Mouse models of allergic airway disease

Advances in Immunology

Volumn 77, Issue , 2001, Pages 263-295

  Lloyd, Clare M ^a   Gonzalo, Jose Angel ^b   Coyle, Anthony J ^b   Gutierrez Ramos, Jose Carlos ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ASTHMA; DISEASE MODEL; HUMAN; IMMUNOLOGY; MOUSE; REVIEW;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; HUMANS; MICE;

EID: 0035222530     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(01)77019-8     Document Type: Article

References (139)

1. Abbas, A. K., Murphy, K. M., and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
2. Alwan, W. H., Record, F. M., and Openshaw, P. J. (1993). Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins. J. Immunol. 150, 5211-5218.
3. Brewer, J. M., Conacher, M., Satoskar, A., Bluethmann, H., and Alexander, J. (1996). In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce Thelper 2 cytokine production. Eur. J. Immunol. 26, 2062-2066.
4. Brewer, J. M., Conacher, M., Hunter, C. A., Mohrs, M., Brombacher, F., and Alexander, J. (1999a). Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J. Immunol. 163, 6448-6454.
5. Brewer, J. P., Kisselgof, A. B., and Martin, T. R. (1999b). Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Am. J. Respir. Crit. Care Med. 160, 1150-1156.
6. Broide, D. H., Gleich, G. J., Cuomo, A. J., Coburn, D. A., Federman, E. C., Schwartz, L. B., and Wasserman, S. I. (1991). Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J. Allergy Clin. Immunol. 88, 637-648.
7. Brusselle, G. G., Kips, J. C., Tavernier, J. H., Van der Heyden, J. G., Cuvelier, C. A., Pauwels, R. A., and Bluethmann, H. (1994). Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 24, 73-80.
8. Busse, W. W. (1990). Respiratory infections: Their role in airway responsiveness and the pathogenesis of asthma. J. Allergy Clin. Immunol. 85, 671-683.
9. Campbell, E. M., Kunkel, S. L., Strieter, R. M., and Lukacs, N. W. (1998). Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J. Immunol. 161, 7047-7053.
10. Campbell, E. M., Charo, I. F., Kunkel, S. L., Strieter, R. M., Boring, L., Gosling, J., and Lukacs, N. W. (1999). Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/-mice: The role of mast cells. J. Immunol. 163, 2160-2167.
11. Cembrzynska-Nowak, M., Szklarz, E., Inglot, A. D., and Teodorczyk-Injeyan, J. A. (1993). Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis. 147, 291-295.
12. Chensue, S. W., Warmington, K. S., Ruth, J. H., Lincoln, P., and Kunkel, S. L. (1995). Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF. J. Immunol. 154, 5969-5976.
13. Chensue, S. W., Warmington, K., Ruth, J. H., Lukacs, N., and Kunkel, S. L. (1997). Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: Analysis of local and regional cytokine and chemokine networks. J. Immunol. 159, 3565-3573.
14. Chiba, Y., Yanagisawa, R., and Sagai, M. (1995). Strain and route differences in airway responsiveness to acetylcholine in mice. Res. Commun. Mol. Pathol. Pharmacol. 90, 169-172.
15. Cohn, L., Homer, R. J., Marinov, A., Rankin, J., and Bottomly, K. (1997). Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186, 1737-1747.
16. Cohn, L., Tepper, J. S., and Bottomly, K. (1998). IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J. Immunol. 161, 3813-3816.
17. Cohn, L., Homer, R. J., MacLeod, H., Mohrs, M., Brombacher, F., and Bottomly, K. (1999a). Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J. Immunol. 162, 6178-6183.
18. Cohn, L., Homer, R. J., Niu, N., and Bottomly, K. (1999b). T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J. Exp. Med. 190, 1309-1318.
19. Constant, S. L., and Bottomly, K. (1997). Induction of Th1 and Th2 CD4+ T cell responses: The alternative approaches. Annu. Rev. Immunol. 15, 297-322.
20. Constant, S. L., Lee, K. S., and Bottomly, K. (2000). Site of antigen delivery can influence T cell priming: Pulmonary environment promotes preferential Th2-type differentiation. Eur. J. Immunol. 30, 840-847.
