Maturation of channels and receptors: consequences for excitability

International Review of Neurobiology

Volumn 45, Issue , 2001, Pages 43-87

  Owens, David F ^a   Kriegstein, Arnold R ^a  

^a Surgeons of Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; ION CHANNEL;

ANIMAL; BRAIN; EPILEPSY; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; NEOCORTEX; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SYNAPSE;

ANIMALS; BRAIN; EPILEPSY; HUMANS; ION CHANNELS; NEOCORTEX; RECEPTORS, CELL SURFACE; SYNAPSES;

EID: 0035202336     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7742(01)45006-9     Document Type: Article

References (284)

1. Agmon, A., and O'Dowd, D. K. (1992). NMDA receptor-mediated currents are prominent in the thalamocortical synaptic response before maturation of inhibition. J. Neurophysiol. 68, 345-349.
2. Agmon, A., Hollrigel, G., and O'Dowd, D. K. (1996). Functional GABAergic synaptic connection in neonatal mouse barrel cortex. J. Neurosci. 16, 4684-4695.
3. Aicardi, J. (1994). Syndromic classification in the management of childhood epilepsy. J. Child. Neurol. 9, Suppl. 2, 14-18.
4. AJlendoerfer, K. L., and Shatz, C. J. (1994). The subplate, a transient neocortical structure: its role in the development of connections between thalamus and cortex. Anna. Rev. Neurosci. 17, 185-218.
5. Angevine, J. B. J., and Sidman, R. L. (1961). Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192, 766-768.
6. Antonopoulos, J., Pappas, I., and Parnavelas, J. (1997). Activation of the GABAA receptor inhibits the proliferative effects of bFGF in cortical progenitor cells. Eur. J. Neurosci. 9, 291-298.
7. Araki, T., Kiyama, H., and Tohyama, M. (1992). GABAA receptor subunit messenger RNAs show differential expression during cortical development in the rat brain. Neuroscience 51,583-591.
8. Armstrong, G. M., and Hille, B. (1998). Voltage-gated ion channels and electrical excitability. Neuron 20, 371-380.
9. Bahn, S., Volk, B., and Wisden, W. (1994). Kainate receptor gene expression in the developing rat brain, y. Neurosci. 14, 5525-5547.
10. Balslev, Y., Saunders, N. R., and Mollgard, K. (1996). Synaptogenesis in the neocortical anläge and early developing neocortex of rat embryos. Ada Anat. 156, 2-10.
11. Barbin, G., Pollard, H., Gaiarsa, J. L., and Ben-Ari, Y. (1993). Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons. Neurosci. Lett. 152, 150-154.
12. Bayer, S. A., and Altman, J. (1991). Neocortical Development, Raven, New York.
13. Bayer, S. A. and Altman, J. (1995). Neurogenesis and neuronal migration. In The Rat Nervous System (G. Paxinos, ed., ed.), pp. 1070-1078. Academic Press, San Diego.
14. Bear, M. F. and Singer, W. (1986). Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature 320, 172-176.
15. Bear, M. F., Kleinschmidt, A., Gu, Q. A., and Singer, W. (1990). Disruption of experiencedependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist.J. Neurosci. 10, 909-925.
16. Becker, G. M., Betz, H., and Schröder, H. (1993). Expression of inhibitory glycine receptors in postnatal rat cerebral cortex. Brain Res. 606, 220-226.
17. Beckh, S., Noda, M., Lubbert, H., and Numa, S. (1989). Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EmboJ. 8, 3611-3661.
18. Behar, T. N., Li, Y., Tran, H. T., Ma, W., Dunlap, V., Scott, G., and Barker, J. L. (1996). GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms.J. Neurosci. 16, 1808-1818.
19. Behar, T. N., Schaffner, A. E., Scott, C. A., O'Connell, C., and Barker, J. L. (1998). Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus.J. Neurosci. 18, 6378-6387.
20. Behar, T. N., Scott, C. A., Greene, C. L., Wen, X., Smith, S. V., Marie, D., Liu, Q. Y., Colton, C. A., and Barker, J. L. (1999). Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.J. Neurosci. 19, 4449-4461.
21. Benardo, L. S., and Wong, R. K. S. (1995). Inhibition in the cortical network. In The Cortical Neuron (M. J. Gutnick and I. Mody, eds.), pp. 141-155. Oxford Univ. Press, New York.
22. Ben-Ari, Y., Cherubini, E., Corradetti, R., and Gaiarsa, J. L. (1989). Giant synaptic potentials in immature rat CA3 hippocampal neurones.J. Physiol. (London) 416, 303-325.
23. Ben-Ari, Y., Khazipov, R., Leinekugel, X., Gaillard, O., and Gaiarsa,]. L. (1997). GABBA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'. Trends Neurosci. 20, 523-529.
24. Bennett, B. D., Huguenard, J. R., and Prince, D. A. (1998). Adrenergic modulation of GABAA receptor-mediated inhibition in rat sensorimotor cortex. J. Neurophysiol. 79, 937-946.
25. Berninger, B., Marty, S., Zafra, F., da Penha Berzaghi, M., and Thoenen, H. (1995). GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro. Development 121, 2327-2335.
26. Berridge, M. J., Bootman, M. D., and Lipp, P. (1998). Calcium-a life and death signal. Nature 395, 645-648.
27. Biervert, C., Schroeder, B. C., Kubisch, C., Berkovic, S. F., Propping, P., Jentsch, T. J., and Steinlein, O. K. (1998). A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406.
28. Billinton, A., Upton, N., and Bowery, N. G. (1999). GABA(B) receptor isoforms GBRla and GBRlb, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum. Br. J. Pharmacol. 126, 1387-1392.
29. Bliss, T. V., and Collingridge, G. L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
30. Blue, M. E., and Parnavelas, J. G. (1983). The formation and maturation of synapses in the visual cortex of the rat. II. Quantitative analysis.J. Neurocytol. 12, 697-712.
31. Borniert, T. P., McKernan, R. M., Farrar, S., le Bourdells, B., Heavens, R. P., Smith, D. W., Hewson, L., Rigby, M. R., Sirinathsinghji, D. J., Brown, N., Wafïbrd, K. A., and Whiting, P. J. (1999). Thêta, a novel gamma-aminobutyric acid type A receptor subunit. Proc. Natl. Aaul. Sa. U.S.A. 96, 9891-9896.
