Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops

FASEB Journal

Volumn 10, Issue 12, 1996, Pages 1426-1434

  Damaj, Bassam B ^a,b   McColl, Shaun R ^c   Neote, Kuldeep ^e   Songqing, N A ^e   Ogborn, Kevin T ^e   Hébert, Caroline A ^d   Naccache, Paul H ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d GENENTECH INC   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

C X C chemokines; calcium mobilization; Gro ; NAP 2; neutrophils; signal transduction

Indexed keywords

ALANINE; CALCIUM; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM MOBILIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

EID: 0029966772     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.12.8903513     Document Type: Article

References (47)

1. Baggiolini, M., Walz, A., and Kunkel, S. L. (1989) Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84, 1045-1049
2. Baggiolini, M., Dewald, B., and Moser, B. (1994) Interleukin-8 and related cytokines. CXC and CC chemokines. Adv. Immunol. 55, 97-179
3. Westwick, J., Li, S. W., and Camp, R. D. (1989) Novel neutrophil-stimulating peptides. Immunol. Today 10, 146-147
4. Hebert, C. A., and Baker, J. B. (1993) Interleukin-8 - a review. Cancer Invest. 11, 743-750
5. Michel, G., Kemeny, L., Peter, R. U., Beete, A., Ried, C., Arenberger, P., and Ruzicka, T. (1992) Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells. FEBS Lett. 305, 241-243
6. Xu, L. L., Kelvin, D. J., Ye, G. Q., Taub, D. D., Benbaruch, A., Oppenheim, J. J., and Wang, J. M. (1995) Modulation of IL-8 receptor expression on purified human T lymphocytes is associated with changed chemotactic responses to IL-8. J. Leukocyte. Biol. 57, 335-342
7. Bacon, K. B., Floresromo, L., Life, P. F., Taub, D. D., Premack, B. A., Arkinstall, S. J., Wells, T. N. C., Schall, T. J., and Power, C. A. (1995) IL-8-induced signal transduction in T lymphocytes involves receptor-mediated activation of phospholipases C and D. J. Immunol. 154, 3654-3666
8. Dahinden, C. A., Kurimoto, Y., DeWeck, A. L., Lindley, I., Dewald, B., and Baggiolini, M. (1989) The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils. J. Exp. Med. 170, 1787-1792
9. McColl, S. R., Hachicha, M., Levasseur, S., Neote, K., and Schall, T. J. (1993) Uncoupling of early signal transduction events from effector function in human peripheral blood neutrophils in response to recombinant macrophage inflammatory protein-1-alpha and protein-1-beta. J. Immunol. 150, 4550-4560
10. L'Heureux, G., Bourgoin, S., Jean, N., McColl, S. R., and Naccache, P. H. (1994) Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: Interleukin-3, but not NAP-2 or GRO-alpha, stimulates phospholipase D activity. Blood 85, 522-531
11. Detmers, P. A., Lo, S. K., Olsen-Egbert, E., Walz, A., Baggiolini, M., and Cohn, Z. A. (1990) Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171, 1155-1162
12. 2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities. J. Biol. Chem. 266, 23128-23134
13. Bignold, L. P., Harkin, D. G., and Rogers, S. D. (1992) Interleukin-8 and neutrophil leucocytes - Adhesion, spreading, polarisation, random motility, chemotaxis and deactivation in assays using sparse-pore polycarbonate (nuclepore) membranes in the Boyden chamber. Int. Arch. Allergy. Immunol. 97, 350-357
14. Holmes, W. E., Lee, J., Kuang, W.-J., Rice, G. C., and Wood, W. I. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253, 1278-1280
15. Murphy, P. M., and Tiffany, H. L. (1991) Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253, 1280-1283
16. Lee, J., Kuang, W. J., Rice, G. C., and Wood, W. I. (1992) Characterization of complementary DNA clones encoding the rabbit IL-8 receptor. J. Immunol. 148, 1261-1264
17. Wu, D. Q., Larosa, G. J., and Simon, M. I. (1993) G-protein-coupled signal transduction pathways for interleukin-8. Science 261, 101-103
18. Leong, S. R., Kabakoff, R. C., and Hebert, C. A. (1994) Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction. J. Biol. Chem. 269, 19343-19348
19. Barnett, M. L., Lamb, K. A., Costello, K. M., and Pike, M. C. (1993) Characterization of interleukin-8 receptors in human neutrophil membranes - regulation by guanine nucleotides. Biochim. Biophys. Acta 1177, 275-282
20. Baggiolini, M., and Clark-Lewis, I. (1992) Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett. 307, 97-101
21. Sebok, K., Woodside, D., Alaoukaty, A., Ho, A. D., Gluck, S., and Maghazachi, A. A. (1993) IL-8 induces the locomotion of human IL-2-activated natural killer cells - involvement of a guanine nucleotide binding (Go) protein. J. Immunol. 150, 1524-1534
22. i2alpha with interleukin-8 receptors. J. Biol. Chem. In press
23. Ohyama, K., Yamano, Y., Chaki, S., Kondo, T., and Inagami, T. (1992) Domains for G-protein coupling in angiotensin II receptor type I: studies by site directed mutagenesis. Biochem. Biophys. Res. Commun. 189, 677-683
