The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels

Human Immunology

Volumn 62, Issue 12, 2001, Pages 1371-1381

  'T Hart, Bert A ^a,b,c   Brok, Herbert P M ^a   Amor, Sandra ^a   Bontrop, Ronald E ^a,d  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Experimental autoimmune encephalomyelitis; Immunology; Multiple sclerosis; Primates

Indexed keywords

CD45 ANTIGEN; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN PRESENTING CELL; ARTICLE; DEMYELINATION; DISEASE PREDISPOSITION; GENETIC CODE; GENETIC RISK; HUMAN; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIMATE; PRIORITY JOURNAL;

EID: 0035205282     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00346-9     Document Type: Article

References (91)

1. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
2. Autoimmunity: Attack, or defence? The case for a primary lesion theory
3. The Transatlantic Multiple Sclerosis Genetics Cooperative: A meta-analysis of genomic screens in multiple sclerosis
4. HLA, molecular mimicry and multiple sclerosis
5. Multiple sclerosis: A modifying influence of HLA class genes in an HLA class II associated autoimmune disease
6. Neurology: Immunoglobulin G Fc-receptor (FcgammaR) IIA and IIIB polymorphisms related to disability in MS
7. Genetic models for CNS inflammation
8. Chemokines in autoimmune diseases
9. Chemokine and chemokine receptors in inflammation of the nervous system: Manifold roles and excuisite regulation
10. Epidemiologic evidence for multiple sclerosis as an infection
11. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesion: A case for antigen-specific antibody mediation
12. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages
13. Experimental autoimmune encephalomyelitis as model of immune-mediated CNS disease
14. A new primate model for multiple sclerosis
15. Non-human primate models of multiple sclerosis
16. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
17. Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors
18. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
19. The use of monoclonal antibodies for treatment of autoimmune disease
20. Multiple sclerosis. Current review of failed and discontinued clinical trials of drug treatment
21. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
22. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-412: Results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial
23. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
24. Autoaggressive T lymphocyte line recognizing the encephalitogenic region of myelin basic protein: In vitro selection from unprimed T lymphocyte populations
25. In healthy primates circulating autoreactive T-cells mediate autoimmune disease
26. Encephalitogenic protential of myelinbasic protein-specific T cells isolated from normal rhesus macaques
27. Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
28. Tolerance, danger and the extended family
29. HLA-class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS in situ and in vitro
30. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
31. CD40-CD40ligand interactions in experimental autoimmune encephalomyelitis and multiple sclerosis
32. Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)
33. Concepts of viral pathogenesis of multiple sclerosis
34. Virus-induced demyelination
35. Progressive multifocal leukoencephalopathy: JC virus induced demyelination in the immune compromised host (review)
36. Can viral envelope glycolipids produce autoimmunity, with reference to the CNS and multiple sclerosis?
37. Temporal development of autoreactive Thl responses and endogenous presentation of self myelin epitopes by central nervous stem-resident APCs in Theiler's virus infected mice
38. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
39. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
40. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
41. Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS
42. Expansion of autoreactive T-cells in multiple sclerosis is independent of exogenous B7 costimulation
43. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance
44. Cellular immune reactivity within the CNS
45. Brain-immune connection: Immunoregulatory properties of CNS-resident cells
46. Adhesion molecules on endothelial cells in the cemntral nervous system: An emerging area in the neuroimmunology of MS
47. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
48. Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes
49. On the role of innate immunity in autoimmune diseases
50. Suppressive effects of TNF-alpha on myelin formation in vitro
51. Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
52. Multiple sclerosis: In situ evidence for antibody and complement mediated demyelination
53. T-cell responses to myelin antigens in multiple sclerosis: Relevance of the predominant autoimmune reactivity to myelin/oligodendrocyte glycoprotein
54. Myelin/oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis in the common marmoset: Presentation of an encephalitogenic T cell epitope by the monomorphic Mhc class II molecule Caja-DRB*W1201
55. Identification of autoantibodies associated with myelin damage in multiple sclerosis
56. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
57. Antimyelin antibodies modulate experimental allergic encephalomyelitis in Biozzi ABH mice
58. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate
59. Epitope specificity of demyelinating monoclonal antibodies directed against the human myelin oligodendrocyte glycoprotein (MOG)
60. Molecular mimicry between a viral peptide and a myelin/oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice
61. Unraveling the neuroimmune mechanisms for the HIV-associated cognitive/motor complex
62. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
63. Frequent enrichment for CD8 T-cells reactive against common herpes viruses in chronic inflammatory lesions: Towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes
64. Viral antibody titers are influenced by HLA-DR2 phenotype
65. The epitope speading cascade of experimental autoimmune encephalomyelitis and multiple sclerosis
66. The small heat-shock protein alpha-B-crystallin as candidate autoantigen in multiple sclerosis
67. Determinant spreading during experimental autoimmune encephalomyelitis: Is it potentiating, protecting, or participating in the disease?
68. The functional significance of epitope spreading and its regulation by costimulatory molecules
69. Pathological role and temporal appearance of newly emerging autoepitopes in relapsing remitting autoimmune encephalomyelitis
70. Regression and spreading of self-recognition during the development of autoimmune demyelinating disease
71. Apoptosis in brain-specific autoimmune disease
72. Contra: Evidence against a primary lesion in the target organ in autoimmune disease
73. Lymphocyte targeting of the brain in adoptive transfer cryolesion EAE
74. HLA-DP: A class II restriction molecule involved in epitope spreading during the development of multiple sclerosis
75. Evolution of major histocompatibility complex polymorphisms and T cell receptor diversity in primates
76. Major histocompatibility complex class II polymorphisms in primates
77. Evolutionary conservation of Mhc-DR/peptide/T cell interactions in primates
78. Activation of a myelin basic protein specific human T cell clone by antigen-presenting cells from rhesus monkeys
79. Identification of an Mhc-DPB1 allele involved in susceptibility to experimental autoimmune encephalomyelitis in rhesus macaques
80. Alelic diversity at the Mhc-DP locus in rhesus macaques (Macaca mulatta)
81. Herpesviruses of primates: An introduction
82. Neuropathogenesis induced by rhesus cytomegalovirus in fetal rhesus monkeys (Macaca mulatta)
83. Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin/oligodendrocyte glycoprotein (MOG). Characterisation of immunodominant MOG T- and B-cell epitopes
84. Creation of a model for multiple sclerosis in Callithrix jacchus marmosets
85. Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis. A correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrixjacchus)
86. The common marmose: A new world primate species with limited Mhc class II variability
87. Actively and passively induced experimental autoimmune encephalomyelitis in common marmosets: A new model for multiple sclerosis
88. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein