Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic

Journal of Neurochemistry

Volumn 71, Issue 3, 1998, Pages 1068-1074

  Patel, Manisha ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Mn (III) tetrakis (benzoic acid) porphyrin; Neuronal apoptosis; Superoxide dismutase

Indexed keywords

FREE RADICAL; METALLOPORPHYRIN; STAUROSPORINE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CELL PROTECTION; CONCENTRATION RESPONSE; EMBRYO; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031818549     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71031068.x     Document Type: Article

References (32)

1. Baker K., Marcus C. B., Huffman K., Kruk H., Malfroy B., and Doctrow S. R. (1998) Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215-221.
2. Bredesen D. E. (1995) Neural apoptosis. Ann. Neurol. 38, 839-851.
3. Day B. J. and Crapo J. D. (1996) A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo. Toxicol. Appl. Pharmacol. 140, 94-100.
4. Day B. J., Shawen S., Liochev S. I., and Crapo J. D. (1995) Superoxide dismutase mimetics protect against paraquat-induced injury, in vitro. J. Pharmacol. Exp. Ther. 275, 1227-1232.
5. Day B. J., Fridovich I., and Crapo J. D. (1997) Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch. Biochem. Biophys. 347, 256-262.
6. Faulkner K. M., Liochev S. I., and Fridovich I. (1994) Stable Mn(III) porphyrins mimic superoxide dismutase activity in vitro and substitute for it in vivo. J. Biol. Chem. 269, 23471-23476.
7. France-Lanord V., Brugg B., Michel, P. P., Yves A., and Ruberg M. (1997) Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 69, 1612-1621.
8. Ghadge G. D., Lee J. P., Bindokas V. P., Jordan J., Ma L., Miller R. J., and Roos R. P. (1997) Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J. Neurosci. 17, 8756.
9. Greene L. A. (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J. Cell Biol. 78, 747-755.
10. Greenlund L. J. S., Deckwerth T. L., and Johnson E. M. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14, 303-315.
11. Hockenbery D., Oltvai Z., Yin X. M., Milliman C. L., and Korsmeyer S. L. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
12. Jacobson M. and Raff M. C. (1995) Programmed cell death in Bcl-2 protection in very low oxygen. Nature 374, 814-816.
13. Jordan J., Ghadge G. D., Prehn J. H. M., Toth P. T., Roos R. P., and Miller R. J. (1995) Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor. Mol. Pharmacol. 47, 1095-1100.
14. Kane D. J., Sarafian T. A., Anton R., Hahn H., Gralla E. B., Valentine J. S., Ord T., and Bredesen D. E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274-1277.
15. Koh J. Y., Gwag B. J., Sensi S. L., Canzoniero L. M. T., Demaro J., Czernansky C., and Choi D. W. (1995) Staurosporine-induced neuronal apoptosis. Exp. Neurol. 135, 153-159.
16. Mangoura D. and Dawson G. (1998) Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation. J. Neurochem. 70, 130-138.
17. Obeid L. M., Linardic C. M., Karolak K. A., and Hannun Y. A. (1993) Programmed cell death induced by ceramide. Science 259, 1769-1771.
18. Patel M. N. and McNamara J. O. (1995) Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors. Neuroscience 69, 763-770.
19. Patel M. N., Hannun Y. A., and McNamara J. O. (1994) Ceramide-induced cell death in cortical culture. Soc. Neurosci. Abstr. 20, 687.
20. Patel M., Day B. J., Crapo J. D., Fridovich I., and McNamara J. O. (1996) Requirement for superoxide in excitotoxic cell death. Neuron 16, 345-355.
21. 2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis. J. Neurochem. 68, 1679-1685.
22. Quintans J., Kilkus J., McShan C. L., Gottschalk A. R., and Dawson G. (1994) Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobin, corticosteroids and irradiation. Biochem. Biophys. Res. Commun. 202, 710-714.
23. Rabizadeh S., Gralla E. B., Borchelt D. R., Gwin R., Valentine J. S., Sisodia S., Wong P., Lee M., Hahn H., and Bredesen D. E. (1995) Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cell. Proc. Natl. Acad. Sci. USA 92, 3024-3028.
24. Rothstein J. D., Bristol L. A., Holster B., Brown R. H., and Kuncl R. W. (1994) Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc. Natl. Acad. Sci. USA 91, 4155-4159.
25. Shulz J. B., Bremen D., Reed J. C., Lommatzsch J., Takayama S., Wüllner U., Löschmann P. A., Klockgether T., and Weller M. (1997) Cooperative interception of neuronal apoptosis by Bcl-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J. Neurochem. 69, 2075-2086.
26. Srinivasan A., Foster L. M., Testa M. P., Ord T., Keane R. W., Bredesen D. E., and Kayalar C. (1996) Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J. Neurosci. 16, 5654-5660.
27. Szabo C., Day B. J., and Salzman A. L. (1996) Evaluation of the native contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 381, 82-86.
28. Tomkins C. E., Edwards S. N., and Tolkovsky A. M. (1994) Apoptosis is induced in the post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF. J. Cell Sci. 107, 1499-1507.
29. Troy C. M. and Shelanski M. L. (1994) Down-regulation of copper/ zinc superoxide dismutase (SOD1) causes neuronal cell death. Proc. Natl. Acad. Sci. USA 91, 6384-6387.
30. Vassault A. (1983) Lactate dehydrogenase, in Methods of Enzymatic Analysis (Bergmeyer H. U. ed), pp. 118-126. Verlag Chemie, Weinheim.
31. Weisner D. A. and Dawson G. (1996) Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. J. Neurochem. 66, 1418-1425.
32. Zingarelli B., Day B. J., Crapo J. D., Salzman A. L., and Szabo C. (1997) The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br. J. Pharmacol. 120, 259-267.