Matrix metalloproteinases generate angiostatin: Effects on neovascularization

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6845-6852

  Cornelius, Lynn A ^a   Nehring, Leslie C ^a   Harding, Elizabeth ^b   Bolanowski, Mark ^b   Welgus, Howard G ^a   Kobayashi, Dale K ^a   Pierce, Richard A ^a   Shapiro, Steven D ^a  

^a BARNES JEWISH HOSPITAL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOSTATIN; ELASTASE; MATRIX METALLOPROTEINASE; PLASMINOGEN;

ARTICLE; CANCER MODEL; CATALYSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN PURIFICATION;

AMIDES; ANGIOSTATINS; ANIMALS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; GELATINASES; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES, PERITONEAL; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS; PLASMINOGEN; PROTEASE INHIBITORS; RECOMBINANT FUSION PROTEINS; TYROSINE;

EID: 0032534596     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Holmgren, L., M. O'Reilly, and J. Folkman. 1995. Dormancy of micrometastasis: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1:149.
2. Gorelik, E. S., S. Segal, and M. Feldman. 1980. Growth of a local tumor exerts a specific inhibitory effect on progression of lung metastasis. Int. J. Cancer 21: 617.
3. O'Reilly, M. S., L. Holmgren, Y. Shing, C. Chen, R. A. Rosenthal, M. Moses, W. S. Lane, Y. Cao, E. H. Sage, and J. Folkman. 1994. A novel angiogenesis inhibitor which mediates the suppression of metastasis by a Lewis lung carcinoma. Cell 79:315.
4. Sugarbaker, E. V., J. Thornewaite, and A. S. Ketchem. 1977. In Progress in Cancer Research and Therapy. S. B. Day and W. P. L. Rogers, eds. Raven Press, New York, p. 227.
5. Gately, S., P. Twardowski, S. Stack, M. Patrick, L. Boggio, D. L. Cundiff, H. W. Schnaper, L. Madison, O. Volpert, N. Bouck, et al. 1996. Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin. Cancer Res. 56:4887.
6. Gately, S. G., P. Twardowski, M. S. Stack, D. L. Cundiff, D. Grella, F. J. Castellino, J. Enghild, H. C. Kwan, F. Lee, R. A. Kramer, et al. 1997. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proc. Natl. Acad. Sci. USA 94:10868.
7. Dong, Z., R. Kumar, X. Yang, and I. J. Fidler. 1997. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell 88:801.
8. Banda, M. J., and Z. Werb. 1981. Mouse macrophage elastase: purification and characterization as a metalloproteinase. Biochem. J. 193:589.
9. Shapiro, S. D., G. L. Griffin, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, H. G. Welgus, R. M. Senior, and T. J. Ley. 1992. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J. Biol. Chem. 267:4664.
10. Shapiro, S., D. K. Kobayashi, and T. J. Ley. 1993. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Biol. Chem. 268:23824.
11. Patterson, B. C., and Q. X. A. Sang. 1997. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9). J. Biol. Chem. 272:28823.
12. Murphy, G., and A. J. P. Docherty. 1992. The matrix metalloproteinases and their inhibitors. Am. J. Respir. Cell Mol. Biol. 7:120.
13. Birkedal-Hansen, H., W. G. Moore, W. Bodden, G. I., L. J. Windsor, B. Birkedal-Hansen, A. DeCarlo, and J. A. Engler. 1993. Martrix metalloproteinases: a review. Crit. Rev. Oral Biol. Med. 4:197.
14. Banda, M. J., A. G. Rice, G. L. Griffin, and R. M. Senior. 1988. α-1 proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 263:4481.
15. Gearing, A. J. H., M. Beckett, M. Christodoulou, M. Churchill, J. Clements, A. H. Davidson, A. H. Drummond, W. A. Galloway, R. Gilbert, J. L. Gordon, et al. 1994. Processing of tumor necrosis factor-α by metalloproteinases. Nature 370:555.
16. Gronski, T. J., R. L. Martin, D. K. Kobayashi, B. C. Walsh, M. C. Holman, M. Hubers, H. E. Van Wart, and S. D. Shapiro. 1997. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J. Biol. Chem. 272:12189.
17. Baragi, V. M., C. J. Fliszar, M. C. Conroy, Q. Z. Ye, J. M. Shipley, and H. G. Welgus. 1994. Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases: C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin. J. Biol. Chem. 269:12692.
