메뉴 건너뛰기




Volumn , Issue 61, 2001, Pages 247-261

The brain in Down syndrome

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN S100B;

EID: 0035226525     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6262-0_20     Document Type: Review
Times cited : (13)

References (90)
  • 1
    • 0033970139 scopus 로고    scopus 로고
    • The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic family, maps to Down critical region
    • Acquati F, Accarino M, Nucci C, Fumagelli P, Jovine L, Ottolenghi S, Taramelli R (2000) The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic family, maps to Down critical region. FEBS Lett 468: 59-64
    • (2000) FEBS Lett , vol.468 , pp. 59-64
    • Acquati, F.1    Accarino, M.2    Nucci, C.3    Fumagelli, P.4    Jovine, L.5    Ottolenghi, S.6    Taramelli, R.7
  • 2
    • 0034622238 scopus 로고    scopus 로고
    • Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
    • Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA (2000) Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiol Aging 21: 511-524
    • (2000) Neurobiol Aging , vol.21 , pp. 511-524
    • Anderson, A.J.1    Stoltzner, S.2    Lai, F.3    Su, J.4    Nixon, R.A.5
  • 3
    • 0030974795 scopus 로고    scopus 로고
    • Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains
    • Arai Y, Suzuki A, Mizuguchi, Takashima S (1997) Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains. Brain Dev 19: 290-294
    • (1997) Brain Dev , vol.19 , pp. 290-294
    • Arai, Y.1    Suzuki, A.2    Mizuguchi3    Takashima, S.4
  • 4
    • 0030462485 scopus 로고    scopus 로고
    • Correlation between the morphology of diffuse and primitive beta-amyloid (A-beta) deposits and the frequency of associated cells in Down's syndrome
    • Armstrong RA (1996) Correlation between the morphology of diffuse and primitive beta-amyloid (A-beta) deposits and the frequency of associated cells in Down's syndrome. Neuropathol Appl Neurobiol 22: 527-530
    • (1996) Neuropathol Appl Neurobiol , vol.22 , pp. 527-530
    • Armstrong, R.A.1
  • 5
    • 0032927816 scopus 로고    scopus 로고
    • MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia
    • Aylward EH, Li Q, Honeycutt NA (1999) MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia. Am J Psychiatry 156: 564-568
    • (1999) Am J Psychiatry , vol.156 , pp. 564-568
    • Aylward, E.H.1    Li, Q.2    Honeycutt, N.A.3
  • 6
    • 0032869406 scopus 로고    scopus 로고
    • Serotonin neurons, neuroplasticity, and homeostasis of neural tissue
    • Azmitia EC (1999) Serotonin neurons, neuroplasticity, and homeostasis of neural tissue. Neuropsychopharm 21: 33S-45S
    • (1999) Neuropsychopharm , vol.21
    • Azmitia, E.C.1
  • 7
    • 0014218440 scopus 로고
    • Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan
    • Bazelon M, Paine RS, Coeiw VA, Hunt P, Houck JC, Mahanand D (1967) Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan. Lancet 1: 1130-1133
    • (1967) Lancet , vol.1 , pp. 1130-1133
    • Bazelon, M.1    Paine, R.S.2    Coeiw, V.A.3    Hunt, P.4    Houck, J.C.5    Mahanand, D.6
  • 8
    • 0022506009 scopus 로고
    • Dentritic atrophy in children with Down's Syndrome
    • Becker LE, Armstrong DL, Chan F (1986) Dentritic atrophy in children with Down's Syndrome. Ann Neurol 20: 520-526
    • (1986) Ann Neurol , vol.20 , pp. 520-526
    • Becker, L.E.1    Armstrong, D.L.2    Chan, F.3
  • 11
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down Syndrome
    • Busciglio J, Yankner BA (1995) Apoptosis and increased generation of reactive oxygen species in Down Syndrome. Nature 378: 776-779
    • (1995) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 13
    • 0032789791 scopus 로고    scopus 로고
    • Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system
    • Castagne V, Gautschi M, Lefevre K, Posada A, Clarke PGH (1999) Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system. Progr Neurobiol 59: 397-423
    • (1999) Progr Neurobiol , vol.59 , pp. 397-423
    • Castagne, V.1    Gautschi, M.2    Lefevre, K.3    Posada, A.4    Clarke, P.G.H.5
  • 14
    • 0028236064 scopus 로고
    • Determination of gene dosage by a quantitative adaptation of the polymerase chain reaction (gd-PCR): Rapid detection of deletions and duplications of gene sequences
    • Celi FS, Cohen MM, Antonarakis SE, Wertheimer E, Roth J, Shuldiner AR (1994) Determination of gene dosage by a quantitative adaptation of the polymerase chain reaction (gd-PCR): rapid detection of deletions and duplications of gene sequences. Genomics 21: 304-310
    • (1994) Genomics , vol.21 , pp. 304-310
    • Celi, F.S.1    Cohen, M.M.2    Antonarakis, S.E.3    Wertheimer, E.4    Roth, J.5    Shuldiner, A.R.6
  • 15
    • 0015126561 scopus 로고
    • Infantile spasms associated with 5-hydroxytryptophan administered in patients with Down's syndrome
    • Coleman M (1971) Infantile spasms associated with 5-hydroxytryptophan administered in patients with Down's syndrome. Neurol 21: 911
    • (1971) Neurol , vol.21 , pp. 911
    • Coleman, M.1
  • 17
    • 0031959496 scopus 로고    scopus 로고
    • p53- and CD95-associated apoptosis in neurodegenerative diseases
    • DelaMonte SM, Sohn YK, Ganju N, Wands JR (1998) p53-and CD95-associated apoptosis in neurodegenerative diseases. Lab Invest 78: 401-411
    • (1998) Lab Invest , vol.78 , pp. 401-411
    • DelaMonte, S.M.1    Sohn, Y.K.2    Ganju, N.3    Wands, J.R.4
  • 18
    • 0032437256 scopus 로고    scopus 로고
    • Signal transduction pathways that regulate cell survival and cell death
    • Dragovich T, Rudin CM, Thompson CB (1998) Signal transduction pathways that regulate cell survival and cell death. Oncogene 17: 3207-3213
    • (1998) Oncogene , vol.17 , pp. 3207-3213
    • Dragovich, T.1    Rudin, C.M.2    Thompson, C.B.3
  • 19
    • 0033805791 scopus 로고    scopus 로고
    • Alzheimer's disease: More than a cholinergic disorder - Evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia
    • Dringenberg HC (2000) Alzheimer's disease: more than a cholinergic disorder - evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia. Behav Brain Res 115: 235-249
    • (2000) Behav Brain Res , vol.115 , pp. 235-249
    • Dringenberg, H.C.1
  • 20
    • 0033007451 scopus 로고    scopus 로고
    • Reverse relationship between β-amyloid precursor protein and β-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease
    • Egensperger R, Weggen S, Ida N, Multhaup G, Schnabel R, Beyreuther K, Bayer TA (1999) Reverse relationship between β-amyloid precursor protein and β-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease. Acta Neuropathol 97: 113-118
    • (1999) Acta Neuropathol , vol.97 , pp. 113-118
    • Egensperger, R.1    Weggen, S.2    Ida, N.3    Multhaup, G.4    Schnabel, R.5    Beyreuther, K.6    Bayer, T.A.7
  • 21
    • 0000521855 scopus 로고
    • Down Syndrome (Trisomy 21)
    • Scriver SR, Beaudet AL, Sly WS, Valle D (eds) McGraw-Hill, New York
    • Epstein CJ (1995) Down Syndrome (Trisomy 21). In: Scriver SR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 749-794
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 749-794
    • Epstein, C.J.1
  • 22
    • 0034662929 scopus 로고    scopus 로고
    • BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
    • Farzan M, Schnitzler CE, Vasilieva N, Leung N, Choe H (2000) BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein. PNAS 97: 9712-9717
    • (2000) PNAS , vol.97 , pp. 9712-9717
    • Farzan, M.1    Schnitzler, C.E.2    Vasilieva, N.3    Leung, N.4    Choe, H.5
  • 23
    • 0028064502 scopus 로고
    • Involvement of free oxygen radicals in β-amyloidosis: An hypothesis
    • Friedlich AL, Butcher LL (1994) Involvement of free oxygen radicals in β-amyloidosis: an hypothesis. Neurobiol Aging 15: 443-455
    • (1994) Neurobiol Aging , vol.15 , pp. 443-455
    • Friedlich, A.L.1    Butcher, L.L.2
  • 24
    • 0025179273 scopus 로고
    • Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult
    • Gedye A (1990) Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult. J Ment Defic Res 34: 195
    • (1990) J Ment Defic Res , vol.34 , pp. 195
    • Gedye, A.1
  • 25
    • 0025856934 scopus 로고
    • Serotonergic treatment for aggression in a Down's syndrome adult showing signs of Alzheimer's disease
    • Gedye A (1991) Serotonergic treatment for aggression in a Down's syndrome adult showing signs of Alzheimer's disease. J Ment Defic 35: 247-258
    • (1991) J Ment Defic , vol.35 , pp. 247-258
    • Gedye, A.1
  • 30
    • 0035144524 scopus 로고    scopus 로고
    • Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome
    • Gulleserian T, Seidl R, Hardmeier R, Cairns N, Lubec G (2001) Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J Invest Med 49: 41-46
    • (2001) J Invest Med , vol.49 , pp. 41-46
    • Gulleserian, T.1    Seidl, R.2    Hardmeier, R.3    Cairns, N.4    Lubec, G.5
  • 31
    • 0024349657 scopus 로고
    • Neuropsychological evaluation of adults with Down's syndrome: Patterns of selective impairment in nondemented old adults
    • Haxby JV (1989) Neuropsychological evaluation of adults with Down's syndrome: patterns of selective impairment in nondemented old adults. J Ment Defic Res 33: 193-197
    • (1989) J Ment Defic Res , vol.33 , pp. 193-197
    • Haxby, J.V.1
  • 32
    • 0026455778 scopus 로고
    • Longitudinal study of neuropsychological functions in older adults with Down syndrome
    • Epstein C, Nadel L (eds) Wiley Liss, New York
    • Haxby JV, Schapiro MB (1992) Longitudinal study of neuropsychological functions in older adults with Down syndrome. In: Epstein C, Nadel L (eds) Down syndrome and Alzheimer disease. Wiley Liss, New York, pp 35-50
    • (1992) Down Syndrome and Alzheimer Disease , pp. 35-50
    • Haxby, J.V.1    Schapiro, M.B.2
  • 33
    • 0012398518 scopus 로고    scopus 로고
    • Jun, Fos, and CREB/ATF transcription factors in the brain: Control of gene expression under normal and pathophysiological conditions
    • Herdegen T (1996) Jun, Fos, and CREB/ATF transcription factors in the brain: control of gene expression under normal and pathophysiological conditions. Neuroscientist 2: 153-161
    • (1996) Neuroscientist , vol.2 , pp. 153-161
    • Herdegen, T.1
  • 34
    • 0027505011 scopus 로고
    • Transgenic mice expressing human βAPP751, but not mice expressing βAPP695, display early Alzheimer's disease-like histopathology
    • Higgins LS, Catalano R, Quon D, Cordell B (1993) Transgenic mice expressing human βAPP751, but not mice expressing βAPP695, display early Alzheimer's disease-like histopathology. Ann NY Acad Sci 695: 224-227
    • (1993) Ann NY Acad Sci , vol.695 , pp. 224-227
    • Higgins, L.S.1    Catalano, R.2    Quon, D.3    Cordell, B.4
  • 35
    • 0034333041 scopus 로고    scopus 로고
