Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat

Pain

Volumn 74, Issue 2-3, 1998, Pages 235-245

  Poon, Anthony ^a   Sawynok, Jana ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Adenosine deaminase; Adenosine kinase; Antinociception; Carrageenan; Inflammation; Thermal hyperalgesia

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 IODOTUBERCIDIN; 5' AMINO 5' DEOXYADENOSINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE DERIVATIVE; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR; CAFFEINE; CARRAGEENAN; CYCLOHEXYLADENOSINE; PENTOSTATIN; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HYPERALGESIA; INFLAMMATION; INTRATHECAL DRUG ADMINISTRATION; LUMBAR PUNCTURE; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; THERMAL INJURY;

ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CARRAGEENAN; DEOXYADENOSINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EDEMA; ENZYME INHIBITORS; EXCIPIENTS; HEAT; HYPERALGESIA; MALE; NEURITIS; NEURONS; NOCICEPTORS; PENTOSTATIN; PHENETHYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; TUBERCIDIN;

EID: 0031914926     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00186-3     Document Type: Article

References (64)

1. Arch J.R.S., Newsholme E.A. Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem. J. 174:1978;965-977.
2. Belfrage M., Sollevi A., Segerdahl M., Sjölund K., Hansson P. Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. Anesth. Analg. 81:1995;713-717.
3. Bong G.W., Rosengren S., Firestein G.S. Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. J. Clin. Invest. 98:1996;2779-2785.
4. Cahill C.M., White T.D., Sawynok J. Spinal opioid receptors and adenosine release: neurochemical and behavioural characterization of opioid subtypes. J. Pharmacol. Exp. Ther. 275:1995;84-93.
5. 2 adenosine receptors in the rat spinal cord. J. Pharmacol. Exp. Ther. 242:1987;905-910.
6. 2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study. J. Pharmacol. Exp. Ther. 247:1988;757-764.
7. Cronstein B.N. A novel approach to the development of anti-inflammatory agents: adenosine released at inflamed sites. J. Invest. Med. 43:1995;50-57.
8. Cronstein B., Naime D., Firestein G. The anti-inflammatory effects of an adenosine kinase inhibitor are mediated by adenosine. Arthritis Rheum. 38:1995;1040-1045.
9. Davies L.P., Cook A.F. Inhibition of adenosine kinase and adenosine uptake in guinea-pig CNS tissue by halogenated tubercidin analogues. Life Sci. 56:1995;PL345-349.
10. Davies L.P., Jamieson D.D., Baird-Lambert J.A., Kazlauskas R. Halogenated pyrrolopyrimidine analogues of adenosine from marine organisms: pharmacological activities and potent inhibition of adenosine kinase. Biochem. Pharmacol. 33:1984;347-355.
11. 2 adenosine receptors in spinal mechanisms of antinociception. Eur. J. Pharmacol. 139:1987;215-223.
12. DeLander G.E., Wahl J.J. Behavior induced by putative nociceptive neurotransmitter is inhibited by adenosine or adenosine analogs coadministered intrathecally. J. Pharmacol. Exp. Ther. 246:1988;565-570.
13. Ekblom A., Segerdahl M., Sollevi A. Adenosine increases the cutaneous heat pain threshold in healthy volunteers. Acta Anaesthesiol. Scand. 39:1995;717-722.
14. Fisher M.N., Newsholme E.A. Properties of rat heart adenosine kinase. Biochem. J. 15:1984;521-528.
15. Franco R., Casadó V., Ciruela R., Saura C., Mallol J., Canela E.I., Lluis C. Cell surface adenosine deaminase much more than an ectoenzyme. Prog. Neurobiol. 52:1997;283-294.
16. 3H]nitrobenzylthioinosine sites in rat spinal cord and primary afferent neurons. Brain Res. 347:1985;321-327.
17. Geiger J.D., Nagy J.I. Distribution of adenosine deaminase activity in rat brain and spinal cord. J. Neurosci. 6:1986;2707-2714.
18. Geiger J.D., La Bella F.S., Nagy J.I. Characterization and localization of adenosine receptors in the rat spinal cord. J. Neurosci. 4:1984;2303-2310.
19. Golembiowska K., White T.D., Sawynok J. Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors. Brain Res. 699:1995;315-320.
20. Golembiowska K., White T.D., Sawynok J. Adenosine kinase inhibitors augment release of adenosine from spinal cord slices. Eur. J. Pharmacol. 307:1996;157-162.
21. Hammond, D.L., Intrathecal administration: methodological considerations. In: H.L. Fields and J.-M. Besson (Eds.), Progress in Brain Research, Elsevier, Amsterdam, 77 (1988) 313-320.
22. Hargreaves K.M., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
23. 2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 251:1989;47-55.
24. Hylden J.L.K., Wilcox G.L. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67:1980;313-316.
25. Hylden J.L.K., Thomas D.A., Iadarola M.J., Nahin R.L., Dubner R. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. Eur. J. Pharmacol. 194:1991;135-143.
26. 2 receptors in rat brain. J. Pharmacol. Exp. Ther. 251:1989;888-893.
27. Jurna I. Cyclic nucleotides and aminophylline produce different effects on nociceptive sensory responses in the rat spinal cord. Naunyn-Schmiedeberg's Arch. Pharmacol. 327:1984;23-30.
28. 1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. Anaesth. Analg. 80:1995;844-847.
29. Karlsten R., Gordh T., Hartvig P., Post C. Effects of intrathecal injection of the adenosine receptor agonists R-phenylisopropyladenosine and N-ethylcarboxamide-adenosine on nociception and motor function in the rat. Anesth. Analg. 71:1990;60-64.