32. Bormann, J. (1988). Electrophysiology of GABAA and GABAB receptor subtypes. Trends Neurosci. 11, 112-116.
33. Bormann, J., and Feigenspan, A. (1995). GABAG receptors. Trends Neurosci. 18, 515-519.
34. Bormann, J., Hamill, O. P., and Sakinann, B. (1987). Mechanism of anion permeation through channels gated by glycine and -y-aminobutyric acid in mouse cultured spinal neurones. J. Physiol. (London) 385, 243-286.
35. Boulder Committee (1970). Embryonic vertebrate central nervous system: revised terminology. Anatomical Record 166, 257-61.
36. Brickley, S. G., Cull-Candy, S. G., and Farrant, M. (1996). Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J. Physiol. (London) 497, 753-759.
37. Brooks-Kayal, A. R., Shumate, M. D., Jin, H., Rikhter, T. Y., and Coulter, D. A. (1998). Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat. Med. 4, 1166-1 172;
38. erratum in Xat. Med. 5, 590 (1999).
39. Brusa, R., Zimmermann, F., Koh, D.-S., Feldmeyer, D., Gass, P., Seeburg, P. H., and Sprengel, R. (1995). Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science 270, 1677-1680.
40. Brysch, W., Creutzfeldt, O. D., Luno, K., Schlingensiepen, R., and Schlingensiepen, K. H. (1991). Regional and temporal expression of sodium channel messenger RNAs in the rat brain during development. Exf). Brain Res. 86, 562-567.
41. Buhl, E. H., Otis, T. S., and Mody, I. (1996). Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271, 369-373.
42. Burgard, E. C., and Hablitz, J. J. (1993a). Developmental changes in NMDA and nonNMDA receptor-mediated synaptic potentials in rat neocortex. J. Neuroplnsiol. 69, 230-240.
43. Burgard, E. C., and Hablitz, J. J. (1993b). \MDA receptor-mediated components of miniature excitatory synaptic currents in developing rat neocortex. J. Xetirophysiol. 70, 1841-1852.
44. Burgess, D. L., Jones, J. M., Meisler, M. H., and Noebels, J. E. (1997). Mutation of the Ca-'channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (Ih) mouse. Cell 88, 385-392.
45. Butler, D. M., Ono, J. K., Chang, T., McCaman, R. E., and Barish, M. E. (1998). Mouse brain potassium channel betal subunit mRNA: cloning and distribution during development.J. Neurobiol. 34, 135-150.
46. Cabelli, R. J., Hohn, A., and Shatz, C. J. (1995). Inhibition of ocular dominance column formation by infusion of N'T-4/5 or BDNF. Science 267, 1662-1666.
47. Cameion, H. A., McEwen, B. S., and Could, E. (1995). Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gvrus. J. Neurosci. 15, 4687-4692.
48. Carmignoto, G., and Vicini, S. (1992). Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258, 1007-101 1.
49. Cases, O., Vitalis, T., Seif, E, De Maever, E., Sotelo, C., and Ciaspar, P. (1996). Eack of barrels in the somatosensory cortex of monoainine oxidase A-deficient mice: role of a serotonin excess during the critical period, \eitron 16, 297-307.
50. Castillo, P. E., Malenka, R. C., and Nicoll, R. A. (1997). Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature 388, 182-186.
51. Castro-Alamancos, M. A., and Connors, B. W. (1997). Thalamocortical synapses. Prog. Neurobiol. 51, 581-606.
52. Catterall, W. A. (1995). Structure and function of voltage-gated ion channels. Annu. Rev. Bwchem. 64, 493-531.
53. Catterall, W. A., (1998). Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium 24, 307-323.
54. Caviness, V., Jr., Takahashi, T., and Nowakowski, R. S. (1995). Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci. 18, 379-383.
55. Charlier, C., Singh, N. A., Ryan, S. G., Lewis, T. B., Reus, B. E., Leach, R. J., and Leppert, M. (1998). A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat. Genet. 18, 53-55.
56. Chen, G., Trombley, P. Q., and van den Pol, A. N. (1996). Excitatory actions of GABA in developing rat hypothalamic neurones. J. Physiol. (London) 494, 451-464.
57. Cherubini, E., Gaiarsa, J. L., and Ben-Ari, Y. (1991). GABA: an excitatory transmitter in early postnatal life. Trends Neurom. 14, 515-519.
58. Choi, D. W. (1994). Glutamate receptors and the induction of excitotoxic neuronal death. Prog-. Brain Res. 100, 47-51.
59. Choi, D. W., Maulucci-Gedde, M., and Kriegstein, A. R. (1987). Glutamate neurotoxicity in cortical cell culture.J. Neurosci. 7, 357-368.
60. Chu, Z., and Hablitz, J. J. (1998). Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex.J. Neurophysiol. 80, 621-627.
61. -cotransporter expression in rat neocortex. Brain Res. Dev. Brain Res. 109, 281-292.
62. Cobas, A., Fairen, A., Alvarez-Bolado, G., and Sanchez, M. P. (1991). Prenatal development of the intrinsic neurons of the rat neocortex: a comparative study of the distribution of GABA-immunoreactive cells and the GABAA receptor. Neuroscience 40, 375-397.
63. Connor, J. A., Hsiu-Yu, T., and Hockberger, P. (1987). Depolarization- and transmitterinduced changes in intracellular Ca2+ of rat cerebellar granule cells in expiant cultures. J. Neurosci. 7, 1384-1400.
64. Connors, B. W., Gutnick, M. J., and Prince, D. A. (1982). Electrophysiological properties of neocortical neurons in vitro. J. Neurophysiol. 48, 1302-1320.
65. Connors, B. W., Malenka, R. C., and Suva, L. R. (1988). Two inhibitory postsynaptic potentials, and GABAA and GABAB receptor-mediated responses in neocortex of rat and cat.J. Physiol. (London) 406, 443-468.
66. Cossart, R., Esclapez, M., Hirsch, J. C., Bernard, C., and Ben-Ari, Y. (1998). GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells. Nat. Neurosci. 1, 470-478.
67. Covarrubias, M., Wei, A. A., and Salkoff, L. (1991). Shaker, Shal, Shab, and Shaw express independent K+ current systems. Neuron 7, 763-773.
68. Crair, M. C. (1999). Neuronal activity during development: permissive or instructive? Curr. Opm. Neurobiol. 9, 88-93.
