메뉴 건너뛰기




Volumn 77, Issue 3, 1999, Pages 216-223

Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance

Author keywords

Apoptosis; Autoimmunity; CD95 (Fas); Experimental autoimmune encephalomyelitis; Immune tolerance; T lymphocyte; Transplantation

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; APOPTOSIS; CONFERENCE PAPER; IMMUNOLOGICAL TOLERANCE; LIVER TRANSPLANTATION; NONHUMAN; RAT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TARGET ORGAN;

EID: 0033013092     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1999.00818.x     Document Type: Conference Paper
Times cited : (68)

References (82)
  • 1
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • 1 Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 1998; 19: 395-404.
    • (1998) Immunol. Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 3
    • 0025981021 scopus 로고
    • T-lymphocyte entry into the central nervous system
    • 3 Hickey WF, Hsu BL, Kimura H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 1991; 28: 254-60.
    • (1991) J. Neurosci. Res. , vol.28 , pp. 254-260
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 4
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • 4 Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science 1998; 280: 243-8.
    • (1998) Science , vol.280 , pp. 243-248
    • Van Parijs, L.1    Abbas, A.K.2
  • 5
    • 0026661264 scopus 로고
    • Apoptosis of αβ T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: Its possible implications for recovery and acquired tolerance
    • 5 Pender MP, McCombe PA, Yoong G, Nguyen KB. Apoptosis of αβ T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: Its possible implications for recovery and acquired tolerance. J Autoimmun. 1992; 5: 401-10.
    • (1992) J Autoimmun. , vol.5 , pp. 401-410
    • Pender, M.P.1    McCombe, P.A.2    Yoong, G.3    Nguyen, K.B.4
  • 6
    • 0003832913 scopus 로고
    • Apoptosis in the target organ of an autoimmune disease
    • Lavin M, Watters D (eds). Chur: Harwood Academic Publishers
    • 6 Pender MP. Apoptosis in the target organ of an autoimmune disease. In: Lavin M, Watters D (eds). Programmed Cell Death: The Cellular and Molecular Biology of Apoptosis. Chur: Harwood Academic Publishers, 1993; 235-44.
    • (1993) Programmed Cell Death: the Cellular and Molecular Biology of Apoptosis , pp. 235-244
    • Pender, M.P.1
  • 7
    • 0024492086 scopus 로고
    • Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
    • 7 Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJT. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989; 337: 181-4.
    • (1989) Nature , vol.337 , pp. 181-184
    • Smith, C.A.1    Williams, G.T.2    Kingston, R.3    Jenkinson, E.J.4    Owen, J.J.T.5
  • 9
    • 0028909197 scopus 로고
    • Fas ligand mediates activation-induced cell death in human T lymphocytes
    • 9 Alderson MR, Tough TW, Davis-Smith T et al. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 1995; 181: 71-7.
    • (1995) J. Exp. Med. , vol.181 , pp. 71-77
    • Alderson, M.R.1    Tough, T.W.2    Davis-Smith, T.3
  • 10
    • 0028983657 scopus 로고
    • Cell-autonomous fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    • 10 Brunner T, Mogil RJ, LaFace D et al. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995; 373: 441-4.
    • (1995) Nature , vol.373 , pp. 441-444
    • Brunner, T.1    Mogil, R.J.2    LaFace, D.3
  • 12
    • 0028893078 scopus 로고
    • Fas(CD95)/Fasl interactions required for programmed cell death after T-cell activation
    • 12 Ju S-T, Panka DJ, Cui H et al. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 1995; 373: 444-8.
    • (1995) Nature , vol.373 , pp. 444-448
    • Ju, S.-T.1    Panka, D.J.2    Cui, H.3
  • 13
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • 13 Ashkenazi A, Dixit VM. Death receptors: Signaling and modulation. Science 1998; 281: 1305-8.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 14
    • 0032536771 scopus 로고    scopus 로고
    • Two CD95 (APO-1/Fas) signaling pathways
    • 14 Scaffidi C, Fulda S, Srinivasan A et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 1998; 17: 1675-87.
    • (1998) EMBO J. , vol.17 , pp. 1675-1687
    • Scaffidi, C.1    Fulda, S.2    Srinivasan, A.3
  • 15
    • 0029609086 scopus 로고
    • Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    • 15 Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 1995; 14: 6136-47.
