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Volumn 462, Issue 2-3, 2000, Pages 179-188

Regulation of p53 stability and activity in response to genotoxic stress

Author keywords

Adaptation; Apoptosis; Genotoxic stress; MDM2; p53

Indexed keywords

MUTAGENIC AGENT; PROTEIN P53;

EID: 0034032170     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(00)00035-1     Document Type: Article
Times cited : (155)

References (79)
  • 1
    • 0029856557 scopus 로고    scopus 로고
    • Three distinct signalling responses by murine fibroblasts to genotoxic stress [see comments]
    • Liu Z.G., Baskaran R., Lea-Chou E.T., Wood L.D., Chen Y., Karin M., Wang J.Y. Three distinct signalling responses by murine fibroblasts to genotoxic stress [see comments]. Nature. 384:1996;273-276.
    • (1996) Nature , vol.384 , pp. 273-276
    • Liu, Z.G.1    Baskaran, R.2    Lea-Chou, E.T.3    Wood, L.D.4    Chen, Y.5    Karin, M.6    Wang, J.Y.7
  • 2
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr C.J. Cancer cell cycles. Science. 274:1996;1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 3
    • 2642656403 scopus 로고    scopus 로고
    • P53 gene mutation: Software and database
    • Beroud C., Soussi T. p53 gene mutation: software and database. Nucleic Acids Res. 26:1998;200-204.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 200-204
    • Beroud, C.1    Soussi, T.2
  • 4
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 5
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 7
    • 0033105716 scopus 로고    scopus 로고
    • Abnormal expression or mutation of TP53 and HPV in vulvar cancer
    • Ngan H.Y., Cheung A.N., Liu S.S., Yip P.S., Tsao S.W. Abnormal expression or mutation of TP53 and HPV in vulvar cancer. Eur. J. Cancer. 35:1999;481-484.
    • (1999) Eur. J. Cancer , vol.35 , pp. 481-484
    • Ngan, H.Y.1    Cheung, A.N.2    Liu, S.S.3    Yip, P.S.4    Tsao, S.W.5
  • 8
    • 0344609626 scopus 로고    scopus 로고
    • P53 and genetic susceptibility to cervical cancer
    • Sonoda Y., Saigo P.E., Boyd J. p53 and genetic susceptibility to cervical cancer. J. Natl. Cancer Inst. 91:1999;557.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 557
    • Sonoda, Y.1    Saigo, P.E.2    Boyd, J.3
  • 11
    • 0032427628 scopus 로고    scopus 로고
    • The role of ATM in DNA damage responses and cancer
    • Canman C.E., Lim D.S. The role of ATM in DNA damage responses and cancer. Oncogene. 17:1998;3301-3308.
    • (1998) Oncogene , vol.17 , pp. 3301-3308
    • Canman, C.E.1    Lim, D.S.2
  • 12
    • 0033566329 scopus 로고    scopus 로고
    • Somatic ATM mutations indicate a pathogenic role of ATM of B-cell chronic lymphocytic leukemia
    • Schaffner C., Stilgenbauer S., Rappold G.A., Dohner H., Lichter P. Somatic ATM mutations indicate a pathogenic role of ATM of B-cell chronic lymphocytic leukemia. Blood. 94:1999;748-753.
    • (1999) Blood , vol.94 , pp. 748-753
    • Schaffner, C.1    Stilgenbauer, S.2    Rappold, G.A.3    Dohner, H.4    Lichter, P.5
  • 14
    • 0030800922 scopus 로고    scopus 로고
    • MDM2: Keeping p53 under control
    • Piette J., Neel H., Marechal V. MDM2: keeping p53 under control. Oncogene. 15:1997;1001-1010.
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Marechal, V.3
  • 15
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell. 95:1998;5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 16
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh S.Y., Ikeda M., Taya Y., Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91:1997;325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 18
    • 0030881590 scopus 로고    scopus 로고
    • Differential regulation of the p21/WAF-1 and MDM2 genes after high-dose UV irradiation: P53-dependent and p53-independent regulation of the MDM2 gene
    • Wu L., Levine A.J. Differential regulation of the p21/WAF-1 and MDM2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the MDM2 gene. Mol. Med. 3:1997;441-451.
    • (1997) Mol. Med. , vol.3 , pp. 441-451
    • Wu, L.1    Levine, A.J.2
  • 19
    • 0030689782 scopus 로고    scopus 로고
    • The p53 targets MDM2 and Fas are not required as mediators of apoptosis in vivo
    • Reinke V., Lozano G. The p53 targets MDM2 and Fas are not required as mediators of apoptosis in vivo. Oncogene. 15:1997;1527-1534.
    • (1997) Oncogene , vol.15 , pp. 1527-1534
    • Reinke, V.1    Lozano, G.2
  • 21
    • 0032518917 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
    • Roth J., Dobbelstein M., Freedman D.A., Shenk T., Levine A.J. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17:1998;554-564.
    • (1998) EMBO J. , vol.17 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 22
    • 0030905284 scopus 로고    scopus 로고
    • MDM2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. MDM2 promotes the rapid degradation of p53. Nature. 387:1997;296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 24
    • 0031724593 scopus 로고    scopus 로고
    • Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
    • Freedman D.A., Levine A.J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18:1998;7288-7293.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7288-7293
    • Freedman, D.A.1    Levine, A.J.2
  • 25
    • 0032980646 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
    • Tao W., Levine A.J. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3077-3080.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 3077-3080
    • Tao, W.1    Levine, A.J.2
  • 26
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R., Tanaka H., Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:1997;25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 27
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain [comment]
    • Kussie P.H., Gorina S., Marechal V., Elenbaas B., Moreau J., Levine A.J., Pavletich N.P. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain [comment]. Science. 274:1996;948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6    Pavletich, N.P.7
  • 28
    • 0033020147 scopus 로고    scopus 로고
    • Regulation of p53 function and stability by phosphorylation
    • Ashcroft M., Kubbutat M.H., Vousden K.H. Regulation of p53 function and stability by phosphorylation. Mol. Cell. Biol. 19:1999;1751-1758.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1751-1758
    • Ashcroft, M.1    Kubbutat, M.H.2    Vousden, K.H.3
  • 29
    • 0033522143 scopus 로고    scopus 로고
    • DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation
    • Blattner C., Tobiasch E., Litfen M., Rahmsdorf H.J., Herrlich P. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene. 18:1999;1723-1732.
    • (1999) Oncogene , vol.18 , pp. 1723-1732
    • Blattner, C.1    Tobiasch, E.2    Litfen, M.3    Rahmsdorf, H.J.4    Herrlich, P.5
  • 30
    • 0030665146 scopus 로고    scopus 로고
    • MDM-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
    • Mayo L.D., Turchi J.J., Berberich S.J. MDM-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res. 57:1997;5013-5016.
    • (1997) Cancer Res. , vol.57 , pp. 5013-5016
    • Mayo, L.D.1    Turchi, J.J.2    Berberich, S.J.3
  • 32
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y., Xiong Y., Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 92:1998;725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 34
    • 0033521621 scopus 로고    scopus 로고
    • Association of p19(ARF) with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53
    • Honda R., Yasuda H. Association of p19(ARF) with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53. EMBO J. 18:1999;22-27.
    • (1999) EMBO J. , vol.18 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 37
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by MDM2
    • Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by MDM2. Nature. 387:1997;299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 38
    • 0030957746 scopus 로고    scopus 로고
    • Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases
    • Erhardt P., Tomaselli K.J., Cooper G.M. Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272:1997;15049-15052.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15049-15052
    • Erhardt, P.1    Tomaselli, K.J.2    Cooper, G.M.3
  • 39
    • 0030955170 scopus 로고    scopus 로고
    • Proteolytic cleavage of the MDM2 oncoprotein during apoptosis
