Understanding and modulating apoptosis in industrial cell culture

Current Opinion in Biotechnology

Volumn 12, Issue 2, 2001, Pages 175-179

  Laken, Haley A ^a   Leonard, Mark W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BCL X; RECOMBINANT PROTEIN;

APOPTOSIS; CELL CULTURE; CONTROLLED STUDY; DRUG MANUFACTURE; EUKARYOTIC CELL; HOST CELL; HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; SHEAR STRESS;

EUKARYOTA;

EID: 0035313535     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(00)00196-8     Document Type: Review

References (37)

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6. Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex
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13. Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture
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15. Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium
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20. N-acetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells
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37. Part I. Bcl-2 and Bcl-Xl limit apoptosis upon infection with alphavirus vectors