TβR-I(6A) is a candidate tumor susceptibility allele

Cancer Research

Volumn 59, Issue 22, 1999, Pages 5678-5682

  Pasche, Boris ^a   Kolachana, Prema ^a   Nafa, Khedoudja ^a   Satagopan, Jaya ^b   Chen, Ye Guang ^a   Lo, Roger S ^a   Brener, Dara ^a   Yang, Diana ^a   Kirstein, Laurie ^a   Oddoux, Carole ^c   Ostrer, Harry ^c   Vineis, Paolo ^e   Varesco, Liliana ^f   Jhanwar, Suresh ^a   Luzzatto, Lucio ^a   Massagué, Joan ^a,d   Offit, Kenneth ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Dept of Epidemiol and Biostatist ^*  (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF TURIN   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; ACTIVIN RECEPTOR 1; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ALLELE; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL CANCER; DELETION MUTANT; FEMALE; GENE FREQUENCY; GERM LINE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; BREAST TUMOR; CASE CONTROL STUDY; COLON TUMOR; ETHNOLOGY; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; GERM CELL TUMOR; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; NEOPLASM; OVARY TUMOR;

ACTIVIN RECEPTORS, TYPE I; ALLELES; ANALYSIS OF VARIANCE; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COLONIC NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERMINOMA; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; NEOPLASMS; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033570376     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Tang, B. W., Bottinger, E. P., Jakowlew, S. B., Bagnall, K. M., Mariano, J., Anver, M. R., Letterio, J. J., and Wakefield, L. M. Transforming growth factor-β-1 is a new form of tumor suppressor with true haploid insufficiency. Nat. Med., 4: 802-807. 1998.
2. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., and Vogelstein, B. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability [see comments]. Science (Washington DC), 268: 1336-1338, 1995.
3. Myeroff, L. L., Parsons, R., Kim, S. J., Hedrick, L., Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y. J., Lee, H. Y., Park, J. G., Lynch, H. T., Roberts, A. B., Vogelstein, B., and Markowitz, S. D. A transforming growth factor ßreceptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res., 55: 5545-5547, 1995.
4. Lu, S. L., Zhang, W. C., Akiyama, Y., Nomizu, T., and Yuasa, Y. Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res., 56: 4595-4598, 1996.
5. Garrigue-Antar, L., Munoz-Antonia, T., Antonia, S. J., Gesmonde, J., Vellucci, V. F., and Reiss, M. Missense mutations of the transforming growth factor ßtype II receptor in human head and neck squamous carcinoma cells. Cancer Res., 55: 3982-3987, 1995.
6. Knaus, P. I., Lindemann, D., DeCoteau, J. F., Perlman, R., Yankelev, H., Hille, M., Kadin, M. E., and Lodish, H. F. A dominant inhibitory mutant of the type II transforming growth factor β receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol. Cell. Biol., 16: 3480-3489, 1996.
7. Goggins, M., Shekher, M., Turnacioglu, K., Yeo, C. J., Hruban, R. H., and Kern, S. E. Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res., 58: 5329-5332, 1998.
8. Wang, J., Sun, L. Z., Myeroff, L., Wang, X. F., Gentry, L. E., Yan, J. H., Liang, J. R., Zborowska, E., Markowitz, S., Willson, J. K. V., and Brattain, M. G. Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem., 270: 22044-22049, 1995.
9. Sun, L., Wu, G., Willson, J. K., Zborowska, E., Yang, J., Rajkarunanayake, I., Wang, J., Gentry, L. E., Wang, X. F., and Brattain, M. G. Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem., 269: 26449-26455, 1994.
10. Hahn, S. A., Schutte, M., Hoque, A. T. M. S., Moskaluk, C. A., Dacosta, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. Dpc4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Washington DC), 271: 350-353, 1996.