69. Crair, M. C., and Malenka, R. C. (1995). A critical period for long-term potentiation at thalamocortical synapses. Nature 375, 325-328.
70. Das, S., Sasaki, Y. F., Rothe, T., Premkumar, L. S., Takasu, M., Crandall, J. E., Dikkes, P., Conner, D. A., Rayudu, P. V., Cheung, W., Chen, H. S., Lipton, S. A., and Nakanishi, N. (1998). Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393, 377-381.
71. Davies, P. A., Hanna, M. C., Hales, T. G., and Kirkness, E. F. (1997). Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature 385, 820-823.
72. De Felipe, J., Marco, P., Fairen, A., and Jones, E. G. (1997). Inhibitory synaptogenesis in mouse somatosensory cortex. Cereb. Cortex. 7, 619-634.
73. Deisz, R. A., Fortin, G., and Zieglgansberger, W. (1991). Voltage dependence of excitatory postsynaptic potentials of rat neocortical neurons. J. Neurophysiol. 65, 371-382.
74. Dingledine, R., Hume, R. I., and Heinemann, S. F. (1992). Structural determinants of barium permeation and rectification in non-N M DA glutamate receptor channels. J. Neiirusri. 12, 4080-4087.
75. Dori, I., and Parnavelas, J. G. (1989). The cholinergic innervation of the rat cerebral cortex shows two distinct phases in development. Exp. Brain Res. 76, 417-423.
76. Douglas, R., and Martin, K. (1998). Neocortex. In The Synaptic Organization of the Brain (G. M. Shepherd, éd.), pp. 459-509. Oxford Univ. Press, New York.
77. Drewe, J. A., Verrna, S., Frech, G., and Joho, R. H. (1992). Distinct spatial and temporal expression patterns of K4 channel mRNAs from different subfamilies. J. Nenrosci. 12, 538-548.
78. Durand, G. M., Kovalchuk, Y., and Konnerth, A. (1996). Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71-75.
79. Epilepsy GoGaTotllA (1989). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30, 389-399.
80. Essrich, G., Lorez, M., Benson, J., Fritschy, J., and Luscher, B. (1998). Postsynaptic clustering of major GABAA receptor subtypes requires the Y- subunit and gephyrin. Net. Neurosci. 1,563-571.
81. Feller, M. B. (1999). Spontaneous correlated activity in developing neural circuits. Neuron 22,653-656.
82. Ficker, E., Taglialatela, M., Wible, B. A., Henley, G. M., and Brown, A. M. (1994). Spermine and spermidine as gating molecules for inward rectifier K channels. Science 266, 1068-1072.
83. Fletcher, G. F., Lutz, G. M., O'Sullivan, T. N., Shaughnessy, J. D., Jr., Hawkes, R., Frankel, VV. N., Copeland, N. Ci., and Jenkins, N. A. (1996). Absence epilepsy in tottering mutant mice is associated with calcium channels defects. Cell 87, 607-617.
84. Flint, A. G., Maisch, U. S., Weishaupt, J., Kriegstein, A. R., and Monyer, H. (1997). NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex.y. Nenrosci. 17, 2469-2476.
85. Flint, A. C., Liu, X., and Kriegstein, A. R. (1998). Nonsynaptic glycine receptor activation during early neocortical development. Neuron 20, 43-53.
86. Flint, A. G., Dammerman, R. S., and Kriegstein. A. R. (1999). Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations. Proc. Natl. Acad. Sci. U.S.A. 96, 12144-12149.
87. Fox, K., Schlaggar, B. L., Glazewski, S., and O'Leary, D. D. (1996). Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex. Proc. Natl. Acad. Sci. U.S.A. 93, 5584-5589.
88. Fox, K., Henley, J., and Isaac, J. (1999). Experience-dependent development of NMDA receptor transmission. AV/J. Neurosci. 2, 297-299.
89. Freeman, J. M. (1995). A clinician's look at the developmental neurobiology of epilepsy. Brain Development and Epilepsy (P. A. Schwart/kroin, S. L. Moshé, J. L. Noebels, J. VV. Swann, eels.), pp. 9-33. Oxford Univ. Press, New York.
90. Frerking, M., Malenka, R. G., and Nicoll, R. A. (1998). Synaptic activation of kainate receptors on hippocampal interneurons. Nat. Neurosci. 1, 479-486.
91. Fritschy, J. M., Paysan, J., Enna, A., and Mohler, H. (I994). Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study. J. Neurosci. 14, 5302-5324.
92. Fritschy, J. M., Meskenaite, V., Weinmann, O., Honer, M., Benke, D., and Mohler, H. (1999). GAB AB-receptor splice variants GBla and GBlb in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur.J. Neurosci. 11, 761-768.
93. Fukuda, A., Mody, I., and Prince, D. A. (1993). Differential ontogenesis of presynaptic and postsynaptic GABAB inhibition in rat somatosensory cortex. J. Neurophysiol. 70, 448-452.
94. Gaiarsa, J. L., Tseeb, V., and Ben-Ari, Y. (1995). Postnatal development of pre- and postsynaptic GABAB-mediated inhibitions in the CA3 hippocampal region of the rat. J. Neurophysiol. 73, 246-255.
95. Geiger, J. R., Melcher, T., Koh, D. S., Sakmann, B., Seeburg, P. H., Jonas, P., and Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Caa+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15, 193-204.
96. Ghosh, A., and Greenberg, M. E. (1995). Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268, 239-247.
97. Ghosh, A., Garnahan, J., and Greenberg, M. E. (1994). Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263, 1618-1623.
98. Glauser, T. A. (1995). Pédiatrie epilepsy syndromes. Curr. Opin. Pediatr. 7, 640-649.
99. Gong, B., Rhodes, K. J., Bekele-Arcuri, Z., and Trimmer, J. S. (1999). Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain. J. Comp. Neural. 412, 342-352.
100. Goodman, C. S., and Shatz, C. J. (1993). Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell 72, 77-98.
101. Hablitz, J. J. (1987). Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex.J. Neurophysiol. 58, 1052-1065.
102. Hallows, J. L., and Tempel, B. L. (1998). Expression of Kv 1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia. J. Neurosci. 18, 5682-5691.
103. Hatten, M. E. (1999). Central nervous system neuronal migration. Annu. Rev. Neurosci. 22, 511-539.
104. Hedblom, E., and Kirkness, E. F. (1997). A novel class of GABAA receptor subunit in tissues of the reproductive system. J. Biol. Chem. 272, 15346-15350.
