The variable genes and gene families of the mouse immunoglobulin κ locus

European Journal of Immunology

Volumn 29, Issue 7, 1999, Pages 2072-2081

  Thiebe, Rainer ^a   Schäble, Karlheinz F ^a   Bensch, Alexander ^a   Brensing Küppers, Jutta ^a   Heim, Verena ^a   Kirschbaum, Thomas ^a   Mitlöhner, Heike ^a   Ohnrich, Marion ^a   Pourrajabi, Soheil ^a   Röschenthaler, Franz ^a   Schwendinger, Jürgen ^a   Wichelhaus, Daniel ^a   Zocher, Ines ^a   Zachau, Hans G ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Gene families; Immunoglobulin V gene; Mouse

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EVOLUTION; GENE LOCUS; GENE SEQUENCE; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOGENE; SEQUENCE HOMOLOGY;

ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PSEUDOGENES;

EID: 0344603599     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199907)29:07<2072::AID-IMMU2072>3.0.CO;2-E     Document Type: Article

References (26)

1. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C., Sequences of proteins of immunological interest. NIH Publication 1980. No. 91-3142, Bethesda, Maryland, USA; http://immuno.bme.nwu.edu.
2. Kofler, R., Geley, S., Kofler H. and Helmberg, A., Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol. Rev. 1992. 128: 1-17.
3. Zocher, I., Röschenthaler, F., Kirschbaum, T., Schäble, K. F., Hörlein, R., Fleischmann, B., Kofler, R., Geley, S., Hameister, E. and Zachau, H. G., Clustered and interspersed gene families in the mouse immunoglobulin (greek small letter script kappa) locus. Eur. J. Immunol. 1995. 25: 3326-3331.
4. George, J. B., Li, S. and Garrard, W. T., Yeast artificial chromosome contigs reveal that distal variable-region genes reside at least 3 megabases from the joining regions in the murine immunoglubulin (greek small letter script kappa) locus. Proc. Natl. Acad. Sci. USA 1995. 92: 12421-12425.
5. Kirschbaum, T., Jaenichen, R. and Zachau, H. G., The mouse immunoglobulin (greek small letter script kappa) locus contains about 140 variable gene segments. Eur. J. Immunol. 1996. 26: 1613-1620.
6. Schupp, I. W., Schlake, T., Kirschbaum, T., Zachau, H. G. and Boehm, T., A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus. Immunogenetics 1997. 45: 180-187.
7. Kirschbaum, T., Pourrajabi, S., Zocher, I., Schwendinger, J., Heim, V., Röschenthaler, F., Kirschbaum, V. and Zachau, H. G., The 3′ part of the immunoglobulin (greek small letter script kappa) locus of the mouse. Eur. J. Immunol. 1998. 28: 1458-1466.
8. Kirschbaum, T., Röschenthaler, F., Bensch, A., Hölscher, B., Lautner-Rieske, A., Ohnrich, M., Pourrajabi, S., Schwendinger, J., Zocher, I. and Zachau, H. G., The central part of the mouse immunoglobulin (greek small letter script kappa) locus. Eur. J. Immunol. 1999. 29: 2057-2064.
9. Röschenthaler, F., Kirschbaum, T., Heim, V., Kirschbaum, V., Schäble, K. F., Schwendinger, J., Zocher, I. and Zachau, H. G., The 5′ part of the mouse immunoglobulin (greek small letter script kappa) locus. Eur. J. Immunol. 1999. 29: 2065-2071.
10. Schäble, K. F. and Zachau, H. G., The variable genes of the human immunoglobulin (greek small letter script kappa) locus. Biol. Chem. Hoppe-Seyler 1993. 374: 1001-1023.
11. Klein, R., Jaenichen, R. and Zachau, H. G., Expressed human immunoglobulin (greek small letter script kappa) genes and their hypermutation. Appendix: Klein, R. and Zachau, H. G., Comparison of human germ-line V(greek small letter script kappa) gene sequences to sequence data from the literature. Eur. J. Immunol. 1993. 23: 3248-3271.
12. Even, J., Griffiths, G. M., Berek, C. and Milstein, C., Light chain germ-line genes and the immune response to 2-phenyloxazolone. EMBO J. 1985. 4: 3439-3445.
13. Milstein, C., Even, J., Jarvis, J. M., Gonzalez-Fernandez, A. and Gherardi, E., Non-random features of the repertoire expressed by the members of one V(greek small letter script kappa) gene family and of the V-J recombination. Eur. J. Immunol. 1992. 22: 1627-1634.
14. Seidl, K. J., MacKenzie, J. D., Wang, D., Kantor, A. B., Kabat, E., Herzenberg, L. A. and Herzenberg, L. A., Frequent occurrence of identical heavy and light chain Ig rearrangements. Int. Immunol. 1997. 9: 689-702.
15. Kroemer, G., Helmberg, A., Bernot, A., Auffrey, C. and Kofler, R., Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes. Immunogenetics 1991. 33: 42-49.
16. Kofler, R., Noonan, D. J., Strohal, R., Balderas, R. S., Moller, N. P. H., Dixon, F. J. and Theofilopoulos, A. N., Molecular analysis of the murine lupus-associated anti-self response: involvement of a large number of heavy and light chain variable region genes. Eur. J. Immunol. 1987. 17: 91-95.
17. Strohal, R., Helmberg, A., Kroemer, G. and Kofler, R., Mouse V(greek small letter script kappa) gene classification by nucleic acid sequence similarity. Immunogenetics 1989. 30: 475-493.
18. Liberg, D., Sigvardsson, M., Bemark, M. and Leanderson, T., Differentiation-specific, octamer-dependent costimulation of transcription. J. Immunol. 1998. 160: 3899-3907.
19. Nadel. B., Tang, A, Escuro, G., Lugo, G. and Feeny, A. J., Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with non-random V(greek small letter script kappa) usage in vivo. J. Exp. Med. 1998. 87: 1495-1503.
20. Dattamajumdar, A. K., Jacobson, D. P., Hood, L. E. and Osman, G. E., Rapid cloning of any rearranged mouse immunoglobulin variable genes. Immunogenetics 1996. 43: 141-151.
21. Whitcomb, E. A. and Brodeur, P. H., Rearrangement and selection in the developing V(greek small letter script kappa) repertoire of the mouse: an analysis of the usage of two V(greek small letter script kappa) gene segments. J. Immunol. 1998. 160: 4904-4913.
22. Juul, L., Hougs, L. and Barington, T., A new apparently functional IGKV gene (VkLa) present in some individuals only. Immunogenetics 1998. 48: 40-46.
23. Shefner, R., Mayer, R., Kaushik, A., D'Eustachio, P., Bona, C. and Diamond, B., Identification of a new V(greek small letter script kappa) gene family that is highly expressed in hybridomas from an autoimmune strain. J. Immunol. 1990. 145: 1609-1614.
24. Tomlinson, I. M., Cox, J. P. L., Gherardi, E., Lesk, A. M. and Chothia, C., The structural repertoire of the human V(greek small letter script kappa) domain. EMBO J. 1995. 14: 4628-4638.
25. Sanger, F., Nicklen, S. and Coulson, A. R., DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 1977. 74: 5463-5467.
26. Kettleborough, C. A., Saldanha, J., Ansell, K. H. and Bendig, M. M., Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction. Eur. J. Immunol. 1993. 23: 206-211.