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Volumn 10, Issue 2, 1997, Pages 103-109

Messy fiber reorganization in the epileptic hippocampus

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HIPPOCAMPUS; HUMAN; MOSSY FIBER; PATHOPHYSIOLOGY; TEMPORAL LOBE EPILEPSY; TISSUE DISTRIBUTION; ANIMAL; DENTATE GYRUS; NERVE CELL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE FIBER; NERVE REGENERATION; PATHOLOGY; PHYSIOLOGY; REVIEW;

EID: 0030609963     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199704000-00006     Document Type: Article
Times cited : (74)

References (50)
  • 1
    • 0024412565 scopus 로고
    • Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
    • de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD: Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 1989, 495:387-395.
    • (1989) Brain Res , vol.495 , pp. 387-395
    • De Lanerolle, N.C.1    Kim, J.H.2    Robbins, R.J.3    Spencer, D.D.4
  • 2
    • 0024444281 scopus 로고
    • Mossy fiber synaptic reorganization in the epileptic human temporal lobe
    • Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L: Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 1989, 26:321-330.
    • (1989) Ann Neurol , vol.26 , pp. 321-330
    • Sutula, T.1    Cascino, G.2    Cavazos, J.3    Parada, I.4    Ramirez, L.5
  • 3
    • 0025022424 scopus 로고
    • Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
    • Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR, Delgado-Escueta AV: Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization In human hippocampal epilepsy. J Neuro-Sci 1990, 10:267-282.
    • (1990) J Neuro-Sci , vol.10 , pp. 267-282
    • Houser, C.R.1    Miyashiro, J.E.2    Swartz, B.E.3    Walsh, G.O.4    Rich, J.R.5    Delgado-Escueta, A.V.6
  • 5
    • 0021917797 scopus 로고
    • Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
    • Tauck D, Nadler J: Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci 1985, 5:1016-1022.
    • (1985) J Neurosci , vol.5 , pp. 1016-1022
    • Tauck, D.1    Nadler, J.2
  • 6
    • 0024208367 scopus 로고
    • Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats
    • Cronin J, Dudek FE: Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain Res 1988, 474:181-184.
    • (1988) Brain Res , vol.474 , pp. 181-184
    • Cronin, J.1    Dudek, F.E.2
  • 7
    • 0023872014 scopus 로고
    • Synaptic reorganization in the hippocampus induced by abnormal functional activity
    • Sutula T, Xiao-Xian H, Cavazos J, Scott G: Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science 1988, 239:1147-1150.
    • (1988) Science , vol.239 , pp. 1147-1150
    • Sutula, T.1    Xiao-Xian, H.2    Cavazos, J.3    Scott, G.4
  • 8
    • 0027143716 scopus 로고
    • Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: Cell loss and mossy fiber sprouting
    • Mello LE, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 1993. 34:985-995.
    • (1993) Epilepsia , vol.34 , pp. 985-995
    • Mello, L.E.1    Cavalheiro, E.A.2    Tan, A.M.3    Kupfer, W.R.4    Pretorius, J.K.5    Babb, T.L.6    Finch, D.M.7
  • 9
    • 0029944724 scopus 로고    scopus 로고
    • Hippocampal cell distributions in temporal lobe epilepsy: A comparison between patients with and without an early risk factor
    • O'Connor WM, Masukawa L, Freese A, Sperling MR, French JA, O'Connor MJ: Hippocampal cell distributions in temporal lobe epilepsy: a comparison between patients with and without an early risk factor. Epilepsia1996, 37:440-449.
    • (1996) Epilepsia , vol.37 , pp. 440-449
    • O'Connor, W.M.1    Masukawa, L.2    Freese, A.3    Sperling, M.R.4    French, J.A.5    O'Connor, M.J.6
  • 10
    • 0028885214 scopus 로고
    • Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures
    • Mathern GW, Pretorius JK, Babb TL: Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures. J Neurosurg 1995, 82:220-227.
    • (1995) J Neurosurg , vol.82 , pp. 220-227
    • Mathern, G.W.1    Pretorius, J.K.2    Babb, T.L.3
  • 11
    • 0025203933 scopus 로고
    • Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy
    • Houser CR: Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy. Brain Res 1990, 535:195-204.