    • (1995) EMBO J. , vol.14 , pp. 6136-6147
    • Strasser, A.1    Harris, A.W.2    Huang, D.C.S.3    Krammer, P.H.4    Cory, S.5
  • 16
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • 16 Li H, Zhu H, Xu C-J, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94: 491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.-J.3    Yuan, J.4
  • 17
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochrondria in response to activation of cell surface death receptors
    • 17 Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochrondria in response to activation of cell surface death receptors. Cell 1998; 94: 481-90.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 18
    • 0027161158 scopus 로고
    • Effect of bcl-2 on fas antigen-mediated cell death
    • 18 Itoh N, Tsujimoto Y, Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 1993; 151: 621-7.
    • (1993) J. Immunol. , vol.151 , pp. 621-627
    • Itoh, N.1    Tsujimoto, Y.2    Nagata, S.3
  • 19
    • 0030037138 scopus 로고    scopus 로고
    • bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis
    • 19 Lee RK, Spielman J, Podack ER. bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis. Int. Immunol. 1996; 8: 991-1000.
    • (1996) Int. Immunol. , vol.8 , pp. 991-1000
    • Lee, R.K.1    Spielman, J.2    Podack, E.R.3
  • 21
    • 0025685264 scopus 로고
    • Interferon γ plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance
    • 21 Liu Y, Janeway CA. Interferon γ plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance. J. Exp. Med. 1990; 172: 1735-9.
    • (1990) J. Exp. Med. , vol.172 , pp. 1735-1739
    • Liu, Y.1    Janeway, C.A.2
  • 22
    • 0027220179 scopus 로고
    • CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin-1, interleukin-2, interferon-γ and accessory cells
    • 22 Groux H, Monte D, Plouvier B, Capron A, Ameisen J-C. CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin-1, interleukin-2, interferon-γ and accessory cells. Eur. J. Immunol. 1993; 23: 1623-9.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1623-1629
    • Groux, H.1    Monte, D.2    Plouvier, B.3    Capron, A.4    Ameisen, J.-C.5
  • 23
    • 0031444817 scopus 로고    scopus 로고
    • CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism
    • 23 Collette Y, Razanajaona D, Ghiotto M, Olive D. CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism. Eur. J. Immunol. 1997; 27: 3283-9.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3283-3289
    • Collette, Y.1    Razanajaona, D.2    Ghiotto, M.3    Olive, D.4
  • 24
    • 0032530746 scopus 로고    scopus 로고
    • Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
    • 24 Schweitzer AN, Sharpe AH. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J. Immunol. 1998; 161: 2762-71.
    • (1998) J. Immunol. , vol.161 , pp. 2762-2771
    • Schweitzer, A.N.1    Sharpe, A.H.2
  • 25
    • 0027537118 scopus 로고
    • Suppression of apoptosis in a cytotoxic t-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2
    • 25 Deng G, Podack ER. Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc. Natl Acad. Sci. USA 1993; 90: 2189-93.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2189-2193
    • Deng, G.1    Podack, E.R.2
  • 27
    • 0029848128 scopus 로고    scopus 로고
    • Microglia induce CD4 T lymphocyte final effector function and death
    • 27 Ford AL, Foulcher E, Lemekert FA, Sedgwick JD. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 1996; 184: 1737-45.
    • (1996) J. Exp. Med. , vol.184 , pp. 1737-1745
    • Ford, A.L.1    Foulcher, E.2    Lemekert, F.A.3    Sedgwick, J.D.4
  • 28
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • 28 Ahmed R, Gray D. Immunological memory and protective immunity: Understanding their relation. Science 1996; 272: 54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 29
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
    • 29 Lenardo MJ. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 1991; 353: 858-61.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 30
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • 30 Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998; 8: 615-23.
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 31
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • 31 Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994; 12: 991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 32
    • 0001445114 scopus 로고
    • Experimental autoimmune encephalomyelitis
    • Pender MP, McCombe PA (eds). Cambridge: Cambridge University Press
    • 32 Pender MP. Experimental autoimmune encephalomyelitis. In: Pender MP, McCombe PA (eds). Autoimmune Neurological Disease. Cambridge: Cambridge University Press, 1995; 26-88.
    • (1995) Autoimmune Neurological Disease , pp. 26-88
    • Pender, M.P.1
  • 33
    • 0025817888 scopus 로고
    • Apoptosis in the nervous system in experimental allergic encephalomyelitis
    • 33 Pender MP, Nguyen KB, McCombe PA, Kerr JFR. Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurol. Sci. 1991; 104: 81-7.
