Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells

Kidney International

Volumn 54, Issue 2, 1998, Pages 399-406

  Ueda, Norishi ^a   Kaushal, Gur P ^a   Hong, Xiaoman ^a   Shah, Sudhir V ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Ceramide; Ceramide synthase; Endonuclease; Fumonisin B1; Hypoxia; LLC PK1 cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; CERAMIDE; CERAMIDE DERIVATIVE; DNA FRAGMENT; FUMONISIN B1; GLUCOSE; SPHINGOSINE ACYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL HYPOXIA; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; KIDNEY CELL; KIDNEY EPITHELIUM; NONHUMAN; PRIORITY JOURNAL;

EID: 0031848460     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00008.x     Document Type: Article

References (49)

1. HANNUN YA: The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269:3125-3128, 1994
2. HANNUN YA: Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1859, 1996
3. PENA LA, FUKS Z, KOLESNICK R: Stress-induced apoptosis and the sphingomyelin pathway. Biochem Pharmacol 53:615-621, 1997
4. UEDA N, SHAH SV: Apoptosis. J Lab Clin Med 124:169-177, 1994
5. SCHUMER M, COLOMBEL MC, SAWCZUK IS, GOBE G, CONNOR J, O'TOOLE KM, OLSSON CA, WISE GJ, BUTTYAN R: Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 140:831-838, 1992
6. NOGAE S, KOJI T, NAKANISHI Y, SAITO T, ABE K, NAKANE PK: Induction of apoptosis in ischemia-reperfusion kidney model: Appearance of DNA strand breaks and expression of FAS mRNA. (abstract) J Am Soc Nephrol 5:905, 1994
7. TERADA Y, TOMITA K, YAMADA T, NONOGUCHI H, MARUMO F: Apoptosis-related genes IL1-beta converting enzyme (ICE), Bcl-2, Fas, Fas-ligand (Fas-L) are expressed in microdissected rat nephron segments and changed in renal damage. (abstract) J Am Soc Nephrol 5:911, 1994
8. TAIRA T, YOSHIMURA A, INUI K, IIZUKA K, IWASAKI S, IDEURA T: Expression of apoptosis-related molecules in repair process from acute renal failure in rats. (abstract) J Am Soc Nephrol 5:910, 1994
9. GOTTLIEB RA, BURLESON KO, KLONER RA, BABIOR BM, ENGLER RL: Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94:1621-1628, 1994
10. UEDA N, WALKER PD, HSU SM, SHAH SV: Activation of a 15-kDa endonuclease in hypoxia/reoxygenation injury without morphologic features of apoptosis. Proc Natl Acad Sci USA 92:7202-7206, 1995
11. 1 cells. Kidney Int 49:355-361, 1996
12. HAGAR H, UEDA N, SHAH SV: Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Am J Physiol 271:F209-F215, 1996
13. 1). Relationships to phospholipid degradation and unesterifed fatty acid accumulation. J Clin Invest 81:745-758, 1988
14. IWATA M, MYERSON D, TOROK-STORB B, ZAGER RA: An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury. J Am Soc Nephrol 5:1307-1313, 1994
15. KUBOTA M, NARITA K, NAKAGOMI T, TAMURA A, SHIMASAKI H, UETA N, YOSHIDA S: Sphingomyelin changes in rat cerebral cortex during focal ischemia. Neurol Res 18:337-341, 1996
16. ZAGER RA, IWATA M, CONRAD DS, BURKHART KM, IGARASHI Y: Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure. Kidney Int 52:60-70, 1997
17. DE CHAVES EIP, BUSSIERE M, VANCE DE, CAMPENOT RB, VANCE JE: Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. J Biol Chem 272:3028-3035, 1997
18. YOO HS, NORRED WP, SHOWKER J, RILEY RT: Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol Appl Pharmacol 138:211-218, 1996
19. BLIGH EG, DYER WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1959
20. VAN VELDHOVEN PP, BISHOP WR, BELL RM: Enzymatic quantification of sphingosine in the picomole range in cultured cells. Anal Biochem 183:177-189, 1989
21. AMES BN, DUBIN DT: The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem 235:769-775, 1960
22. UEDA N, SHAH SV: Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells. J Clin Invest 90:2593-2597, 1992
23. JAYADEV S, LIU B, BIELAWSKA AE, LEE JY, NAZAIRE F, PUSHKAREVA MY, OBEID LM, HANNUN YA: Role for ceramide in cell cycle arrest. J Biol Chem 270:2047-2052, 1995
24. OBEID LM, LINARDIC CM, KAROLAK LA, HANNUN YA: Programmed cell death induced by ceramide. Science 259:1769-1771, 1993