    • (1990) Brain Res , vol.535 , pp. 195-204
    • Houser, C.R.1
  • 12
    • 0029934818 scopus 로고    scopus 로고
    • Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization
    • Mathem GW, Babb TL, Mischel PS, Vinters HV, Pretorius JK, Leite JP, Peacock WJ: Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization. Brain 1996, 119:965-987.
    • (1996) Brain , vol.119 , pp. 965-987
    • Mathem, G.W.1    Babb, T.L.2    Mischel, P.S.3    Vinters, H.V.4    Pretorius, J.K.5    Leite, J.P.6    Peacock, W.J.7
  • 13
    • 0028905017 scopus 로고
    • Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients
    • Masukawa LM, O'Connor WM, Lynott J, Burdette LJ, Uruno K, McGonigle P, O'Connor MJ: Longitudinal variation In cell density and mossy fiber reorganization In the dentate gyrus from temporal lobe epileptic patients. Brain Res 1995, 678:65-75
    • (1995) Brain Res , vol.678 , pp. 65-75
    • Masukawa, L.M.1    O'Connor, W.M.2    Lynott, J.3    Burdette, L.J.4    Uruno, K.5    McGonigle, P.6    O'Connor, M.J.7
  • 14
    • 0028870168 scopus 로고
    • Quantified patterns of mossy fiber sprouting and neuron densities in hippocampal and lesional seizures
    • Mathern GW, Pretorius JK, Babb TL: Quantified patterns of mossy fiber sprouting and neuron densities in hippocampal and lesional seizures. J Neurosurg 1995, 82:211-219.
    • (1995) J Neurosurg , vol.82 , pp. 211-219
    • Mathern, G.W.1    Pretorius, J.K.2    Babb, T.L.3
  • 15
    • 0027409383 scopus 로고
    • Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epllepsy
    • Isokawa M, Levesque MF, Babb TL, Engel J Jr: Single mossy fiber axonal systems of human dentate granule cells studied In hippocampal slices from patients with temporal lobe epllepsy. J Neurosci 1993, 13:1511-1522.
    • (1993) J Neurosci , vol.13 , pp. 1511-1522
    • Isokawa, M.1    Levesque, M.F.2    Babb, T.L.3    Engel Jr., J.4
  • 16
    • 0029042668 scopus 로고
    • Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus
    • Franck JE, Pokorny J, Kunkel DD, Schwartzkroin PA: Physiologic and morphologic characteristics of granule cell circuitry In human epileptic hippocampus. Epilepsia 1995, 36:543-558.
    • (1995) Epilepsia , vol.36 , pp. 543-558
    • Franck, J.E.1    Pokorny, J.2    Kunkel, D.D.3    Schwartzkroin, P.A.4
  • 17
    • 0028911542 scopus 로고
    • Hippocampal mossy fiber sprouting and synapse formation after status epllepticus in rats: Visualization after retrograde transport of biocytin
    • Okazaki MM, Evenson DA, Nadler JV: Hippocampal mossy fiber sprout• ing and synapse formation after status epllepticus in rats: visualization after retrograde transport of biocytin. J Comp Neurol 1995, 352:515-534. Retrograde labeling with biocytin after chemoconvulsant-induced status epilepticus in rats demonstrates recurrent granule cell-granule cell synapses in the dentate molecular layer. These results are the strongest evidence to date for the formation of a recurrent excitatory circuit following seizure-induced hippocampal injury.
    • (1995) J Comp Neurol , vol.352 , pp. 515-534
    • Okazaki, M.M.1    Evenson, D.A.2    Nadler, J.V.3
  • 18
    • 0026558337 scopus 로고
    • Electrophysiology of dentate granule cells after kainate-lnduced synaptic reorganization of the mossy fibers
    • Cronin J, Obenaus A, Houser CR, Dudek FE: Electrophysiology of dentate granule cells after kainate-lnduced synaptic reorganization of the mossy fibers. Brain Res 1992, 573:305-310.
