Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: The encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule

Journal of Immunology

Volumn 165, Issue 2, 2000, Pages 1093-1101

  Brok, Herbert P M ^a   Uccelli, Antonio ^b   De Rosbo, Nicole Kerlero ^c   Bontrop, Ronald E ^a   Roccatagliata, Luca ^b   De Groot, Natasja G ^a   Capello, Elisabetta ^a   Laman, Jon D ^d   Nicolay, Klaas ^e   Mancardi, Gian Luigi ^b   Ben Nun, Avraham ^c   'T Hart, Bert A ^a  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b UNIVERSITY OF GENOA   (Italy)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENCEPHALITOGENIC PROTEIN; EPITOPE; GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; IMMUNITY; MARMOSET; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0034661721     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.2.1093     Document Type: Article

References (29)

1. Massacesi, L., C. P. Genain, D. Lee-Parritz, N. L. Letvin, D. Canfield, and S. L. Hauser. 1995. Actively and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann. Neurol. 37:519.
2. Genain, C. P., and S. L. Hauser. 1997. Creation of a model for multiple sclerosis in Callithrix jacchus marmosets. J. Mol. Med. 75:187.
3. 't Hart, B. A., J. Bauer, H.-J. Muller, B. Melchers, K. Nicolay, H. Brok, R. E. Bontrop, H. Lassmann, and L. Massacesi. 1998. Histological characterization of magnetic resonance imaging-delectable brain white matter lesions in a primate model of multiple sclerosis. Am. J. Pathol. 153:649.
4. Slierendregt, B. L., M. Hall, B. A. 't Hart, N. Otting, J. Anholts, W. Verduyn, J. S. Lanchbury, and R. E. Bontrop. 1995. Identification of an Mhc-DPBI allele involved in the susceptibility to experimental autoimmune encephalomyelitis in rhesus macaques. Int. Immunol. 7:1671.
5. Antunes, S. G., N. G. de Groot, H. Brok, G. Doxiadis, A. A. L. Menezes, N. Otting, and R. E. Bontrop. 1998. The common marmoset: a new world primate species with limited Mhc class II variability. Proc. Natl. Acad. Sci. USA 95: 11745.
6. Genain, C. P., D. Lee-Parritz, M. H. Nguyen, L. Massacesi, N. Joshi, R. Ferrante, K. Hoffman, M. Mosely, N. L. Letvin, and S. L. Hauser. 1994. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 94:1339.
7. Genain, C. P., M. H. Nguygen, N. L. Letvin, R. Pearl, R. L. Davis, M. Adelman, M. B. Lees, C. Linington, and S. L. Hauser. 1995. Antibody facilitation of multiple sclerosis-like lesions in a non-human primate. J. Clin. Invest. 96: 2966.
8. Genain, C. P., B. Cannella, S. L. Hauser, and C. S. Raine. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:170.
9. McFarland, H. I., A. A. Lobito, M. M. Johnson, J. T. Nyswaner, J. A. Frank, G. R. Palardy, N. Tresser, C. P. Genain, J. P. Mueller, L. A. Matis, and M. J. Lenardo. 1999. Determinant spreading associated with demyelination in a non-human primate model of multiple sclerosis. J. Immunol 162:2384.
10. Picus, J.W., R. Aldrich, and N.L. Letvin. 1985. A naturally occurring bone marrow chimeric primate. Transplantation 39:297.
11. Deibler G., R. E. Martensson, and M.W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:139.
12. Kerlero de Rosbo, N. M. Hoffman, I. Mendel, I. Yust, J. Kaye, R. Bakimer, S. Fletcher, O. Ahramsky, R. Milo, A. Karni, and A. Ben-Nun. 1997. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 27:3059.
13. b mice. Eur. J. Immunol. 26:2470.
14. Bontrop, R. E., N. Otting, N. G. de Groot, and G. G. M. Doxiadis. 1999. Major histocompatibility complex class II polymorphisms in primates. Immunol. Rev. 167:339.
15. Bontrop, R. E., N. Otting, B. L. Slierendregt, and J. L. Lanchbury. 1995. Evolution of major histocompatibility complex polymorphisms and T cell receptor diversity in primates. Immunol. Rev. 143:33.
16. Uccelli, A., J. R. Oksenberg, M. Jeong, C. P. Genain, T. Rombos, E. E. M. Jaeger, D. Giunti, J. S. Lanchbury, and S. L. Hauser. 1997. Characterization of the TCRB chain repertoire in the New World monkey Callithrix jaccchus. J. Immunol. 158: 1201.
17. Raine, C. S., B. Cannella, S. L. Hauser, and C. P. Genain. 1999. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesion: a case for antigen-specific antibody mediation. Ann. Neurol. 46:144.
18. Kerlero de Rosbo, N., and A. Ben-Nun. 1998. T-cell responses to myelin antigens in multiple sclerosis: relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J. Autoimmun. 11:287.
19. Piddlesden, S. J., H. Lassmann, F. Zimprich, B. P. Morgan, and C. Linington. 1993. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am. J. Pathol. 143:555.
20. Storch, M. K., S. Piddlesden, M. Haltia, M. Iivanainen, P. Morgan, and H. Lassmann. 1998. Multiple sclerosis: in situ evidence for antibody-and complement-mediated demyelination. Ann. Neurol. 43:465.
21. Kerlero de Rosbo, N., R. Milo, M. B. Lees, D. Burger, C. C. Bernard, and A. Ben-Nun. 1993. Reactivity to myelin antigens in multiple sclerosis: peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92:2602.
22. Storch, M. K., A. Stefferl, U. Brehm, R. Weissert, E. Wallstrom, M. Kerschensteiner, T. Olsson, C. Linington, and H. Lassmann. 1998. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:681.
23. Hjelmstrom, P., A. E. Juedes, J. Fjell, and N. H. Nuddle. 1998. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J. Immunol. 161:4480.
24. Wong, F. S., B. N. Dittel, and C. A. Janeway, Jr. 1999. Transgenes and knockout mutations in animal models of type I diabetes and multiple sclerosis. Immunol. Rev. 169:93.
25. Ryan, M., L. McCarthy, R. Rappuoli, B. P. Mahon, and K. H. G. Mills. 1998. Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. Int. Immunol. 10:651.
26. Brady, M. T., B. P. Mahow, and K. H. G. Mills. 1998. Pertussis infection and vaccination induces Th1-cells. Immunol. Today 19:534.
27. Kerlero de Rosbo, N., and A. Ben-Nun. 1999. Experimental autoimmune encephalomyelitis induced by various antigens of the central nervous system: overview and relevance to multiple sclerosis. In The Decade of Autoimmunity, Y. Shoenfeld, ed. Elsevier Sciences, Amsterdam, pp. 169-177.
28. Genain C. P., N. Belmar, P. Diaz-Villoslada, and S. L. Hauser. 1998. Fine specificities of T cell and B cell responses to myelin/oligodendrocyte glycoprotein in common marmosets. J. Neuroimmunol. 90:34(Abstr. 174).
29. Hjelmström, P., J. E. Penzotti, R. M. Henne, and T. P. Lybrand. 1998. A molecular model of myelin oligodendrocyte glycoprotein. J. Neurochem. 71: 1742.