The One-two of T Helper Cells: Does Interferon-γ Knock Out the Th2 Hypothesis for Asthma?

American Journal of Respiratory Cell and Molecular Biology

Volumn 14, Issue 4, 1996, Pages 316-318

  Holtzman, Michael J ^a   Sampath, Deepak ^a   Castro, Mario ^a   Look, Dwight C ^a   Jayaraman, Sundararajan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ANIMAL; ASTHMA; HELPER CELL; HUMAN; IMMUNOLOGY; MOUSE; NOTE; PHYSIOLOGY; T LYMPHOCYTE; TH2 CELL;

ANIMALS; ASTHMA; HUMANS; INTERFERON TYPE II; MICE; T-LYMPHOCYTES; T-LYMPHOCYTES, HELPER-INDUCER; TH2 CELLS;

EID: 0030119415     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.14.4.8600934     Document Type: Review

References (24)

1. Ying, S., S. R. Durham, C. J. Corrigan, Q. Hamid, and A. B. Kay. 1995. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am. J. Respir. Cell Mol. Biol. 12:477-487.
2. Lack, G., H. Renz, J. Saloga, K. L. Bradley, J. Loader, D. Y. M. Leung, G. Larsen, and E. W. Gelfand. 1994. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152:2546-2554.
3. McMenamin, C., C. Pimm, M. McKersey, and P. G. Holt. 1994. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 265:1869-1871.
4. Gavett, S. H., D. J. O'Hearn, X. Li, S.-K. Huang, F. D. Finkelman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527-1536.
5. Palliard, X., R. De Waal Malefijt, H. Yssel, D. Blanchard, I. Chretien, J. Abrams, J. De Vries, and H. Spits. 1988. Simultaneous production of IL-2, IL-4, and IFN-γ by activated human CD4+ and CD8+ T cell clones. J. Immunol. 141:849-855.
6. Wierenga, E., M. Snoek, C. deGroot, I. Chretien, J. D. Bos, H. M. Jansen, and M. L. Kapsenberg. 1990. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J. Immunol. 144:4651-4656.
7. Parronchi, P., D. Macchia, M.-P. Piccinni, P. Biswas, C. Simonelli, E. Maggi, M. Ricci, A. A. Ansari, and S. Romagnani. 1991. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl. Acad. Sci. USA 88:4538-4542.
8. Del Prete, G. F., M. De Carli, C. Mastromauro, R. Biagiotti, D. Macchia, P. Falagiani, M. Ricci, and S. Romagnani. 1991. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (Type 1 T helper or Type 2 T helper) profile of cytokine production. J. Clin. Invest. 88:346-350.
9. Del Prete, G. F., M. De Carli, M. M. D'Elios, P. Maestrelli, M. Ricci, L. Fabbri, and S. Romagnani. 1993. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur. J. Immunol. 23:1445-1449.
10. Fasler, S., G. Aversa, A. Terr, K. Thestrup-Pedersen, J. E. de Vries, and H. Yssel. 1995. Peptide-induced anergy in allergen-specific human Th2 cells results in lack of cytokine production and B cell help for IgE synthesis. J. Immunol 155:4199-4206.
11. Brinkmann, V., and C. Kristofic. 1995. TCR-stimulated naive human CD4+45RO- T cells develop into effector cells that secrete IL-13, IL-5, and IFN-γ, but no IL-4, and help efficient IgE production by B cells. J. Immunol. 154:3078-3087.
12. Calhoun, W. J., K. L. Hinton, and R. E. Friedenheim. 1995 Evidence for simultaneous Th1 and Th2 lymphocyte activation in allergic asthma following segmental antigen challenge. Am. J. Respir. Crit. Care Med. 151: A778. (Abstr.)
13. Lederer, J. A., J. S. Liou, M. D. Todd, L. H. Glimcher, and A. H. Lichtman. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77-86.
14. Cippitelli, M., A. Sica, V. Viggiano, J. Ye, P. Ghosh, M. J. Birrer, and H. A. Young. 1995. Negative transcriptional regulation of the interferon-γ promoter by glucocorticoids and dominant negative mutants of c-Jun. J. Biol. Chem. 270:12548-12556.
15. Krug, N., J. Madden, A. E. Redington, P. Lackie, R. Djukanovic, U. Schauer, S. T. Holgate, A. J. Frew, and P. H. Howarth. 1996. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am. J. Respir. Cell Mol. Biol. 14:319-326.
16. Corrigan, C. J., and A. B. Kay, 1990. CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am. Rev. Respir. Dis. 141:970-977.
17. Cembrzynska-Nowak, M., E. Szklarz, A. D. Inglot, and J. A. Teodorczyk-Injeyan. 1993. Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis. 147:291-295.
18. Powers, G. D., A. K. Abbas, and R. A. Miller. 1988. Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations. J. Immunol. 140:3352-3357.
19. Nakajima, S., W. T. Roswit, D. C. Look, and M. J. Holtzman. 1995. A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes Vδ1+ γδ T cell adherence and tissue retention. J. Immunol. 155:1117-1131.
20. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J.-C. Virchow, Jr. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 148:109-115.
21. Coyle, A. J., F. Erard, C. Bertrand, S. Walti, H. Pircher, and G. Le Gros. 1995. Virus-specific CD8+ cells can switch to interleukin-5 production and induce airway eosinophilia. J. Exp. Med. 181:1229-1233.
22. Holtzman, M. J., S. L. Brody, and D. C. Look. 1995. Does gene therapy call for "STAT" immunity and inflammation at the epithelial barrier? Am. J. Respir. Cell Mol. Biol. 12:127-129.
23. Greenlund, A. C., M. O. Morales, B. L. Viviano, H. Yan, J. Krolewski, and R. D. Schreiber. 1995. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2:677-687.
24. Look, D. C., M. R. Pelletier, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman. 1995. Statl depends on transcriptional synergy with Spl. J. Biol. Chem. 270:30264-30267.