    • (1991) J. Neurol. Sci. , vol.104 , pp. 81-87
    • Pender, M.P.1    Nguyen, K.B.2    McCombe, P.A.3    Kerr, J.F.R.4
  • 34
    • 0027773017 scopus 로고
    • Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis: Evidence for programmed cell death as a mechanism to control inflammation in the brain
    • 34 Schmied M, Breitschopf H, Gold R et al. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis: Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 1993; 143: 446-52.
    • (1993) Am. J. Pathol. , vol.143 , pp. 446-452
    • Schmied, M.1    Breitschopf, H.2    Gold, R.3
  • 36
    • 0030200641 scopus 로고    scopus 로고
    • + T lymphocytes in the spinal cord during recovery from experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein
    • + T lymphocytes in the spinal cord during recovery from experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. J. Neurol. Sci. 1996; 139: 1-6.
    • (1996) J. Neurol. Sci. , vol.139 , pp. 1-6
    • McCombe, P.A.1    Nickson, I.2    Tabi, Z.3    Pender, M.P.4
  • 37
    • 0029065604 scopus 로고
    • Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: Further evidence of apoptotic deletion of autoreactive T cells in the central nervous system
    • 37 Tabi Z, McCombe PA, Pender MP. Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: Further evidence of apoptotic deletion of autoreactive T cells in the central nervous system. Int. Immunol. 1995; 7: 967-73.
    • (1995) Int. Immunol. , vol.7 , pp. 967-973
    • Tabi, Z.1    McCombe, P.A.2    Pender, M.P.3
  • 38
    • 0031715518 scopus 로고    scopus 로고
    • T-cell apoptosis in inflammatory brain lesions: Destruction of T cells does not depend on antigen recognition
    • 38 Bauer J, Bradl M, Hickey WF et al. T-cell apoptosis in inflammatory brain lesions: Destruction of T cells does not depend on antigen recognition. Am. J. Pathol. 1998; 153: 715-24.
    • (1998) Am. J. Pathol. , vol.153 , pp. 715-724
    • Bauer, J.1    Bradl, M.2    Hickey, W.F.3
  • 39
    • 0026541471 scopus 로고
    • In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis: Evidence suggesting that most infiltrating T cells do not proliferate in the target organ
    • 39 Ohmori K, Hong Y, Fujiwara M, Matsumoto Y. In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis: Evidence suggesting that most infiltrating T cells do not proliferate in the target organ. Lab. Invest. 1992; 66: 54-62.
    • (1992) Lab. Invest. , vol.66 , pp. 54-62
    • Ohmori, K.1    Hong, Y.2    Fujiwara, M.3    Matsumoto, Y.4
  • 40
    • 0028224997 scopus 로고
    • Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis
    • 40 Nguyen KB, McCombe PA, Pender MP. Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J. Autoimmun. 1994; 7: 145-52.
    • (1994) J. Autoimmun. , vol.7 , pp. 145-152
    • Nguyen, K.B.1    McCombe, P.A.2    Pender, M.P.3
  • 41
    • 0030635799 scopus 로고    scopus 로고
    • Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone
    • 41 Nguyen KB, McCombe PA, Pender MP. Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone. J. Neuropathol. Exp. Neurol. 1997; 56: 58-69.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 58-69
    • Nguyen, K.B.1    McCombe, P.A.2    Pender, M.P.3
  • 42
    • 0031815933 scopus 로고    scopus 로고
    • Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95)
    • 42 White CA, McCombe PA, Pender MP. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). Int. Immunol. 1998; 10: 935-41.
    • (1998) Int. Immunol. , vol.10 , pp. 935-941
    • White, C.A.1    McCombe, P.A.2    Pender, M.P.3
  • 44
    • 0025613973 scopus 로고
    • Programmed T lymphocyte death: Cell activation-and steroid-induced pathways are mutually antagonistic
    • 44 Zacharchuk CM, Merćep M, Chakraborti PK, Simons SS, Ashwell JD. Programmed T lymphocyte death: Cell activation-and steroid-induced pathways are mutually antagonistic. J. Immunol. 1990; 145: 4037-45.