21. Corry, D. B., Folkesson, H. G., Warnock, M. L., Erie, D. J., Matthay, M. A., Wiener-Knonish, J. P., and Locksley, R. M. (1996). Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperresponsiveness. J. Exp. Med. 183, 109-117.
22. Coyle, A. J., Tsuyuki, S., Bertrand, C., Huang, S., Aguet, M., Alkan, S. S., and Anderson, G. P. (1996a). Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J. Immunol. 156, 2680-2685.
23. Coyle, A. J., Wagner, K., Bertrand, C., Tsuyuki, S., Bews, J., and Heusser, C. (1996b). Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: Inhibition by a non-anaphylactogenic anti-IgE antibody. J. Exp. Med. 183, 1303-1310.
24. Coyle, A. J., Lloyd, C., Tian, J., Nguyen, T., Erikkson, C., Wang, L., Ottoson, P., Persson, P., Delaney, T., Lehar, S., Lin, S., Poisson, L., Meisel, C., Kamradt, T., Bjerke, T., Levinson, D., and Gutierrez-Ramos, J.-C. (1999). Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J. Exp. Med. 190, 895-902.
25. Coyle, A. J., Lehar, S., Lloyd, C. M., Tian, J., Delaney, T., Manning, S., Nguyen, T., Burwell, T., Schneider, H., Gosselin, M., Rudolph-Owen, L., Rudd, C., and Gutierrez-Ramos, J.-C. (2000). The CD28 related molecule ICOS is required for effective T cell dependent immune responses. Immunity 13, 95-105.
26. Dent, L. A., Strath, M., Mellor, A. L., and Sanderson, C. J. (1990). Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172, 1425-1431.
27. De Sanctis, G. T., Wolyniec, W W., Green, F. H., Qin, S., Jiao, A., Finn, P. W., Noonan, T., Joetham, A. A., Gelfand, E., Doerschuk, C. M., and Drazen, J. M. (1997). Reduction of allergic airway responses in P-selectin-deficient mice. J. Appl. Physiol. 83, 681-687.
28. De Sanctis, G. T., MacLean, J. A., Qin, S., Wolyniec, W W., Grasemann, H., Yandava, C. N., Jiao, A., Noonan, T., Stein-Streilein, J., Green, F. H., and Drazen, J. M. (1999). Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J. Clin. Invest. 103, 507-515.
29. Drazen, J. M., Arm, J. P., and Austen, K. F. (1996). Sorting out the cytokines of asthma. J. Exp. Med. 183, 1-5.
30. Drazen, J. M., Finn, P. W., and De Sanctis, G. T. (1999). Mouse models of airway responsiveness: Physiological basis of observed outcomes and analysis of selected examples using these outcome indicators. Annu. Rev. Physiol. 61, 593-625.
31. Durham, S. R., Ying, S., Varney, V. A., Jacobson, M. R., Sudderick, R. M., Mackay, I. S., Kay, A. B., and Hamid, Q. A. (1996). Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. J. Allergy Clin. Immunol. 97, 1356-1365.
32. Erb, K. J., Holloway, J. W., Sobeck, A., Moll, H., and Le Gros, G. (1998). Infection of mice with Mycobacterium bovis-bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J. Exp. Med. 187, 561-569.
33. USA Eum, S. Y., Haile, S., Lefort, J., Huerre, M., and Vargaftig, B. B. (1995). Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness. Proc. Natl. Acad. Sci. USA 92, 12290-12294.
34. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I., and Young, I. G. (1996). Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183, 195-201.
35. Frick, O. L., German, D. F., and Mills, J. (1979). Development of allergy in children. I. Association with virus infections. J. Allergy Clin. Immunol. 63, 228-241.
36. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 10, 587-593.
37. Gavett, S. H., O'Hearn, D. J., Li, X., Huang, S.-K., Finkelman, F. D., and Wills-Karp, M. (1995). Interleukin-12 inhibits antigen-induced airway hyperresponsiveness, inflammation and Th2 cytokine expression in mice. J. Exp. Med. 182, 1527-1536.
38. Gern, J. E., Lemanske, R. F. J., and Busse, W. W. (1999). Early life origins of asthma. J. Clin. Invest. 104, 837-843.
39. Gerwin, N., Gonzalo, J.-A., Lloyd, C., Coyle, A. J., Reiss, Y., Banu, N., Wang, B., Xu, H., Avraham, H., Engelhardt, B., Springer, T. A., and Gutierrez-Ramos, J.-C. (1999). Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2-deficient mice results in extended hyperresponsiveness. Immunity 10, 9-19.