    • (1992) Brain Res , vol.573 , pp. 305-310
    • Cronin, J.1    Obenaus, A.2    Houser, C.R.3    Dudek, F.E.4
  • 19
    • 0025717405 scopus 로고
    • Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The 'dormant basket cell' hypothesis and its possible relevance to temporal lobe epilepsy
    • Sloviter RS: Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus In the rat: the 'dormant basket cell' hypothesis and its possible relevance to temporal lobe epilepsy. Hippocampus 1991, 1:41-66.
    • (1991) Hippocampus , vol.1 , pp. 41-66
    • Sloviter, R.S.1
  • 20
    • 0026594823 scopus 로고
    • Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats
    • Sloviter RS: Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci Lett 1992, 137:91-96.
    • (1992) Neurosci Lett , vol.137 , pp. 91-96
    • Sloviter, R.S.1
  • 21
    • 0030044394 scopus 로고    scopus 로고
    • Functional alterations in the dentate gyrus after Induction of long-term potentiation, kindling and mossy fiber sprouting
    • Golarai G, Sutula TP: Functional alterations In the dentate gyrus after Induction of long-term potentiation, kindling and mossy fiber sprouting. J Neurophysiol 1996, 75:343-353.
    • (1996) J Neurophysiol , vol.75 , pp. 343-353
    • Golarai, G.1    Sutula, T.P.2
  • 22
    • 0029991960 scopus 로고
    • Extracellular slow negative transient in the dentate gyrus of human epileptic hippocampus in vitro
    • Isokawa M, Fried I: Extracellular slow negative transient in the dentate gyrus of human epileptic hippocampus in vitro. Neuroscience 1995, 72:31-37.
    • (1995) Neuroscience , vol.72 , pp. 31-37
    • Isokawa, M.1    Fried, I.2
  • 23
    • 0029937283 scopus 로고    scopus 로고
    • Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainatetreated epileptic rats
    • Wuann J, Dudek FE: Electrographic seizures and new recurrent excita• tory circuits In the dentate gyrus of hippocampal slices from kainatetreated epileptic rats. J Neurosci 1996, 16:4438-4448. Using hilar stimulation and glutamate microdrops applied to the DGC layer, the authors provide further electrophysiologic evidence for a functional recurrent excitatory circuit in the dentate gyrus of kainate-treated rats that is temporally associated with mossy fiber reorganization.
    • (1996) J Neurosci , vol.16 , pp. 4438-4448
    • Wuann, J.1    Dudek, F.E.2
  • 24
    • 0030593034 scopus 로고    scopus 로고
    • Zinc-Induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model
    • A-mediated inhibition of DGCs is reduced upon exposure to zinc, which is present in the terminals of sprouted mossy fibers and may serve to increase excitability in the dentate gyrus.
    • (1996) Science , vol.271 , pp. 369-373
    • Buhl, E.H.1    Otis, T.S.2    Mody, I.3
  • 25
    • 0029097850 scopus 로고
    • Zinc reduces dentate granule cell hyper-excitability in epileptic humans
    • Williamson A, Spencer D: Zinc reduces dentate granule cell hyper-excitability in epileptic humans. NeuroReport 1995, 6:1562-1564.
    • (1995) NeuroReport , vol.6 , pp. 1562-1564
    • Williamson, A.1    Spencer, D.2
  • 26
    • 0028840599 scopus 로고
    • Hippocampal granule cells express glutamic acid decarboxylase-67 after llmbic seizures in the rat
    • Schwarzer C, Sperk G: Hippocampal granule cells express glutamic acid decarboxylase-67 after llmbic seizures In the rat. Neuroscience 1995, 69:705-709.
    • (1995) Neuroscience , vol.69 , pp. 705-709
    • Schwarzer, C.1    Sperk, G.2
  • 27
    • 0029813744 scopus 로고    scopus 로고
    • Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus
    • Sloviter RS, Dichter MA, Rachinsky TL, Dean E, Goodman JH, Sollas AL, • Martin DL: Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J Comp Neurol 1996, 373:593-618. This study used immunocytochemical methods to provide evidence that DGCs are capable of synthesizing GABA, and that this activity is enhanced in the perforant path stimulation seizure model. These intriguing findings raise the possibility that DGCs may be capable of inhibitory neurotransmission as a compensatory mechanism in the epileptic state.