    • (1990) J. Immunol. , vol.145 , pp. 4037-4045
    • Zacharchuk, C.M.1    Merćep, M.2    Chakraborti, P.K.3    Simons, S.S.4    Ashwell, J.D.5
  • 45
    • 0028938363 scopus 로고
    • Fas and activation-induced fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids
    • 45 Yang Y, Merćep M, Ware CF, Ashwell JD. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J. Exp. Med. 1995; 181: 1673-82.
    • (1995) J. Exp. Med. , vol.181 , pp. 1673-1682
    • Yang, Y.1    Merćep, M.2    Ware, C.F.3    Ashwell, J.D.4
  • 46
    • 0032005153 scopus 로고    scopus 로고
    • The roles of Fas, Fas ligand and Bcl-2 in T cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis
    • 46 White CA, McCombe PA, Pender MP. The roles of Fas, Fas ligand and Bcl-2 in T cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1998; 82: 47-55.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 47-55
    • White, C.A.1    McCombe, P.A.2    Pender, M.P.3
  • 47
    • 0031922935 scopus 로고    scopus 로고
    • Soluble antigen therapy induces apoptosis of autoreactive T cells preferentially in the target organ rather than in the peripheral lymphoid organs
    • 47 Ishigami T, White CA, Pender MP. Soluble antigen therapy induces apoptosis of autoreactive T cells preferentially in the target organ rather than in the peripheral lymphoid organs. Eur. J. Immunol. 1998; 28: 1626-35.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1626-1635
    • Ishigami, T.1    White, C.A.2    Pender, M.P.3
  • 48
    • 0026628844 scopus 로고
    • Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
    • 48 Matsumoto Y, Ohmori K, Fujiwara M. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. Immunology 1992; 76: 209-16.
    • (1992) Immunology , vol.76 , pp. 209-216
    • Matsumoto, Y.1    Ohmori, K.2    Fujiwara, M.3
  • 49
    • 0029892006 scopus 로고    scopus 로고
    • Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death: A model for T-cell apoptosis in vivo
    • 49 Gold R, Schmied M, Tontsch U et al. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death: A model for T-cell apoptosis in vivo. Brain 1996; 119: 651-9.
    • (1996) Brain , vol.119 , pp. 651-659
    • Gold, R.1    Schmied, M.2    Tontsch, U.3
  • 50
    • 0031917693 scopus 로고    scopus 로고
    • Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis
    • 50 Kohji T, Tanuma N, Aikawa Y et al. Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis. J. Neuroimmunol. 1998; 82: 168-74.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 168-174
    • Kohji, T.1    Tanuma, N.2    Aikawa, Y.3
  • 51
    • 0022591581 scopus 로고
    • Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to ia-positive cells with dendritic morphology
    • 51 Matsumoto Y, Hara N, Tanaka R, Fujiwara M. Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology. J. Immunol. 1986; 136: 3668-76.
    • (1986) J. Immunol. , vol.136 , pp. 3668-3676
    • Matsumoto, Y.1    Hara, N.2    Tanaka, R.3    Fujiwara, M.4
  • 52
    • 0024534407 scopus 로고
    • Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids
    • 52 MacPhee IAM, Antoni FA, Mason DW. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J. Exp. Med. 1989; 169: 431-45.
    • (1989) J. Exp. Med. , vol.169 , pp. 431-445
    • MacPhee, I.A.M.1    Antoni, F.A.2    Mason, D.W.3
  • 53
    • 0029906438 scopus 로고    scopus 로고
    • Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis
    • 53 Smith T, Schmied M, Hewson AK, Lassmann H, Cuzner ML. Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis. J. Autoimmun. 1996; 9: 167-74.
    • (1996) J. Autoimmun. , vol.9 , pp. 167-174
    • Smith, T.1    Schmied, M.2    Hewson, A.K.3    Lassmann, H.4    Cuzner, M.L.5
  • 54
    • 0031570116 scopus 로고    scopus 로고
    • Apoptosis within spontaneously accepted mouse liver allografts: Evidence for deletion of cytotoxic T cells and implications for tolerance induction
    • 54 Qian S, Lu L, Fu F et al. Apoptosis within spontaneously accepted mouse liver allografts: Evidence for deletion of cytotoxic T cells and implications for tolerance induction. J. Immunol. 1997; 158: 4654-61.
