Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: Characterisation of immunodominant T- and B-cell epitopes

Journal of Neuroimmunology

Volumn 110, Issue 1-2, 2000, Pages 83-96

  Kerlero De Rosbo, Nicole ^a   Brok, Herbert P M ^b   Bauer, Jan ^c   Kaye, Joel F ^a   'T Hart, Bert A ^b   Ben Nun, Avraham ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Autoimmunity; Central nervous system; Multiple sclerosis; Non human primate; T lymphocytes

Indexed keywords

AMINO ACID; EPITOPE; GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; DEMYELINATION; DISEASE MODEL; DISEASE PREDISPOSITION; FEMALE; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RHESUS MONKEY; T LYMPHOCYTE;

ANIMAL; AUTOANTIBODIES; CELL LINEAGE; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNIZATION; IMMUNODOMINANT EPITOPES; MACACA MULATTA; MALE; MULTIPLE SCLEROSIS; MYELIN-ASSOCIATED GLYCOPROTEIN; SUPPORT, NON-U.S. GOV'T;

EID: 0342844271     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00306-4     Document Type: Article

References (42)

1. Abo S., Bernard C., Webb M., Johns T., Alafaci A., Ward L., Simpson R.J., Kerlero de Rosbo N. Preparation of highly purified human myelin oligodendrocyte glycoprotein in quantities sufficient for encephalitogenicity and immunogenicity studies. Int. Biochem. Mol. Immunol. 30:1993;945-958.
2. Adelmann M., Wood J., Benzel I., Fiori P., Lassmann H., Matthieu J.-M., Gardinier M.V., Dornmair K., Linington C. The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat. J. Neuroimmunol. 63:1995;17-27.
3. Amiguet P., Gardinier M.V., Zanetta J.-P., Matthieu J.-M. Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein (MOG). J. Neurochem. 58:1992;1676-1682.
4. Amor S., Groome N., Linington C., Morris M.M., Dornmair K., Gardinier M.V., Matthieu J.-M., Baker D. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 154:1994;4349-4356.
5. Bontrop R.E., Otting N., Slierendregt B.L., Lanchbury J.S. Evolution of major histocompatibility complex polymorphisms and T-cell receptor diversity in primates. Immunol. Rev. 143:1995;33-62.
6. Bontrop R.E., Otting N., de Groot N.G., Doxiadis G.G.M. Major histocompatibility complex class II polymorphisms in primates. Immunol. Rev. 167:1999;339-350.
7. Brok, H.P.M., Uccelli, A., Kerlero de Rosbo, N., Bontrop, R.E., Roccatagliata, L., de Groot, N.G., Capello, E., Laman, J.D., Nicolay, K., Mancardi, G.-L., Ben-Nun, A., 't Hart, B.A., 2000. Myelin/oligodendrocyte glycoprotein induced autoimmune encephalomyelitis in common marmosets: Presentation of an encephalitogenic T-cell epitope by a monomorphic MHC class II molecule. J. Immunol. in press.
8. Devaux B., Enderlin F., Wallner B., Smilek D.E. Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide. J Neuroimmunol. 75:1997;169-173.
9. Genain C.P., Hauser S.L. Allergic encephalomyelitis in common marmosets: pathogenesis of a multiple sclerosis-like lesion. Methods. 10:1996;420-434.
10. Genain C.P., Lee-Paritz D., Ngyuen M.-H., Massacesi L., Joshi N., Ferrante R., Hoffman K., Moseley M., Letvin N.L., Hauser S.L. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 94:1994;1339-1345.
11. Genain C.P., Nguyen M.-H., Letvin N.L., Pearl R., Davis R.L., Adelman M., Lees M.B., Linington C., Hauser S.L. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. J. Clin. Invest. 96:1995;2966-2974.
12. Genain C.P., Abel K., Belmar N., Villinger F., Rosenberg D.P., Linington C., Raine C.S., Hauser S.L. Late complications of immune deviation therapy in a nonhuman primate. Science. 274:1996;2054-2057.
13. Genain C.P., Cannella B., Hauser S.L., Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:1999;170-175.
14. 't Hart B.A., Bauer J., Muller H.-J., Melchers B., Nicolay K., Brok H., Bontrop R.E., Lassmann H., Massacesi L. Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis. A correlative study in the experimental autoimmune encephalomyelitis in common marmosets (Callithrix jacchus). Am. J. Pathol. 153:1998;649-663.
15. Johns T., Kerlero de Rosbo N., Menon K.K., Abo S., Gonzales M.F., Bernard C. Myelin oligodendrocyte glycoprotein induces demyelinating encephalomyelitis resembling multiple sclerosis. J. Immunol. 154:1995;5536-5541.
16. Kerlero de Rosbo N., Ben-Nun A. T cell responses to myelin antigens in multiple sclerosis. Relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J. Autoimmun. 11:1998;287-299.
17. Kerlero de Rosbo N., Ben-Nun A. Experimental autoimmune encephalomyelitis induced by various antigens of the central nervous system: overview and relevance to multiple sclerosis. Shoenfeld Y. The Decade of Autoimmunity 1987-1997. 1999;169-177 Elsevier, Amsterdam.