105. Hendry, S. H., Schwark, H. D., Jones, E. G., and Yan, J. (1987). Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex. J. Neurosci. 7, 1503-1519.
106. Hensch, T. K., Fagiolini, M., Malaga, N., Stryker, M. P., Baekkeskov, S., and Rash, S. F. (1998). Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science 282, 1504-1508.
107. Hess, E. J. (1996). Identification of the weaver mouse mutation: the end of the beginning. Neuron 16, 1073-1076.
108. Hestrin, S., Nicoll R. A., Perkel, D. J., and Sah, P. (1990). Analysis of excitatory synaptic action in pyramidal cells using whole-cell recording from rat hippocampal splices. J. Physiol. (London) 422, 203-225.
109. Hille, B. (1992). Ionic Channels of Excitable Membranes. Sinauer, Sunderland, Massachusetts.
110. Hollmann, M., and Heinemann, S. (1994). Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
111. Hollmann, M., Maron, C., and Heinemann, S. (1994). N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluRl. Neuron 13, 1331-1343.
112. Hollrigel, Ci. S., and Soltesz, I. (1997). Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus.J. Neurosa. 17, 5119-5128.
113. Holmes, G. L., and Ben-Ari, Y. (1998). Seizures in the developing brain: perhaps not so benign after all. Neuron 21, 1231-1234.
114. Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A., Harrison, N. L., Krasowski, M. D., Rick, C. E., Korpi, E. R., Makela, R., Brilliant, M. H., Hagiwara, N., Ferguson, C., Snyder, K., and Olsen, R. W. (1997). Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc. Natl. Acad. Sei. U.S.A. 94, 4143-4148.
115. Hosokawa, Y., Sciancalepore, M., Stratta, F., Martina, M., and Gherubini, E. (1994). Developmental changes in spontaneous GABAA-mediated synaptic events in rat hippocampal GA3 neurons. Ear. J. Neurosci. 6, 805-813.
116. Houser, G. R., Vaughn, J. E., Hendry, S. H. G.Jones, E. G., and Peters, A. (1984). GABA neurons in the cerebral cortex. In Gerebral Cortex (E. G. Jones and A. Peters, eds.), pp. 63-89. Plenum, New York.
117. Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vockler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., and Olney, J. W. (1999). Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283, 70-74.
118. Isaac,]. T. R., Giair, M. D., Nicoll, R. A., and Malenka, R. G. (1997). Silent synapses during development of thalamocortical inputs. Neuron 18, 269-280.
119. Isom, L. E., De Jongh, K. S., and Gatterall, W. A. (1994). Auxiliary subunits of voltagegated ion channels. Neuron 12, 1183-1194.
120. Iwasato, T., Erzurumlu, R. S., Huerta, P. T., Chen, D. F., Sasaoka, T., Ulupinar, E., and Tonegawa, S. (1997). NMDA receptor-dependent refinement of somatotopic maps. Neuron 19, 1201-1210.
121. Jan, E. Y., and Jan, Y. N. (1997a). Cloned potassium channels from eukaryotes and prokaryotes. Annu. Rev. Neurosei. 20, 91-123.
122. Jan, E. Y., and Jan, Y. N. (1997b). Voltage-gated and inwardly rectifying potassium channels. J. Physiol. (London) 505, 267-282.
123. Jessell, T. M., and Kandel, E. R. (1993). Synaptic transmission: a bidirectional and selfmodifiable form of cell-cell communication. Cell 72, Suppl, 1-30.
124. Jonas, P., and Burnashev, N. (1995). Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron 15, 987-990.
125. Jonas, P., Racca, G., Sakmann, B., Seeburg, P. H., and Monyer, H. (1994). Differences in Ga2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 12, 1281-1289.
126. Jones, E. G. (1995). Overview: basic elements of the cortical network. In The Cortical Neuron (M. J. Gutnick and I. Mody, eds.), pp. 111-122. Oxford Univ. Press, New York.
127. Jones, K. A., Borowsky, B., Tamm, J. A., Craig, D. A., Durkin, M. M., Dai, M., Yao, W. J., Johnson, M., Gunwaldsen, C., Huang, E. Y., Tang, G., Shen, Q., Salon, J. A., Morse, K., Eaz, T., Smith, K. E., Nagarathnam, D., Noble, S. A., Branchek, T. A., and Gerald, G. (1998). GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396, 674-679.
128. Kaila, K. (1994). Ionic basis of GABAA receptor channel function in the nervous system. Prog. Neurobiol. 42, 489-537.
129. Kaila, K., Eamsa, K., Smirnov, S., Taira, T., and Voipio, J. (1997). Eong-lasting GABAmediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K + transient. J. Neurosci. 17, 7662-7672.
130. Kalsbeek, A., Voorn, P., Buijs, R. M., Pool, C. W., and Uylings, H. B. (1988). Development of the dopaminergic innervation in the prefrontal cortex of the rat. J. Comp. Neural. 269, 58-72.
131. Kandier, K., and Katz, L. C. (1998). Coordination of neuronal activity in developing visual cortex by gap junction-mediated biochemical communication. J. Neurosci. 18, 1419-1427.
132. Kapur, J. (1999). Status epilepticus in epileptogenesis. Curr. Opin. Neural. 12, 191-195.
133. Kash, S. F., Johnson, R. S., Tecott, L. H., Noebels, J. L., Mayfield, R. D., Hanahan, D., and Baekkeskov, S. (1997). Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc. N all. Acad. Sei. U.S.A. 94, 14060-14065.
134. Katz, L. C., and Shatz, C. J. (1996). Synaptic activity and the construction of cortical circuits. Science 274, 1133-1138.
135. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W., and Bettler, B. (1997). Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386, 239-246.
136. Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., Karschin, A., and Bettler, B. (1998). GABA(B)receptor subtypes assemble into functional heteromeric complexes. Nature 396, 683-687.
137. Kidd, F. L., and Isaac, J. T. (1999). Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses. Nature 400, 569-573.
138. Kim, H. G., Fox, K., and Connors, B. W. (1995). Properties of excitatory synaptic events in neurons of primary somatosensory cortex of neonatal rats. Cereb. Cortex 5, 148-157.
