Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina

Molecular Therapy

Volumn 3, Issue 5, 2001, Pages 688-696

  McGee Sanftner, L H ^a   Rendahl, K G ^b   Quiroz, D ^b   Coyne, M ^b   Ladner, M ^b   Manning, W C ^b   Flannery, J G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Gene therapy; rAAV vector; Retinal degeneration; Tet inducible transgene

Indexed keywords

DOXYCYCLINE; DRINKING WATER; GREEN FLUORESCENT PROTEIN; TETRACYCLINE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EYE; FLUORESCENCE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE SILENCING; GENE TARGETING; GENETIC TRANSDUCTION; HISTOLOGY; IN VIVO STUDY; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RAT; REPORTER GENE; RETINA; RETINA CELL; RETINA DEGENERATION; VIRUS RECOMBINANT; WESTERN BLOTTING;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0034984667     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0308     Document Type: Article

References (38)

1. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa
2. Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats
3. Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction
4. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
5. Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: Relationship to endothelial dysfunction and laser treatment
6. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: A role of VEGF and possible treatment for SRN in age-related macular degeneration
7. Adenovirus-mediated regulable target gene expression in vivo
8. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
9. Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer
10. Regulation of gene expression in vivo following transduction by two separate rAAV vectors
11. Control of memory formation through regulated expression of a CaMKII transgene
12. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
13. Lentiviral vectors: Regulated gene expression
14. Inducible long-term gene expression in brain with adeno-associated virus gene transfer
15. Tight Control of gene expression in mammalian cells by tetracycline-responsive promoters
16. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
17. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
18. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector
19. Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin
20. Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease
21. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
22. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease
23. Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors
24. rAAV vector-mediated sarcogylcan gene transfer in a hamster model for limb girdle muscular dystrophy
25. In vivo model of adeno-associated virus vector persistence and rescue
26. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa
27. Rescue of photoreceptor function by AAV-mediated gene transfer in a mouse model of inherited retinal degeneration
28. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2
29. Additional transduction events after subretinal readministration of recombinant adeno-associated virus
30. Adeno-associated virus type 2 DNA replication in vivo: Mutation analyses of the D sequence in viral inverted terminal repeats
31. Definition of an efficient synthetic poly(A) site
32. Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
33. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses
34. Parvovirus B19-induced perturbation of human megakaryocytopoiesis in vitro
35. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus
36. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
37. Tetracycline-reversible silencing of eukaryotic promoters
38. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression