Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome

Advances in Pharmacology

Volumn 38, Issue C, 1996, Pages 379-402

  De Haan, Judy B ^a   Wolvetang, Ernst J ^a   Cristiano, Francesca ^a   Iannello, Rocco ^a   Bladier, Cecile ^b   Kelner, Michael J ^c   Kola, Ismail ^a  

^a MONASH UNIVERSITY   (Australia)

^b Cadarache Laboratoire de Phytotechnologie ^*  (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956761605     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60992-8     Document Type: Article

References (72)

1. Abate C., Patel L., Rauscher III F.J., and Curren T. Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249 (1990) 1157-1161
2. Allsopp T.E., Wyatt S., Paterson H.F., and Davies A.M. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73 (1993) 295-307
3. Amstad P., Peskin A., Shah G., Mirault M.E., Moret R., Zbinden I., and Cerutti P. The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress. Biochemistry 30 (1991) 9305-9313
4. Aruoma O.I., and Halliwell B. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron: Are lactoferrin and transferrin promoters of hydroxyl-radical generation?. Biochem. J. 241 (1987) 273-278
5. Avraham K.B., Sugerman H., Rotshenker S., and Groner Y. Down's syndrome: Morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice. J. Neurocytol. 20 (1991) 208-215
6. Badwey J.A., and Karnovsky M.L. Active oxygen species and the functions of phagocytic leukocytes. Annu. Rev. Biochem. 49 (1980) 695-726
7. Bjorksten B., Marklund S., and Hagglof B. Enzymes of leucocyte oxidative metabolism in Down's syndrome. Acta Paediatr. Scand. 73 (1984) 97-101
8. Brooksbank B.W.L., and Balazs R. Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Down's syndrome fetal brain. Brain Res. 318 (1984) 37-44
9. Busciglio J., and Yanker B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378 (1995) 776-779
10. Caffey J. "Paediatric X-Ray Diagnosis". 7th Ed. 1 (1978), Yearbook Medical Publishers Inc., Chicago 155-157
11. Ceballos I., Delabar J.M., Nicole A., Lynch R.E., Hallewell R.A., Kamoun P., and Sinet P.M. Expression of transfected human Cu-Zn superoxide dismutase gene in mouse L cells and NS20Y neuroblastoma cells induces enhancement of glutathione peroxidase activity. Biochim. Biophys. Acta 949 (1988) 58-64
12. Ceballos I., Nicole A., Briand P., Grimber G., Delacourte A., Flament S., Blouin J.L., Thevenin M., Kamoun P., and Sinet P.M. Expression of human Cu-Zn superoxide dismutase gene in transgenic mice: Model for gene dosage effect in Down syndrome. Free Rad. Res. Commun. 12-13 (1991) 581-589
13. Chada S., Le Beau M.M., Casey L., and Newburger P.E. Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6 (1990) 268-271
14. Chen H.-M., and Boxer L.M. IIl-binding sites are negative regulators of bcl-2 expression in pre-B cells. Mol. Cell. Biol. 15 (1995) 3840-3847
15. Cristiano F., De Haan J.B., Iannello R., and Kola I. Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage. Mech. Ageing Dev. 80 (1995) 93-105
16. De Haan J.B., Cristiano F., Iannello R.C., Bladier C., Kelner M.J., and Kola I. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum. Mol. Genet. 5 (1996) 283-292
17. De Haan J.B., Cristiano F., Iannelio R.C., and Kola I. Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem. Mol. Biol. Int. 35 (1995) 1281-1297
18. De Haan J.B., Newman J.D., and Kola I. Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains. Mol. Brain Res. 13 (1992) 179-186
19. Deng H.-X., Hentati A., Tainer J.A., Iqbal Z., Cayabyab A., Hung W.Y., Getzoff E.D., Hu P., Herzfeldt B., and Roos R.P. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261 (1993) 1047
20. Dipasquale B., Marini A.M., and Youle R.J. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem. Biophys. Res. Commun. 181 (1991) 1442-1448
21. Ellis H.M., and Horvitz H.R. Genetic control of programmed cell death in the nematode C. elegans. Cell 44 (1986) 817-829
22. Fahim M.A., and Robins N. Ultrastructural studies of young and old mouse-neuromuscular junctions. J. Neurocytol. 11 (1982) 641-656
23. Feaster W.W., Kwok L.W., and Epstein C. Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21. Am. J. Hum. Genet. 29 (1977) 563-570
24. Fong C., and Brodeur G.M. Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukomogenesis. Cancer Genet. Cytogenet. 28 (1987) 55-76
