Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain

European Journal of Neuroscience

Volumn 12, Issue 8, 2000, Pages 2847-2855

  Bolton, Sarah J ^a,b   Jones, Declan N C ^a   Darker, John G ^a   Eggleston, Drake S ^a   Jacqueline Hunter, A ^a   Walsh, Frank S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Brain; In vivo; Inflammation; Neurotoxicity

Indexed keywords

PENETRATIN; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; BRAIN REGION; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM FUNCTION; CONCENTRATION RESPONSE; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGE FACTORS; AMINO ACID SEQUENCE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARRIER PROTEINS; CELLS, CULTURED; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; DRUG DELIVERY SYSTEMS; ENCEPHALITIS; HOMEODOMAIN PROTEINS; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; KIDNEY; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; NEUROBIOLOGY; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033811166     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00171.x     Document Type: Article

References (24)

1. Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro
2. The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues
3. CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown
4. Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats
5. Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats
6. The excitotoxic concept
7. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
8. The third helix of the Antennapedia homeodomain translocates through biological membranes
9. Trojan peptides: The penetratin system for intracellular delivery
10. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide
11. Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide
12. Antennapedia homeobox peptide regulates neural morphogenesis
13. Alpha-2,8-Polysialic acid is the neuronal surface receptor of Antennapedia homeobox peptide
14. The behavioural effects of corticotropin-releasing factor-related peptides in rats
15. Periodate-lysine-paraformaldehyde fixative. A new fixative for immunoelectron microscopy
16. Evidence for dendritic competition in the developing retina
17. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
18. Getting hydrophilic compounds into cells: Lessons from homeopeptides
19. New advances in the transport of doxorubicin through the blood-brain-barrier by a peptide-vector mediated strategy
20. Localization of receptors for the dipsogenic action of angiotensin II in the subfornical organ of the rat
21. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway
22. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway
23. Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide