Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation

Antioxidants and Redox Signaling

Volumn 2, Issue 2, 2000, Pages 263-275

  Fernández Ayala, Daniel J M ^a   Martín, Sergio F ^b   Barroso, María P ^b   Gómez DÍAZ, Consuelo ^a   Villalba, José M ^b   Rodríguez Aguilera, Juan C ^a   López Lluch, Guillermo ^a   Navas, Plácido ^a  

^a UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CERAMIDE; SPHINGOMYELIN PHOSPHODIESTERASE; UBIDECARENONE;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL PROTECTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPID TRANSPORT; OXIDATIVE STRESS; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0343962580     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2000.2.2-263     Document Type: Article

References (67)

1. 2 production and sphingomyelin metabolism. J. Biol. Chem. 267, 20044-20050.
2. BARROSO, M.P., GÓMEZ-DÍAZ, C., LÓPEZ-LLUCH, G., MALAGON, M.M., CRANE, F.L., and NAVAS, P. (1997a). Ascorbate and a-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2. Arch. Biochem. Biophys. 343, 243-248.
3. BARROSO, M.P., GÓMEZ-DÍAZ, C., VILLALBA, J.M., BURÓN, M.I., LÓPEZ-LLUCH, G., and NAVAS, P. (1997b). Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. J. Bioenerg. Biomemb. 29, 259-267.
4. BEYER, R.E. (1994). The role of ascorbate in antioxidant protection of biomembranes: interaction with vitamin E and coenzyme Q. J. Bioenerg. Biomembr. 26, 349-358.
5. BLIGH, E., and DYER, W. (1959). A rapid method for total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
6. BRUCE-KELLER, A.J., BEGLEY, J.G., FU, W., BUTTERFIELD, D.A., BREDESEN, D.E., HUTCHINS, J.B., HENSLEY, K., and MATTSON, M.P. (1998). Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid β-peptide. J. Neurochem. 70, 31-39.
7. CARDONE, M.H., ROY, N., STENNICKE, H.R., SALVESEN, G.S., FRANKE, T.F., STANBRIDGE, E., FRISCH, S., and REED, J.C. (1998). Regulation of death protease caspase-9 by phosphotylation. Science 282, 1318-1321.
8. CRANE, F.L., SUN, I.L., CLARK, M.G., GREBING, C., and LÖW, H. (1985). Transplasma-membrane redox systems in growth and development. Biochim. Biophys. Acta 811, 233-264.
9. DOBROWSKY, R.F., and HANNUN, Y.A. (1992). Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem. 267, 5048-5051.
10. ENARI, M., HASE, A., and NAGATA, S. (1995). Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 14, 5201-5208.
11. ENARI, M., TALANIAN, R.V., WONG, W.W., and NAGATA, S. (1996). Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.
12. FREI, B. (1994). Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am. J. Med. 97, 5S-13S.
13. GARCÍA-CALVO, M., PETERSON, E.P., LEITING, B., RUEL, R., NICHOLSON, D.W., and THORNBERRY, N.A. (1998). Inhibition of human caspases by peptide-base and macromolecular inhibitors. J. Biol. Chem. 273, 32608-32613.
14. GARCÍA-RUÍZ, C., COLLEL, A., MARÍ, M., MORALES, A., and FERNANDEZ-CHECA, J.C. (1997). Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369-11377.
15. GELEY, S., HARTMANN, B.L., and KOFLER, R. (1997). Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett. 400, 15-18.
16. GREELUND, L.J.S., BECKWERT, T.L., and JOHNSON, E.M.J. (1995). Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14, 303-314.
17. GUDZ, T.I., TSERNG, K.-I., and HOPPEL, C.L. (1997) Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem. 272, 24154-24158.
18. HANNUN, Y.A. (1994). The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269, 3125-3128.
19. HANNUN, Y.A. (1996). Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859.
20. 2 activation. Arch. Biochem. Biophys. 289, 47-52.
21. HOCKENBERY, D.M., OLTVAI, Z.N., YIN, X-M., MILLIMAN, C.L., and KORSMEYER, S.J. (1993). Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
22. ISHIZAKI, Y., CHENG, L., MUDGE, A.W., and RAFF, M.C. (1995). Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells. Mol. Biol. Cell. 6, 1443-1458.
