TGFβ signaling and cancer

Experimental Cell Research

Volumn 264, Issue 1, 2001, Pages 111-116

  Hata, Akiko ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; DNA BINDING PROTEIN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; SMAD4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

APOPTOSIS; CANCER; CARCINOGENESIS; CELL GROWTH; GENE DELETION; GROWTH REGULATION; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; ANIMAL; BIOLOGICAL MODEL; CELL DIVISION; GENETICS; HUMAN; MOUSE; MUTATION; NEOPLASM; PHYSIOLOGY;

ANIMALS; CELL DIVISION; DNA-BINDING PROTEINS; HUMANS; MICE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035835770     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5140     Document Type: Article

References (41)

1. Transcriptional control by the TGFβ/Smad signaling system
2. A Smad transcriptional corepressor
3. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
4. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
5. Differential inhibition of Smad6 and Smad7 on bone morphogen
6. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells
7. Regulation of Smad7 promoter by direct association with Smad3 and Smad4
8. Induction of Smad6 mRNA by bone morphogenetic proteins
9. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest
10. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
11. A role for transcriptional repression ofp21CIP1 by c-Myc in overcoming transforming growth factor β-induced cell cycle arrest
12. Myc downregulation by transforming growth factor β required for activation of the p15(Ink4b). G1 arrest pathway
13. The role of transforming growth factorβ (TGFβ). in human cancer
14. Transforming growth factor-β and cancer: A love-hate relationship?
15. Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
16. Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers
17. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
18. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
19. Parathyroid hormone-related protein and bone metastases
20. TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
21. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
22. Microsatellite instability and mutations of the transforming growth factor type II receptor gene in colorectal cancer
23. Mutation analysis of coding sequences of the entire transforming growth factor β type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers
24. Transforming growth factor β type I receptor kinase mutant associated with metastatic breast cancer
25. A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma
26. TβR-I(6A). is a candidate tumor susceptibility allele
27. Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
28. Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer
29. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
30. Mutations in the SMAD4/DPC4 gene in juvenile polyposis
31. Mad-related genes in the human
32. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
33. Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers
34. Mutations increasing autoinhibition inactivate the tumour suppressors Smad2 and Smad4
35. Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin-proteasome pathway
36. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
37. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4). and APC genes
38. Smad3 mutant mice develop metastatic colorectal carcinoma
39. Increased Smad expression and activation are associated with apoptosis in normal and malignant prostate after castration
40. The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
41. Smad6 suppresses TGF-β-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer