Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5485-5493

  Lassmann, S ^a   Kincaid, C ^a   Asensio, V C ^a   Campbell, I L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE SYNTHASE; PERTUSSIS VACCINE; RANTES; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; MACROPHAGE; MICROGLIA; MOTOR ACTIVITY; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REFLEX; TRANSGENIC MOUSE; TREMOR;

EID: 0035500931     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5485     Document Type: Article

References (93)

1. Immunogenetics and the cause of autoimmune disease
2. Viruses, cytokines, antigens, and autoimmunity
3. The basis of autoimmunity. I. Mechanisms of aberrant self-recognition
4. The basis of autoimmunity. II. Genetic predisposition
5. MS: A localized immune disease of the central nervous system
6. MS: A CNS and systemic autoimmune disease
7. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis
8. Genes and susceptibility to multiple sclerosis
9. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
10. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity and cytotoxicity
11. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis: Complexity of the response and dominance of nested epitopes due to recruitment of multiple T-cell clones
12. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
13. T-cell recognition of an immunodominant myelin basic protein in multiple sclerosis
14. Viral infection in patients with multiple sclerosis and HLA-DR matched controls
15. Influence of infection on exacerbations of multiple sclerosis
16. Clinical viral infections and multiple sclerosis
17. Animal models
18. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
19. Differential regulation of the IL-12-p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide
20. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: Role of phagocytosis
21. Microbial products induce autoimmune disease by an IL-12-dependent pathway
22. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
23. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CDl4-dependent pathway
24. + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β
25. Interleukin 12 acts directly on CD4-T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming
26. Action of pertussigen (pertussis toxin) on serum IgE and on Fcε receptors on lymphocytes
27. Potentiation of delayed-type hypersensitivity by pertussigen or cyclophosphamide with release of different lymphokines
28. Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin
29. Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein
30. Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: Adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1B7-2 and CD28
31. Pertussigen enhances antigen-driven interferon-γ production by sensitized lymphoid cells
32. Acute experimental auto-immune encephalomyelitis in mice: Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system
33. Peripheral injections' of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis
34. The effect of Freund's adjuvants on blood-cerebrospinal fluid barrier permeability
35. The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells
36. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
37. Interleukin-12: A cytokine at the interface of inflammation and immunity
38. IL-12-deficient mice are defective but not devoid of type 1 cytokine responses
39. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
40. IL-12 in autoimmunity
41. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
42. An interleukin (IL)-10/ IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
43. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
44. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
45. + T cells via CD40 ligand
46. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
47. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis
48. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor-a and tumor necrosis factor-β
49. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia
50. IL-12 production by central nervous system microglia is inhibited by astrocytes
51. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
52. CD40 engagement stimulates IL-12p70 production by human microglial cells: Basis for Th1 polarization in the CNS
53. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
54. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition
55. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
56. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
57. - RNA
58. Analysis of gene expression by multiprobe RNase protection assay
59. + T cells from young and old mice
60. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
61. Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus
62. Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
63. The gene family encoding the mouse ribosomal protein L32 contains a uniquely expressed intron-containing gene and an unmutated processed gene
64. IL-12: A key cytokine in immune regulation
65. The role of IL-12 in the induction of organ-specific autoimmune diseases
66. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline
67. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12: Preferential expansion of interferon-γ-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms
68. Immune surveillance and autoantigen recognition in the central nervous system
69. The central nervous system as an immunocompetent organ: Role of glial cells in antigen presentation
70. Traffic of hematogenous cells through the central nervous system
71. T-lymphocyte entry into the central nervous system
72. T-cell apoptosis in inflammatory brain lesions: Destruction of T cells does not depend on antigen recognition
73. In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity
74. Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation
75. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
76. Type 1 diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens: Nonimmunized nonobese diabetic mice can develop autoimmune encephalitis
77. Inflammatory cytokines in the brain: Does the CNS shape immune responses?
78. The critical role of IL-12 and the IL-12Rb2 subunit in the generation of pathogenic autoreactive Th1 cells
79. IL-12β2-deficient mice are defective in IL-12-mediated signaling despite the presence of high-affinity IL-12 binding sites
80. Differentiation of murine NK, cells into distinct subsets based on variable expression of the IL-12Rβ2 subunit
81. Regulation of interleukin (IL)-12 receptor β2 subunit expression by endogenous IL-12: A critical step in the differentiation of pathogenic autoreactive T cells
82. IL-12R: Distribution and regulation of receptor expression
83. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
84. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
85. Regulation of interleukin-12 receptor β1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells
86. T-cell responses to myelin antigens in multiple sclerosis: Relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein
87. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
88. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
89. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis
90. T-cell turnover in vivo and the role of cytokines
91. + T cells in the absence of TCR ligation
92. + T cells upon NK T or T cell activation
93. + T cells contributes to the rapid production of IFN-γ in response to bacterial pathogens