    • Chen L., Marechal V., Moreau J., Levine A.J., Chen J. Proteolytic cleavage of the MDM2 oncoprotein during apoptosis. J. Biol. Chem. 272:1997;22966-22973.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22966-22973
    • Chen, L.1    Marechal, V.2    Moreau, J.3    Levine, A.J.4    Chen, J.5
  • 40
    • 0032548105 scopus 로고    scopus 로고
    • A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells
    • Pochampally R., Fodera B., Chen L., Shao W., Levine E.A., Chen J. A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene. 17:1998;2629-2636.
    • (1998) Oncogene , vol.17 , pp. 2629-2636
    • Pochampally, R.1    Fodera, B.2    Chen, L.3    Shao, W.4    Levine, E.A.5    Chen, J.6
  • 41
    • 0033591433 scopus 로고    scopus 로고
    • Activation of an MDM2-specific caspase by p53 in the absence of apoptosis
    • Pochampally R., Fodera B., Chen L., Lu W., Chen J. Activation of an MDM2-specific caspase by p53 in the absence of apoptosis. J. Biol. Chem. 274:1999;15271-15277.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15271-15277
    • Pochampally, R.1    Fodera, B.2    Chen, L.3    Lu, W.4    Chen, J.5
  • 46
    • 0029941651 scopus 로고    scopus 로고
    • P53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
    • Huang L.C., Clarkin K.C., Wahl G.M. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 56:1996;2940-2944.
    • (1996) Cancer Res. , vol.56 , pp. 2940-2944
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 47
    • 0031025079 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
    • Rathmell W.K., Kaufmann W.K., Hurt J.C., Byrd L.L., Chu G. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res. 57:1997;68-74.
    • (1997) Cancer Res. , vol.57 , pp. 68-74
    • Rathmell, W.K.1    Kaufmann, W.K.2    Hurt, J.C.3    Byrd, L.L.4    Chu, G.5
  • 48
    • 0033532174 scopus 로고    scopus 로고
    • The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase
    • Kachnic L.A., Wu B., Wunsch H., Mekeel K.L., DeFrank J.S., Tang W., Powell S.N. The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase. J. Biol. Chem. 274:1999;13111-13117.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13111-13117
    • Kachnic, L.A.1    Wu, B.2    Wunsch, H.3    Mekeel, K.L.4    Defrank, J.S.5    Tang, W.6    Powell, S.N.7
  • 49
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo R.A., McLure K.G., Lees-Miller S.P., Rancourt D.E., Lee P.W. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394:1998;700-704.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.5
  • 51
    • 0030693181 scopus 로고    scopus 로고
    • JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases
    • Hu M.C., Qiu W.R., Wang Y.P. JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. Oncogene. 15:1997;2277-2287.
    • (1997) Oncogene , vol.15 , pp. 2277-2287
    • Hu, M.C.1    Qiu, W.R.2    Wang, Y.P.3
  • 52
    • 0032478331 scopus 로고    scopus 로고
    • Stabilization and activation of p53 are regulated independently by different phosphorylation events
    • Chernov M.V., Ramana C.V., Adler V.V., Stark G.R. Stabilization and activation of p53 are regulated independently by different phosphorylation events. Proc. Natl. Acad. Sci. U.S.A. 95:1998;2284-2289.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 2284-2289
    • Chernov, M.V.1    Ramana, C.V.2    Adler, V.V.3    Stark, G.R.4
  • 55
    • 0032127947 scopus 로고    scopus 로고
    • Suppression of the p300-dependent MDM2 negative-feedback loop induces the p53 apoptotic function
    • Thomas A., White E. Suppression of the p300-dependent MDM2 negative-feedback loop induces the p53 apoptotic function. Genes Dev. 12:1998;1975-1985.
    • (1998) Genes Dev. , vol.12 , pp. 1975-1985
    • Thomas, A.1    White, E.2
  • 56
    • 0032539816 scopus 로고    scopus 로고
    • Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
    • Kapoor M., Lozano G. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation. Proc. Natl. Acad. Sci. U.S.A. 95:1998;2834-2837.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 2834-2837
    • Kapoor, M.1    Lozano, G.2
  • 57
    • 0032572792 scopus 로고    scopus 로고
    • DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site
    • Blaydes J.P., Hupp T.R. DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site. Oncogene. 17:1998;1045-1052.