    • In search of an enzyme: The β-secretase of Alzheimer's disease is an aspartic proteinase
    • Howlett DR, Simmons DL, Dingwall C, Christie G (2000) In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase. Trends Neurosci 23: 565-570
    • (2000) Trends Neurosci , vol.23 , pp. 565-570
    • Howlett, D.R.1    Simmons, D.L.2    Dingwall, C.3    Christie, G.4
  • 36
    • 0002556006 scopus 로고
    • Serotonin and behavior, a general hypothesis
    • Bloom F, Kupfer D (eds) Raven Press, New York
    • Jacobs B, Fornal C (1995) Serotonin and behavior, a general hypothesis. In: Bloom F, Kupfer D (eds) Psychopharmacology: the fourth generation of progess. Raven Press, New York, pp 461-469
    • (1995) Psychopharmacology: The Fourth Generation of Progess , pp. 461-469
    • Jacobs, B.1    Fornal, C.2
  • 38
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl-2 and its role in regulating apoptosis
    • Kroemer G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 3: 614-620
    • (1997) Nature Med , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 40
    • 0027300281 scopus 로고
    • Neurotransmitters as growth regulatory signals: Role of receptors and second messengers
    • Lauder JM (1993) Neurotransmitters as growth regulatory signals: role of receptors and second messengers. Trends Neurosci 16: 233-240
    • (1993) Trends Neurosci , vol.16 , pp. 233-240
    • Lauder, J.M.1
  • 41
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogenous amyloid-β-peptides and ApoE in Down syndrome: Implications for initial events in amyloid plaque formation
    • Lemere CA, Blustzjan JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ (1996) Sequence of deposition of heterogenous amyloid-β-peptides and ApoE in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 3: 16-32
    • (1996) Neurobiol Dis , vol.3 , pp. 16-32
    • Lemere, C.A.1    Blustzjan, J.K.2    Yamaguchi, H.3    Wisniewski, T.4    Saido, T.C.5    Selkoe, D.J.6
  • 42
    • 0034652309 scopus 로고    scopus 로고
    • Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
    • Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J (2000) Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein. PNAS 97: 1456-1460
    • (2000) PNAS , vol.97 , pp. 1456-1460
    • Lin, X.1    Koelsch, G.2    Wu, S.3    Downs, D.4    Dashti, A.5    Tang, J.6
  • 44
    • 0023889961 scopus 로고
    • The pathological association between Down syndrome and Alzheimer disease
    • Mann DA (1988) The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Dev 43: 99-136
    • (1988) Mech Ageing Dev , vol.43 , pp. 99-136
    • Mann, D.A.1
  • 45
    • 0021814284 scopus 로고
    • Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age
    • Mann DM, Yates PO, Marcyniuk B, Rawndra CR (1985) Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J Ment Defic Res 29: 125-135
    • (1985) J Ment Defic Res , vol.29 , pp. 125-135
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3    Rawndra, C.R.4
  • 46
    • 0022496162 scopus 로고
    • Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders
    • Mann DMA, Yates PO (1986) Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. Hum Neurobiol 5: 147-158
    • (1986) Hum Neurobiol , vol.5 , pp. 147-158
    • Mann, D.M.A.1    Yates, P.O.2
  • 47
    • 0025038831 scopus 로고
    • Some morphological observations on the brains of patients with Down's syndrome: Their relationship to age and dementia
    • Mann DMA, Royston MC, Ravindra CR (1990) Some morphological observations on the brains of patients with Down's syndrome: their relationship to age and dementia. J Neurol Sci 99: 153
    • (1990) J Neurol Sci , vol.99 , pp. 153
    • Mann, D.M.A.1    Royston, M.C.2    Ravindra, C.R.3
  • 48
    • 0029670080 scopus 로고    scopus 로고
    • Accumulation of S100β mRNA and protein in cerebellum during infancy in Down syndrome and control subjects
    • Marks A, O'Hanlon D, Lei M, Percy ME, Becker LE (1996) Accumulation of S100β mRNA and protein in cerebellum during infancy in Down syndrome and control subjects. Mol Brain Res 36: 343-348
    • (1996) Mol Brain Res , vol.36 , pp. 343-348
    • Marks, A.1    O'Hanlon, D.2    Lei, M.3    Percy, M.E.4    Becker, L.E.5
  • 49
    • 0034665698 scopus 로고    scopus 로고
    • Caspase-3 activation and inflammatory responses in rat hippocampus inoculated with a recombinant adenovirus expressing the Alzheimer amyloid precursor protein
    • Masumura M, Hata R, Nishimura I, Uetsuki T, Sawada T, Yoshikawa K (2000) Caspase-3 activation and inflammatory responses in rat hippocampus inoculated with a recombinant adenovirus expressing the Alzheimer amyloid precursor protein. Mol Brain Res 80: 219-227
    • (2000) Mol Brain Res , vol.80 , pp. 219-227
    • Masumura, M.1    Hata, R.2    Nishimura, I.3    Uetsuki, T.4    Sawada, T.5    Yoshikawa, K.6
  • 50
    • 0034537209 scopus 로고    scopus 로고
    • Mechanisms underlying neural cell death in neurodegenerative diseases: Alterations of a developmentally-mediated cellular rheostat
    • Mehler MF, Gokhan S (2000) Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat. Trends Neurosci 23: 599-605
    • (2000) Trends Neurosci , vol.23 , pp. 599-605
    • Mehler, M.F.1    Gokhan, S.2
  • 52
    • 0031471277 scopus 로고    scopus 로고
    • Apoptosis-related protein expression in the hippocampus in Alzheimer's disease
    • Nagy Z, Esiri MM (1997) Apoptosis-related protein expression in the hippocampus in Alzheimer's disease. Neurobiol Aging 18: 565-571
    • (1997) Neurobiol Aging , vol.18 , pp. 565-571
    • Nagy, Z.1    Esiri, M.M.2
  • 53
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: A dysfunction of amyloid precursor protein
    • Neve RL, McPhie DL, Chen Y (2000) Alzheimer's disease: a dysfunction of amyloid precursor protein. Brain Res 886: 54-66
    • (2000) Brain Res , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 54
    • 0029003501 scopus 로고
    • Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
    • Owen-Schaub LB, Zhang W, Cusack JC (1995) Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 15: 3032-3040
    • (1995) Mol Cell Biol , vol.15 , pp. 3032-3040
    • Owen-Schaub, L.B.1    Zhang, W.2    Cusack, J.C.3
  • 55
    • 0028055038 scopus 로고
    • Down' syndrome: Upregulation of β-amyloid protein precursor and τ mRNAs and their defective coordination
    • Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, Ihara Y (1994) Down' syndrome: upregulation of β-amyloid protein precursor and τ mRNAs and their defective coordination. J Neurochem 62: 1062-1066
    • (1994) J Neurochem , vol.62 , pp. 1062-1066
    • Oyama, F.1    Cairns, N.J.2    Shimada, H.3    Oyama, R.4    Titani, K.5    Ihara, Y.6
  • 57
    • 0033597884 scopus 로고    scopus 로고
    • Alternative, nonsecretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8
    • Pellegrini L, Passer BJ, Tabaton M, Ganjei JK, D'Adamio L (1999) Alternative, nonsecretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8. J Biol Chem 274: 21011-21016
    • (1999) J Biol Chem , vol.274 , pp. 21011-21016
    • Pellegrini, L.1    Passer, B.J.2    Tabaton, M.3    Ganjei, J.K.4    D'Adamio, L.5
  • 58
    • 0034237167 scopus 로고    scopus 로고