    • (1996) J Comp Neurol , vol.373 , pp. 593-618
    • Sloviter, R.S.1    Dichter, M.A.2    Rachinsky, T.L.3    Dean, E.4    Goodman, J.H.5    Sollas, A.L.6    Martin, D.L.7
  • 28
    • 0029082199 scopus 로고
    • The limbic system-associated membrane protein is an lg superfamlly member that mediates selective neuronal growth and axon targeting
    • Pimenta A, Zhukareva V, Barbe M, Reinoso B, Grimley C, Henzel W, • Fischer I, Levitt P: The limbic system-associated membrane protein is an lg superfamlly member that mediates selective neuronal growth and axon targeting. Neuron 1995, 15:287-297. LAMP has previously been shown to be expressed in cortical and subcortical neurons within the 'limbic' system (including DGCs), and is specifically located on growth cones and axons during pathway formation in early development. In this study, the authors demonstrate that intrahippocampal injection of an anti-LAMP antibody during the second postnatal week of the rat results in aberrant growth of mossy fibers.
    • (1995) Neuron , vol.15 , pp. 287-297
    • Pimenta, A.1    Zhukareva, V.2    Barbe, M.3    Reinoso, B.4    Grimley, C.5    Henzel, W.6    Fischer, I.7    Levitt, P.8
  • 29
    • 0024763935 scopus 로고
    • A membrane glycoprotein associated with the limbic system mediates the formation of the septohippocampal pathway in vitro
    • Keller F, Rimvall K, Barbe M, Levitt P: A membrane glycoprotein associated with the limbic system mediates the formation of the septohippocampal pathway in vitro. Neuron 1989, 3:551-561.
    • (1989) Neuron , vol.3 , pp. 551-561
    • Keller, F.1    Rimvall, K.2    Barbe, M.3    Levitt, P.4
  • 30
    • 0025165240 scopus 로고
    • Isolation, biochemical characterization and ultrastructural localization of the limbic system-associated membrane protein (LAMP), a protein expressed on neurons comprising functional neural circuits
    • Zacco A, Cooper V, Chantier P, Hyland-Fisher S, Horton H, Levitt P: Isolation, biochemical characterization and ultrastructural localization of the limbic system-associated membrane protein (LAMP), a protein expressed on neurons comprising functional neural circuits. J Neurosci 1990, 10:73-90.
    • (1990) J Neurosci , vol.10 , pp. 73-90
    • Zacco, A.1    Cooper, V.2    Chantier, P.3    Hyland-Fisher, S.4    Horton, H.5    Levitt, P.6
  • 31
    • 0029995299 scopus 로고    scopus 로고
    • The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
    • Lowenstein D, Arsenault L: The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons. J Neurosci 1996, 16:1759-1769.
    • (1996) J Neurosci , vol.16 , pp. 1759-1769
    • Lowenstein, D.1    Arsenault, L.2
  • 32
    • 0030271826 scopus 로고    scopus 로고
    • Dentate granule cell layer collagen expiant cultures: Spontaneous axonal growth and induction by brain-derived neurotrophic factor or basic flbroblast growth factor
    • Lowenstein D, Arsenault L: Dentate granule cell layer collagen expiant • cultures: spontaneous axonal growth and induction by brain-derived neurotrophic factor or basic flbroblast growth factor. Neuroscience 1996, 74:1197-1208. This study demonstrates the feasibility of growing microdissected regions of the dentate granule and pyramidal cell layers within a 3-dimensional collagen matrix. The cultures allow for direct, real-time visualization of growing axons into the matrix, and therefore provide a system for the study of axon guidance molecules on developing mossy fibers.
    • (1996) Neuroscience , vol.74 , pp. 1197-1208
    • Lowenstein, D.1    Arsenault, L.2
  • 33
    • 0028822351 scopus 로고
    • Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors
    • Patel M, McNamara J: Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors. Neuroscience 1995, 69:763-770.
