Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription

Journal of Cellular Biochemistry

Volumn 70, Issue 2, 1998, Pages 281-287

  De Luca, Pasquale ^a,b   Majello, Barbara ^a,b   Lania, Luigi ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

Repressor; Retinoblastoma protein; TATA binding protein; TSA

Indexed keywords

CELL CYCLE PROTEIN; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; HISTONE DEACETYLASE; REGULATOR PROTEIN; REPRESSOR PROTEIN; RETINOBLASTOMA PROTEIN; RNA POLYMERASE II; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR E2F; TRICHOSTATIN A;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA;

CELL LINE; CHROMATIN; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEINS; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0031803929     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19980801)70:2<281::AID-JCB13>3.0.CO;2-Q     Document Type: Article

References (27)

1. Bartek J, Bartkova J, Lukas J (1996): The retinoblastoma protein pathway and the restriction point. Curr Op Cell Biol 8:805-814.
2. Brehm A, Miska EA, McCance DJ, Reid J, Bannister AJ, Kouzarides T (1998): Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597-601.
3. Bremner R, Cohen BL, Sopta M, Hamel PA, Ingles CJ, Gallie BL, Phillips RA (1995): Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol 15:3256-3265.
4. Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todorov G, Rothblum LI (1995): Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product [see comments]. Nature 374:177-180.
5. Chatterjee S, Struhl K (1995): Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain. Nature 374:820-822.
6. De Luca P, Majello B, Lania L (1996): Sp3 represses transcription when tethered to promotrer DNA or targeted to promoter proximal RNA. J Biol Chem 271:8533-8536.
7. Gossen M, Bujard H (1992): Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sc USA 89:5547-5551.
8. Grunstein M (1997): Histone acetylation in chromatin structure and transcription. Nature 389:349-352.
9. Helin K, Harlow E, Fattaey A (1993): Inhibition of E2F-1 transactivation by direct binding of the retonoblastoma protein. Mol Cell Biol 13:6501-6508.
10. Hernandez N (1993): TBP, a universal eukaryotic transcription factor? Genes Dev 7:1291-308.
11. Hiebert SW, Chellappan SP, Horowitz JM, Nevins JR (1992): The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 6:177-185.
12. Klages N, Strubin M (1995): Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo. Nature 374:822-823.
13. Luo RX, Postigo AA, Dean DC (1998): Rb intercts with histone deacetylase to repress transcription. Cell 92: 463-473.
14. Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, LeVillai JP, Troalen F, Trouche D, Harel-Bellan A (1998): Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-604.
15. Majello B, De Luca P, Lania L (1997): Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 272:4021-4027.
16. Pazin MJ, Kadonaga JT (1997): What's up and down with histone deacetylation and transcription? Cell 89:325-328.
17. Penguc G, Lania L (1996): KRAB-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements. Proc Natl Acad Sci USA 93:1015-1020.
18. Sanchez I, Dynlacht B (1996): Transcriptional control of the cell cycle. Curr Opin Cell Biol 8:318-324.
19. Seipel K, Georgiev O, Gerber H-P, Schaffner W (1993): C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional activation, respectively. Nucl Acids Res 21:5609-5615.
20. Sellers WR, Rodgers JW, Kaelin W, Jr. (1995): A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci USA 92:11544-11548.
21. Taunton J, Hassig CA, Schreiber SL (1996): A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3. Science 272:498-411.
22. Weinberg RA (1995): The retinoblastoma protein and cell cycle. Cell 81:323-330.
23. Weintraub SJ, Chow KN, Luo RX, Zhang SH, He S, Dean DC (1995): Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
24. Weintraub SJ, Prater CA, Dean DC (1992): Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358:259-261.
25. White RJ, Trouche D, Martin K, Jackson SP, Kouzarides T (1996): Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382:88-90.
26. Wolffe AP, Pruss D (1996): Targeting chromatin distruption: transcription regulators that acetylase histones. Cell 84:817-819.
27. Xiao H, Lis TJ, Jeang K-T (1997): Promoter activity of Tat at steps subsequent to TATA-binding protein recruitment. Mol Cell Biol 17:6898-6905.