40. Ghildyal, N., Friend, D. S., Freelund, R., Austen, K. F., McNeil, H. P., Schiller, V., and Stevens, R. L. (1994). Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J. Immunol. 153, 2624-2630.
41. Gleich, G. J., and Kita, H. (1997). Bronchial asthma: Lessons from murine models. Proc. Natl. Acad Sci. USA 94, 2101-2102.
42. Gonzalo, J.-A., Lloyd, C. M., Kremer, L., Finger, E., Martinez-A., C., Siegelman, M. H., Cybulsky, M. I., and Gutierrez-Ramos, J.-C. (1996a). Eosinophil recruitment to the lung in a murine model of allergic inflammation., The role of T cells, chemokines and adhesion receptors. J. Clin. Invest. 98, 2332-2345.
43. Gonzalo, J.-A., Jia, G.-Q., Aguirre, V., Friend, D., Coyle, A. J., Jenkins, N. A., Lin, G.-S., Katz, H., Lichtman, A., Copeland, N., Kopf, M., and Gutierrez-Ramos, J.-C. (1996b). Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity 4, 1-14.
44. Gonzalo, J.-A., Lloyd, C. M., Wen, D., Albar, J. P., Wells, T. N. C., Proudfoot, A., Martinez-A., C., Dorf, M., Bjerke, T., Coyle, A. J., and Gutierrez-Ramos, J.-C. (1998). The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airways hyperresponsiveness. J. Exp. Med. 188, 157-167.
45. Gonzalo, J.-A., Pan, Y., Lloyd, C. M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C. A., Proudfoot, A. E., Coyle, A. J., Gearing, D., and Gutierrez-Ramos, J.-C. (1999). Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J. Immunol. 163, 403-411.
46. Grun, J. L., and Maurer, P. H. (1989). Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: The role of endogenous interleukin 1 in proliferative responses. Cell. Immunol. 121, 134-145.
47. Grunig, G., Corry, D. B., Leach, M. W., Seymour, B. W., Kurup, V. P., and Rennick, D. M. (1997). Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J. Exp. Med. 185, 1089-1099.
48. Grunig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., and Corry, D. B. (1998). Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263.
49. Hackett, B. P., and Gitlin, J. D. (1992). Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice. Proc. Natl. Acad. Sci. USA 89, 9079-9083.
50. Hall, L. R., Mehlotra, R. K., Higgins, A. W., Haxhiu, M. A., and Pearlman, E. (1998). An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness. Infect. Immun. 66, 4425-4430.
51. Hamelmann, E., Oshiba, A., Paluh, J., Bradley, K., Loader, J., Potter, T. A., Larsen, G. L., and Gelfand, E. W. (1996). Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183, 1719-1729.
52. Hamelmann, E., Cieslewicz, G., Schwarze, J., Ishizuka, T., Joetham, A., Heusser, C., and Gelfand, E. W. (1999a). Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 160, 934-941.
53. Hamelmann, E., Tadeda, K., Oshiba, A., and Gelfand, E. W. (1999b). Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness - A murine model. Allergy 54, 297-305.
54. Hansen, G., Berry, G., DeKruyff, R. H., and Umetsu, D. T. (1999). Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175-183.
55. Hansen, G., McIntire, J. J., Yeung, V. P., Berry, G., Thorbecke, G. J., Chen, L., DeKruyff, R. H., and Umetsu, D. T. (2000). CD4(+) T helper cells engineered to produce latent TGF-betal reverse allergen-induced airway hyperreactivity and inflammation. J. Clin. Invest. 105, 61-70.
56. Hogan, S. P., Koskinen, A., Matthaei, K. I., Young, I. G., and Foster, P. S. (1998). Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice. Am. J. Respir. Crit. Care Med. 157, 210-218.
57. Holtzman, M. J., Sampath, D., Castro, M., Look, D. C., and Jayaraman, S. (1996). The one-two of T helper cells: Does interferon-gamma knock out the Th2 hypothesis for asthma? Am. J. Respir. Cell Mol. Biol. 14, 316-318.
58. Hunt, J. E., Stevens, R. L., Austen, K. F., Zhang, J., Xia, Z., and Ghildyal, N. (1996). Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse. J. Biol. Chem. 271, 2851-2855.
59. Iwamoto, I., Nakajima, H., Endo, H., and Yoshida, S. (1993). Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J. Exp. Med. 177, 573-576.
60. Iwamoto, I., Kumano, K., Kasai, M., Kurasawa, K., and Nakao, A. (1996). Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways. Am. J. Respir. Crit. Care Med. 154, 1257-1260.
61. Janssen, E. M., Wauben, M. H., Jonker, E. H., Hofman, G., Van Eden, W., Nijkamp, F. P., and Van Oosterhout, A. J. (1999). Opposite effects of immunotherapy with ovalbumin and the immuno-dominant T cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 21, 21-29.
62. Jia, G.-Q., Gonzalo, J.-A., Lloyd, C., Kremer, L., Lu, L., Martinez-A., C., Wershil, B. K., and Gutierrez-Ramos, J.-C. (1996). Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J. Exp. Med. 184, 1939-1951.
63. Jutel, M., Wyss-Coray, T., Carballido, J. M., Blaser, K., Muller, U. R., and Pichler, W. J. (1995). Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns. Clin. Exp. Allergy 25, 1108-1117.
64. Kaminuma, O., Mori, A., Ogawa, K., Nakata, A., Kikkawa, H., Naito, K., Suko, M., and Okudaira, H. (1997). Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones. Am. J. Respir. Cell. Mol. Biol. 16, 448-454.
65. Kauffman, H. F., Tomee, J. F., van der Werf, T. S., De Monchy, J. G., and Koeter, G. K. (1995). Review of fungus-induced asthmatic reactions. Am. J. Respir. Crit. Care. Med. 151, 2109-2115.
66. Korsgren, M., Erjefalt, J. S., Korsgren, O., Sundler, F., and Persson, C. G. (1997). Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J. Exp. Med. 185, 885-892.
67. Krinzman, S. J., De Sanctis, G. T., Cernadas, M., Mark, D., Wang, Y., Listman, J., Kobzik, L., Donovan, C., Nassr, K., Katona, I., Christiani, D. C., Perkins, D. L., and Finn, P. W. (1996). Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. J. Clin. Invest. 98, 2693-2699.
68. Krug, N., Madden, J., Redington, A. E., Lackie, P., Djukanovic, R., Schauer, V., Holgate, S. T., Frew, A. J., and Howarth, P. H. (1996). T cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma [see comments]. Am. J. Respir. Cell Mol. Biol. 14, 319-326.
69. Kumar, A., Sorkness, R. L., Kaplan, M. R., and Lemanske, R. F. J. (1997). Chronic, episodic, reversible airway obstruction after viral bronchiolitis in rats. Am. J. Respir. Crit. Care Med. 155, 130-134.
70. Kurup, V. P., and Kumar, A. (1991). Immunodiagnosis of aspergillosis. Clin. Microbiol. Rev. 4, 439-456.
71. Lambrecht, B. N., Salomon, B., Klatzmann, D., and Pauwels, R. A. (1998). Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J. Immunol. 160, 4090-4097.
72. Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D., and Lee, N. A. (1997). Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J. Exp. Med. 185, 2143-2156.
73. Levitt, R. C., Mitzner, W., and Kleeberger, S. R. (1990). A genetic approach to the study of lung physiology: Understanding biological variability in airway responsiveness. Am. J. Physiol. 258, L157-L164.
74. Li, L., Xia, Y., Nguyen, A., Feng, L., and Lo, D. (1998). Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation. J. Immunol. 161, 3128-3135.
75. Li, X. M., Schofield, B. H., Wang, Q. F., Kim, K. H., and Huang, S. K. (1998). Induction of pulmonary allergic responses by antigen-specific Th2 cells. J. Immunol. 160, 1378-1384.
76. Lloyd, C. M., Delany, T., Nguyen, T., Tian, J., Martinez-A., C., Coyle, A. J., and Gutierrez-Ramos, J.-C. (2000). CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J. Exp. Med. 191, 265-273.
77. Lloyd, C. M., Gonzalo, J. A., Nguyen, T., Delaney, T., Tian, J., Oettgen, H., Bjerke, T., Coyle, A. J., and Gutierrez-Ramos, J.-C. (2001). Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis. J. Immunol. (In press.)