    • (1997) J. Immunol. , vol.158 , pp. 4654-4661
    • Qian, S.1    Lu, L.2    Fu, F.3
  • 55
    • 0018423356 scopus 로고
    • Experimental allergic encephalomyelitis in the Lewis rat: Studies on the mechanism of recovery from disease and acquired resistance to reinduction
    • 55 Willenborg DO. Experimental allergic encephalomyelitis in the Lewis rat: Studies on the mechanism of recovery from disease and acquired resistance to reinduction. J. Immunol. 1979; 123: 1145-50.
    • (1979) J. Immunol. , vol.123 , pp. 1145-1150
    • Willenborg, D.O.1
  • 56
    • 0014155149 scopus 로고
    • Altered distribution of lesions after repeated passive transfers of allergic encephalomyelitis
    • 56 Levine S, Hoenig EM, Wenk EJ. Altered distribution of lesions after repeated passive transfers of allergic encephalomyelitis. Proc. Soc. Exp. Biol. Med. 1967; 126: 454-8.
    • (1967) Proc. Soc. Exp. Biol. Med. , vol.126 , pp. 454-458
    • Levine, S.1    Hoenig, E.M.2    Wenk, E.J.3
  • 57
    • 0019131988 scopus 로고
    • Experimental allergic encephalomyelitis: Inhibition of clinical signs and paradoxical enhancement of lesions in second attacks
    • 57 Levine S, Sowinski R. Experimental allergic encephalomyelitis: Inhibition of clinical signs and paradoxical enhancement of lesions in second attacks. Am. J. Pathol. 1980; 101: 375-86.
    • (1980) Am. J. Pathol. , vol.101 , pp. 375-386
    • Levine, S.1    Sowinski, R.2
  • 58
    • 0029034068 scopus 로고
    • Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
    • 58 Martin R, McFarland HF. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sci. 1995; 32: 121-82.
    • (1995) Crit. Rev. Clin. Lab. Sci. , vol.32 , pp. 121-182
    • Martin, R.1    McFarland, H.F.2
  • 59
    • 0002150344 scopus 로고
    • Multiple sclerosis
    • Pender MP, McCombe PA (eds). Cambridge: Cambridge University Press
    • 59 Pender MP. Multiple sclerosis. In: Pender MP, McCombe PA (eds). Autoimmune Neurological Disease. Cambridge: Cambridge University Press, 1995; 89-154.
    • (1995) Autoimmune Neurological Disease , pp. 89-154
    • Pender, M.P.1
  • 60
    • 0028578038 scopus 로고
    • Patterns of oligodendroglia pathology in multiple sclerosis
    • 60 Ozawa K, Suchanek G, Breitschopf H et al. Patterns of oligodendroglia pathology in multiple sclerosis. Brain 1994; 117: 1311-22.
    • (1994) Brain , vol.117 , pp. 1311-1322
    • Ozawa, K.1    Suchanek, G.2    Breitschopf, H.3
  • 62
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • 62 Charriaut-Marlangue C, Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 1995; 7: 61-4.
    • (1995) Neuroreport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 63
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • 63 Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 1995; 21: 1465-8.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 64
    • 0032495663 scopus 로고    scopus 로고
    • Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis
    • 64 Pender MP. Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis. Lancet 1998; 351: 978-81.
    • (1998) Lancet , vol.351 , pp. 978-981
    • Pender, M.P.1
  • 65
    • 0028037766 scopus 로고
    • Apoptotic cell death of T-lymphocytes in experimental autoimmune neuritis of the Lewis rat
    • 65 Zettl UK, Gold R, Hartung H-P, Toyka KV. Apoptotic cell death of T-lymphocytes in experimental autoimmune neuritis of the Lewis rat. Neurosci. Lett. 1994; 176: 75-9.
    • (1994) Neurosci. Lett. , vol.176 , pp. 75-79
    • Zettl, U.K.1    Gold, R.2    Hartung, H.-P.3    Toyka, K.V.4
  • 66
    • 0029970247 scopus 로고    scopus 로고
    • In situ demonstration of T cell activation and elimination in the peripheral nervous system during experimental autoimmune neuritis in the Lewis rat
    • 66 Zettl UK, Gold R, Toyka KV, Hartung H-P. In situ demonstration of T cell activation and elimination in the peripheral nervous system during experimental autoimmune neuritis in the Lewis rat. Acta Neuropathol. 1996; 91: 360-7.