18. Stricklin, G. P., E. A. Bauer, J. J. Jefferey, and A. Z. Eisen. 1977. Human skin collagenase: isolation of precursor and active forms from both fibroblasts and organ cultures. Biochemistry 16:1607.
19. Shipley, J. M., G. A. R. Doyle, C. J. Fliszar, Q.-Z. Ye, L. L. Johnson, S. D. Shapiro, H. G. Welgus, and R. M. Senior. 1996. The structural basis for the elastolytic activity of the 92 kDa and 72 kDa gelatinases. J. Biol. Chem. 271: 4335.
20. Carmichael, D. F., A. Sommer, R. C. Thompson, D. C. Anderson, C. G. Smith, H. G. Welgus, and G. P. Stricklin. 1986. Primary structure and cDNA cloning of human fibroblast collagenase inhibitor. Proc. Natl. Acad Sci. USA 83:2407.
21. Weingarten, H., and J. Feder. 1985. Spectophotometric assay for vertebrate collagenase. Anal. Biochem. 147:11437.
22. Hippenmeyer, P., and M. Highkin. 1993. High level, stable production of recombinant proteins in mammalian cell culture using the herpesvirus VP 16 transactivator. Bio/Technology 11:1037.
23. Moore, W., and C. A. Spilburg. 1986. Purification of human collagenases with a hydroxamic acid affinity column. Biochemistry 25:5189.
24. Shipley, J. M., R. L. Wesselschmidt, D. K. Kobayshi, T. J. Ley, and S. D. Shapiro. 1996. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc. Natl. Acad. Sci. USA 93:3942.
25. Kubota, Y., H. K. Kleinman, G. R. Martin, and T. J. Lawley. 1988. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J. Cell Biol. 107:1589.
26. Cao, Y., R. W. Ji, D. Davidson, J. Schaller, D. Marti, S. Sohndel, S. G. McCance, M. S. O'Reilly, M. Llinas, and J. Folkman. 1996. Kringle domains of human angiostatin: characterization of the anti-proliferative activity on endothelial cells. J. Biol. Chem. 271:29461.
27. Stathakis, P., M. Fitzgerald, L. J. Matthias, C. N. Chesterman, and P. Hogg. 1997. Generation of angiostatin by reduction and proteolysis of plasmin: catalysis by a plasmin reductase secreted by cultured cells. J. Biol Chem. 272:20641.
28. Carmeleit, P., L. Moons, R. Lijnen, J. Crawley, P. Tipping, A. Drew, Y. Eeckout, S. D. Shapiro, F. Lupu, and D. Collen. 1997. Urokinase-generated plasmin is a candidate activator of matrix metalloproteinases during atherosclerotic aneurysm formation. Nat. Genet. 17:439.
29. Folkman, J., K. Watson, D. Ingber, and D. Hanahan. 1989. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339:58.
30. Folkman, J. 1990. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst. 82:4.
31. Goldberg, G. I., B. L. Marmer, G. A. Grant, and A. Z. Eisen. 1989. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc. Natl. Acad. Sci. USA 86:2632.
32. 3 integrin complex on human microvascular endothelial cells. J. Invest. Dermatol. 103:295.
33. 3 for angiogenesis. Science 264:569.
34. Stetler-Stevenson, W. G., and M. L. Cocoran. 1997. Tumor angiogenesis: functional similarities with tumor invasion. EXS 701:413.
35. Powell, W. C., and L. M. Matrisian. 1996. Complex roles of matrix metalloproteinases in tumor progression. Curr. Top. Microbiol. Immunol. 213:1.
36. Good, D. J., P. J. Polverini, F. Rastinejad, M. M. Le-Beau, R. S. Lemons, W. A. Frazier, and N. P. Bouck. 1990. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA 87:6624.
37. O'Reilly, M., T. Boehm, Y. Shing, N. Fukai, G. Vasios, W. S. Lane, E. Flynn, J. R. Birkhead, B. R. Olsen, and J. Folkman. 1997. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277.
38. Mostafa, L. K., D. B. Jones, and D. H. Wright. 1980. Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: studies of the chorioallantoic membrane (CAM) of the chick embryo. J. Pathol. 132:191.
39. Polverini, P. J., and S. J. Leibovich. 1984. Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab. Invest. 51:635.
40. Sunderkotter, C., K. Steinbrink, M. Goebeler, R. Bhardwaj, and C. Sorg. 1994. Macrophages and angiogenesis. J. Leukocyte Biol. 55:410.
41. Cao, Y., A. Chen, S. S. An, R.-W. Ji, D. Davidson, Y. Cao, and M. Llinas. 1997. Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J. Biol. Chem. 272:22924. The Journal of Immunology, 1998, 161: 6853-6860.