139. Kleinschmidt, A., Bear, M. F., and Singer, W. (1987). Blockade of NMDA receptors disrupts experience-dependent plasticity of kitten striate cortex. Science 238, 355-358.
140. Komuro, H., and Rakic, P. (1993). Modulation of neuronal migration by NMDA receptors. Science 260, 95-97.
141. Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., and Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. N all. Acad. Sa. U.S.A. 92, 8856-8860.
142. Kriegstein, A. R., Suppes, T., and Prince, D. A. (1987). Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitra. Brain Res. 431, 161-171.
143. Krnjevic, K., and Schwartz. (1967). The action of gamma-aminobutyric acid on cortical neurons. Exp. Brain Res., 3, 320-336.
144. Krubitzer, L. (1995). The organization of neocortex in mammals: are species differences really so different? Trends Neurosci. 18, 408-417.
145. Kuner, R., Kohr, G., Grunewald, S., Eisenhardt, G., Bach, A., and Kornau, H. C. (1999). Role of heteromer formation in GABAB receptor function. Science 283, 74-77.
146. Kuryatov, A., Gerzanich, V., Nelson, M., Olale, F., and Lindstrom, J. (1997). Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors. J. Neurosci. 17, 9035-9047.
147. Lambert, N., and Grover, L. (1995). The mechanism of biphasic GABA responses. Science 269, 928-929.
148. Lauder, J. M., Han, V. K., Henderson, P., Verdoorn, T., and Towle, A. C. (1986). Prenatal ontogeny of the GABAergic system in the rat brain: an immunocytochemical study. Neuroscience 19, 465-493.
149. Laurie, D. J., Wisden, W., and Seeburg, P. H. (1992). The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosis. 12, 4151-4172.
150. Lavdas, A. A., Blue, M. E., Lincoln, J., and Parnavelas, J. G. (1997). Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex. J. Neurom. 17, 7872-7880.
151. Leinekugel, X., Tseeb, V., Ben-Ari, Y., and Bregestovski, P. (1995). Synaptic GABAA activation induces Ca2+ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices..J. Physio!. 487, 319-329.
152. Leinekugel, X., Medina, I., Khalilov, I., Ben-Ari, Y., and Khazipov, R. (1997). Ca + oscillations mediated by the synergistic excitatory actions of GABAA and \MDA receptors in the neonatal hippocampus. Neuron 18, 243-255.
153. Lernia, J. (1997). Kainate reveals its targets. Neuron 19, 1 155-1158.
154. Lester, R. A., Clements, J. D., Westbrook, G. L., and Jahr, G. E. (1990). Ghannel kinetics determine the time course of N M DA receptor-mediated synaptic currents. Nature 346, 565-567.
155. Letts, V. A., Felix, R., Biddlecome, G. H., Arikkath, J., Mahaffey, G. L., Valenzuela, A., Bartlett, F. S., 2nd, Mori, Y., Campbell, K. P., and Frankel, W. N. (1998). The mouse stargazer gene encodes a neuronal Ca- + -channel gamma subunit. Nat. Genet. 19, 340-347.
156. LeVine, H., 3rd (1999). Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins. Mol. Neurobiol. 19, 111-149.
157. Levitt, P., and Moore, R. Y. (1979). Development of the noradrenergic innervation of néocortex. Brain Res. 162, 243-259.
158. Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., and Murphy, E. H. (1997). Ne\v evidence for neurotransmitter influences on brain development. Trends Neurosci. 20, 269-274.
159. Li, Y. X., Schaffner, A. E., Walton, M. K., and Barker, J. L. (1998). Astrocytes regulate developmental changes in the chloride ion gradient of embryonic rat ventral spinal cord neurons in culture.J. Physiol. (London) 509, 847-858.
160. Liao, D., Zhang, X., O'Brien, R., Ehlers, M. I)., and Huganir, R. L. (1999). Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat. Neurosci. 2, 37-43.
161. Lidov, H. G., and Molliver, M. E. (1982). An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res. Bull. 8,389-430.
162. Lidow, M. S., and Wang, F. (1995). Neurotransmitter receptors in the developing cerebral cortex. Grit. Rev. Neurobiol. 9, 395-418.
163. Lin, M.-FL, Takahashi, M. P., Takahashi, Y., and Tsumoto, T. (1994). Intracellular calcium increase induced by GABA in visual cortex of fetal and neonatal rats and its disappearance with development. Neurosci. Res. 20, 85-94.
164. Lorenzon, N. M., and Foehring, R. C. (1995). Characterization of pharmacologically identified voltage-gated calcium channel currents in acutely isolated rat neocortical neurons. II. Postnatal development.J. Neurophysiol. 73, 1443-1451.
165. Lo'Furco, J. J., and Kriegstein, A. R. (1991). Clusters of coupled neuroblasts in embryonic neocortex. Science 252, 563-566.
166. Loturco, J.J.., Blanton, M. G., and Kriegstein, A. R. (1991). Initial expression and endogenous activation of NMDA channels in early neocortical development. J. Neurosci. 11,792-799.
167. LoTurco, J. J., Owens, D. F., Heath, M. J. S., Davis, M. B. F., and Kriegstein, A. R. (1995). GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron 15, 1287-1298.
168. Luhmann, H. J., and Prince, D. A. (1991). Postnatal maturation of the GABAergic system in rat neocortex.J. Neurophysiol. 65, 247-263.
169. Ma, W., and Barker, J. L. (1995). Complementary expressions of transcripts encoding GAD67 and GABAA receptor alpha 4, beta 1, and gamma 1 subunits in the proliferative zone of the embryonic rat central nervous system.J. Neurosci. 15, 2547-2560.
170. MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., and Barker, J. L. (1986). NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321, 519-522.
171. Macdonald, R. L., and Olsen, R. W., (1994). GABAA receptor channels. Annu. Rev. Neurosci. 17, 569-602.
172. MacKinnon, R. (1991). Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 350, 232-235.
173. + channel excitability in embryonic rat cortical cells. Eur. J. Neurosci. 10, 2532-2546.
174. Marin-Padilla, M. (1998). Cajal-Retzius cells and the development of the neocortex. Trends Neurosci. 21, 64-71.
175. Marty, S., Berninger, B., Garroll, P., and Thoenen, H. (1996). GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brainderived neurotrophic factor. Neuron 16, 565-570.