78. Longphre, M., Li, D., Gallup, M., Drori, E., Ordonez, C. L., Redman, T., Wenzel, S., Bice, D. E., Fahy, J. V., and Basbaum, C. (1999). Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J. Clin. Invest. 104, 1375-1382.
79. Lukacs, N. W., Strieter, R. M., Chensue, S. W., and Kunkel, S. L. (1994). Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 10, 526-532.
80. Lukacs, N. W., Standiford, T. J., Chensue, S. W., Kunkel, R. G., Strieter, R. M., and Kunkel, S. L. (1996). C - C chemokine-induced eosinophil chemotaxis during allergic airway inflammation. J. Leukocyte Biol. 60, 573-578.
81. Lukacs, N. W., Oliveira, S. H., and Hogaboam, C. M. (1999). Chemokines and asthma: Redundancy of function or a coordinated effort? J. Clin. Invest. 104, 995-999.
82. MacLean, J. A., Ownbey, R., and Luster, A. D. (1996). T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophilia. J. Exp. Med. 184, 1461-1469.
83. MacLean, J. A., Sauty, A., Luster, A. D., Drazen, J. M., and De Sanctis, G. T. (1999). Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am. J. Respir. Cell Mol. Biol. 20, 379-387.
84. McMenamin, C., and Holt, P. G. (1993). The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC). class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178, 889-899.
85. McMenamin, C., Pimm, C., McKersey M., and Holt, P. G. (1994). Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science 265, 1869-1871.
86. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., and Coffman, R. L. (1986). Two types of murine helper T cell clone. 1. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
87. Murphy, K. M., Heimberger, A. B., and Loh, D. Y. (1990). Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250, 1720-1723.
88. Nicolaides, N. C., Holroyd, K. J., Ewart, S. L., Eleff, S. M., Kiser, M. B., Dragwa, C. R., Sullivan, C. D., Grasso, L., Zhang, L. Y., Messler, C. J., Zhou, T., Kleeberger, S. R., Buetow, K. H., and Levitt, R. C. (1997). Interleukin 9: A candidate gene for asthma. Proc. Natl. Acad. Sci. USA 94, 13175-13180.
89. Ong, R. K., and Doyle, R. L. (1998). Tropical pulmonary eosinophilia. Chest 113, 1673-1679.
90. Openshaw, P. J. (1995). Immunity and immunopathology to respiratory syncytial virus. The mouse model. Am. J. Respir. Crit. Care Med. 152, S59-S62.
91. Oshiba, A., Hamelmann, E., Takeda, K., Bradley, K. L., Loader, J. E., Larsen, G. L., and Gelfand, E. W. (1996). Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig). E and IgG1 in mice. J. Clin. Invest. 97, 1398-1408.
92. Ottesen, E. A., and Nutman, T. B. (1992). Tropical pulmonary eosinophilia. Annu. Rev. Med. 43, 417-424.
93. Pacheco, A., Cuevas, M., Carbelo, B., Maiz, L., Pavon, M. J., Perez, I., and Quirce, S. (1998). Eosinophilic lung disease associated with Candida albicans allergy. Eur. Respir. J. 12, 502-504.
94. Padrid, P. A., Mathur, M., Li, X., Herrmann, K., Qin, Y., Cattamanchi, A., Weinstock, J., Elliott, D., Sperling, A. I., and Bluestone, J. A. (1998). CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J. Respir. Cell Mol. Biol. 18, 453-462.
95. Pare, P. D., and Bai, T. R. (1995). The consequences of chronic allergic inflammation. Thorax 50, 328-332.
96. Parish, C. R., and Liew, F. Y. (1972). Immune response to chemically modified flagellin. 3. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 135, 298-311.
97. Persson, C. G., Erjefalt, J. S., Korsgren, M., and Sundler, F. (1997). The mouse trap. Trends Pharmacol. Sci. 18, 465-467.
98. Peters, S. P. (1990). Mast cells and histamine in asthma. J. Allergy Clin. Immunol. 86, 642-646.
99. Randolph, D. A., Carruthers, C. J., Szabo, S. J., Murphy, K. M., and Chaplin, D. D. (1999a). Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J. Immunol. 162, 2375-2383.