18. Kerlero de Rosbo N., Honegger P., Lassmann H., Matthieu J.-M. Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein. J. Neurochem. 55:1990;583-587.
19. Kerlero de Rosbo N., Milo R., Lees M.B., Burger D., Bernard C., Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92:1993;2602-2608.
20. Kerlero de Rosbo N., Mendel I., Ben-Nun A. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur. J. Immunol. 25:1995;985-993.
21. Kerlero de Rosbo N., Hoffman M., Mendel I., Yust I., Kaye J., Bakimer R., Flechter S., Abramsky O., Milo R., Karni A., Ben-Nun A. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 27:1997;3059-3069.
22. Kissmeyer-Nielsen F., Thorsby E. Human transplantation antigens. Appendix: current methods in histocompatibility testing. Transplant. Rev. 4:1969;1-76.
23. Lassmann H., Linington C. The role of antibodies against myelin surface antigens in demyelination in chronic relapsing EAE. Crescenzi G.S. A Multidisciplinary Approach to Myelin Diseases. 1987;219-225 Plenum, New York.
24. Levine S. Hyperacute, neutrophilic and localized forms of experimental allergic encephalomyelitis: a review. Acta Neuropathol. 28:1974;179-189.
25. Lindert R.-B., Haase C.G., Brehm U., Linington C., Wekerle H., Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain. 122:1999;2089-2099.
26. Linington C., Lassmann H. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre t the myelin/oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 17:1987;61-69.
27. Linington C., Webb M., Woodhams P.L. A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody. J. Neuroimmunol. 6:1984;387-396.
28. Linington C., Berger T., Perry L., Weerth S., Hinze-Selch D., Zhang Y., Lu H., Lassmann H., Wekerle H. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol. 23:1993;1364-1372.
29. Liu J., Marino M.W., Wong G., Grail D., Dunn A., Bettadapura J., Slavin A.J., Old L., Bernard C. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat. Med. 4:1998;78-83.
30. Massacesi L., Joshi N., Lee-Parritz D., Rombos A., Letvin N.L., Hauser S.L. Experimental allergic encephalomyelitis in cynomolgus monkeys. Quantitation of T cell responses in peripheral blood. J. Clin. Invest. 90:1992;399-404.
31. McFarland H.I., Lobito A.A., Johnson M.M., Nyswaner J.T., Frank J.A., Palardy G.R., Tresser N., Genain C.P., Mueller J.P., Matis L.A., Lenardo M.J. Determinant spreading associated with demyelination in a nonhuman primate. J. Immunol. 162:1999;2384-2390.
32. Meinl E., 't Hart B.A., Bontrop R.E., Hoch R.M., Iglesias A., de Waal Malefyt R., Fickenscher H., Muller-Fleckenstein I., Fleckenstein B., Wekerle H., Hohfeld R., Jonker M. Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys. Int. Immunol. 7:1995;1489-1495.
33. Meinl E., Hoch R.M., Dornmair K., de Waal Malefyt R., Bontrop R.E., Jonker M., Lassmann H., Hohlfeld R., Wekerle H., 't Hart B. Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. Am. J. Pathol. 150:1997;445-453.
34. b mice: fine specificity and T cell receptor Vβ expression of encephalitogenic T cells. Eur. J. Immunol. 25:1995;1951-1959.
35. b mice. Eur. J. Immunol. 26:1996;2470-2479.
36. Mittal K.K., Mickey M.P., Singal D.P., Terasaki P.I. Serotyping for homotransplantation 18. Refinement of microdroplet lymphocyte cytotoxicity test. Tansplantation. 6:1968;913-927.
37. Otting N., Doxiadis G.G., Versluis L., de Groot N.G., Anholts J., Verduin W., Rozemuller E., Claas F., Tilanus M.G., Bontrop R.E. Characterization and distribution of Mhc-DPB1 alleles in chimpanzee and rhesus macaque populations. Hum. Immunol. 59:1998;656-664.
38. Piddlesden S., Lassmann H., Zimprich F., Morgan B.P., Linington C. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am. J. Pathol. 143:1993;555-564.
39. Raine C.S., Cannella B., Hauser S.L., Genain C.P. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis: a case for antigen-specific antibody mediation. Ann. Neurol. 46:1999;144-160.
40. Slierendregt B.L., Otting N., van Besouw N., Jonker M., Bontrop R.E. Expansion and contraction of rhesus macaque DRB regions by duplication and deletion. J. Immunol. 152:1994;2298-2307.
41. Slierendregt B.L., Hall M., 't Hart B., Otting N., Anholts J., Verduin W., Claas F., Jonker M., Lanchbury J.S., Bontrop R.E. Identification of an Mhc-DPB1 allele involved in susceptibility to experimental autoimmune encephalomyelitis in rhesus macaques. Int. Immunol. 7:1995;1671-1679.
42. Storch M.K., Stefferl A., Brehm U., Weissert R., Wallström E., Kerschensteiner M., Olsson T., Linington C., Lassmann H. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:1998;681-694.