176. Masssengill, J. L., Smith, M. A., Son, D. I., and O'Dowd, D. K. (1997). Differential expression of K4-AP currents and Kv3.1 potassium channel transcripts in cortical neurons that develop distinct firing phenotypes. J. Neurosci. 17, 3136-3147.
177. Mayer, M. L., Westbrook, G. L., and Guthrie, P. B. (1984). Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309, 261-263.
178. McAllister, A. K., Lo, D. C., and Katz, L. G. (1995). Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15, 791-803.
179. McCormick, D. A. (1989). GABA as an inhibitory neurotransmitter in human cerebral cortex. J. Neurophysiol. 62, 1018-1027.
180. McGormick, D. A., and Prince, D. A. (1987). Post-natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. J. Physiol. (London] 393, 743-762.
181. McCormick, D. A., Connors, B. W., Lighthall, J. W., and Prince, D. A. (1985). Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. J. Neurophysiol. 54, 782-806.
182. McKernan, R. M., and Whiting, P. J. (1996). Which GABAA-receptor subtypes really occur in the brain? TINS 19, 139-143.
183. McLean, H. A., Gaillard, O., Khazipov, R., Ben-Ari, Y., and Gaiarsa, J. L. (1996). Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus.J. Neurophysiol. 76, 1036-1046.
184. McNamara, J. O. (1999). Emerging insights into the genesis of epilepsy. Nature 399, A15-A22.
185. Mehta, A. K., and Ticku, M. K. (1999). An update on GABAA receptors. Brain Res. Brain Res. Rev. 29, 196-217.
186. Meier, E., Hertz, L., and Schousboe, A. (1991). Neurotransmitters as developmental signals. Neurochem. Int. 19, 1-15.
187. Micheva, K. D., and Beaulieu, C. (1995a). An anatomical substrate for experience-dependent plasticity of the rat barrel field cortex. Proc. Natl. Acad. Sri. U.S.A. 92, 11834-11838.
188. Micheva, K. D., and Beaulieu, C. (1995b). Postnatal development of GABA neurons in the rat somatosensory barrel cortex: a quantitative study. Eur.J. Neurosci. 7, 419-430.
189. Micheva, K. D., and Beaulieu, C. (1996). Quantitative aspects of synaptogenesis in the rat barrel field cortex with special reference to GABA circuitry. J. Cornp. Neural. 373, 340-354.
190. Mienville, J. M., and Barker, J. L. (1997). Potassium current expression during prenatal corticogenesis in the rat. Neuroscience 81, 163-172.
191. Mienville, J. M., Lange, G. D., and Barker, J. L. (1994). Reciprocal expression of cell-cell coupling and voltage-dependent Na current during embryogenesis of rat telencephalon. Brain Res. Dev. Brain Res. 77, 89-95.
192. Mohler, H., and Fritschy, J. M. (1999). GABAB receptors make it to the top-as dimers. Trends Pharmacol. Sa. 20, 87-89.
193. Molnar, Z., and Blakemore, G. (1995). How do thalamic axons find their way to the cortex? Trends Neurosci. 18, 389-397.
194. Monyer, H., Seeburg, P. H., and Wisden, W. (1991). Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing. Neuron 6, 799-810.
195. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., and Seeburg, P. H. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
196. Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., and Seeburg, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
197. Moshé, S. L., Shinnar, S., and Swann, J. W. (1995). In Brain Development and Epilepsy (P. A. Schwartzkroin, S. L. Moshé, J. L. Noebels, and J. W. Swann eds.), pp. 34-65. Oxford University Press, New York.
198. Mountcastle, V. B. (1998). Perceptual Neuroscience: The Gerebral Gortex. Harvard Univ. Press, Gambridge, Massachusetts.
199. Nicoll, R. A. (1988). The coupling of neurotransmitter receptors to ion channels in the brain. Science 241, 545-551.
200. Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., and Prochiantz, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307, 462-465.
201. O'Leary, D. D. (1989). Do cortical areas emerge from a protocortex? Trends Neurosci. 12, 400-406.
202. Olsen, R. W., DeLorey, T. M., Handforth, A., Ferguson, C., Mihalek, R. M., and Homanics, G. E. (1997). Epilepsy in mice lacking GABAA-receptor delta (§) subunits. Epilepsia 38, Suppl. 8, 123.
203. O'Rourke, N. A., Dailey, M. E., Smith, S. J., and McGonnell, S. K. (1992). Diverse migratory pathways in the developing cerebral cortex. Science 258, 299-302.
204. Owens, D. F., and Kriegstein, A. R. (1998). Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone.J. Neurosci. 18, 5374-5388.
205. Owens, D. F., Boyce, L. H., Davis, M. B. E., and Kriegstein, A. R. (1996). Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated patch recordings and calcium imaging.J. Neurosci. 16, 6414-6423.
206. Owens, D. F., Liu, X., and Kriegstein, A. R. (1999). Ghanging properties of GABA(A) receptor-mediated signaling during early neocortical development.J. Neurophysiol'. 82, 570-583.
207. Ozawa, S., Kamiya, H., and Tsuzuki, K. (1998). Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54, 581-618.
208. Palackal, T., Moretz, R., Wisniewski, H., and Sturman, J. (1986). Abnormal visual cortex development in the kitten associated with maternal dietary taurine deprivation. J. Neurosci. Res. 15, 223-239.
209. Palackal, T., Kujawa, M., Moretz, R., Neuringer, M., and Sturman, J. (1991). Laminar analysis of the number of neurons, astrocytes, oligodendrocytes and microglia in the visual cortex (area 17) of 3-month-old rhesus monkeys fed a human infant soyprotein formula with or without taurine supplementation from birth. Dev. Neurosci. 13, 20-33.
210. Parra, P., Gulyas, A. I., and Miles, R. (1998). How many subtypes of inhibitory cells in the hippocampus? Neuron 20, 983-993.
211. Pasti, L., Volterra, A., Pozzan, T., and Carmignoto, G. (1997). Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ.J. Neurosci. 17, 7817-7830.
212. Patil, N., Cox, D. R., Bhat, D., Faham, M., Myers, R. M., and Peterson, A. S. (1995). A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat. Genet. 11, 126-129.
213. Paysan, J., Kossei, A., Bolz, J., and Fritschy, J. M. (1997). Area-specific regulation of gamma-aminobutyric acid type A receptor subtypes by thalamic afférents in developing rat neocortex. Proc. Natl. Acad. Sei. U.S.A. 94, 6995-7000.
