A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon

Journal of Hepatology

Volumn 24, Issue 1, 1996, Pages 38-47

  Fattovich, Giovanna ^a,b   Giustina, Giuliano ^b   Favarato, Susanna ^b   Ruol, Arturo ^b   Macarri, G ^c   Orlandi, E ^c   Iaquinto, G ^d   Ambrosone, L ^d   Francavilla, A ^e   Pastore, G ^e   Santantonio, M T ^e   Romagno, D ^f   Bolondi, L ^g   Sofia, S ^g   Marchesini, A ^g   Pisi, E ^g   Mazzella, G ^g   Roda, E ^g   Attaro, L ^g   Chiodo, E ^g   Mori, E ^g   Verucchi, G ^g   Lanzini, A ^h   Salmi, A ⁱ   Calvi, B ⁱ   Bozzetti, E ^j   Radaeli, E ^j   Bernasconi, M ^k   Pilleri, G ^k   Bacca, D ^l   Romano, G ^l   Mastrapasqua, G ^m   Cozzolongo, R ⁿ   Cacopardo, B ^o   Nunnari, A ^o   Blasi, A ^p   Sala, L O ^p   Minoli, G ^q   Sangiovanni, A ^q   Spinzi, G C ^q   Colombo, A ^r   Camassa, M ^s   Riva, D ^s   Maggi, G ^t   Boccia, S ^u   Gualandi, G ^v   Nucci, A ^w   Pacini, F ^w   Marino, N ^x   Mazzotta, E ^x   La Mura, A ^y   Pompei, A G ^y   Casinelli, K ^z   Petrosillo, N ^z   Giacchino, R ^aa   Timitilli, A ^aa   Spiga, E ^ab   Corsetti, M ^ac   Menicagli, V ^ad   Tucci, A ^ad   Bissoli, E ^ae   Raimondo, G ^af   Rodino, G ^af   Bellobuono, A ^ag   Ideo, G ^ag   Colombo, M ^ah   Pacchetti, S ^ah   Rumi, M R ^ah   Battezzati, P M ^ah   Bruno, S ^ah   Podda, M ^ah   Zuin, M ^ah   Fargion, S ^ah   Fiorelli, G ^ah   Gellmann, E ^ai   Vandelli, C ^aj   Ventura, E ^aj   Manenti, F ^aj   Villa, E ^aj   Caporaso, N ^ak   Coltorti, M ^ak   Morisco, E ^ak   Del Vecchio Blanco, C ^ak   di Santolo, S Scotto ^ak   Di Nunzio, S ^ak   Ruggiero, G ^ak   Zampino, R ^ak   Ascione, A ^al   De Luca, M ^al   Galeota Lanza, A ^al   Aprea, L ^ak   Sagnelli, E ^ak   Felaco, E M ^ak   Piccinino, E ^ak   Ballare, M ^am   Monteverde, A ^am   Tappero, G ^an   Sanna, G ^ao   Alberti, A ^b   Bonetti, P ^b   Casarin, C ^b   Diodati, G ^b   Tremolada, E ^b   Naccarato, R ^b   Chiaramonte, M ^b   Floreani, M R ^b   Almasio, P ^ap   Craxi, A ^ap   Loiacono, O ^ap   Pagliaro, L ^ap   Fiaccadori, E ^aq   Giuberti, T ^aq   Belloni, G ^ar   Bernardini, E ^as   Buscarini, L ^at   Sbolli, G ^at   Giudici Cipriani, A ^au   Marenco, G ^au   Mazzaro, C ^av   Massari, M ^aw   Fornaciari, G ^aw   Plancher, A ^aw   Gasbarrini, G ^ax   Grieco, A ^ax   Luchetti, R ^ax   Rapaccini, G L ^ax   Bombardieri, G ^ax   Di Virgilio, D ^ay   Bruno, G ^az   Ricci, G L ^az   Hassan, G ^ba   Mari, T ^ba   Scalisi, I ^bb   Colloredo, G ^bc   Frunzio, A ^bd   Tabone, M ^be   Costa, C ^bf   Rosina, E ^bf   Saracco, G ^bf   Verme, G ^bf   Frezza, M ^bg   Urban, E ^bg   Capra, E ^a   Casaril, M ^a   Corrocher, R ^a   Benetti, G P ^bh   more..