100. Randolph, D. A., Stephens, R., Carruthers, C. J., and Chaplin, D. D. (1999b). Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. J. Clin. Invest. 104, 1021-1029.
101. Rankin, J. A., Picarella, D. E., Geba, G. P., Temann, U. A., Prasad, B., DiCosmo, B., Tarallo, A., Stripp, B., Whitsett, J., and Flavell, R. A. (1996). Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93, 7821-7825.
102. Ray, P., Tang, W., Wang, P., Homer, R., Kuhn, C., Flavell, R. A., and Elias, J. A. (1997). Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J. Clin. Invest. 100, 2501-2511.
103. Renz, H., Smith, H. R., Henson, J. E., Ray, B. S., Irvin, C. G., and Gelfand, E. W. (1992). Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89, 1127-1138.
104. Rosenstreich, D. L., Eggleston, P., Kattan, M., Baker, D., Slavin, R. G., Gergen, P., Mitchell, H., McNiff-Mortimer, K., Lynn, H., Ownby, D., and Malveaux, F (1997). The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N. Engl. J. Med. 336, 1356-1363.
105. Rothenberg, M. E., MacLean, J. A., Pearlman, E., Luster, A. D., and Leder, P. (1997). Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185, 785-790.
106. Scheerens, H., Buckley, T. L., Davidse, E. M., Garssen, J., Nijkamp, F. P., and van Loveren, H. (1996). Toluene diisocyanate-induced in vitro tracheal hyperreactivity in the mouse. Am. J. Respir. Crit. Care Med. 154, 858-865.
107. Scheerens, H., Buckley, T. L., Muis, T. L., Garssen, J., Dormans, J., Nijkamp, F. P., and van Loveren, H. (1999). Long-term topical exposure to toluene diisocyanate in mice leads to antibody production and in vivo airway hyperresponsiveness three hours after intranasal challenge. Am. J. Respir. Crit. Care Med. 159, 1074-1080.
108. Schramm, C. M., Puddington, L., Yiamouyiannis, C. A., Lingenheld, E. G., Whiteley, H. E., Wolyniec, W. W., Noonan, T C., and Thrall, R. S. (2000). Proinflammatory roles of T cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 22, 218-225.
109. Schwarze, J., Hamelmann, E., Bradley, K. L., Takeda, K., and Gelfand, E. W. (1997). Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J. Clin. Invest. 100, 226-233.
110. Schwarze, J., Cieslewicz, G., Joetham, A., Ikemura, T., Hamelmann, E., and Gelfand, E. W. (1999a). CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. J. Immunol. 162, 4207-4211.
111. Schwarze, J., Makela, M., Cieslewicz, G., Dakhama, A., Lahn, M., Ikemura, T., Joetham, A., and Gelfand, E. W. (1999b). Transfer of the enhancing effect of respiratory syncytial virus infection on subsequent allergic airway sensitization by T lymphocytes. J. Immunol. 163, 5729-5734.
112. Shibuya, K., Naoe, S., and Yamaguchi, H. (1999). Animal models of A. fumigatus infections. Contrib. MicroBiol. 2, 130-138.
113. Stafford, S., Li, H., Forsythe, P. A., Ryan, M., Bravo, R., and Alam, R. (1997). Monocyte chemotactic protein-3 (MCP-3)/fibroblast-induced cytokine (FIC) in eosinophilic inflammation of the airways and the inhibitory effects of an anti-MCP-3/FIC antibody. J. Immunol. 158, 4953-4960.
114. Stampfli, M. R., Wiley, R. E., Neigh, G. S., Gajewska, B. U., Lei, X. F., Snider, D. P., Xing, Z., and Jordana, M. (1998). GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J. Clin. Invest. 102, 1704-1714.
115. Stampfli, M. R., Cwiartka, M., Gajewska, B. U., Alvarez, D., Ritz, S. A., Inman, M. D., Xing, Z., and Jordana, M. (1999). Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am. J. Respir. Cell Mol. Biol. 21, 586-596.
116. Tang, W., Geba, G. P., Zheng, T., Ray, P., Homer, R. J., Kuhn, C., Flavell, R. A., and Elias, J. A. (1996). Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J. Clin. Invest. 98, 2845-2853.
117. Taylor, G., Stott, E. J., Hughes, M., and Collins, A. P. (1984). Respiratory syncytial virus infection in mice. Infect. Immun. 43, 649-655.