214. Pearlman, A. L., Faust, P. L., Hatten, M. E., and Brunstrom, J. E. (1998). New directions for neuronal migration. Curr. Opin. Neurobiol. 8, 45-54.
215. Perney, T. M., Marshall, J., Martin, K. A., Hockfield, S., and Kaczmarek, L. K. (1992). Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brain. J. Neurophysiol. 68, 756-766.
216. Petralia, R. S., Esteban, J. A., Wang, Y. X., Partridge,]. G., Zhao, H. M., Wenthold, R. J., and Malinow, R. (1999). Selective acquisition of AM PA receptors over postnatal development suggests a molecular basis for silent synapses. Nat. Neurosci. 2, 31-36.
217. Polleux, F., Dehay, C., Moraillon, B., and Kennedy, H. (1997). Regulation of neuroblast cell-cycle kinetics plays a crucial role in the generation of unique features of neocortical areas.J. Neurosci. 17, 7763-7783.
218. Poulter, M. O., Barker, J. L., O'Carroll, A. M., Lolait, S. J., and Mahan, L. C. (1992). Differential and transient expression of GABAA receptor alpha-subunit mRNAs in the developing rat CNS.J. Neurosci. 12, 2888-2900.
219. Poulter, M. O., Barker,]. L., O'Carroll, A. M., Lolait, S. J., and Mahan, L. C. (1993). Coexistent expression of GABAA receptor beta 2, beta 3 and gamma 2 subunit messenger RNAs during embryogenesis and early postnatal development of the rat central nervous system. Neuroscience 53, 1019-1033.
220. Puranam, R. S., and McNamara, J. O. (1999). Seizure disorders in mutant mice: relevance to human epilepsies. Curr. Opin. Neurobiol. 9, 281-287.
221. Quinlan, E. M., Philpot, B. D., Huganir, R. L., and Bear, M. F. (1999). Rapid, experiencedependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat. Neurosci. 2, 352-357.
222. Rabow, L. E., Russek, S. J., and Färb, D. H. (1995). From ion currents to genomic analysis: recent advances in GABAA receptor research. Synapse 21, 189-274.
223. Rakic, P. (1974). Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition. Science 183, 425-427.
224. Rakic, P. (1988). Specification of cerebral cortical areas. Science 241, 170-176.
225. Reichling, D. B., Kyrozis, A., Wang, J., and MacDermott, A. B. (1994). Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons. J. Physiol. (London) 476, 411-421.
226. Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., and Kaila, K. (1999). The K+/Cr-co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397, 251-255.
227. Rockel, A. J., Hiorns, R. W., and Powell, T. P. (1980). The basic uniformity in structure of the neocortex. Brain 103, 221-244.
228. Rodriguez-Moreno, A., Herreras, O., and Lerma, J. (1997). Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19, 893-901.
229. Roerig, B., and Katz, L. C. (1997). Modulation of intrinsic circuits by serotonin 5-HT3 receptors in developing ferret visual cortex. J. Neurosci. 17, 8324-8338.
230. Roerig, B., Nelson, D. A., and Katz, L. C. (1997). Fast synaptic signaling by nicotinic acetylcholine and serotonin 5-HT3 receptors in developing visual cortex. J. Neurosci. 17, 8353-8362.
231. - cotransport distinguishes depolarizing from hyperpolarizing GABAA receptor-mediated responses in spinal neurons. J. Neurosci. 16, 82-91.
232. Rosenmund, C., Stern-Bach, Y., and Stevens, C. F. (1998). The tetrameric structure of a glutamate receptor channel. Science 280, 1596-1599.
233. Roy, D. R., and Barnstable, C. J. (1999). Temporal and spatial pattern of expression of cyclic nucleotide-gated channels in developing rat visual cortex. Cereb. Cortex. 9, 340-347.
234. Sadikot, A. F., Burhan, A. M., Belanger, M. C., and Sasseville, R. (1998). NMDA receptor antagonists influence early development of GABAergic interneurons in the mammalian striatum. Brain Res. Dev. Bruin Res. 105, 35-42.
235. Salin, P. A., and Prince, D. A. (1996). Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex. J. Neurophysiol. 75, 1573-1588.
236. Schiller, J., Schiller, Y., Stuart, G., and Sakmann, B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. J. Physiol. (London) 505, 605-616.
237. -channels in embryonic rat spinal and olfactory bulb cells. J. Physio!. (London) 488, 371-386.
238. Shi, S. H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., and Malinow, R. (1999). Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811-1816.
239. Signorini, S., Liao, Y. J., Duncan, S. A., Jan, L. Y., and Stoffel, M. (1997). Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel G1RK2. Proc. Nntl. Ac ad. Sei. U.S.A. 94, 923-927.
240. Singh, N. A., Gharlier, C., Stauffer, D., DuPont, B. R., Leach, R. J., Melis, R., Ronen, G. M., Bjerre, I., Quattlebaum, T., Murphy, J. V., McHarg, M. L., Gagnon, D., Rosales, T. O., Peiffer, A., Anderson, V. E., and Leppert, M. (1998). A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. AY/J. Genet. 18, 25-29.
241. Sloviter, R. S. (1999). Status epilepticus-induced neuronal injury and network reorganization. Epilepsia 40, S34-S39; discussion S40-S41.
242. Smart, S. L., Lopantsev, V., Zhang, C. L., Robbins, C]. A., Wang, H., Chiu, S. Y., Schwartzkroin, P. A., Messing, A., and Tempel, B. L. (1998). Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819.
243. Smith, S. J., and Augustine, G. J. (1988). Calcium ions, active zones and synaptic transmitter release. Trends Neurosci. 11, 458-464.
244. Sommer, B., Keinanen, K., Verdoorn, T. A., VVisden, VV., Burnashev, N., Herb, A., Kohler, M., Fakagi, T., Sakmann, B., and Seeburg, P. H. (1990). Flip and flop: a cellspecific functional switch in glutamate-operated channels of the CNS. Science 249, 1580-1585.
245. Sommer, B., Kohler, M., Sprengel, R., and Seeburg, P. H. (1991). RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
246. Staley, K.J., Soldo, B. L., and Proctor, W. R. (1995). Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science 269, 977-981.
247. Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., and Berkovic, S. F. (1995). A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat. Genet. 11, 201-203.
