IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2912-2921

  Sin, Jeong Im ^a   Kim, Jong J ^a   Arnold, Renee L ^b   Shroff, Khushroo E ^b   McCallus, Don ^b   Pachuk, Cathy ^b   McElhiney, Sue P ^b   Wolf, Mary W ^b   Pompa de Bruin, Sylvia J ^b   Higgins, Terry J ^b   Ciccarelli, Richard B ^b   Weiner, David B ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Wyeth Lederle Vaccines   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; HERPES VACCINE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1; RANTES; RECOMBINANT INTERLEUKIN 12; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; HERPES SIMPLEX VIRUS 2; INTERFERON PRODUCTION; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, LY; CYTOKINES; FEMALE; HERPESVIRUS 2, HUMAN; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RANTES; TH1 CELLS; VACCINES, DNA; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES;

EID: 0033104744     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Robertson, M. J., R. J. Soiffer, S. F. Wolf, T. J. Manley, C. Donahue, D. Young, S. H. Hermann, and J. Ritz. 1992. Responses of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med. 175:779.
2. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulator factor (NKSF): a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
3. Germann, T., M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S.-C. Jin, E. Schmitt, and E. Rude. 1993. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1762.
4. Rakhmlevich, A., J. Turner, M. Ford, D. McCabe, W. Sun, P. Sondel, K. Grota, and N. Yang. 1996. Gene gun-mediated skin transfection with interleukin-12 gene results in regression of established primary and metastatic murine tumors. Proc. Natl. Acad. Sci. USA 93:6291.
5. Yu, W. G., M. Ogawa, J. Mu, K. Umehara, T. Tsujimura, H. Fujiwara, and T. Hamaoka. 1997. IL-12-induced tumor regression correlates with in situ activity of IFN-γ produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways. J. Leukcoyte Biol. 62:450.
6. Dias, S., H. Thomas, and F. Balkwill. 1998. Multiple molecular and cellular changes associated with tumor stasis and regression during IL-12 therapy of a murine breast cancer model. Int. J. Cancer 75:151.
7. Bi, Z., P. Quandt, T. Komatsu, M. Barna, and C. S. Reiss. 1995. IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J. Immunol. 155:5684.
8. Orange, J. S., and C. A. Biron. 1996. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:4746.
9. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 in the responses and susceptibility to experimental viral infections. J. Immunol. 152:1253.
10. Rossol, S., G. Marinos, P. Carucci, M. V. Singer, R. Williams, and N. V. Naoumov. 1997. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99:3025.
11. Carr, J. A., J. Rogerson, M. J. Mulqueen, N. A. Roberts, and R. F. G. Booth. 1997. Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections. J. Virol. 71:7799.
12. Miller, M. A., M. J. Skeen, and H. K. Ziegler. 1996. Protective immunity to Listeria monocytogenes elicited by immunization with heat-killed Listeria and IL-12: potential mechanism of IL-12 adjuvanticity. Ann. NY Acad. Sci. 797:207.
13. Kim, J. J., V. Ayyavoo, M. L. Bagarazzi, M. A. Chattergoon, K. Dang, B. Wang, J. D. Boyer, and D. B. Weiner. 1997. In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158:816.
14. Iwasaki, A., B. J. Stiernholm, A. K. Chan, N. L. Berstein, and B. H. Barber. 1997. Enhanced CTL responses mediated by plasmid DNA immunogens encoding co-stimulatory molecules and cytokines. J. Immunol. 158:4591.
15. Iwasaka, T., J. F. Sheridan, and L. Aurelian. 1983. Immunity to herpes simplex virus type 2: recurrent lesions are associated with the induction of suppressor cells and soluble suppressor factors. Infect. Immun. 42:955.
16. Sethi, K. K., Y. Omata, and K. E. Schneweis. 1983. Protection of mice from lethal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes. J. Gen. Virol. 64:443.
17. + T lymphocytes. J. Immunol. 155:259.
18. McKendall, R. R. 1983. Delayed IgG-mediated clearance of herpes simplex virus type 1 from the CNS but not the footpad during the early stages of infection: possible result of relative integrity of the blood-brain barrier. J. Gen. Virol. 64: 1965.