23. JARVIS, W.D., KOLESNICK, R.N., FORNARI, F.A., TRAYLOR, R.S., GEWIRTZ, D.A., and GRANT, S. (1994). Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc. Natl. Acad. Sci. USA 91, 73-77.
24. JAYADEV, S., LINARDIC, C.M., and HANNUN, Y.A. (1994). Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J. Biol. Chem. 269, 5757-5763.
25. JAYADEV, S., LIU, B., BIELAWSKA, A.E., LEE, J.Y., NAZAIRE, F., PUSHKAREVA, M.Y., OBEID, L.M., and HANNUN, Y.A. (1995). Role for ceramide in cell cycle arrest. J. Biol. Chem. 270, 2047-2052.
26. 2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J. Biol. Chem. 272, 17196-17203.
27. KANE, D.J., SARAFIN, T.A., ANTON, R., HAHN, H., GRALLA, E.B., VALENTINE, J.S., ÖRD, T., and BREDENSEN, D.E. (1993). Bcl-2 inhibition of neuronal death: decreased generation of reactive oxygen species. Science 262, 1274-1277.
28. KIM, M-Y., LINARDIC, C., OBEID, L., and HANNUN, Y.A. (1991). Identification of sphingomyelin turnover as an effector for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J. Biol. Chem. 266, 484-489.
29. LEE, J.Y., HANNUN, Y.A., and OBEID, L.M. (1996). Ceramide inactivates cellular protein kinase Ca. J. Biol. Chem. 271, 13169-13174.
30. LIU, B., and HANNUN, Y.A. (1997). Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J. Biol. Chem. 272, 16281-16287.
31. MACHO, A., BLÁZQUEZ, M-V., NAVAS, P., and MUNOZ, E. (1998). Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity. Cell Growth Differ. 9, 277-286.
32. MACHO, A., CALZADO, M.A., MUÑOZ-BLANCO, J., GÓMEZ-DÍAZ, C., GAJATE, C., MOLLINEDO, F., NAVAS, P., and MUÑOZ, E. (1999). Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ. 6, 155-165.
33. MANDALA, S.M., THORNTON, R., TU, Z., KURTZ, M.B., NICKELS, J., BROACH, J., MENZELEEV, R., and SPIEGEL, S. (1998). Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. USA 95, 150-155.
34. MARTIN, J., NEWMEYER, D.D., MATHIAS, S., FARSCHON, D.M., WANG, H-G., REED, J.C., KOLESNICK, R.N., and GREEN, D.R. (1995a). Cell-free reconstitution of Fas-, UV radiation-and ceramide-induced apoptosis. EMBO J. 14, 5191-5200.
35. MARTIN, S.J., O'BRIEN, G.A., NISHIOKA, W.K., McGAHON, A.J., MAHBOUBI, A., SAIDO, T.C., and GREEN, D.R. (1995b). Proteolisis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270, 6425-6428.
36. MARTINUS, R.D., LINNANE, A.W., and NAGLEY, P. (1993). Growth of human namalwa cells lacking oxidative phosphorylation can be sustained by redox compounds ferricyanide or coenzyme Q putatively acting through the plasma membrane oxidase. Biochem. Molec. Biol. Int. 31, 997-100510.
37. MIZUSHIMA, N., KOIKE, R., KOHSAKA, H., KUSHI, Y., HANDA, S., YAGITA, H., and MIYASAKA, N. (1996). Ceramide induces apoptosis via CPP32 activation. FEBS Lett. 395, 267-271.
38. MONNEY, L., OLIVIER, R., OTTER, I., JANSEN, B., POIRIER, G.G., and BORNER, C. (1998). Role of an acidic compartment in tumor-necrosis-factor-α-induced production of ceramide, activation of caspase-3 and apoptosis. Eur. J. Biochem. 251, 295-303.
39. NAVARRO, F., VILLALBA, J.M., CRANE, F.L., MACKELLAR, W.C., and NAVAS, P. (1995). A phospholipid dependent NADH coenzyme Q reductase from liver plasma membrane. Biochem. Biophys. Res. Commun. 212, 138-143.
40. NAVARRO, F., NAVAS, P., BURGESS, J.R., BELLO, R.I., DE CABO, R., ARROYO, A., and VILLALBA, J.M. (1998). Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane. FASEB J. 12, 1665-1673.
41. 2 activation in tumor cell killing by tumour necrosis factor. Immunology 64, 81-85.
42. NEWMEYER, D.D., FARSCHON, D.M., and REED, J.C. (1994). Cell-free apoptosis in Xenopus eggs extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79, 353-364.
43. OBEID, L.M., LINARDIC, C.M., KAROLAK, L.A., and HANNUN, Y.A. (1993). Programmed cell death induced by ceramide. Science 259, 1769-1771.
44. 3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264, 19076-19080.
45. 3-induced HL-60 cell differentiation. J. Biol. Chem. 265, 15832-15831.
46. 3-induced HL-60 cell differentiation. J. Biol. Chem. 269, 4070-4077.