25. Frischer H., Chu L.K., Ahmad T., Justice P., and Smith G.F. In: Brewer G.J. (Ed). "The Red Cell: Fifth Ann Arbor Conference" (1981), Alan R. Liss, New York 269-283
26. Gilles L., Ferradini C., Foos J., Pucheault J., Allard D., Sinet P.M., and Jerome H. The estimation of red blood cell superoxide dismutase activity by pulse radiolysis in normal and trisomic cells. Hum. Genet. 31 (1976) 197-202
27. Groner Y., Elroy-Stein O., Avraham K.B., Yarom R., Schickler M., Knobler H., and Rotman G. Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human CdZn-superoxide dismutase gene. J. Physiol.-Paris 84 (1990) 53-77
28. Harper J.W., Adami G.R., Wei N., Keyomarsi K., and Elledge S.J. The p21 Cdk-interacting protein is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75 (1993) 805-816
29. Hockenbery D.M. bcl-2 in cancer, development and apoptosis. J. Cell Sci. 18 (1994) 51-55
30. Hockenbery D.M., Oltvai Z.N., Yin X.-M., Milliman C.L., and Korsmeyer S.J. Bcl-2 functions in an anti-oxidant pathway to prevent apoptosis. Cell 75 (1993) 241-251
31. Hockenbery D.M., Zutter M., Hickey W., Nahm M., and Korsmeyer S.J. Bcl-2 protein is topographically restricted in tissues characterised by apoptotic cell death. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 6961-6965
32. Imlay J.A., Chin S.M., and Linn S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240 (1988) 640-642
33. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla-Butler E., Selverstone-Valentine J., Ord T., and Bredesen D.E. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262 (1993) 1274-1277
34. Kelner M.J., and Bagnell R. Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector: Explanation for variations in paraquat resistance. J. Bioi. Chem. 265 (1990) 10872-10875
35. Kelner M.J., and Bagnell R. Alteration of growth rate and fibronectin by imbalances in superoxide dismutase and glutathione peroxidase activity. Biol. React. Intermed. IV (1990) 305-309
36. Kelner M.J., Bagnell R., Montoya M., Estes L., Uglik S.F., and Cerutti P. Transfection with human copper-zinc superoxide dismutase induces bidirectional alterations in other antioxidant enzymes, proteins, growth factor response, and paraquat resistence. Free Rad. Biol. Med. 18 (1995) 497-506
37. Kerr J.F.R., Wyllie A.H., and Currie A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
38. Korenberg J.R., Kawashima H., Pulst S.M., Ikeuchi T., Ogasawara N., Yamamoto K., Schonberg S.A., West R., Allen L., Magenis E., Ikawa K., Taniguchi N., and Epstein C.J. Molecular definition of a region of chromosome 21 that causes features of Down syndrome phenotype. Am. J. Hum. Genet. 47 (1990) 236-246
39. Kumazaki T., Robetorye R.S., Robetorye S.C., and Smith J.R. Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area. Exp. Cell Res. 195 (1991) 13-19
40. Loo D.T., Copani A., Pike C.J., Whitemore E.R., Walencewicz A.J., and Cotman C.W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7951-7955
41. Martin G.M. Genetic syndromes in man with potential relevence to the pathology of aging. In: Schneider E.L. (Ed). "Genetic Effects of Aging" (1977), National Foundation, March of Dimes
42. Mayer M., and Noble M. N-Acetyl cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 7496-7500
43. Mitchell I.J., Lawson S., Moser B., Laidlaw S.M., Cooper A.J., Walkinshaw G., and Waters C.M. Glutamate-induced apoptosis results in a loss of striated neurons in the parkisonian rat. Neuroscience 63 (1994) 1-5
44. Murdock J.C., and Evans J.H. An objective in vitro study of ageing in the skin of patients with Down's syndrome. J. Ment. Defic. Res. 22 (1978) 131-135
45. Neve J., Sinet P.M., Molle L., and Nicole A. Selenium, zinc and copper levels in Down's syndrome (trisomy 21): Blood levels and relations with glutathione peroxidase and superoxide dismutase. Clin. Chim. Acta 133 (1983) 209-214
46. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., and Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Biol. 211 (1994) 90-98
47. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (1993) 609-619
48. Oppenheim R.W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14 (1991) 453-501
49. Patterson D.H. The causes of Down syndrome. Sci. Am. 257 (1987) 42-49