19. Pachuk, C. J., R. Arnold, K. Herold, R. B. Ciccarelli, and T. J. Higgins. 1998. Humoral and cellular immune responses to herpes simplex virus-2 glycoprotein D generated by facilitated DNA immunization of mice. Curr. Top. Microbiol. Immunol. 226:79.
20. Milligan, G. N., and D. I. Bernstein. 1995. Generation of humoral immune responses against herpes simplex virus type 2 in the murine female genital tract. Virology 206:234.
21. Ortega, G., P. E. Korty, E. M. Shevach, and T. R. Malek. 1996. Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a non-polymorphic Ly-6 specificity. J. Immunol. 137:3240.
22. Codias, E. K., C. Cray, R. D. Baler, R. B. Levy, and T. R. Malek. 1989. Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes. Immunogenetics 29:98.
23. Oppenheim, J. J., C. O. Zachariae, N. Mukaida, and K. Matsushima. 1991. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol. 9:617.
24. Schall, T. J. 1991. Biology of the RANTES/SIS cytokine family. Cytokine 3:165.
25. + T cells. Science 270:1811.
26. Manickan, E., S. Kanangat, R. J. Rouse, Z. Yu, and B. T. Rouse. 1997. Enhancement of immune responses to naked DNA vaccine by immunization with transfected dendritic cells. J. Leukocyte Biol. 61:125.
27. Milligan, G. N., and D. I. Bernstein. 1995. Analysis of herpes simplex virus-specific T cells in the murine female genital tract following genital infection with herpes simplex virus type 2. Virology 212:481.
28. Bourne, N., L. R. Stanberry, D. I. Bernstein, and D. Lew. 1996. DNA immunization against experimental genital herpes simplex virus infection. J. Infect. Dis. 173:800.
29. Kriesel, J. D., S. L. Spruance, R. A. Daynes, and B. A. Araneo. 1996. Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. J. Infect. Dis. 173:536.
30. Nahmias, A. J., J. Dannenbarger, C. Wickliffe, and J. Muther. 1980. Clinical Aspects of Infection with Herpes Simplex Virus 1 and 2. Elsevier, New York.
31. Price, R. W., M. A. Walz, C. Wohlenberg, and A. L. Notkins. 1975. Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. Science 188:938.
32. Long, D., T. J. Madara, M. P. de Leon, G. H. Cohen, P. C. Montgomery, and R. J. Eisenberg. 1984. Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2. Infect. Immun. 43:761.
33. Manickan, E., Z. Yu, R. J. D. Rouse, W. S. Wire, and B. T. Rouse. 1995. Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27. Viral Immunol. 8:53.
34. Ghiasi, H., R. Kaiwar, A. Nesburn, and S. Wechsler. 1992. Baculovirus-expressed herpes simplex virus type 1 glycoprotein C protects mice from lethal HSV-1 infection. Antiviral Res. 18:291.
35. Ghiasi, H., R. Kaiwar, A. Nesburn, S. Slanina, and S. Wechsler. 1992. Baculovirus-expressed glycoprotein E (gE) of herpes simplex virus type-1 (HSV-1) protects mice against lethal intraperitoneal and lethal ocular HSV-1 challenge. Virology 188:469.
36. Ghiasi, H., R. Kaiwar, A. Nesburn, and S. Wechsler. 1992. Expression of herpes simplex virus type 1 glycoprotein I in baculovirus: preliminary biochemical characterization and protection studies. J. Virol. 66:2505.
37. Boyer, J. D., K. E. Ugen, B. Wang, M. Agadjanyan, L. Gilbert, M. L. Bagarazzi, M. Chattergoon, P. Frost, A. Javadian, W. V. Williams, et al. 1997. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat. Med. 3:526.
38. Donnelly, J. J., D. Martinez, K. U. Jansen, R. W. Ellis, D. L. Montgomery, and M. A. Liu. 1996. Protection against papilloma virus with a polynucleotide vaccine. J. Infect. Dis. 173:314.
39. Sin, J. I., J. H. Sung, Y. S. Suh, A. H. Lee, J. H. Chung, and Y. C. Sung. 1997. Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: effect of co-injection with a granulocyte, macrophage-colony stimulating factor gene. Vaccine 15:1827.
40. Ulmer, J. B., J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. L. Dwarki, S. H. Gromkowski, R. Deck, C. M. DeVitt, A. Friedman, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745.
