Seizures during alpha interferon therapy

Journal of Hepatology

Volumn 24, Issue 1, 1996, Pages 48-51

  Shakil, A Obaid ^a   Di Bisceglie, Adrian M ^a   Hoofnagle, Jay H ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Alpha interferon; Chronic hepatitis; Seizures; Side effects

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; ALPHAN1 INTERFERON; PHENYTOIN; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON;

ADULT; ARTICLE; CASE REPORT; CHRONIC HEPATITIS; HUMAN; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEIZURE; VIRUS HEPATITIS;

EID: 0030048528     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80185-1     Document Type: Article

References (18)

1. Hoofnagle JH. Therapy of acute and chronic viral hepatitis. Adv Intern Med 1994; 39: 241-75.
2. Perrillo RP, Schiff ER, Davis GL, Bodenheimer HC Jr, Lindsay K, Payne J, Dienstag JL, O'Brien C, Tamburro C, Jacobson IM, Sampliner R, Feit D, Lefkowitch J, Kuhns M, Meschievitz C, Sanghvi B, Albrecht J, Gibas A, and the Hepatitis Interventional Therapy Group. A randomized controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323: 295-301.
3. Wong DKH, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. Ann Intern Med 1993; 119: 312-23.
4. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC Jr, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, Van Thiel DH, Tamburro C, Lefkowitch J, Albrecht J, Meschievitz C, Ortego TJ, Gibas A, and the Hepatitis Interventional Therapy Group. Treatment of chronic hepatitis C with recombinant interferon alfa: a multicenter randomized, controlled trial. N Engl J Med 1989; 321: 1501-6.
5. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH. Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N Engl J Med 1989; 321: 1506-10.
6. Renault PF, Hoofnagle JH. Side effects of alpha interferon. Semin Liver Dis 1989; 9: 273-7.
7. Smedley H, Katrak M, Sikora K, Wheeler T. Neurological effects of recombinant human interferon. Br Med J 1983; 286: 262-4.
8. Renault PF, Hoofnagle JH, Park Y, Mullen KD, Peters M, Jones DB, Rustgi V, Jones EA. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med 1987; 147: 1577-80.
9. Hoofnagle JH, Di Bisceglie AM, Waggoner JG, Park Y. Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B. Gastroenterology 1993; 104: 1116-21.
10. Mayet W-J, Hess G, Gerken G, Rossol S, Voth R, Manns M, Meyer zum Buschenfelde K-H. Treatment of chronic type B hepatitis with recombinant x-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology 1989; 10: 24-8.
11. Lisker-Melman M, Di Bisceglie AM, Usala SJ, Weintraub B, Murray LM, Hoofnagle JH. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. Gastroenterology 1992; 102: 2155-60.
12. Deyton LR, Walker RE, Kovacs JA. Reversible cardiac dysfuntion associated with interferon alfa therapy in AIDS patients with Kaposi's sarcoma. N Engl J Med 1989; 321: 1246-9.
13. Averbuch SD, Austin HA, Sherwin SA, Antonovych T, Bunn PA, Longo DL. Acute interstitial nephritis with the nephrotic syndrome following recombinant leukocyte A interferon therapy for mycosis fungoides. N Engl J Med 1984; 310: 32-5.
14. Kirkwood JM, Ernstoff MS, Davis CA, Reiss M, Ferraresi R, Rudnick SA. Comparison of intramuscular and intravenous recombinant alpha-2 interferon in melanoma and other cancers. Ann Intern Med 1985; 103: 32-6.
15. Janssen HLA, Berk L, Vermeulen M, Schalm SW. Seizures associated with low-dose α-interferon [Letter]. Lancet 1990; 336: 1580.
16. Hauser WA, Hesdorffer DC. Epilepsy: frequency, causes and consequences. New York; Demos Publications and Epilepsy Foundation of America; 1990: 1-51.
17. Calvet M-C, Gresser I. Interferon enhances the excitability of cultured neurones. Nature 1979; 278: 558-60.
18. Guyer DR, Tiedeman J, Yannuzzi LA, Slakter JS, Parke D, Kelley J, Tang RA, Marmo M, Abrams G, Miller JW, Gragoudas ES. Interferon-associated retinopathy. Arch Ophthalmol 1993; 111: 350-5.