marker to follow virus dissemination in tissues of infected animals
    • Rodríguez, J. F., D. Rodríguez, J. R. Rodríguez, E. B. McGowan, and M. Esteban. 1988. Expression of the firefly luciferase gene in vaccinia virus: a highly sensitive gene marker to follow virus dissemination in tissues of infected animals. Proc. Natl. Acad. Sci. USA 85:1667-1671.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1667-1671
    • Rodríguez, J.F.1    Rodríguez, D.2    Rodríguez, J.R.3    McGowan, E.B.4    Esteban, M.5
  • 45
    • 0029985795 scopus 로고    scopus 로고
    • Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance
    • Rolph, M. S., I. A. Ramshaw, K. A. Rotkett, J. Ruby, and W. B. Cowden. 1996. Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance. Virology 217:470-477.
    • (1996) Virology , vol.217 , pp. 470-477
    • Rolph, M.S.1    Ramshaw, I.A.2    Rotkett, K.A.3    Ruby, J.4    Cowden, W.B.5
  • 48
    • 0030843346 scopus 로고    scopus 로고
    • The role of cellular immunity in protection against HIV-1 infection
    • Rowland-Jones, S. L., H. Tan, and A. J. McMichael. 1997. The role of cellular immunity in protection against HIV-1 infection. Adv. Immunol. 65:277-346.
    • (1997) Adv. Immunol. , vol.65 , pp. 277-346
    • Rowland-Jones, S.L.1    Tan, H.2    McMichael, A.J.3
  • 49
  • 51
    • 0031924077 scopus 로고    scopus 로고
    • Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    • Schneider, J., S. Gilbert, T. J. Blanchard, T. Hanke, K. J. Robson, C. M. Hannan, M. Becker, R. Sinden, G. L. Smith, and A. V. S. Hill. 1998. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat. Med. 4:397-402.
    • (1998) Nat. Med. , vol.4 , pp. 397-402
    • Schneider, J.1    Gilbert, S.2    Blanchard, T.J.3    Hanke, T.4    Robson, K.J.5    Hannan, C.M.6    Becker, M.7    Sinden, R.8    Smith, G.L.9    Hill, A.V.S.10
  • 52
    • 0030735550 scopus 로고    scopus 로고
    • Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: Effect of coinjection with a granulocytemacrophage colony stimulation factor gene
    • Sin, J. I., J. H. Sung, V. S. Suh, A. H. Lee, J. H. Chung, and Y. C. Sung. 1997. Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: effect of coinjection with a granulocytemacrophage colony stimulation factor gene. Vaccine 15:1827-1833.
    • (1997) Vaccine , vol.15 , pp. 1827-1833
    • Sin, J.I.1    Sung, J.H.2    Suh, V.S.3    Lee, A.H.4    Chung, J.H.5    Sung, Y.C.6
  • 54
    • 0033579881 scopus 로고    scopus 로고
    • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis
    • Tarrant, T. K., P. B. Silver, J. L. Wahltesn, L. V. Rizzo, C. C. Chan, B. Wiggert, and R. R. Caspi. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis. J. Exp. Med. 189:219-230.
    • (1999) J. Exp. Med. , vol.189 , pp. 219-230
    • Tarrant, T.K.1    Silver, P.B.2    Wahltesn, J.L.3    Rizzo, L.V.4    Chan, C.C.5    Wiggert, B.6    Caspi, R.R.7
  • 55
    • 0028043326 scopus 로고
    • Interleukin 12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri, G. 1994. Interleukin 12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008-4027.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 57
    • 0028902839 scopus 로고
    • Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
    • Xiang, Z., and H. C. J. Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129-135.
    • (1995) Immunity , vol.2 , pp. 129-135
    • Xiang, Z.1    Ertl, H.C.J.2
  • 58
    • 0033605274 scopus 로고    scopus 로고
    • IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine
    • Xin, K. Q., K. Hamajima, S. Sasaki, T. Tsuji, S. Watabe, E. Okada, and K. Okuda. 1999. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine 17:858-866.
    • (1999) Vaccine , vol.17 , pp. 858-866
    • Xin, K.Q.1    Hamajima, K.2    Sasaki, S.3    Tsuji, T.4    Watabe, S.5    Okada, E.6    Okuda, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.