Dendritic integration in mammalian neurons, a century after Cajal

Neuron

Volumn 16, Issue 4, 1996, Pages 701-716

  Yuste, Rafael ^a   Tank, David W ^b  

^a Columbia University ^*  (United States)

^b LUCENT TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITE; ELECTROPHYSIOLOGY; MOTONEURON; NERVE CELL; NERVE CONDUCTION; PRIORITY JOURNAL; PURKINJE CELL; PYRAMIDAL NERVE CELL; REVIEW; SIGNAL PROCESSING; SPIKE WAVE;

EID: 0029975851     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80091-4     Document Type: Review

References (209)

1. Abeles, M., Bergman, H., Margalit, E., and Vaadia, E. (1993). Spatiotemporal firing patterns in the frontal cortex of behaving monkeys. J. Neurophysiol. 70, 1629-1638.
2. Allbritton, N.L., Meyer, T., and Stryer, L. (1992). Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258, 1812-1815.
3. Amitai, Y., Friedman, A., Connors, B.W., and Gutnick, M.J. (1993). Regenerative activity in apical dendrites of pyramidal cells in neocortex. Cerebral Cortex 3, 26-38.
4. Andersen, P., Holmquist, B., and Voorhoeve, P.E. (1966). Excitatory synapses on hippocampal apical dendrites activated by entorhinal stimulation. Acta Physiol. Scand. 66, 461-472.
5. Antic, S., and Zecevic, D. (1995). Optical signals from neurons with internally applied voltage-sensitive dyes. J. Neurosci. 15, 1392-1405.
6. 2+-storing compartment associated with GABAergic synapses in the axon initial segment of hippocampal pyramidal neurones. Exp. Brain Res. 101, 216-230.
7. Bernarder, O., Douglas, R.D., Martin, K.A., and Koch, C. (1991). Synaptic background activity influences spatiotemporal integration in single pyramidal cells. Proc. Natl. Acad. Sci. USA 88, 11569-11573.
8. Bernarder, O., Koch, C., and Douglas, R.J. (1994). Amplification and linearization of distal synaptic input to cortical pyramidal cells. J. Neurophysiol. 72, 2743-2753.
9. Bernardo, L.S., Masukawa, L.M., and Prince, D.A. (1982). Electrophysiology of isolated hippocampal pyramidal dendrites. J. Neurosci. 2, 1614-1622.
10. Blanton, M.G., Lo Turco, J.J., and Kriegstein, A.R. (1989). Whole-cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J. Neurosci. Meth. 30, 203-210.
11. Borst, A., and Egelhaaf, M. (1992). In vivo imaging of calcium accumulation in fly interneurons as elicited by visual motion stimulation. Proc. Natl. Acad. Sci. USA 89, 4139-4143.
12. Borst, A., and Egelhaaf, M. (1994). Dendritic processing of synaptic information by sensory interneurons. Trends Neurosci. 17, 257-273.
13. Brock, L.G., Coombs, J.S., and Eccles, J.C. (1952). The recording of potentials from motoneurones with an intracellular electrode. J. Physiol. 117, 431-460.
14. Buhl, E.H., Halasy, K., and Somogyi, P. (1994). Diverse sources of hippocampal unitary inhibitory postynaptic potentials and the number of synaptic release sites. Nature 368, 823-828.
15. Bullock, T.H. (1977). Introduction to Nervous Systems (San Francisco: Freeman).
16. Callaway, J.C., and Ross, W.N.(1995). Frequency-dependent propagation of sodium action potentials in dendrites of hippocampal CA1 pyramidal neurons. J. Neurophysiol. 74, 1-9.
17. 2+] in the dendrites of cerebellar Purkinje neurons. J. Neurosci. 15, 2777-2787.
18. Cauller, L.J., and Connors, B.W. (1992). Functions of very distal dendrites: experimental and computational studies of layer I synapses on neocortical pyramidal cells. In Single Neuron Computation, T. McKenna, ed. (San Diego: Academic Press), pp. 199-229.
19. Cauller, L.J., and Connors, B.W. (1994). Synaptic physiology of horizontal afferents to layer 1 in slices of rat S1 neocortex. J. Neurosci. 14, 751-762.
20. Cauller, L.J., and Kulics, A.T. (1991). The neural basis of the behaviourally relevant N1 component of the somatosensory-evoked potentials of S1 cortex of awake monkeys: evidence that backward cortical projection signals conscious touch sensation. Exp. Brain Res. 84, 607-619.