47. PREISS, J., LOOMIS, C.R., BISHOP, W.R., STEIN, R., NIEDEL, J.E., and BELL, K.M. (1986). Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras-and sis-transformed normal rat kidney cells. J. Biol. Chem. 261, 8597-8600.
48. RAFF, M.C. (1992). Social controls on cell survival and cell death. Nature 356, 397-400.
49. RAFF, M.C., BARRES, B.A., BURNE, J.F., COLES, H.S., ISHIZAKI, Y., and JACOBSON, M.D. (1993). Programmed cell death and the control of the survival: lessons from the nervous system. Science 262, 695-700.
50. RAINES, M.A., KOLESNICK, R.N., and GOLDE, D.W. (1993). Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. J. Biol. Chem. 268, 14572-14575.
51. RUVOLO, P.P., DENG, X., ITO, T., CARR, B.K., and MAY, S. (1999). Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274, 20296-20300.
52. SALGO, M.G., CORONGIU, F.P., and SEVANIAN, A. (1993). Enhanced interfacial catalysis and hydrolytic specifity of phospholipase A2 toward peroxidized phosphatidylcholine vesicles. Arch. Biochem. Biophys. 304, 123-132.
53. SLATER, A.F.G., STEFAN, C., NOBEL, I., VAN DEN DOBBELSTEEN, D.J., and ORRENIUS, S. (1996). Intracellular redox changes during apoptosis. Cell Death Differ. 3, 57-62.
54. SMYTH, M.J., PERRY, D.K., ZHANG, J.D., POIRIER, G.G., HANNUN, Y.A., and OBEID, L.M. (1996). prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 316, 25-28.
55. STORRIE, B., and MADDEN, E.A. (1990). Isolation of subcellular organelles. Methods Enzymol. 182, 203-225.
56. 10. Protoplasma 184, 214-219.
57. SUSIN, S.A., ZAMZAMI, N., CASTEDO, M., DAUGAS, E., WANG, H-G., GELEI, S., FASSY, F., REED, J.C., and KROEMER, G. (1997a). The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis. J. Exp. Med. 186, 25-37.
58. SUSIN, S.A., ZAMZAMI, N., LAROCHETTE, N., DALLAPORTA, B., MARZO, Y., BRENNER, C., HIRSCH, T., PETIT, P.X., GEUSKENS, M., and KROEMER, G. (1997b). A cytofluorometric assay of nuclear apoptosis induced in a cell-free system: application to ceramide-induced apoptosis. Exp. Cell Res. 236, 397-403.
59. TEPPER, A., DE VRIES, E., VAN BLITTERSWIJT, W.J., and BORST, J. (1999) Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95-and DNA damage-induced apoptosis. J. Clin. Invest. 103, 971-978.
60. TILLY, J.L., and TILLY, K.I. (1995). Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology 136, 242-252.
61. VAN BROCKLYN, J.R., LEE, M-J., MENZELEEV, R., OLIVERA, A., EDSALL, L., CUVILIER, O., THOMAS, D.M., COOPMAN, P.J.P., THANGADA, S., LIU, X.M., HLA, T., and SPIEGEL, S. (1998). Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142, 229-240.
62. VILLALBA, J.M., NAVARRO, F., CORDOBA, F., SERRANO, A., ARROYO, A., CRANE, F.L., and NAVAS, P. (1995). Coenzyme Q reductase from liver plasma membrane: purification and role in transplasma membrane electron transport. Proc. Natl. Acad. Sci. USA 92, 4887-4891.
63. WEIL, M., JACOBSON, M.D., COLES, H.S.R., DAVIES, T.J., GARDNER, R.L., RAFF, K.D., and RAFF, M.C. (1996). Constitutive expression of the machinery for programmed cell death. J. Cell Biol. 133, 1053-1059.
64. WOLF, C.M., REYNOLDS, J.E., MORANA, S.J., and EASTMAN, A. (1997). The temporal relationship between protein phosphatase, ICE/CED-3 protease, intracellular acidification, and DNA fragmentation in apoptosis. Exp. Cell Res. 230, 22-27.
65. WOLFF, R.A., DOBROWSKY, R.T., BIELAWSKA, A., OBEID, L.M., and HANNUN, Y.A. (1994). Role of ceramide-activated protein phosphatase in ceramide mediated signal transduction. J. Biol. Chem. 269, 19605-19609.
66. WOLVETANG, E.J., LARM, J.A., MOUTSOULAS, P., and LAWEN, A. (1996) Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators. Cell Growth Differ. 7, 1315-1325.
67. YOSHIMURA, S., BANNO, Y., NAKASHIMA, S., TAKENAKA, K., SAKAI, H., NISHIMURA, Y., SAKAI, N., SHIMIZY, S., EGUCHI, Y., TSUJIMOTO, Y., and NOZAWA, Y. (1998). Ceramide formation leads to caspase-3 activation during hypoxic PC12 death. J. Biol. Chem. 273, 6921-6927.