    • The neurometabolic landscape of cognitive decline: In vivo studies with positron emission tomography in Alzheimer's disease
    • Pietrini P, Alexander GE, Furey ML, Hampel H, Guazelli M (2000) The neurometabolic landscape of cognitive decline: in vivo studies with positron emission tomography in Alzheimer's disease. Int J Psychophysiol 37: 87-98
    • (2000) Int J Psychophysiol , vol.37 , pp. 87-98
    • Pietrini, P.1    Alexander, G.E.2    Furey, M.L.3    Hampel, H.4    Guazelli, M.5
  • 59
    • 0023620006 scopus 로고
    • Gene dosage of the amyloid beta precursor protein in Alzheimer's disease
    • Podlisny MB, Lee G, Selkoe DJ (1987) Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science 238(4827): 669-671
    • (1987) Science , vol.238 , Issue.4827 , pp. 669-671
    • Podlisny, M.B.1    Lee, G.2    Selkoe, D.J.3
  • 62
    • 0023798563 scopus 로고
    • Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue
    • Reynolds GP, Warner CEJ (1988) Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue. Neurosci Lett 94: 224-227
    • (1988) Neurosci Lett , vol.94 , pp. 224-227
    • Reynolds, G.P.1    Warner, C.E.J.2
  • 63
    • 0030942897 scopus 로고    scopus 로고
    • Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome
    • Risser D, Lubec G, Cairns N, Herrera-Marschitz M (1997) Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci 60: 1231-1237
    • (1997) Life Sci , vol.60 , pp. 1231-1237
    • Risser, D.1    Lubec, G.2    Cairns, N.3    Herrera-Marschitz, M.4
  • 64
    • 0001059974 scopus 로고    scopus 로고
    • The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
    • Roßner S, Ueberham U, Schliebs R, Schliebs R, Perez-Polo JR, Bigl V (1998) The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Progr Neurobiol 56: 541-569
    • (1998) Progr Neurobiol , vol.56 , pp. 541-569
    • Roßner, S.1    Ueberham, U.2    Schliebs, R.3    Schliebs, R.4    Perez-Polo, J.R.5    Bigl, V.6
  • 67
  • 68
    • 0026621718 scopus 로고
    • Nature of mental retardation and dementia in Down syndrome: Study with PET, CT, and neuropsychology
    • Schapiro MB, Haxby JV, Grady CL (1992) Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiol Aging 13: 723-734
    • (1992) Neurobiol Aging , vol.13 , pp. 723-734
    • Schapiro, M.B.1    Haxby, J.V.2    Grady, C.L.3
  • 69
    • 0033593483 scopus 로고    scopus 로고
    • Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome
    • Seidl R, Fang-Kircher S, Bidmon B, Cairns N, Lubec G (1999) Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neurosci Lett 260: 9-12
    • (1999) Neurosci Lett , vol.260 , pp. 9-12
    • Seidl, R.1    Fang-Kircher, S.2    Bidmon, B.3    Cairns, N.4    Lubec, G.5
  • 73
    • 0033983967 scopus 로고    scopus 로고
    • Overexpression of the neuritotrophic cytokine S100β precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice
    • Sheng JG, Mrak RE, Bales KR (2000) Overexpression of the neuritotrophic cytokine S100β precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice. J Neurochem 74: 295-301
    • (2000) J Neurochem , vol.74 , pp. 295-301
    • Sheng, J.G.1    Mrak, R.E.2    Bales, K.R.3
  • 74
    • 0032465384 scopus 로고    scopus 로고
    • What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease
    • Smith MA, Perry G (1998) What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease. J Chem Neuroanat 16: 35-41
    • (1998) J Chem Neuroanat , vol.16 , pp. 35-41
    • Smith, M.A.1    Perry, G.2
  • 75
    • 0348213795 scopus 로고
    • Premature senility in Down's syndrome
    • St. Clair DF, Blackwood D (1985) Premature senility in Down's syndrome. Lancet Jul 6:34
    • (1985) Lancet Jul , vol.6 , pp. 34
    • St Clair, D.F.1    Blackwood, D.2
  • 76
    • 0032747486 scopus 로고    scopus 로고
    • Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
    • Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Brück W, Jellinger K, Lassmann H (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol 155: 1459-1466
    • (1999) Am J Pathol , vol.155 , pp. 1459-1466
    • Stadelmann, C.1    Deckwerth, T.L.2    Srinivasan, A.3    Bancher, C.4    Brück, W.5    Jellinger, K.6    Lassmann, H.7
  • 78
    • 0034682403 scopus 로고    scopus 로고
    • The DNA sequence of human chromosome 21
    • The chromosome 21 mapping and sequencing consortium (2000) The DNA sequence of human chromosome 21. Nature 405: 311-319
    • (2000) Nature , vol.405 , pp. 311-319
  • 80
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 83
    • 0016097607 scopus 로고
    • The use of 5-HTP in the treatment of Down's syndrome
    • Weise P, Koch R, Shaw KNF, Rosenfeld MJ (1974) The use of 5-HTP in the treatment of Down's syndrome. Pediatr 54: 165-167
    • (1974) Pediatr , vol.54 , pp. 165-167
    • Weise, P.1    Koch, R.2    Shaw, K.N.F.3    Rosenfeld, M.J.4
  • 84
    • 0031446195 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the neurotrophic factor S-100 beta show neuronal cytoskeletal and behavioral signs of altered aging processes: Implications for Alzheimer's disease and Down's syndrome
    • Whitaker-Azmitia PM, Wingate M, Borella A, Gerlai R, Roder J, Azmitia EC (1997) Transgenic mice overexpressing the neurotrophic factor S-100 beta show neuronal cytoskeletal and behavioral signs of altered aging processes: implications for Alzheimer's disease and Down's syndrome. Brain Res 776: 51-60
    • (1997) Brain Res , vol.776 , pp. 51-60
    • Whitaker-Azmitia, P.M.1    Wingate, M.2    Borella, A.3    Gerlai, R.4    Roder, J.5    Azmitia, E.C.6
  • 85
    • 0028674281 scopus 로고
    • Abnormal neurogenesis and synaptogenesis in Down syndrome brain
    • Wisniewski KE, Kida E (1994) Abnormal neurogenesis and synaptogenesis in Down syndrome brain. Dev Brain Dysfunct 7: 289-301
    • (1994) Dev Brain Dysfunct , vol.7 , pp. 289-301
    • Wisniewski, K.E.1    Kida, E.2
  • 86
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down syndrome
    • Wisniewski KE, Wisniewski HM, Wen GY (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down syndrome. Ann Neurol 17: 278-282
    • (1985) Ann Neurol , vol.17 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 88
    • 0021049766 scopus 로고
    • Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome
    • Yates CM, Simpson J, Gordon A, Maloney AFJ, Allison Y, Ritchie IM, Urquhart A (1983) Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res 280: 119-126
    • (1983) Brain Res , vol.280 , pp. 119-126
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3    Maloney, A.F.J.4    Allison, Y.5    Ritchie, I.M.6    Urquhart, A.7
  • 89
    • 0022633954 scopus 로고
    • Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease
    • Yates CM, Simpson J, Gordon A (1986) Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neurosci Lett 65: 189-192
    • (1986) Neurosci Lett , vol.65 , pp. 189-192
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3
  • 90
    • 0032544564 scopus 로고    scopus 로고
    • Apaf1 is required for mitochondrial pathways of apoptosis and brain development
    • Yoshida H, Kong Y-Y, Yoshida R (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94: 739-750
    • (1998) Cell , vol.94 , pp. 739-750
    • Yoshida, H.1    Kong, Y.-Y.2    Yoshida, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.