Chromatin remodeling at the Ig loci prior to V(D)J recombination

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 866-874

  Maes J ^a   O'Neill, L P ^a   Cavelier, P ^a   Turner, B M ^a   Rougeon, F ^a   Goodhardt, M ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; HISTONE H4; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; NUCLEASE;

ACETYLATION; ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CHROMATIN; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE REARRANGEMENT; GENETIC RECOMBINATION; IMMUNOGLOBULIN GENE; IMMUNOPRECIPITATION; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROLYMPHOCYTE;

EID: 0035879185     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.866     Document Type: Article

References (61)

1. Somatic generation of antibody diversity
2. Recent advances in understanding V(D)J recombination
3. Accessibility control of V(D)J recombination: Lessons from gene targeting
4. B-lymphocyte development and biology
5. Mechanism and control of immunoglobulin gene rearrangement
6. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
7. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
8. Histone acetyltransferase complexes
9. ATP-dependent chromatin-remodeling complexes
10. Methylation-induced repression-belts, braces, and chromatin
11. Histone deacetylases: Silencers for hire
12. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
13. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
14. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
15. Methylation status and DNase I sensitivity of immunoglobulin genes: Changes associated with rearrangement
16. Methylation patterns of immunoglobulin genes in lymphoid cells: Correlation of expression and differentiation with undermethylation
17. The coupling between enhancer activity and hypomethylation of κ immunoglobulin genes is developmentally regulated
18. Methylation status of immunoglobulin κ gene segments correlates with their recombination potential
19. κ Chain monoallelic demethylation and the establishment of allelic exclusion
20. Rearranged and germline immunoglobulin κ genes: Different states of DNase I sensitivity of constant κ genes in immunocompetent and nonimmune cells
21. DNase I sensitivity of immunoglobulin light chain genes in Abelson murine leukemia virus transformed pre-B cell lines
22. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
23. Influence of immunoglobulin heavy and light-chain expression on B-cell differentiation
24. Induction of polyoma specific transplantation antigenicity in Moloney leukemia cells
25. A developmentally modulated chromatin structure at the mouse immunoglobulin κ 3′ enhancer
26. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
27. The Igκ L chain allelic groups among the Igκ haplotypes and Igκ crossover populations suggest a gene order
28. Two isoforms of the kidney androgen-regulated protein are encoded by two alleles of a single gene OF1 mice
29. Comparison of mouse and rabbit Eiκ enhancers indicates that different elements within the enhancer may mediate activation of transcription and recombination
30. Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner
31. A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation
32. Immunoglobulin heavy chain loci of mouse and man
33. The variable genes and gene families of the mouse immunoglobulin κ locus
34. Chromosomal subunits in active genes have an altered conformation
35. A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene
36. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription
37. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
38. A role for histone acetylation in the developmental regulation of VDJ recombination
39. Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human β-globin locus
40. Histone acetylation and globin gene switching
41. A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus
42. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes
43. Chromatin remodeling directly activates V(D)J recombination
44. Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment
45. CREB-binding proteirdp300 are translational coactivators of p65
46. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
47. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
48. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex
49. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
50. Repression by Ikaros and Aiolos ís mediated through histone deacetylase complexes
51. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: Implications for the control of TCR-β locus recombination
52. CpG methylation, chromatin structure and gene silencing: A three-way connection
53. Stimulation of )J recombination by histone acetylation
54. Synergy of demethylation and histone deacetylase inhibition in the reexpression of genes silenced in cancer
55. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells
56. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
57. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
58. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division
59. DNA methylation and chromatin modification
60. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells