The contribution of epigenetic changes to abnormal centrosomes and genomic instability in breast cancer

Journal of Mammary Gland Biology and Neoplasia

Volumn 6, Issue 2, 2001, Pages 203-212

  Salisbury, Jeffrey L ^a  

^a MAYO CLINIC   (United States)

Author keywords

Aneuploidy; Cell cycle; Cell polarity; Centriole; Centrosome; Chromosomal instability

Indexed keywords

BRCA1 PROTEIN; PROTEIN P53;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GRADING; CELL CYCLE; CELL FUNCTION; CELL LINEAGE; CELL POLARITY; CENTRIOLE; CENTROSOME; CHROMOSOME DUPLICATION; CYTOSKELETON; EPIGENETICS; GENE DOSAGE; GENE DUPLICATION; GENETIC STABILITY; HUMAN; MICROTUBULE ASSEMBLY; MICROTUBULE ORGANIZING CENTER; MITOSIS SPINDLE; MUTATION; NONHUMAN; PARTICLE SIZE; SOLID TUMOR; SYSTEMATIC REVIEW; ANEUPLOIDY; ANIMAL; BREAST TUMOR; CHROMOSOME ABERRATION; DRUG EFFECT; FEMALE; GENETICS; PATHOLOGY; PHYSIOLOGY; RADIATION EXPOSURE; REVIEW;

ANEUPLOIDY; ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL CYCLE; CELL POLARITY; CENTRIOLES; CENTROSOME; CHROMOSOME ABERRATIONS; FEMALE; GENE DOSAGE; HUMANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035319724     PISSN: 10833021     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011312808421     Document Type: Article

References (92)

1. R. Li, A. Sonik, R. Stindl, D. Rasnick, and P. Duesberg (2000). Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy. Proc. Natl. Acad. Sci. U.S.A. 97:3236-3241.
2. A. M. Martin and B. L. Weber (2000). Genetic and hormonal risk factors in breast cancer. J. Natl. Cancer Inst. 92:1126-1135.
3. R. Callahan and G. H. Smith (2000). MMTV-induced mammary tumorigenesis: Gene discovery, progression to malignancy and cellular pathways [see comments]. Oncogene 19:992-1001.
4. F. P. Perera (2000). Molecular epidemiology: On the path to prevention? J. Natl. Cancer Inst. 92:602-612.
5. B. Vogelstein and K. W. Kinzler (1993). The multistep nature of cancer. Trends Genet. 9:138-141.
6. S. B. Baylin and J. G. Herman (2000). DNA hypermethylation in tumorigenesis: Epigenetics joins genetics. Trends Genet. 16: 68-174.
7. B. Lewin (1998). The mystique of epigenetics. Cell. 93: 01-303.
8. D. R. Kellogg (1989). Centrosomes. Organizing cytoplasmic events [news]. Nature 340:99-100.
9. E. Karsenti and B. Maro (1986). Centrosomes and the spatial distribution of microtubules in animal cells. TIBS. 11: 60-463.
10. D. Mazia, P. Harris, and T. Bibring (1960). The multiplicity of the mitotic centers and time-course of their duplication and separation. J. Biophysic. Biochem. Cytol. 7:1-20.
11. A. B. Pardee (1989). G1 events and regulation of cell proliferation. Science. 246:603-608.
12. I. R. Adams and J. V. Kilmartin (2000). Spindle pole body duplication: A model for centrosome duplication? Trends Cell Biol. 10: 29-335.
13. D. Wheatley (1982). The Centriole: A Central Enigma of Cell Biology Elsevier Biomedical Press, Amsterdam, 232.
14. P. Chang and T. Stearns (2 000). δ-tubulin and E-tubulin: Two new human centrosomal tubulins reveal new aspects of centrosome structure and function [see comments]. Nat. Cell Biol. 2:30-35.
15. B. M. Lange and K. Gull (1995). A molecular marker for centriole maturation in the mammalian cell cycle. J. Cell Biol. 130: 19-927.
16. M. M. Mogensen, A. Malik, M. Piel, V. Bouckson-Castaing, and M. Bornens (2000). Microtubule minus-end anchorage at centrosomal and noncentrosomal sites: The role of ninein. J. Cell Sci. 113:3013-3023.
17. M. Piel, P. Meyer, A. Khodjakov, C. L. Rieder, and M. Bornens (2000). The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J. Cell Biol. 149:317-330.
18. E. B. Wilson (1925). The Cell in Development and Heredity, Third Edition, Macmillan Company New York, p. 1232.
19. G. Sluder, F. J. Miller, R. Cole, and C. L. Rieder (1990). Protein synthesis and the cell cycle: Centrosome reproduction in sea urchin eggs is not under translational control. J. Cell Biol. 110: 025-2032.
20. G. Sluder, F. J. Miller, and C. L. Rieder (1986). The reproduction of centrosomes: Nuclear versus cytoplasmic controls. J. Cell Biol. 103:1873-1881.
21. A. Maniotis and M. Schliwa (1991). Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells. Cell 67:495-504.
22. G. Sluder, F. J. Miller, and C. L. Rieder (1989). Reproductive capacity of sea urchin centrosomes without centrioles. Cell Motil. Cytoskeleton. 13:264-273.
23. W. F. Marshall and J. L. Rosenbaum (1999). Cell division: The renaissance of the centriole. Curr. Biol. 9:R218-220.
24. W. F. Marshall and J. L. Rosenbaum (2000). How centrioles work: Lessons from green yeast. Curr. Opin. Cell Biol. 12:119-125.
25. E. H. Hinchcliffe, C. Li, E. A. Thompson, J. L. Maller, and G. Sluder (1999). Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science. 283:851-854.
26. E. Karsenti (1999). Centrioles reveal their secrets [news]. Nat. Cell Biol. 1:E62-64.
27. K. R. Lacey, P. K. Jackson, and T. Stearns (1999). Cyclin-dependent kinase control of centrosome duplication. Proc. Natl. Acad. Sci. U.S.A. 96:2817-2822.
28. J. G. Mussman, H. F. Horn, P. E. Carroll, M. Okuda, P. Tarapore, L. A. Donehower, and K. Fukasawa (2000). Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene 19:1635-1646.
29. Kip1, polyploidy and centrosome overduplication. EMBO J. 19:2069-2081.
30. M. Winey (1999). Cell cycle: Driving the centrosome cycle. Curr. Biol. 9:R449-452.
31. E. Stubblefield and B. Brinkley, (1967). Architecture and function of the mammalian centriole. In K. B. Warren, (Ed.), The Origin and Fate of Cell Organelles, Academic Press, New York and London, p. 175-218.
32. R. S. Kochanski and G. G. Borisy (1990). Mode of centriole duplication and distribution. J. Cell Biol. 110:1599-1605.
33. E. Bullitt, M. P. Rout, J. V. Kilmartin, and C. W. Akey (1997). The yeast spindle pole body is assembled around a central crystal of Spc42p. Cell 89:1077-1086.
34. G. Albrecht-Buehler and A. Bushnell (1979). The orientation of centrioles in migrating 3T3 cells. Exp. Cell Res. 120:111-118.
35. D. Q. Ding, Y. Chikashige, T. Haraguchi, and Y. Hiraoka (1998). Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J. Cell Sci. 111:701-712.
36. J. Beisson and M. Jerka-Dziadosz (1999). Polarities of the centriolar structure: Morphogenetic consequences. Biol. Cell. 91: 67-378.
37. J. Beisson and T. M. Sonneborn (1965). Cytoplasmic inheritance of the organization of the cell cortex of Paramecium aurelia. Proc. Natl. Acad. Sci. U.S.A. 3:275-282.
38. J. Frankel (1989). Pattern Formation Cilate Studies and Models, Oxford University Press, New York, p. 314.
39. T. M. Sonneborn (1975). Positional information and nearest neighbor interactions in relation to spatial patterns in ciliates. Ann. Biol. 14:565-584.
40. G. Schatten (1994). The centrosome and its mode of inheritance: The reduction of the centrosome during gametogenesis and its restoration during fertilization. Dev. Biol. 165:299-335.
41. B. R. Brinkley and T. M. Goepfert (1998). Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected. Cell Motil. Cytoskeleton. 41:281-288.
42. P. Duesberg (1999). Are centrosomes or aneuploidy the key to cancer? Science 284:2091-2092.
43. J. L. Salisbury, C. M. Whitehead, W. L. Lingle, and S. L. Barrett (1999). Centrosomes and cancer. Biol. Cell. 91:451-460.
44. P. E. Carroll, M. Okuda, H. F. Horn, P. Biddinger, P. J. Stambrook, L. L. Gleich, Y. Q. Li, P. Tarapore, and K. Fukasawa (1999). Centrosome hyperamplification in human cancer: Chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18: 935-1944.
45. W. L. Lingle, W. H. Lutz, J. N. Ingle, N. J. Maihle, and J. L. Salisbury (1998). Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity. Proc. Natl. Acad. Sci. U.S.A. 95:2950-2955.
46. G. A. Pihan, A. Purohit, J. Wallace, H. Knecht, B. Woda, P. Quesenberry, and S. J. Doxsey (1998). Centrosome defects and genetic instability in malignant tumors. Cancer Res. 58:3974-3985.
47. H. Zhou, J. Kuang, L. Zhong, W. L. Kuo, J. W. Gray, A. Sahin, B. R. Brinkley, and S. Sen (1998). Tumor amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20:189-193.
48. W. L. Lingle and J. L. Salisbury (1999). Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Amer. J. Pathol. 155:1941-1951.
49. T. Tanaka, M. Kimura, K. Matsunaga, D. Fukada, H. Mori, and Y. Okano (1999). Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res. 59:2041-2044.
50. S. Sen (2000). Aneuploidy and cancer. Curr. Opin. Oncol. 12: 2-88.
51. P. Duesberg and D. Rasnick (2000). Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil. Cytoskeleton. 47:81-107.
52. T. Boveri (1907). Zellenstudien IV: Die entwicklung dispermer Seeigeleier. Ein beitrag zur befruchtungslehre und zur theorie des kernes. Jena. Zeitschr. Naturw. 43:1-292.
53. T. Boveri (1914). Zur Frage der Entstehung Maligner Tumoren, Baltimore: Jena: Fischer Verlag (1929 English translation by M. Boveri reprinted as "[I#The Origin of Malignant Tumors," The Williams and Wilkins Co.) p. 119.
54. -/- cells in prolonged culture. Exp. Cell Res. 258: 10-321.
55. J. M. Hall, M. K. Lee, B. Newman, J. E. Morrow, L. A. Anderson, B. Huey, and M. C. King (1990). Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250:1684-1689.
56. Y. Miki, J. Swensen, D. Shattuck-Eidens, P. A. Futreal, K. Harshman, S. Tavtigian, Q. Liu, C. Cochran, L. M. Bennett, W. Ding, et al. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71.
57. C. X. Deng and S. G. Brodie (2000). Roles of BRCA1 and its interacting proteins [In Process Citation]. Bioessays 22:728-737.
58. L. C. Hsu and R. L. White (1998). BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. U.S.A. 95: 2983-12988.
59. T. Ludwig, D. L. Chapman, V. E. Papaioannou, and A. Efstratiadis (1997). Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11: 226-1241.
60. S. X. Shen, Z. Weaver, X. Xu, C. Li, M. Weinstein, L. Chen, X. Y. Guan, T. Ried, and C. X. Deng (1998). A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability. Oncogene 17:3115-3124.
61. X. Xu, Z. Weaver, S. P. Linke, C. Li, J. Gotay, X. W. Wang, C. C. Harris, T. Ried, and C. X. Deng (1999). Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell. 3:389-395.
62. A. Tutt, A. Gabriel, D. Bertwistle, F. Connor, H. Paterson, J. Peacock, G. Ross, and A. Ashworth (1999). Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr. Biol. 9:1107-1110.
63. C. R. Brown, S. J. Doxsey, E. White, and W. J. Welch (1994). Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes. J. Cell Physiol. 160:47-60.
64. P. Giannakakou, D. L. Sackett, Y. Ward, K. R. Webster, M. V. Blagosklonny, and T. Fojo (2000). p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat. Cell Biol. 2:709-717.
65. K. Fukasawa, T. Choi, R. Kuriyama, S. Rulong, and G. F. Vande Woude (1996). Abnormal centrosome amplification in the absence of p53. Science. 271:1744-1747.
66. X. J. Wang, D. A. Greenhalgh, A. Jiang, D. He, L. Zhong, D. Medina, B. R. Brinkley, and D. R. Roop (1998). Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene 17:35-45.
67. K. Somasundaram, H. Zhang, Y. X. Zeng, Y. Houvras, Y. Peng, G. S. Wu, J. D. Licht, B. L. Weber, and W. S. El-Deiry (1997). Arrest of the cell cycle by the tumor-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature 389:187-190.
68. H. Zhang, K. Somasundaram, Y. Peng, H. Tian, D. Bi, B. L. Weber, and W. S. El-Deiry (1998). BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16:1713-1721.
69. Y. Matsumoto, K. Hayashi, and E. Nishida (1999). Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr. Biol. 9:429-432.
70. (cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 93:1390-1398.
71. A. McShea, T. Samuel, J. T. Eppel, D. A. Galloway, and J. O. Funk (2000). Identification of CIP-1 -associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle. J. Biol. Chem. 275:23181-23186.
72. P. Bork, K. Hofmann, P. Bucher, A. F. Neuwald, S. F. Altschul, and E. V. Koonin (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11: 8-76.
73. D. P. Harkin, J. M. Bean, D. Miklos, Y. H. Song, V. B. Truong, C. Englert, F. C. Christians, L. W. Ellisen, S. Maheswaran, J. D. Oliner, and D. A. Haber (1999). Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell. 97: 75-586.
74. S. B. Baylin (1997). Tying it all together: Epigenetics, genetics, cell cycle, and cancer [see comments]. Science 277:1948-1949.
75. J. Newell-Price, A. J. Clark, and P. King (2000). DNA methylation and silencing of gene expression. Trends Endocrinol. Metab. 11: 42-148.
76. F. Sleutels, D. P. Barlow, and R. Lyle (2000). The uniqueness of the imprinting mechanism. Curr. Opin. Genet. Dev. 10:229-233.
77. T. H. Bestor (1988). Cloning of a mammalian DNA methyltransferase. Gene. 74:9-12.
78. WAF1. Science 277:1996-2000.
79. A. P. Feinberg (2000). DNA methylation, genomic imprinting and cancer. Curr Top. Microbiol. Immunol. 249:87-99.
80. L. M. Mielnick, H. L. Asch, and B. B. Asch (2001). Genes, chromatin, and breast cancer: An epigenetic tale. J. Mam. Gland Biol. Neoplasia 6(2):169-182.
81. H. J. Chial, T. H. Giddings, Jr., E. A. Siewert, M. A. Hoyt, and M. Winey (1999). Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc. Natl. Acad. Sci. U.S.A. 96:10200-10205.
82. H. J. Chial and M. Winey (1999). Mechanisms of genetic instability revealed by analysis of yeast spindle pole body duplication. Biol. Cell. 91:439-450.
83. E. Cohen-Jonathan, E. J. Bernhard, and W. G. McKenna (1999). How does radiation kill cells? Curr. Opin. Chem. Biol. 3:77-83.
84. C. Sato, R. Kuriyama, and K. Nishizawa (1983). Microtubule-organizing centers abnormal in number, structure, and nucleating activity in X-irradiated mammalian cells. J. Cell Biol. 96:776-782.
85. N. Sato, K. Mizumoto, M. Nakamura, and M. Tanaka (2000). Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells. Exp. Cell Res. 255:321-326.
86. F. A. Mettler, A. C. Upton, C. A. Kelsey, R. N. Ashby, R. D. Rosenberg, and M. N. Linver (1996). Benefits versus risks from mammography: A critical reassessment. Cancer 77:903-909.
87. H. Schatten and A. Chakrabarti (1998). Centrosome structure and function is altered by chloral hydrate and diazepam during the first reproductive cell cycles in sea urchin eggs. Eur. J. Cell Biol. 75:9-20.
88. H. Schatten, C. N. Hueser, and A. Chakrabarti (2000). Centrosome alterations induced by formamide cause abnormal spindle pole formations. Cell Biol. Int. 24:611-620.
89. D. A. Compton (1999). New tools for the antimitotic toolbox. Science 286:913-914.
90. T. U. Mayer, T. M. Kapoor, S. J. Haggarty, R. W. King, S. L. Schreiber, and T. J. Mitchison (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286:971-974.
91. T. M. Kapoor, T. U. Mayer, M. L. Coughlin, and T. J. Mitchison (2000). Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J. Cell Biol. 150: 75-988.
92. I. Shureiqi and D. E. Brenner (1999). Chemoprevention of epithelial cancers. Curr. Opin. Oncol. 11:408-413.