    • (1995) Neuroscience , vol.69 , pp. 763-770
    • Patel, M.1    McNamara, J.2
  • 35
    • 0028868529 scopus 로고
    • Factors influencing mossy fiber collateral sprouting in organotypic slice cultures of neonatal mouse hippocampus
    • Coltman B, Earley E, Shahar A, Dudek F, Ide C: Factors influencing mossy fiber collateral sprouting in organotypic slice cultures of neonatal mouse hippocampus. J Comp Neurol 1995, 362:209-222.
    • (1995) J Comp Neurol , vol.362 , pp. 209-222
    • Coltman, B.1    Earley, E.2    Shahar, A.3    Dudek, F.4    Ide, C.5
  • 36
    • 0029050698 scopus 로고
    • Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats
    • Van der Zee C, Rashid K, Le K, Moore K, Stanisz J, Diamond J, Racine R, Fahnestock M: Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats. J Neurosic1995, 15:5316-5323.
    • (1995) J Neurosic , vol.15 , pp. 5316-5323
    • Van Der Zee, C.1    Rashid, K.2    Le, K.3    Moore, K.4    Stanisz, J.5    Diamond, J.6    Racine, R.7    Fahnestock, M.8
  • 37
    • 0028849806 scopus 로고
    • A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy
    • Rashid K, Van der Zee CE, Ross GM, Chapman C, Stanisz J, Riopelle R, • Racine R, Fahnestock M: A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting In a rat model of epilepsy. Proc Natl Acad Sci USA 1995, 92:9495-9499. Consistent with the findings in their previous study [36] the authors show that infusion of a peptide fragment that inhibits binding of NGF to its receptor (TrkA) during kindling delays the development of various stages of seizures. This is associated with a decrease in mossy fiber sprouting, although the effects of the peptide on seizures and sprouting cannot be separated. Importantly, this study demonstrates the potential utility of chronic infusion of function-blocking peptides in studies of epileptogenesis.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9495-9499
    • Rashid, K.1    Van Der Zee, C.E.2    Ross, G.M.3    Chapman, C.4    Stanisz, J.5    Riopelle, R.6    Racine, R.7    Fahnestock, M.8
  • 38
    • 0028819748 scopus 로고
    • Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy
    • Holtzman D, Lowenstein D: Selective inhibition of axon outgrowth by • antibodies to NGF in a model of temporal lobe epilepsy. J Neurosci 1995, 15:7062-7070. This study shows that intraventricular infusion of an anti-NGF antibody attenuates cholinergic but not mossy fiber sprouting following pilocarpine-induced seizures. The approach emphasizes the importance of recognizing that numerous neuronal networks related to the dentate gyrus may be reorganizing during epileptogenesis. The study also demonstrates further the potential value of using in-vivo infusions to address mechanisms of network plasticity.
    • (1995) J Neurosci , vol.15 , pp. 7062-7070
    • Holtzman, D.1    Lowenstein, D.2
  • 39
    • 0029832803 scopus 로고    scopus 로고
    • NMDA receptor dependence of kindling and mossy fiber sprouting: Evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain
    • Sutula T, Kock J, Golarai G, Watanabe Y, McNamara JO: NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. J Neuroscl 1996, 16:7398-7406.
    • (1996) J Neuroscl , vol.16 , pp. 7398-7406
    • Sutula, T.1    Kock, J.2    Golarai, G.3    Watanabe, Y.4    McNamara, J.O.5
  • 42
    • 0028220411 scopus 로고
    • Expression of GAP-43 in the granule cells of rat hippocampus after seizure-Induced sprouting of mossy fibers: In situ hybridization and Immunocytochemical studies
    • Bendotti C, Pende M, Samanin R: Expression of GAP-43 in the granule cells of rat hippocampus after seizure-Induced sprouting of mossy fibers: In situ hybridization and Immunocytochemical studies. Eur J Neurosci 1994, 6:509-515.