24. Moro, O., Lameh, J., Hogger, P., and Sadee, W. (1993) Hydrophobic amino acid in the i2-loop plays a key role in receptor-G-protein coupling. J. Biol. Chem. 268, 22273-22276
25. Bihoreau, C., Monnot, C., Davies, E., Teutsch, B., Bernstein, K. E., Corvol, P., and Clauser, E. (1993) Mutation of asp(74) of the rat angiotensin-II receptor confers changes in antagonist affinities and abolishes G-protein coupling. Proc. Natl. Acad. Sci. USA 90, 5133-5137
26. Hawes, B. E., Luttrell, L. M., Exum, S. T., and Lefkowitz, R. J. (1994) Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. J. Biol. Chem. 269,15776-15785
27. Prossnitz, E. R., Quehenberger, O., Cochrane, C. G., and Ye, R. D. (1993) The role of the third intracellular loop of the neutrophil N-formyl peptide receptor in G-protein coupling. Biochem. J. 294, 581-587
28. Schreiber, R. E., Prossnitz, E. R., Ye, R. D., Cochrane, C. G., and Bokoch, G. M. (1994) Domains of the human neutrophil N-formyl peptide receptor involved in G-protein coupling - mapping with receptor-derived peptides. J. Biol. Chem. 269, 326-331
29. Bommakanti, R. K., Dratz, E. A., Siemsen, D. W., and Jesaitis, A. J. (1995) Extensive contact between G(i2) and N-formyl peptide receptor of human neutrophils: mapping of binding sites using receptor-mimetic peptides. Biochemistry 34, 6720-6728
30. Hebert, C. A., Chuntharapai, A., Smith, M., Colby, T., Kim, J., and Horuk, R. (1993) Partial functional mapping of the human interleukin-8 type-a receptor - identification of a major ligand binding domain. J. Biol. Chem. 268, 18549-18553
31. Neve, K. A., Cox, B. A., Henningsen, R. A., Spanoyannis, A., and Neve, R. L. (1991) Pivotal role for aspartate in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenyl cyclase. Mol. Pharmacol. 39, 733-739
32. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450
33. Faucher, N., and Naccache, P. H. (1987) Relationship between pH, sodium and shape changes in chemotactic factor-stimulated human neutrophils. J. Cell. Physiol. 132, 483-491
34. 2+ monitored with a new, intracellularly trapped fluorescent indicator. J. Cell Biol. 94, 3325-3334
35. Sander, B., Andersson, J., and Andersson, U. (1991) Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol. Rev. 119, 65-93
36. 2-terminal region of the receptor. J. Immunol. 152, 1783-1789
37. Rollet, E., Caon, A. C., Roberge, C. J., Liao, N. W., Malawista, S. E., McColl, S. R., and Naccache, P. H. (1994) Tyrosine phosphorylalion in activated human neutrophils - comparison of the effects of different classes of agonists and identification of the signaling pathways involved. J. Immunol. 153, 353-363
38. Schreiber, R. E., Prossnitz, E. R., Ye, R. D., Cochrane, C. G., Jesaitis, A. J., and Bokoch, G. M. (1993) Reconstitution of recombinant N-formyl chemotactic peptide receptor with G-protein. J. Leukocyte Biol. 53, 470-474
39. Lee, J., Horuk, R., Rice, G. C., Bennett, G. L., Camerato, T., and Wood, W. I. (1992) Characterization of 2 high affinity human interleukin-8 receptors. J. Biol. Chem. 267, 16283-16287
40. Petersen, F., Flad, H. D., and Brandt, E. (1994) Neutrophil-activating peptides NAP-2 and IL-8 bind to the same sites on neutrophils but interact in different ways - discrepancies in binding affinities, receptor densities, and biologic effects. J. Immunol. 152, 2467-2478
41. Watson, S., and Arkinstall, S. (1994) The G-Protein Linked Receptor Facts Book, U. S. Ed, Academic Press, San Diego
42. Loetscher, P., Seitz, M., Clark-Lewis, I., Baggiolini, M., and Moser, B. (1994) Both interleukin-8 receptors independently mediate chemotaxis - Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341, 187-192
43. Magazin, M., Vita, N., Cavrois, E., Lefort, S., Guillemot, J.-C., and Ferrara, P. (1992) The biological activities of Gro-beta and IL-8 on human neutrophils are overlapping but not identical. Eur. Cytokine. Netw. 3, 461-467
44. Ben-Baruch, A., Bengali, K. M., Biragyn, A., Johnston, J. J., Wang, J. M., Kim, J., Chuntharapai, A., Michiel, D. F., Oppenheim, J. J., and Kelvin, D. J. (1995) Interleukin-8 receptor beta - the role of the carboxyl terminus in signal transduction. J. Biol. Chem. 270, 9121-9128
45. Prossnitz, E. R., Schreiber, R. E., Bokoch, G. M., and Ye, R. D. (1995) Binding of low affinity N-formyl peptide receptors to G protein. J. Biol. Chem. 270, 10686-10694
46. Mohammadi, M., Dionne, C. A., Li, W., Li, N., Spivak, T., Honegger, A. M., Jaye, M., and Schlessinger, J. (1992) Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature (London) 358, 681-684
47. Valiquette, M., Bonin, H., and Bouvier, M. (1993) Mutation of tyrosine-350 impairs the coupling of the beta-2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation. Biochemistry 32, 4979-4985