The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs

Anesthesia and Analgesia

Volumn 85, Issue 3, 1997, Pages 675-680

  Wang, Baoguo ^a   Tang, Jun ^a   White, Paul F ^a,d   Foster, Alan C ^b   Grettenberger, Heather M ^b   Kopcho, Joe ^b   Wender, Ronald H ^c  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b Gensia Inc   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ANILINO 5 PHENYLPYRROLO[2,3 D]PYRIMIDINE 7 (5 DEOXYRIBOSIDE); ADENOSINE KINASE INHIBITOR; DESFLURANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; GENERAL ANESTHESIA; HEART RATE; HEMODYNAMICS; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE KINASE; ADJUVANTS, ANESTHESIA; ANESTHETICS, INHALATION; ANIMALS; BLOOD PRESSURE; DOGS; FEMALE; HEART RATE; INFUSIONS, INTRAVENOUS; ISOFLURANE; PYRIMIDINES;

EID: 0030768387     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199709000-00035     Document Type: Article

References (30)

1. Sawynok J, Sweeney MI. The role of purines in nociception. Neuroscience 1989;32:557-69.
2. Segerdahl M, Ekblom A, Sollevi A. The influence of adenosine, ketamine and morphine on experimentally induced ischemic pain in healthy volunteers. Anesth Analg 1994;79:787-91.
3. Segerdahl M, Ekblom A, Sandelin K, et al. Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics. Anesth Analg 1995;80:1145-9.
4. 1 selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. Anesth Analg 1995;80:844-7.
5. Seitz PA, ter Riet MT, Rush W, Merrell WJ. Adenosine decreases the minimum alveolar concentration of halothane in dogs. Anesthesiology 1990;73:990-4.
6. Conradson TB, Dixon CMS, Clarke B, Barnes PJ. Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole. Acta Physiol Scand 1987;129:387-91.
7. Newberg LA, Milde JH, Michenfelder JD. Cerebral and systemic effects of hypotension induced by adenosine or ATP in dogs. Anesthesiology 1985;62:429-36.
8. Stiles GL. Adenosine receptors. J Biol Chem 1992;267:6451-4.
9. Shimizu H, Tanaka S, Kodama T. Adenosine kinase of mammalian brain: partial purification and its role for the uptake of adenosine. J Neurochem 1972;19:687-8.
10. Mullane K. Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovasc Res 1993;27:43-7.
11. Keil II GJ, DeLander GE. Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor. Life Sci 1992;51:171-6.
12. Keil II GJ, DeLander GE. Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice. Eur J Pharmacol 1994; 271:37-46.
13. Poon A, White T, Sawynok J. Antinociceptive activity of adenosine analogs and an adenosine kinase inhibitor depends on stimulus intensity in the formalin test. Soc Neurosci Abstr 1995; 21:263.9.
14. Wienser JB, Ugarkar B, Castellino AJ, et al. Antinociceptive activity of novel adenosine kinase inhibitors. Soc Neurosci Abstr 1995;21:314.10.
15. Wienser JB, Zimring ST, Castellino AJ, et al. Anticonvulsant profile of a novel adenosine kinase inhibitor, GP683, in rodents. J Pharmacol Exp Ther. In press.
16. Eger EI II, Saidman LJ, Brandstater B. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 1965;26:756-63.
17. Miller RD, ed. Anesthesia. 3rd ed. Vol. 1. New York: Churchill Livingstone, 1990:1001-29.
18. Murphy MR, Hug CC Jr. The anesthetic potency of fentanyl in terms of its reduction of enflurane MAC. Anesthesiology 1982; 57:485-8.
19. Murphy MR, Hug CC Jr. The enflurane sparing effect of morphine, butorphanol, and nalbuphine. Anesthesiology 1982;57: 489-92.
20. Hall RI, Murphy MR, Hug CC Jr. The enflurane sparing effect of sufentanil in dogs. Anesthesiology 1987;67:518-25.
21. Hall RI, Szlam F, Hug CC Jr. The enflurane-sparing effect of alfentanil in dogs. Anesth Analg 1987;66:1287-91.
22. Hall RI, Murphy MR, Szlam F, Hug CC Jr. Dezocine-MAC reduction and evidence for myocardial depression in the presence of enflurane. Anesth Analg 1987;66:1169-74.
23. 2-adrenergic agonist, in halothane-anesthetized dogs. Anesth Analg 1988;67:611-5.
24. Rich GF, Schacterle R, Moscicki JC, et al. Ketorolac does not decrease the MAC of halothane or depress ventilation in rats. Anesth Analg 1992;75:99-102.
25. Crawford MW, Lerman J, Saldivia V, et al. The effect of adenosine-induced hypotension on systemic and splanchnic hemodynamics during halothane or sevoflurane anesthesia in the rat. Anesthesiology 1994;80:159-67.
26. Cronstein BN. Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 1994;76:5-13.
27. Sawynok J, Sweeney MI, White TD. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br J Pharmacol 1986;88:923-30.
28. Li J, Perl ER. Adenosine inhibition of synaptic transmission in the substantia gelatinosa. J Neurophysiol 1994;72:1611-21.
29. Santicioli P, Del Bianco E, Tramontana M, Maggi CA. Adenosine inhibits action potential-dependent release of calcitonin gene-related peptide- and substance P-like immunoreactives from primary afferents in rat spinal cord. Neurosci Lett 1992; 144:211-4.
30. 1 receptors mediate the presynaptic inhibition of calcitonin gene-related peptide release by adenosine in the rat spinal cord. Eur J Pharmacol 1993;231:139-42.