The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

Journal of Biological Chemistry

Volumn 274, Issue 48, 1999, Pages 33913-33920

  Zhong, Mei ^a   Munzer, Jon Scott ^a   Basak, Ajoy ^b   Benjannet, Suzanne ^a   Mowla, Seyed J ^a   Decroly, Etienne ^a,c   Chrétien, Michel ^b   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CELL ENZYME; CHAPERONE; FURIN; GLYCOPROTEIN GP 160; KEXIN; NEUROTROPHIN; PROTEIN SUBUNIT; SUBTILISIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; VACCINIA VIRUS;

AMINO ACID SEQUENCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; COS CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; FURIN; GENE EXPRESSION; HUMANS; MASS SPECTROMETRY; MICE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTOR; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; SUBTILISINS; TUMOR CELLS, CULTURED;

ANIMALIA; BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; VACCINIA; VACCINIA VIRUS;

EID: 0033607676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.48.33913     Document Type: Article

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