Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, MDR3 P-glycoprotein with a panel of monoclonal antibodies

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5269-5277

  Scheffer, G L ^a   Kool, M ^a   Heijn, M ^a   De Haas, M ^a   Pijnenborg, A C L M ^a   Wijnholds, J ^a   Van Helvoort, A ^a   De Jong, M C ^a   Hooijberg, J H ^a   Mol, C A A M ^a   Van der Linden, M ^a   De Vree, J M L ^a   Van der Valk, P ^a   Oude Elferink, R P J ^a   Borst, P ^a   Scheper, R J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HYBRID PROTEIN; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE 3 P GLYCOPROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME SPECIFICITY; EPITOPE MAPPING; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SCREENING TEST;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; CROSS REACTIONS; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORMALDEHYDE; FROZEN SECTIONS; GUINEA PIGS; HUMAN; IMMUNOHISTOCHEMISTRY; MICE; NEOPLASM PROTEINS; PARAFFIN EMBEDDING; RATS; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SWINE; TISSUE FIXATION; TUMOR CELLS, CULTURED;

EID: 0034665559     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Multidrug resistance
2. P-Glycoprotein and multidrug resistance
3. Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
4. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
5. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
6. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
7. MRP3, an organic anion transporter able to transport anti-cancer drugs
8. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
9. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATPase-dependent drug transport
10. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
11. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
12. A multidrug resistance transporter from human MCF-7 breast cancer cells [erratum in PNAS USA, 96: 2569, 1999]
13. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
14. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
15. ABC transporters-from microorganisms to man
16. ATP-binding-cassette (ABC) transport systems: Functional and structural aspects of the ATP-hydrolyzing subunits/domains
17. Biochemistry of multidrug resistance mediated by the multidrug transporter
18. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
19. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
20. Sequence of mdr3 cDNA encoding a human P-glycoprotein
21. Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies
22. The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein
23. Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes
24. Expression of the mdr3 gene in prolymphocytic leukemia: Association with cyclosporin A-induced increase in drug accumulation
25. Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine
26. Identification of a sister gene to P-glycoprotein
27. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
28. Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein
29. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
30. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
31. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
32. Molecular aspects of hepatobiliary transport
33. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
34. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
35. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
36. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
37. A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome
38. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
39. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRPI and its apical isoform MRP2
40. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
41. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
42. pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
43. Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
44. Mutations in ABCC6 cause pseudoxanthoma elasticum
45. Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum
46. Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multidrug resistance
47. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
48. Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies
49. Functional role for the 170- to 180-kDa glycoprotein specific to drag-resistant tumor cells as revealed by monoclonal antibodies
50. Tissue distribution of the human MDR3 P-glycoprotein
51. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies
52. Preparation and characterization of a murine monoclonal antibody (MDR3M) reactive with mdr3 gene product
53. A new monoclonal antibody that specifically recognises the MDR-3-encoded gene product
54. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
55. Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies
56. Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1
57. Epitope mapping of monoclonal antibodies specific for the 190-kDa multi-drug resistance protein (MRP)
58. Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines
59. Multifactorial drug resistance in an Adriamycin-resistant human small cell lung carcinoma cell line
60. Adriamycin resistance in HL60 cells and accompanying modification of a surface membrane protein contained in drug-sensitive cells
61. Cross-resistance between cisplatin and antimony in a human ovarian carcinoma cell line
62. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
63. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
64. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
65. Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport
66. Ultra-sensitive FISH using peroxidase-mediated deposition of biotinor fluorochrome tyramides
67. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
68. Potent interaction of flavopiridol with MRP1
69. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
70. Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
71. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
72. ATP-and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
73. Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein MRP
74. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
75. Tissue distribution of the multidrug resistance protein
76. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte
77. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone and topotecan resistant cell lines
78. Membrane topology and glycosylation of the human multidrug resistance-associated protein
79. Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus
80. Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein
81. Structure of the human MDR3 gene and physical mapping of the human MDR locus