    • (1998) Oncogene , vol.17 , pp. 1045-1052
    • Blaydes, J.P.1    Hupp, T.R.2
  • 58
    • 0030610565 scopus 로고    scopus 로고
    • The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
    • Lu H., Fisher R.P., Bailey P., Levine A.J. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol. Cell. Biol. 17:1997;5923-5934.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5923-5934
    • Lu, H.1    Fisher, R.P.2    Bailey, P.3    Levine, A.J.4
  • 59
    • 0029969418 scopus 로고    scopus 로고
    • P53 is linked directly to homologous recombination processes via Rad51/Reca protein interaction
    • Sturzbecher H.W., Donzelmann B., Henning W., Knippschild U., Buchhop S. p53 is linked directly to homologous recombination processes via Rad51/Reca protein interaction. EMBO J. 15:1996;1992-2002.
    • (1996) EMBO J. , vol.15 , pp. 1992-2002
    • Sturzbecher, H.W.1    Donzelmann, B.2    Henning, W.3    Knippschild, U.4    Buchhop, S.5
  • 67
    • 0030013337 scopus 로고    scopus 로고
    • Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
    • Attardi L.D., Lowe S.W., Brugarolas J., Jacks T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J. 15:1996;3693-3701.
    • (1996) EMBO J. , vol.15 , pp. 3693-3701
    • Attardi, L.D.1    Lowe, S.W.2    Brugarolas, J.3    Jacks, T.4
  • 68
    • 0032568037 scopus 로고    scopus 로고
    • Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis
    • Canman C.E., Kastan M.B. Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. Oncogene. 16:1998;957-966.
    • (1998) Oncogene , vol.16 , pp. 957-966
    • Canman, C.E.1    Kastan, M.B.2
  • 70
    • 0032160407 scopus 로고    scopus 로고
    • Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
    • Pan H., Yin C., Dyson N.J., Harlow E., Yamasaki L., Van Dyke T. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell. 2:1998;283-292.
    • (1998) Mol. Cell , vol.2 , pp. 283-292
    • Pan, H.1    Yin, C.2    Dyson, N.J.3    Harlow, E.4    Yamasaki, L.5    Van Dyke, T.6
  • 72
    • 0032541325 scopus 로고    scopus 로고
    • The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
    • Venot C., Maratrat M., Dureuil C., Conseiller E., Bracco L., Debussche L. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. EMBO J. 17:1998;4668-4679.
    • (1998) EMBO J. , vol.17 , pp. 4668-4679
    • Venot, C.1    Maratrat, M.2    Dureuil, C.3    Conseiller, E.4    Bracco, L.5    Debussche, L.6
  • 73
    • 0033597221 scopus 로고    scopus 로고
    • Transcriptional activation of the human glutathione peroxidase promoter by p53
    • Tan M., Li S., Swaroop M., Guan K., Oberley L.W., Sun Y. Transcriptional activation of the human glutathione peroxidase promoter by p53. J. Biol. Chem. 274:1999;12061-12066.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12061-12066
    • Tan, M.1    Li, S.2    Swaroop, M.3    Guan, K.4    Oberley, L.W.5    Sun, Y.6
  • 74
    • 0031887249 scopus 로고    scopus 로고
    • Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
    • Yu J., Zhang Y., McIlroy J., Rordorf-Nikolic T., Orr G.A., Backer J.M. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol. Cell. Biol. 18:1998;1379-1387.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1379-1387
    • Yu, J.1    Zhang, Y.2    McIlroy, J.3    Rordorf-Nikolic, T.4    Orr, G.A.5    Backer, J.M.6
  • 75
    • 0032514801 scopus 로고    scopus 로고
    • Regulation of the p85/p110alpha phosphatidylinositol 3′-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains
    • Yu J., Wjasow C., Backer J.M. Regulation of the p85/p110alpha phosphatidylinositol 3′-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains. J. Biol. Chem. 273:1998;30199-30203.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30199-30203
    • Yu, J.1    Wjasow, C.2    Backer, J.M.3
  • 77
    • 0033602361 scopus 로고    scopus 로고
    • Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity
    • Zhu J., Jiang J., Zhou W., Zhu K., Chen X. Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity. Oncogene. 18:1999;2149-2155.
    • (1999) Oncogene , vol.18 , pp. 2149-2155
    • Zhu, J.1    Jiang, J.2    Zhou, W.3    Zhu, K.4    Chen, X.5


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