Ocular gene therapy: Quo vadis?

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 10, 2000, Pages 2821-2826

  Hauswirth, W W ^a   Beaufrere, L ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN; RIBOZYME; VIRUS VECTOR;

APOPTOSIS; CATARACT; GENE THERAPY; HUMAN; OPTIC NERVE; PRIORITY JOURNAL; RETINA DETACHMENT; RETINA DISEASE; RETINA GANGLION CELL; RETINOBLASTOMA; REVIEW;

ANIMALS; APOPTOSIS; EYE DISEASES; GENE THERAPY; GENETIC VECTORS; HUMANS; TRANSFECTION;

EID: 0033827451     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Retinal gene therapy 1998: Summary of a workshop
2. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa
3. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse
4. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
5. Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina
6. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus
7. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats
8. Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouse
9. bcl-2 Gene therapy exacerbates excitotoxicity
10. Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration
11. Attenuation of ischemiainduced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus
12. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy
13. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer
14. Encapsidated adenovirus mini-chromosome-mediated delivery of genes to the retina: Application to the rescue of photoreceptor degeneration
15. Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina
16. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
17. Pigment epithelium derived factor delays the death of photoreceptors in mouse models of inherited retinal
18. Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
19. Self-destructive and self-protective processes in the damaged optic nerve: Implications for glaucoma
20. Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy
21. Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression
22. Prolonged delivery of brain derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells
23. Introduction of DNA into the rat and primate trabecular meshwork by fusogenic liposomes
24. Gene transfer to the human trabecular meshwork by anterior segment perfusion
25. Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow: Relevance for potential gene therapy of glaucoma
26. Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis
27. Reporter expression persists 1 year after adeno-associated virus- mediated gene transfer to the optic nerve
28. Adenoviral gene therapy with catalase suppresses experimental optic neuritis
29. Suicide gene therapy for treatment of retinoblastoma in a murine model
30. An experimental application of gene therapy for human retinoblastoma
31. Mutant herpes simplex virus-mediated suppression of retinoblastoma
32. Phosphorothioate oligo nucleotides induction into experimental choroidal neovascularization by HVJ-liposome system
33. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes
34. Retrovirus-mediated gene transfer targeted to retinal photocoagulation sites
35. Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides
36. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors
37. Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene: Can proliferative vitreoretinopathy be a target of gene therapy?
38. Experimental gene therapy for an in vitro model of proliferative vitreoretinopathy
39. Growth inhibition of cultured human Tenon's fibroblastic cells by targeting the E2F transcription factor
40. Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment
41. Adenovirus-mediated suicide gene transduction: Feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits
42. Controlled gene gun delivery and expression of DNA within the cornea
43. Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery
44. Adenovirus-mediated gene delivery to the corneal endothelium
45. Adenovirus-mediated gene transfer to the ocular surface epithelium
46. Ex vivo transduction of corneal epithelial progenitor cells using a retroviral vector
47. Treatment of severe ocular surface disorders with corneal epithelial stem-cell transplantation
48. Targeted gene transfer to corneal endothelium in vivo by electric pulse
49. Target gene transfer of tissue plasminogen activator to cornea by electric pulse inhibits intracameral fibrin formation and corneal cloudiness
50. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector