Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3080-3087

  Love, P E ^a   Lee, J ^a   Shores, E W ^a  

^a HFM 538 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL SELECTION; FLOW CYTOMETRY; GENE EXPRESSION; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THEORY; THYMOCYTE; TRANSGENE;

EID: 0034665510     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3080     Document Type: Article

References (37)

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13. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
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15. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
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17. The level of CD8 expression can determine the outcome of thymic selection
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19. + thymocytes: A model based on T cell receptor avidity
20. + cells based on high affinity TCR signals
21. Crippling of CD3-ζ ITAMs does not impair T cell receptor signaling
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24. + double-positive stage
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30. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
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32. The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor subunits and the CD3 γ-, δ-, and ε-chains
33. Tyrosine-phosphorylated T cell receptor ζ-chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
34. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation
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36. A role for CD5 in TCR-mediated signal transduction and thymocyte selection
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