21. Cheramy, A., Leviel, V., and Glowinski, J. (1981). Dendritic release of dopamine in the substantia nigra. Nature 289, 537-542.
22. Claiborne, B.J., Amaral, D.G., and Cowan, W.M. (1986). A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus. J. Comp. Neurol. 246, 435-458.
23. Connor, J.A. (1986). Digital imaging of free calcium changes and of spatial gradients in growing processes in single, mammalian central nervous system cells. Proc. Natl. Acad. Sci. USA 83, 6179-6183.
24. Connors, B.W., and Kriegstein, A.R. (1986). Cellular physiology of the turtle visual cortex: distinctive properties of pyramidal and stellate neurons. J. Neurosci. 6, 164-177.
25. Connors, B.W., Bernardo, L.S., and Prince, D.A. (1983). Coupling between neurons of the developing rat neocortex. J. Neurosci. 3, 773-782.
26. Coombs, S.J., Eccles, J.C., and Fatt, P. (1955a). Excitatory synaptic actions in motoneurons. J. Physiol. 130, 374-395.
27. Coombs, S.J., Eccles, J.C., and Fatt, P. (1955b). The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potential. J. Physiol. 130, 396-413.
28. Coombs, S.J., Curtis, D.R., and Eccles, J.C. (1957). The interpretation of spike potentials of motorneurones. J. Physiol. 139, 198-231.
29. Deiters, O. (1865). Untersuchungen über Gehirn und Rückenmark des Menschen und der Säugethiere. (Braunschweig).
30. Denk, W., Strickler, J.H., and Webb, W.W. (1990). Two-photon laser scanning fluorescence microscopy. Science 248, 73-76.
31. Denk, W., Delaney, K.R., Gelperin, A., Kleinfeld, D., Strowbridge, B.W., Tank, D.W., and Yuste, R. (1994). Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy. J. Neurosci. Meth. 54, 151-162.
32. Denk, W., Sugimori, M., and Llinás, R. (1995). Two types of calcium response limited to single spines in cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 8279-8282.
33. DeRobertis, E.D.P., and Bennett, H.S. (1955). Some features of the submicroscopic morphology of synapses in frog and earthworm. J. Biophys. Biochem. Cytol. 1, 47-58.
34. Deschenes, M. (1981). Dendritic spikes induced in fast pyramidal tract neurons bythalamic stimulation. Exp. Brain Res. 43, 304-308.
35. De Schutter, E. (1992). A consumer guide to neuronal modeling software. Trends. Neurosci. 15, 462-464.
36. De Schutter, E., and Bower, J.M. (1994). Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proc. Natl. Acad. Sci. USA 91, 4736-4740.
37. Dodt, H.-U., and Zieglgänsberger, W. (1990). Visualizing unstained neurons in living brain slices by infrared DIC. Brain Res. 537, 333-336.
38. Dodt, H.-U., and Zieglgänsberger, W. (1994). Infrared videomicroscopy: a new look at neuronal structure and function. Trends Neurosci. 17, 453-458.
39. Dowling, J.E. (1968). Synaptic organization of the frog retina: an electron microscopic analysis comparing the retinas of frogs and primates. Proc. R. Soc. Lond. (B) 170, 205-228.
40. Dubin, M.W. (1970). The inner plexiform layer of the vertebrate retina: a quantitative and comparative electron microscope analysis. J. Comp. Neurol. 140, 479-506.
41. Dunlap, K., and Fischbach, G.D. (1978). Neurotransmitters decrease the calcium component of sensory neuron action potentials. Nature 276, 837-838.
42. Eccles, J.C. (1964). The Physiology of Synapses (Berlin: Springer), pg. 104.
43. Eccles, J.C., Libet, B., and Young, R.R. (1958). The behavior of chromatolysed motoneurons studied by intracellular recording. J. Physiol. (Lond.) 143, 11-40.
44. Edwards, F.A., Konnerth, A., Sakmann, B., and Takahashi, T. (1989). Athin slice preparation for patch recordings from neurones of mammalian central nervous system. Pflügers Arch. 414, 600-612.
45. 2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature 373, 155-158.
46. Fatt, P. (1957). Sequence of events in synaptic activation of a motoneurone. J. Neurophysiol. 20, 61-80.
47. Fetcho, J.R., and O'Malley, D.M. (1995). Visualization of active neural circuitry in the spinal chord of intact zebrafish. J. Neurophys. 73, 399-406.