248. Steinlein, O. K., Magnusson, A., Stoodt, J., Bertrand, S., Weiland, S., Berkovic, S. F., Nakken, K. O., Propping, P., and Bertrand, D. (1997). An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy. Hum. Mol. Genêt. 6, 943-947.
249. Stevens, C. F. (1998). Neuronal diversity: too many cell types for comfort? Curr. Biol. 8, R708-R710.
250. Sutkowski, E. M., and Catterall, W. A. (1990). Beta 1 subunits of sodium channels. Studies with subunit-specific antibodies. J. Biol. Chem. 265, 12393-12399.
251. Sutor, B., Hablitz, J. J., Rucker, F., and ten Bruggencate, G. (1994). Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy.J. Neurophys. 72, 1756-1768.
252. Swann, J. W., Pierson, M. G., Smith, K. L., and Lee, C. L. (1999). Developmental neuroplasticity: roles in early life seizures and chronic epilepsy. In Advances in Neurology (A. V. Delgaso-Escueta et al., eds.), pp. 203-216. Lippincott, Williams & Wilkins, Philadelphia.
253. Tanaka, O., Sakagami, H., and Kondo, H. (1995). Localization of mRNAs of voltagedependent Ca(2 + )-channels: four subtypes of alpha 1- and beta-subunits in developing and mature rat brain. Brain Res. Mol. Brain Res. 30, 1-16.
254. Tarasenko, A. N., Isaev, D. S., Eremin, A. V., and Kostyuk, P. G. (1998). Developmental changes in the expression of low-voltage-activated Ca2+ channels in rat visual cortical neurones. J. Physiol. (London) 509, 385-394.
255. Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F., and Julius, D. (1995). Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374, 542-546.
256. Ullrich, N. (1999). The role of ion channels in cell proliferation. Neuroscientist 5, 70-73.
257. Vandenberg, C. A. (1987). Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc. N all. Acad. Sei. U.S.A. 84, 2560-2564.
258. van den Pol, A. N., Obrietan, K., and Chen, G. (1996). Excitatory actions of GABA after neuronal trauma, y. Neurosci. 16, 4283-4292.
259. van den Pol, A. N., Gao, X. B., Patrylo, P. R., Ghosh, P. K., and Obrietan, K. (1998). Glutamate inhibits GABA excitatory activity in developing neurons. J. Neurosci. 18, 10749-10761.
260. Verdoorn, T. A., Draguhn, A., Ymer, S., Seeburg, P. H., and Sakmann, B. (1990). Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron 4, 919-928.
261. Verdoorn, T. A., Burnashev, N., Monyer, H., Seeburg, P. H., and Sakmann, B. (1991). Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252, 1715-1718.
262. Vignes, M., and Gollingridge, G. L. (1997). The synaptic activation of kainate receptors. Nature 388, 179-182.
263. +-channel betal subunit gene SCN1B. Nat. Genet. 19, 366-370.
264. Wang, H. S., Pan, Z., Shi, W., Brown, B. S., Wymore, R. S., Cohen, I. S., Dixon, J. E., and McKinnon, D. (1998). KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890-1893.
265. Wang, J., Reichling, D. B., Kyrozis, A., and MacDermott, A. B. (1994). Developmental loss of GABA- and glycine-induced depolarization and Ca- + transients in embryonic rat dorsal horn neurons in culture. Enr.J. Nenrosci. 6, 1275-1280.
266. Wei, A., Covarrubias, M., Butler, A., Baker, K., Pak, M., and Salkoff, L. (1990). K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science 248, 599-603.
267. Wess, J. (1997). G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB ]. 11, 346-354.
268. White, J. H., Wise, A., Main, M. J., Green, A., Fraser, N. J., Disney, G. H., Barnes, A. A., Emson, P., Foord, S. M., and Marshall, F. H. (1998). Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396, 679-682.
269. Whiting, P. J., McAllister, G., Vassilatis, D., Borniert, T. P., Heavens, R. P., Smith, D. W., Hewson, L., O'Donnell, R., Rigby, M. R., Sirinathsinghji, D. J., Marshall, Ci., Thompson, S. A., Wafford, K. A., and Vasilatis, D. (1997). Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties. J. Neurosci. 17, 5027-5037.
270. Wickman, K., and Clapham, D. E. (1995). Ion channel regulation by Ci proteins. Physiol. Rev. 75, 865-885.
271. Wiesel, T. N. (1982). Postnatal development of the visual cortex and the influence of environment. Nature 299, 583-591.
272. Wu, G.-Y., Malinow, R., and Cline, H. T. (1996). Maturation of a central glutamatergic synapse. Science 274, 972-976.
273. Wu, W., Ziskind-Conhaim, L., and Sweet, M. (1992). Early development of glycine and GABA-mediated synapses in rat spinal cord. J. Neurosci. 12, 3935-3945.
274. Wuarin, J. P., and Dudek, F. E. (1996). Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats..J. Neurosci. 16, 4438-4448.
275. Xiang, Z., Huguenard, J. R., and Prince, D. A. (1998a). Gholinergic switching within neocortical inhibitory networks. Science 281, 985-988.
276. Xiang, Z., Huguenard, J. R., and Prince, D. A. (1998b). GABA-A receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J. Physiol. (London) 506, 715-730.
277. Yamashita, M., and Fukuda, Y. (1993). Calcium channels and GABA receptors in the early embryonic chick retina. J. Nenrobiol. 24, 1600-1614.
278. Yarowsky, P. J., Krueger, B. K., Olson, C. E., Clevinger, E. C., and Koos, R. D. (1991). Brain and heart sodium channel subtype mRNA expression in rat cerebral cortex. Proc. Natl. Acad. Sei. U.S.A. 88, 9453-9457;
279. erratum in Proc. Natl. Acad. Sei. U.S.A. 89, 3669 (1992).
280. Yellen, Ci. (1999). The bacterial K+ channel structure and its implications for neuronal channels. Curr. Opin. Neurobiol. 9, 267-273.
281. Yuste, R., and Katz, E. C. (1991). Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters. Neuron 6, 333-344.
282. Yuste, R., and Tank, D. W. (1996). Dendritic integration in mammalian neurons, a century after Cajal. Neuron 16, 701-716.
283. Zhou, F. M., and Hablitz, J. J. (1997). Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons. J. Neurophysiol. 78, 2287-2295.
284. Zucker, R. S. (1999). Calcium- and activity-dependent synaptic plasticity. Curr. Opin. Neurobiol. 9, 305-313.