    • (1994) Eur J Neurosci , vol.6 , pp. 509-515
    • Bendotti, C.1    Pende, M.2    Samanin, R.3
  • 43
    • 0030039640 scopus 로고    scopus 로고
    • Rapid induction by kainic acid of both axonal growth and F1 /Gap-43 protein in the adult rat hippocampal granule cells
    • Cantallops I, Routtenberg A: Rapid induction by kainic acid of both axonal growth and F1 /Gap-43 protein in the adult rat hippocampal granule cells. J Comp Neurol 1996, 366:303-319.
    • (1996) J Comp Neurol , vol.366 , pp. 303-319
    • Cantallops, I.1    Routtenberg, A.2
  • 44
    • 0031043885 scopus 로고    scopus 로고
    • Relationship between GAP-43 expression in the dentate gyrus and synaptic reorganization of hippocampal mossy fibers in rats treated with kainic acid
    • in press
    • Bendotti C, Baldessari S, Pende M, Southgate T, Guglielmetti F, Samanin R: Relationship between GAP-43 expression in the dentate gyrus and synaptic reorganization of hippocampal mossy fibers in rats treated with kainic acid. Eur J Neurosci (in press).
    • Eur J Neurosci
    • Bendotti, C.1    Baldessari, S.2    Pende, M.3    Southgate, T.4    Guglielmetti, F.5    Samanin, R.6
  • 45
    • 0027199194 scopus 로고
    • Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin
    • Represa A, Pollard H, Moreau J, Ghilini G, Krestchatisky M, Ben-Ari Y: Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin. Neurosci Lett 1993, 156:149-152.
    • (1993) Neurosci Lett , vol.156 , pp. 149-152
    • Represa, A.1    Pollard, H.2    Moreau, J.3    Ghilini, G.4    Krestchatisky, M.5    Ben-Ari, Y.6
  • 46
    • 0029102038 scopus 로고
    • Gllosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity
    • Niquet J, Jorquera I, Faissner A, Ben-Ari Y, Represa A: Gllosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity. J Neurocytol 1995, 24:611-624.
    • (1995) J Neurocytol , vol.24 , pp. 611-624
    • Niquet, J.1    Jorquera, I.2    Faissner, A.3    Ben-Ari, Y.4    Represa, A.5
  • 47
    • 0028866034 scopus 로고
    • Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
    • Aigner L, Arber S, Kapfhammer J, Laux T, Schneidere C, Botteri F, Brenner • HR, Caroni P: Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice. Cell 1995, 83:269-278. The authors produced transgenic mice that have persistent expression of GAP-43 at levels similar to the transient peak normally seen during development. Besides causing prominent sprouting of motor neurons at the neuromuscular junction, overexpression of GAP-43 was associated with sprouting of mossy fibers in stratum oriens of CA3. Interestingly, the same transgenic mice with enhanced mossy fiber sprouting had spontaneous seizures, but the sprouting was still seen when animals were treated with phenobarbital. This paper is part of a growing body of literature describing the use of transgenic technology to study neuronal network plasticity.
    • (1995) Cell , vol.83 , pp. 269-278
    • Aigner, L.1    Arber, S.2    Kapfhammer, J.3    Laux, T.4    Schneidere, C.5    Botteri, F.6    Brenner, H.R.7    Caroni, P.8
  • 48
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne M, Goodman C: The molecular biology of axon guid• ance. Science 1996, 274:1123-1133. A superb, up-to-date review of the mechanisms and molecules that play a role in axonal pathfinding.
    • (1996) Science , vol.274 , pp. 1123-1133
    • Tessier-Lavigne, M.1    Goodman, C.2
  • 50
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesls is increased by seizures and contributes to aberrant network plasticity in the adult hippocampus
    • In press
    • Parent J, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH: Dentate granule cell neurogenesls is increased by seizures and contributes to aberrant network plasticity in the adult hippocampus. J Neurosci 1997 (In press).
    • (1997) J Neurosci
    • Parent, J.1    Yu, T.W.2    Leibowitz, R.T.3    Geschwind, D.H.4    Sloviter, R.S.5    Lowenstein, D.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.