    • (1996) Acta Neuropathol. , vol.91 , pp. 360-367
    • Zettl, U.K.1    Gold, R.2    Toyka, K.V.3    Hartung, H.-P.4
  • 67
    • 0031036205 scopus 로고    scopus 로고
    • Antigen therapy eliminates T cell inflammation by apoptosis: Effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2
    • 67 Weishaupt A, Gold R, Gaupp S, Giegerich G, Hartung H-P, Toyka KV. Antigen therapy eliminates T cell inflammation by apoptosis: Effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc. Natl Acad. Sci. USA 1997; 94: 1338-43.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 1338-1343
    • Weishaupt, A.1    Gold, R.2    Gaupp, S.3    Giegerich, G.4    Hartung, H.-P.5    Toyka, K.V.6
  • 68
    • 0029019590 scopus 로고
    • Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat
    • 68 Zettl UK, Gold R, Toyka KV, Hartung H-P. Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat. J. Neuropathol. Exp. Neurol. 1995; 54: 540-7.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 540-547
    • Zettl, U.K.1    Gold, R.2    Toyka, K.V.3    Hartung, H.-P.4
  • 72
    • 0030776194 scopus 로고    scopus 로고
    • High-dose/ activation-associated tolerance: A mechanism for allograft tolerance
    • 72 Bishop GA, Sun J, Sheil AGR, McCaughan GW. High-dose/ activation-associated tolerance: A mechanism for allograft tolerance. Transplantation 1997; 64: 1377-82.
    • (1997) Transplantation , vol.64 , pp. 1377-1382
    • Bishop, G.A.1    Sun, J.2    Sheil, A.G.R.3    McCaughan, G.W.4
  • 73
    • 0030457356 scopus 로고    scopus 로고
    • Tolerance to rat liver allografts. IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes
    • 73 Sun J, Sheil AGR, Wang C et al. Tolerance to rat liver allografts. IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes. Transplantation 1996; 62: 1725-30.
    • (1996) Transplantation , vol.62 , pp. 1725-1730
    • Sun, J.1    Sheil, A.G.R.2    Wang, C.3
  • 76
    • 0030972396 scopus 로고    scopus 로고
    • Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
    • 76 Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc. Natl Acad. Sci. USA 1997; 94: 3943-7.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3943-3947
    • Allison, J.1    Georgiou, H.M.2    Strasser, A.3    Vaux, D.L.4
  • 77
    • 0029087277 scopus 로고
    • Altered target organ: A mechanism of postrecovery resistance to murine autoimmune oophoritis
    • 77 Lou Y-H, McElveen F, Adams S, Tung KSK. Altered target organ: A mechanism of postrecovery resistance to murine autoimmune oophoritis. J. Immunol. 1995; 155: 3667-73.
    • (1995) J. Immunol. , vol.155 , pp. 3667-3673
    • Lou, Y.-H.1    McElveen, F.2    Adams, S.3    Tung, K.S.K.4
  • 78
    • 0031028533 scopus 로고    scopus 로고
    • Fas and Fas ligand expression in the salivary glands of patients with primary sjögren's syndrome
    • 78 Kong L, Ogawa N, Nakabayashi T et al. Fas and Fas ligand expression in the salivary glands of patients with primary Sjögren's syndrome. Arthritis Rheum. 1997; 40: 87-97.
    • (1997) Arthritis Rheum. , vol.40 , pp. 87-97
    • Kong, L.1    Ogawa, N.2    Nakabayashi, T.3
  • 80
    • 0028916863 scopus 로고
    • Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes
    • 80 Nakajima T, Aono H, Hasunuma T et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum. 1995; 38: 485-91.
    • (1995) Arthritis Rheum. , vol.38 , pp. 485-491
    • Nakajima, T.1    Aono, H.2    Hasunuma, T.3
  • 81
    • 0029073368 scopus 로고
    • Apoptosis of T lymphocytes in coronavirus-induced encephalomyelitis
    • 81 Barac-Latas V, Wege H, Lassmann H. Apoptosis of T lymphocytes in coronavirus-induced encephalomyelitis. Regional Immunol. 1994; 6: 355-7.
    • (1994) Regional Immunol. , vol.6 , pp. 355-357
    • Barac-Latas, V.1    Wege, H.2    Lassmann, H.3
  • 82
    • 0031740004 scopus 로고    scopus 로고
    • + T cells and rapid elimination of effector cells by apoptosis
    • + T cells and rapid elimination of effector cells by apoptosis. Eur. J. Immunol. 1998; 28: 3448-55.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3448-3455
    • Nuti, S.1    Rosa, D.2    Valiante, N.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.