50. Peled-Kamar M., Lotem J., Okon E., Sachs L., and Groner Y. Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overex-pressing Cd/Zn-superoxide dismutase: Implications for Down syndrome. EMBO J. 14 (1995) 4985-4993
51. Pendergrass W., Angello J., and Norwood T.H. The relationship between cell size, the activity of DNA polymerase alpha and proliferative activity in human diploid fibroblast-like cell cultures. Exp. Gerontol. 24 (1989) 383-393
52. Raff M.C., Barres B.A., Burne J.F., Coles H.S., Ishizake Y., and Jacobson M.D. Programmed cell death and the control of cell survival: Lessons from the nervous system. Science 262 (1993) 695-700
53. Rehder H. Pathology of trisomy 21, with particular reference to persistent common atrioventricular canal of the heart. In: Burgio G.R., Fraccaro M., Tiepolo L., and Wolf U. (Eds). "Trisomy 21: An International Symposium" (1981), Springer-Verlag, Berlin 57-73
54. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng D.X., Rahmani Z., Krizus A., Mckenna-Yasek D., Cayabyab A., Gaston S.M., Berger R., Tanzi R.E., Halperrin J.J., Hertzfeldt B., Van Den Bergh R., Hung W.Y., Bird T., Deng G., Mulder D.W., Smyth C., Laing N.G., Soriano E., Pericak-Vance M.A., Haines J., Rouleau G.A., Gusella J.S., Horvitz H.R., and Brown Jr. R.H. Mutations in Cd/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (1993) 59-62
55. Schmidt K.N., Amstad P., Cerutti P., and Baeuerle P.A. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-KB. Chem. Biol. 2 (1995) 13-22
56. Schreck R., Rieber P., and Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 10 (1991) 2247-2258
57. Sinet P.M., Michelson A.M., Bazin A., Lejeune J., and Jerome H. Increase in glutathione peroxidase activity in erythrocytes from trisomy 21 subjects. Biochem. Biophys. Res. Commun. 67 (1975) 910-915
58. Sinet P.M., Michelson A.M., Bazin A., Lejeune J., and Jerome H. Superoxide dismutase activities of blood platelets in trisomy 21. Biochem. Biophys. Res. Commun. 67 (1975) 904-909
59. Smith J.R., and Perierra-Smith O.M. Altered gene expression during cellular aging. Genome 31 (1989) 386-389
60. Sumarsono S.H., Wilson T.J., Tymms M.J., Venter D., Corrick C.M., Kola R., Lahoud M., Papas T.S., Seth A., and Kola I. Ets transgenic mice develop skeletal abnormalities analogous to those found in Down syndrome. Nature 379 (1996) 534-537
61. Takashima A., Noguchi K., Sato K., Hoshino T., and Imahori K. Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7789-7793
62. Tam C.F., and Walford R.L. Alteration in cyclic nucleotides and cyclase-specific activites in T lymphocytes of aging in normal humans and patients with Down's syndrome. J. Immunol. 125 (1980) 1665-1670
63. Tamura K., Manabe T., Andoh K., Kyogoku T., Oshio G., and Tobe T. Effect of intraarterial active oxygen species on the rat pancreas. Hepatogastroenterology 39 (1992) 152-157
64. Tan Y.H., Tischfield J., and Ruddle F.H. The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase B traits to chromosome 21. J. Exp. Med. 137 (1973) 317-330
65. Veis D.J., Sorenson C.M., Shutter J.R., and Korsmeyer S.J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75 (1993) 229-240
66. Wieacker P., Mueller D.R., Mayerova A., Grzeschik K.H., and Ropers H.H. Assignment of the gene coding for human catalase to the short arm of chromosome 11. Ann. Genet. 23 (1980) 73-77
67. Wisniewski K.E., Wisniewski H.M., and Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17 (1985) 278-282
68. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284 (1980) 555-556
69. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., and Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 366 (1993) 701-704
70. Yarom R., Sagher U., Havivi Y., Peled I.J., and Wexler M.R. Myofibres in tongues of Down's syndrome. J. Neurol. Sci. 73 (1986) 279-287
71. Yarom R., Sherman Y., Sagher U., Peled I.J., and Wexler M.R. Elevated concentrations of elements and abnormalities of neuromuscular junctions in tongue muscles of Down's syndrome. J. Neurol. Sci. 88 (1987) 41-53
72. Yarom R., Sapoznikov D., Havivi Y., Avraham K.B., Schickler M., and Groner Y. Prematwe aging changes in neuromuscular junctions of transgenic mice with extra human CuZnSOD gene: A model for tongue pathology in Down's syndrome. J. Neurol. Sci. 88 (1988) 41-53