11. Barrett, M. T., Schutte, M., Kern, S. E., and Reid, B. J. Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma. Cancer Res., 56: 4351-4353, 1996.
12. Kim, S. K., Fan, Y., Papadimitrakopoulou, V., Clayman, G., Hittelman, W. N., Hong, W. K., Lotan, R., and Mao, L. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res., 56: 2519-2521, 1996.
13. Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., Sidransky, D., Casero, R. A., Jr., Meltzer, P. S., Hahn, S. A., and Kern, S. E. DPC4 gene in various tumor types. Cancer Res., 56: 2527-2530, 1996.
14. Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L. C., Bapat, B., Gallinger, S., Andrulis, I. L., Thomson, G. H., Wrana, J. L., and Attisano, L. Madr2 maps to 18q21 and encodes a tgfbeta-regulated mad-related protein that is functionally mutated in colorectal carcinoma. Cell, 86: 543-552, 1996.
15. Lu, S. L., Kawabata, M., Imamura, T., Akiyama, Y., Nomizu, T., Miyazono, K., and Yuasa, Y. HNPCC associated with germline mutation in the TGF-β type II receptor gene. Nat. Genet., 19: 17-18, 1998.
16. Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M., and Aaltonen, L. A. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (Washington DC), 280: 1086-1088, 1998.
17. Wang, J., Man, W., Zborowska, E., Liang, J., Wang, X., Willson, J. K. V., Sun, L., and Brattain, M. G. Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells. J. Biol. Chem., 271: 17366-17371, 1996.
18. Kim, I.Y., Ahn, H-J., Zelner, D. J., Shaw, J. W., Sensibar, J. A., Kim, J-H., Kato, M., and Lee, C. Genetic change in transforming growth factor β (TGF-β) receptor type I gene correlates with insensitivity to TGF-β 1 in human prostate cancer cells. Cancer Res., 56; 44-48, 1996.
19. Chen, T. P., Carter, D., Garrigueantar, L., and Reiss, M. Transforming growth factor β type 1 receptor kinase mutant associated with metastatic breast cancer. Cancer Res., 58: 4805-4810, 1998.
20. Pasche, B., Luo, Y., Rao, P. H., Mimer, S. D., Dmitrovsky, E., Caron, P., Luzzatto, L., Offit, K., Cordoncardo, C., Renault, B., Satagopan, J. M., Murty, V. S., and Massague, J. Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res., 58: 2727-2732, 1998.
21. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., and Massague, J. Mechanism of activation of the TGF-β receptor. Nature (Lond.), 370: 341-347, 1994.
22. Reynisdottir, I., Polyak, K., Iavarone, A., and Massague, J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9: 1831-1845, 1995.
23. Laiho, M., Weis, F. M., Boyd, F. T., Ignotz, R. A., and Massague, J. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J. Biol. Chem., 266: 9108-9112, 1991.
24. Cárcamo, J., Zentella, A., and Massagué, J. Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol. Cell. Biol., 15: 1573-1581, 1995.
25. Weis-Garcia, F., and Massague. J. Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J., 15: 276-289, 1996.
26. Massague, J. Identification of receptor proteins for type-β transforming growth factor. Methods Enzymol., 146; 143-153: 143-153, 1987.
27. Wells, R. G., Yankelev, H., Lin, H. Y., and Lodish, H. F. Biosynthesis of the type I and type II TGF-β receptors-implications for complex formation. J. Biol. Chem., 272: 11444-11451, 1997.
28. Chen, T. P., de Vries, E. G. E., Hollema, H., Yegen, H. A., Vellucci, V. F., Strickler, H. D., Hildesheim, A., and Reiss, M. Structural alterations of transforming growth factor-β receptor genes in human cervical carcinoma. Int. J. Cancer, 82: 43-51, 1999.
29. Franzén, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., and Heldin, C-H. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell, 75: 681-692, 1993.
30. Habuchi, T., Devlin, J., Elder, P. A., and Krowles, M. A. Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci. Oncogene, 11: 1671-1674, 1995.
31. Lynch, H. T., Smyrk, T., and Lynch, J. An update of HNPCC (Lynch syndrome). Cancer Genet. Cytogenet., 93: 84-99, 1997.