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d General Hospital of Avellino   (Italy)

^e UNIVERSITY OF BARI   (Italy)

^f Pediatric Unit   (Italy)

^g UNIVERSITY OF BOLOGNA   (Italy)

^h UNIVERSITY OF BRESCIA   (Italy)

ⁱ 'S Orsola' General Hospital of Brescia   (Italy)

^j General Hospital of Brescia   (Italy)

^k 'San Michele' General Hospital of Cagliari   (Italy)

^l General Hospital of Casarano   (Italy)

^m 'San Giacomo Apostolo' General Hospital of Castelfranco Veneto   (Italy)

ⁿ 'S de Bellis' General Hospital of Castellana Grotte   (Italy)

^o UNIVERSITY OF CATANIA   (Italy)

^p Universities/Hospitals of Catania   (Italy)

^q 'Valduce' General Hospital of Como   (Italy)

^r 'S Anna' General Hospital of Como   (Italy)

^s General Hospital of Desio   (Italy)

^t General Hospital of Erba   (Italy)

^u 'S Anna' General Hospital of Ferrara   (Italy)

^v Divisione Malattie Infettive   (Italy)

^w University Hospital of Firenze   (Italy)

^x SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^y General Hospital of Formia   (Italy)

^z General Hospital of Frosinone   (Italy)

^aa G GASLINI INSTITUTE   (Italy)

^ab 'Delogu' General Hospital of Ghilarza   (Italy)

^ac 'Misericordia' General Hospital of Grosseto   (Italy)

^ad 'Campo di Marte' General Hospital of Lucca   (Italy)

^ae 'Fornaroli' General Hospital of Magenta   (Italy)

^af UNIVERSITY OF MESSINA   (Italy)

^ag OSPEDALE NIGUARDA CA GRANDA   (Italy)

^ah UNIVERSITY OF MILAN   (Italy)

^ai PARKINSON INSTITUTE   (Italy)

^aj UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^ak UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^al 'A Cardarelli' Hospital of Napoli   (Italy)

^am General Hospital of Novara   (Italy)

^an SAN LUIGI GONZAGA HOSPITAL   (Italy)

^ao General Hospital of Oristano   (Italy)

^ap UNIVERSITY OF PALERMO   (Italy)

^aq UNIVERSITY OF PARMA   (Italy)

^ar UNIVERSITY OF PAVIA   (Italy)

^as 'S Rinaldi' General Hosital of Pescina   (Italy)

^at General Hospital of Piacenza   (Italy)

^au 'Santa Corona' General Hospital of Pietra Ligure   (Italy)

^av General Hospital of Pordenone   (Italy)

^aw 'S Maria Nuova' Hospital of Reggio Emilia   (Italy)

^ax CATHOLIC UNIVERSITY   (Italy)

^ay 'G Vannini' General Hospital of Rome   (Italy)

^az SAPIENZA UNIVERSITY OF ROME   (Italy)

^ba 'S Giacomo' General Hospital of Rome   (Italy)

^bb General Hospital of Salemi   (Italy)

^bc 'Bolognini' General Hospital of Seriate   (Italy)

^bd 'S Annunziata' General Hospital of Taranto   (Italy)

^be MAURIZIANO HOSPITAL   (Italy)

^bf MOLINETTE HOSPITAL   (Italy)

^bg UNIVERSITY OF TRIESTE   (Italy)

^bh General Hospital of Vizzolo Predabissi   (Italy)

more..

Author keywords

Chronic viral hepatitis; Interferon alfa; Side effects

Indexed keywords

ALPHA INTERFERON; LYMPHOBLAST INTERFERON; RECOMBINANT INTERFERON;

ADOLESCENT; ADULT; AFFECTIVE NEUROSIS; AGED; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; HEART ARRHYTHMIA; HUMAN; INFANT; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; SUICIDE; THYROID DISEASE; VIRUS HEPATITIS;

ADOLESCENT; ADULT; AGED; AUTOIMMUNE DISEASES; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HEPATITIS, VIRAL, HUMAN; HUMANS; INFANT; INFANT, NEWBORN; INTERFERON TYPE I, RECOMBINANT; MALE; MENTAL DISORDERS; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 0030039651     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80184-X     Document Type: Article

References (23)