30. 1 adenosine receptor. Neurosci. Lett. 121:1991;267-270.
31. Keil G.J., DeLander G.E. Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-inhibitor. Life Sci. 51:1992;171-176.
32. Keil G.J., DeLander G.E. Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice. Eur. J. Pharmacol. 271:1994;37-46.
33. Keil G.J., DeLander G.E. Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission. Eur. J. Pharmacol. 312:1996;7-14.
34. Lee Y.W., Yaksh T.L. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J. Pharmacol. Exp. Ther. 277:1996;1642-1648.
35. Lloyd H.G.E., Fredholm B.B. Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices. Neurochem. Int. 26:1995;387-395.
36. Malmberg A.B., Yaksh T.L. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology. 79:1993;270-281.
37. Mao J., Price D.D., Mayer D. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain. 62:1995;259-274.
38. Massillon D., Stalmans W., Van de Werve G., Bollen M. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem. J. 299:1994;123-128.
39. Meghji, P., Adenosine production and metabolism. In: T. Stone (Ed.), Adenosine in the Nervous System, Academic Press, London, 1991, pp. 25-42.
40. Miller R.L., Adamczyk D.L., Miller W.H., Koszalka G.W., Rideout J.L., Beacham III L.M., Chao E.Y., Haggerty J.J., Krenitsky T.A., Elion G.B. Adenosine kinase from rabbit liver, II. Substrate and inhibitor specificity. J. Biol. Chem. 254:1979;2346-2352.
41. Nagy J.I., Daddona P.E. Anatomical and cytochemical relationships of adenosine deaminase-containing primary afferent neurons in the rat. Neuroscience. 15:1985;799-813.
42. Pak M.A., Haas H.L., Decking U.K.M., Schrader J. Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacology. 33:1994;1049-1053.
43. Parkinson F.E., Geiger J.D. Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells. J. Pharmacol. Exp. Ther. 277:1996;1397-1401.
44. Poon A., Sawynok J. Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. Eur. J. Pharmacol. 286:1995;177-184.
45. Poon A., Sawynok J. Spinal analgesia by adenosine agonists and inhibitors of adenosine metabolism, with synergy between an adenosine kinase and an adenosine deaminase inhibitor. Br. J. Pharmacol. 119(Proc. Suppl.):1996;204P.
46. Poon A., Sawynok J., Allen G.V., Esser M.J. Local antiinflammatory and systemic antinociceptive effects produced by a combination of adenosine kinase and adenosine deaminase inhibitors. Soc. Neurosci. Abstr. 23:1997;1814.
47. Reeve A.J., Dickenson A.H. The roles of spinal adenosine receptors in the control of acute and more persistent nociceptive responses of dorsal horn neurones in the anaesthetized rat. Br. J. Pharmacol. 116:1995;2221-2228.
48. Rosengren S., Bong G.W., Firestein G.S. Antiinflammatory effects of an adenosine kinase inhibitor: decreased neutrophil accumulation and vascular leakage. J. Immunol. 154:1995;5444-5451.
49. Salter M.W., DeKoninck Y., Henry J.L. Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn. Prog. Neurobiol. 41:1993;125-155.
50. Sawynok, J., Adenosine and pain. In: J.W. Phillis (Ed.), Adenosine and Adenine Nucleotides as Regulators of Cellular Function, CRC Press, Boca Raton, FL, 1991, pp. 391-400.
51. Sawynok J., Sweeney M.I., White T.D. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br. J. Pharmacol. 88:1986;923-930.
52. Sawynok J., Sweeney M.I., White T.D. Adenosine release may mediate spinal analgesia by morphine. Trends Pharmacol. Sci. 10:1989;186-189.
53. Sawynok J., Reid A., Poon A. Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test. Pain. 74:1998;75-81.
54. Segerdahl M., Ekblom A., Sollevi A. The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. Anesth. Analg. 79:1994;787-791.
55. Sollevi A., Belfrage M., Lundeberg T., Segerdahl M., Hansson P. Systemic adenosine infusion: a new treatment modality to alleviate neuropathic pain. Pain. 61:1995;155-158.
56. Sosnowski M., Yaksh T.L. Role of spinal adenosine receptors in modulating the hyperesthesia produced by spinal glycine receptor antagonism. Anesth. Analg. 69:1989;587-592.
57. Stanfa L.C., Sullivan A.F., Dickenson A.H. Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenin induced inflammation. Pain. 50:1992;345-354.
58. Sweeney M.I., White T.D., Sawynok J. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. J. Pharmacol. Exp. Ther. 243:1987;657-665.
59. + release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord. J. Pharmacol. Exp. Ther. 248:1989;447-454.
60. Weil-Fugazza J., Godefroy F., Manceau V., Besson J.M. Increased norepinephrine and uric acid levels in the spinal cord of arthritic rats. Brain Res. 374:1986;190-194.
61. Winter C.A., Risley H.A., Nuss G.W. Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111:1962;544-547.
62. Wu P.H., Barraco R.A., Phillis J.W. Further studies on the inhibition of adenosine uptake into rat brain synaptosomes by adenosine derivatives and methylxanthines. Gen. Pharmacol. 15:1984;251-254.
63. Yaksh T.L., Rudy T.A. Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17:1976;1031-1036.
64. Zhang G., Franklin P.H., Murray T.F. Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. J. Pharmacol. Exp. Ther. 264:1993;1415-1424.