25. ZHANG J, ALTER N, REED JC, BORNER C, OBEID LM, HANNUN YA: Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci USA 93:5325-5328, 1996
26. JARVIS WD, KOLESNICK RN, FORNARI FA, TRAYLOR RS, GEWIRTZ DA, GRANT S: Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci USA 91:73-77, 1994
27. ESTEVE P, DEL PESO L, LACAL JC: Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. Oncogene 11:2657-2665, 1995
28. HARTFIELD PJ, MAYNE GC, MURRAY AW: Ceramide induces apoptosis in PC12 cells. FEBS Lett 401:148-152, 1997
29. KIM MY, LINARDIC C, OBEID L, HANNUN Y: Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. J Biol Chem 266:484-489, 1991
30. CAI Z, BETTAIEB A, MAHDANI NE, LEGRES LG, STANCOU R, MASLIAH J. CHOUAIB S: Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-α-mediated cytotoxicity. J Biol Chem 272:6918-6926, 1997
31. QUINTANS J, KILKUS J, MCSHAN CL, GOTTSCHALK AR, DAWSON G: Ceramide mediates the apoptotic response of WEH1 231 cells to anti-immunoglobulin. corticosteroids and irradiation. Biochem BioPhys Res Commun 202:710-714, 1994
32. CHMURA SJ, NODZENSKI E, BECKETT MA, KUFE DW, QUINTANS J, WEICHSELBAUM RR: Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 57:1270-1275, 1997
33. HAIMOVITZ-FRIEDMAN A, KAN CC, EHLEITER D, PERSAUD RS, MCLOUGHLIN M, FUKS Z, KOLESNICK RN: Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180:525-535, 1994
34. TEPPER CG, JAYADEV S, LIU B, BIELAWSKA A, WOLFF R, YONEHARA S, HANNUN YA, SELDIN MF: Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci USA 92: 8443-8447, 1995
35. CIFONE MG, DE MARIA R, RONCAIOLI P, RIPPO MR, AZUMA M, LANIER LL, SANTONI A, TESTI R: Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 180: 1547-1552, 1994
36. MATHIAS S, YOUNES A, KAN CC, ORLOW I, JOSEPH C, KOLESNICK RN: Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259:519-522, 1993
37. DOBROWSKY RT, WERNER MH, CASTELLINO AM, CHAO MV, HANNUN YA: Activation of the sphingomyelin cycle through the low-affinity neurotropin receptor. Science 256:1596-1599, 1994
38. BOSE R, VERHEIJ M, HAIMOVITZ-FRIEDMAN A, SCOTTO K, FUKS Z, KOLESNICK R: Ceramide synthase mediates daunorubicin-induced apoptosis:An alternative mechanism for generating death signals. Cell 82:405-414, 1995
39. NICULESCU F, RUS H, SHIN S, LANG T, SHIN ML: Generation of diacylglycerol and ceramide during homologous complement activation. J Immunol 150:214-224, 1993
40. VERHEIJ M, BOSE R, LIN XH, YAO B, JARVIS WD, GRANT S, BIRRER MJ, SZABO E, ZON LI, KYRIAKIS JM, HAIMOVITZ-FRIEDMAN A, FUKS Z, KOLESNICK RN: Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis. Nature 380:75-79, 1996
41. MORELL P, RADIN NS: Specificity in ceramide biosynthesis from long chain hases and various fatty acyl Coenzyme A's. J Biol Chem 245:342-350, 1970
42. SRIBNEY M: Enzymatic synthesis of ceramide. Biochim Biophys Acta 125:542-547, 1966
43. SINGH I, KISHIMOTO Y: Ceramide synthesis in rat brain: Characterization of the synthesis requiring pyridine nucleolide. Arch Biochem Biophys 202:93-100, 1980
44. SHIMENO H, SOEDA S, YASUKOUCHI M, OKAMURA N, NAGAMATSU A: Fatty acyl-Co A:sphingosine acyltransferase in bovine brain mitochondria:its solubilization and reconstitution onto the membrane lipid liposomes. Biol Pharm Bull 18:1335-1339, 1995
45. MANDON EC, EHSES I, ROTHER J, VAN ECHTEN G, SANDHOFF K: Subcellular localization and membrane topology of serine palmitoyl-transferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J Biol Chem 267:11144-11148, 1992
46. HIRCHBERG K, RODGER J, FUTERMAN AH: The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem J 290:751-757, 1993
47. BIELAWSKA A, CRANE HM, LIOTTA D, OBEID LM, HANNUN YA: Selectivity of ceramide-mediated biology. Lack of activity of erythrodihydroceramide. J Biol Chem 268:26226-26232, 1993
48. ARORA AS, JONES BJ, PATEL TC, BRONK SF, GORES GJ: Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat. Hepatology 25:958-963, 1997
49. IWATA M, HERRINGTON J, ZAGER RA: Sphingosine: A mediator of acute renal tubular injury and subsequent cytoresistance. Proc Natl Acad Sci USA 92:8970-8974, 1995