1. Wong DKH, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med 1993; 119: 312-23.
2. Saracco G, Rosina F, Abate ML, Chiandussi L, Gallo V, Cerutti E, Di Napoli A, Solinas A, Deplano A, Tocco A, Cossu P, Chien D, Kuo G, Polito A, Weiner AJ, Houghton M, Verme G, Bonino F, Rizzetto M. Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon-2b. Hepatology 1993; 18: 1300-5.
3. Janssen HLA, Brouwer JT, Nevens F, Sanchez-Tapias JM, Craxì A, Hadziyanni S. Fatal hepatic decompensation associated with interferon alfa. Br Med J 1993; 306: 107-8.
4. Durand JM, Kaplanski G, Portal I, Scheiner C, Berland Y, Soubeyrand J. Liver failure due to recombinant alpha interferon. Lancet 1991; 338: 1268-9.
5. Marcellin P, Colin JF, Boyer N, Bernuau J, Degott C, Hirschauer C, Benhamou JP. Fatal exacerbation of chronic hepatitis B induced by recombinant alpha-interferon. Lancet 1991; 338: 828.
6. Lisker-Melman M, Di Bisceglie AM, Usala SJ, Weintraub B, Murray LM, Hoofnagle JH. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. Gastroenterology 1992; 102: 2155-60.
7. Fabris P, Betterle C, Floreani A, Greggio NA, De Lazzari F, Naccarato R, Chiaramonte M. Development of type 1 diabetes mellitus during interferon alfa therapy for chronic HCV hepatitis. Lancet 1992; 340: 548.
8. Renault PF, Hoofnagle JH, Park Y, Mullen KD, Peters M, Jones DB, Rustgi V, Jones EA. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med 1987; 147: 1577-80.
9. McDonald EM, Mann AH, Thomas HC. Interferons as mediators of psychiatric morbidity. An investigation in a trial of recombinant α-interferon in hepatitis-B carriers. Lancet 1987; 2: 1175-8.
10. Janssen HLA, Berk L, Vermeulen M, Schalm SW. Seizures associated with low-dose α-interferon. Lancet 1990; ii: 1580.
11. Stiehm ER. Interferon: immunobiology and clinical significance. Ann Intern Med 1982; 96: 80-93.
12. Kassianides C, Di Bisceglie AM, Hoofnagle JH, Mullen K, Peters M, Rustgi V, Jones B, Lisker-Melman M, Park Y, Waggoner JG, Jones EA. Alpha-interferon therapy in patients with decompensated chronic type B hepatitis. In: Zuckerman AJ, ed. Viral Hepatitis and Liver Disease. New York: Alan R Liss, 1988; 840-3.
13. Nevens F, Goubau P, Van Eyken P, Desmyter J, Desmet V, Fevery J. Treatment of decompensated viral hepatitis B-induced cirrhosis with low doses of interferon alpha. Liver 1993; 13: 15-9.
14. Janssen HLA, Brouwer JT, van der Mast RC, Schalm SW. Suicide associated with alfa-interferon therapy for chronic viral hepatitis. J Hepatol 1994; 21: 241-3.
15. Ronnblom LE, Aim GV, Oberg KE. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med 1991; 115: 178-83.
16. Mayet WJ, Hess G, Gerken G, Rossol S, Voth R, Manns M, Meyer Zum Buschenfelde KH. Treatment of chronic type B hepatitis with recombinant α-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology 1989; 10: 24-8.
17. Fattovich G, Betterle C, Brollo L, Pedini B, Giustina G, Realdi G, Alberti A, Ruol A. Autoantibodies during α-interferon therapy for chronic hepatitis B. J Med Virol 1991; 34: 132-5.
18. Tran A, Quaranta JF, Benzaken S, Thiers V, Chau HT, Hastier P, Regnier D, Dreyfus G, Pradier C, Sadoul JL, Hebuterne X, Rampai P. High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy. Hepatology 1993; 18: 253-7.
19. Pawlotsky JM, Yahia MB, Andre C, Voisin MC, Intrator L, Roudot-Thoraval F, Deforges L, Duvoux C, Zafrani ES, Duval J, Dhumeaux D. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study. Hepatology 1994; 19: 841-8.
20. Garancini P, Gallus G, Calori G, Formigaro F, Micossi P. Incidence and prevalence rates of diabetes mellitus in Italy from routine data: a methodological assessment. Eur J Epidemiol 1991; 7: 55-63.
21. Quesada JR, Talpaz M, Rios A, Kurzrock R, Gutterman JU. Clinical toxicity of interferons in cancer patients: a review. J Clin Oncol 1986; 4: 234-43.
22. Deyton LR, Walker RE, Kovacs JA, Herpin B, Parker M, Masur H, Fauci AS, Lane HC. Reversible cardiac dysfunction associated with interferon alfa therapy in AIDS patients with Kaposi's sarcoma. N Engl J Med 1989; 321: 1246-9.
23. Menotti A, Giampaoli S. Frequenza delle malattie cardiovascolari in Italia negli anni Ottanta. Epidemiol Prev 1991; 48: 71-6.