118. Temann, U. A., Geba, G. P., Rankin, J. A., and Flavell, R. A. (1998). Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J. Exp. Med. 188, 1307-1320.
119. Temelkovski, J., Hogan, S. P., Shepherd, D. P., Foster, P. S., and Kumar, R. K. (1998). An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 53, 849-856.
120. Tepper, R. I., Levinson, D. A., Stanger, B. Z., Campos-Torres, J., Abbas, A. K., and Leder, P. (1990). IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62, 457-467.
121. Tsuyuki, S., Bertrand, C., Erard, F., Trifilieff, A., Tsuyuki, J., Wesp, M., Anderson, G. P., and Coyle, A. J. (1995). Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways. J. Clin. Invest. 96, 2924-2931.
122. Tsuyuki, S., Tsuyuki, J., Einsle, K., Kopf, M., and Coyle, A. J. (1997). Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J. Exp. Med. 185, 1671-1679.
123. Uhl, E. W., Castleman, W. L., Sorkness, R. L., Busse, W. W., Lemanske, R. F. J., and McAllister, P. K. (1996). Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats. Am. J. Respir. Crit. Care Med. 154, 1834-1842.
124. van Halteren, A. G., van der Cammen, M. J., Cooper, D., Savelkoul, H. F., Kraal, G., and Holt, P. G. (1997). Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction. J. Immunol. 159, 3009-3015.
125. Varney, V. A., Hamid, Q. A., Gaga, M., Ying, S., Jacobson, M., Frew, A. J., Kay, A. B., and Durham, S. R. (1993). Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J. Clin. Invest. 92, 644-651.
126. Wang, L. F., Lin, J. Y., Hsieh, K. H., and Lin, R. H. (1996). Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J. Immunol. 156, 4077-4082.
127. Watanabe, A., Mishima, H., Renzi, P. M., Xu, L. J., Hamid, Q., and Martin, J. G. (1995). Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in brown Norway rats. J. Clin. Invest. 96, 1303-1310.
128. Wilkinson, M. J., Wells, C., and Behnke, J. M. (1990). Necator americanus in the mouse: Histopathological changes associated with the passage of larvae through the lungs of mice exposed to primary and secondary infection. Parasitol. Res. 76, 386-392.
129. Wills-Karp, M., and Ewart, S. L. (1997). The genetics of allergen-induced airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 156, S89-S96.
130. Wills-Karp, M., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L., and Donaldson, D. D. (1998). Interleukin-13: Central mediator of allergic asthma. Science 282, 2258-2261.
131. Wise, J. T., Baginski, T. J., and Mobley, J. L. (1999). An adoptive transfer model of allergic lung inflammation in mice is mediated by CD4+CD62LlowCD25+ T cells. J. Immunol. 162, 5592-5600.
132. Wynn, T. A., and Cheever, A. W. (1995). Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol. 7, 505-511.
133. Yang, Y., Loy, J., Ryseck, R. P., Carrasco, D., and Bravo, R. (1998). Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood 92, 3912-3923.
134. Yasue, M., Yokota, T., Suko, M., Okudaira, H., and Okumura, Y. (1998). Comparison of sensitization to crude and purified house dust mite allergens in inbred mice. Lab. Anim. Sci. 48, 346-352.
135. Yssel, H., Fasler, S., Lamb, J., and de Vries, J. E. (1994). Induction of non-responsiveness in human allergen-specific type 2 T helper cells. Curr. Opin. Immunol. 6, 847-852.
136. Yu, C. K., Lee, S. C., Wang, J. Y., Hsiue, T. R., and Lei, H. Y. (1996). Early-type hypersensitivity-associated airway inflammation and eosinophilia induced by Dermatophagoides farinae in sensitized mice. J. Immunol. 156, 1923-1930.
137. Zhang, Y., Lamm, W. J., Albert, R. K., Chi, E. Y., Henderson, W. R. J., and Lewis, D. B. (1997). Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am. J. Respir. Crit. Care Med. 155, 661-669.
138. Zhu, Z., Homer, R. J., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., and Elias, J. A. (1999). Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103, 779-788.
139. Zuany-Amorim, C., Hailé, S., Leduc, D., Dumarey, C., Huerre, M., Vargaftig, B. B., and Pretolani, M. (1995). Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95, 2644-2651.