41. Xiang, Z. Q., S. Spitalnik, M. Tran, W. H. Wunner, J. Cheng, and H. C. J. Ertl. 1994. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199:132.
42. Xiang, Z., and H. C. Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129.
43. Chow, Y.-H., W.-L. Huang, W.-K. Chi, Y.-D. Chu, and M.-H. Tao. 1997. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J. Virol. 71:169.
44. Kim, J. J., M. L. Bagarazzi, N. Trivedi, Y. Hu, M. A. Chattergoon, K. Dang, S. Mahalingam, M. G. Agadjanyan, J. D. Boyer, B. Wang, et al. 1997. Engineering of in vivo immune responses to DNA immunization via co-delivery of costimulatory molecule genes. Nat. Biotech. 15:641.
45. Kim, J. J., N. N. Trivedi, L. Nottingham, L. Morrison, A. Tsai, Y. Hu, S. Mahalingam, K. Dang, L. Ahn, N. K. Doyle, et al. 1998. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur. J. Immunol. 28: 1089.
46. Tumpey, T. M., H. Cheng, X.-T. Yan, J. E. Oakes, and R. N. Lausch. 1998. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. J. Leukocyte Biol. 63:486.
47. Kim, J. J., L. K. Nottingham, J. I. Sin, A. Tsai, L. Morrison, K. Dang, Y. Hu, K. Kazahaya, M. Bennett, T. Dentchev, et al. 1998. CD8 positive T-cells influence antigen-specific immune responses through the expression of chemokines. J. Clin. Invest. 102:1112.
48. Rager-Zisman, B., and A. C. Allison. 1976. Mechanism of immunologic resistance to herpes simplex virus (HSV-1) infection. J. Immunol. 116:35.
49. Notkins, A. L. 1974. Immune mechanisms by which the spread of viral infections is stopped. Cell. Immunol. 11:478.
50. Eis-Hubinger, A. M., D. S. Schmidt, and K. E. Schneweis. 1993. Anti-glycoprotein B monoclonal antibody protects T cell depleted mice against herpes simplex virus by inhibition of virus replication at the inoculated mucous membrane. J. Gen. Virol. 74:379.
51. Kohl, S., S. E. Starr, J. M. Oleske, S. L. Shore, R. B. Ashman, and A. J. Nahmias. 1977. Human monocyte-macrophage-mediated antibody dependent cytotoxicity to herpes simplex virus-infected cells. J. Immunol. 118:729.
52. Norrild, B., S. L. Shore, and A. J. Nahmias. 1979. Herpes simplex virus glycoproteins: participation of individual herpes simplex virus type 1 glycoprotein antigens in immunocytosis and their correlation with previously identified glycopolypeptides. J. Virol. 32:741.
53. Shore, S. L., T. L. Cromeans, and B. Norrild. 1979. Early damage of herpes infected cells by antibody-dependent cellular cytotoxicity: relative roles of virus-specific cell surface antigens and input virus. J. Immunol. 123:2239.
54. + CTL clones recognize HSV-2 infected fibroblasts after treatment with IFN-γ or when virion host shutoff functions are disabled. J. Immunol. 156:3901.
55. + T cells produce γ-interferon in patients with recurrent herpes labialis. J. Immunol. 132:197.
56. Smith, P. M., R. M. Wolcott, R. Chervenak, and S. R. Jennings. 1994. Control of acute cutaneous herpes simplex virus infection: T cell-mediated viral clearance is dependent upon interferon-γ (IFN-γ). Virology 202:76.
57. Samuel, C. E. 1991. Antiviral actions of interferon: interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1.
58. Croen, K. D. 1993. Evidence for antiviral effect of nitric oxide: inhibition of herpes simplex virus type 1 replication. J. Clin. Invest. 91:2446.
59. Erbe, D. V., J. E. Collins, L. Shen, R. F. Graziano, and M. W. Fanger. 1990. The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells. Mol. Immunol. 27:57.
60. Habu, S., K. I. Akamatsu, N. Tamaoki, and K. Okumura. 1984. In vivo significance of NK cell on resistance against virus (HSV-1) infections in mice. J. Immunol. 133:2743.
61. Minato, N., L. Reid, H. Cantor, P. Lengyel, and B. R. Bloom. 1980. Mode of regulation of natural killer cell activity by interferon. J. Exp. Med. 152:124.