48. Fine, A., Amos, W.B., Durbin, R.M., and McNaughton, P.A. (1988). Confocal microscopy: applications in neurobiology. Trends Neurosci. 11, 345-351.
49. Forehand, C.J., and Purves, D. (1984). Regional innervation of rabbit ciliary ganglion cells by the terminals of preganglionic axons. J. Neurosci. 4, 1-12.
50. Fromherz, P., and Müller, C.O. (1994). Cable properties of a straight neurite of a leech neuron probed by a voltage-sensitive dye. Proc. Natl. Acad. Sci. USA 91, 4604-4608.
51. Fuortes, M.G.F., Frank, K., and Becker, M.C. (1957). Steps in the production of the motoneuron spikes. J. Gen. Physiol. 40, 735-752.
52. Gamble, E., and Koch, C. (1987). The dynamics of free calcium in dendritic spines in response to repetitive input. Science 236, 1311-1315.
53. Gilbert, C., and Wiesel, T.N. (1979). Morphology and intracortical projections of functionally characterised neurons in the cat visual cortex. Nature 280, 120-125.
54. Glenn, L.L., Whitney, J.F., Rewitzer, J.S., Salamone, J.A., and Mariash, S.A. (1988). Method for stable intracellular recordings of spinal α-motoneurons during treadmill walking in awake, intact cats. Brain Res. 439, 396-401.
55. Goeppert-Mayer, M. (1931). Ueber Elementareakte mit zwei Quantensprungen. Ann. Physik 9, 273-283.
56. González, J.E., and Tsien, R.Y. (1995). Voltage sensing by fluorescence resonacne energy transfer in single cells. Biophys. J. 69, 1272-1280.
57. Gray, C.M., Konig, P., Engel, A.K., and Singer, W. (1989). Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature 338, 334-337.
58. Grinvald, A., Ross, W.N., and Farber, I. (1981). Simultaneous optical measurements of electrical activity from mutiple sites on processes of cultured neurons. Proc. Natl. Acad. Sci. USA 78, 3145-3249.
59. Gustafsson, B., Wigstrom, H., Abraham, W.C., and Huang Y.-Y. (1987). Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials. J. Neurosci. 7, 774-780.
60. Guthrie, P.B., Segal, M., and Kater, S.B. (1991). Independent regulation of calcium revealed by imaging dendritic spines. Nature 354, 76-80.
61. Gutnick, M.J., and Prince, D.A. (1981). Dye coupling and possible electrotonic coupling in the guinea pig neocortical slice. Science 211, 67-70.
62. Haag, J., and Borst, A. (1996). Amplification of high-frequency synaptic inputs by active dendritic membrane processes. Nature 379, 639-641.
63. Hatsopoulos, N., Gabbiani, F., and Laurent, G. (1995). Elementary computation of object approach by a wide-field visual neuron. Science 270, 1000-1003.
64. Häusser, M., Stuart, G., Racca, C., and Sakmann, B. (1995). Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 15, 637-647.
65. Hebb, D.O. (1949). The Organization of Behaviour (New York: Wiley).
66. Heiligenberg, W. (1991). Neural Nets in Electric Fish: Computational Neuroscience Series (Cambridge, Massachusetts: MIT Press).
67. Hermann, L. (1905). Beiträge zur Physiologie und Physiks des Nerven. Pflügers Arch. 109, 95-120.
68. Hillman, D., Chen, S., Aung, T.T., Cherksey, B., Sugimori, M., and Llinás, R.R. (1991). Localization of P-type calcium channels in the central nervous system. Proc. Natl. Acad. Sci. USA 88, 7076-7080.
69. Hirsch, J.A., and Gilbert, C.D. (1991). Synaptic physiology of horizontal connections in the cat's visual cortex. J. Neurosci. 11, 1800-1809.
70. Hirsch, J.A., Alonso, J.-M., and Reid, R.C. (1995). Visually evoked calcium action potentials in cat striate cortex. Nature 378, 612-616.
71. His, W. (1893). Über den Aufbau unseres Nervensystems. Berl. Klin. Wochenschr. 40, 41.
72. Hodgkin, A.L., and Keynes, R.D. (1957). Movements of labelled calcium in squid giant axons. J. Physiol. 138, 253-281.
73. Hodgkin, A.L., and Rushton, W.A.H. (1946). The electrical constants of a crustacean nerve fiber. Proc. R. Soc. Lond. (B) 133, 444-479.
74. Hopfield, J.J. (1995). Pattern recognition computation using action potential timing for stimulus representation. Nature 376, 33-36.
75. Houchin, J. (1973). Procion Yellow electrodes for intracellular recording and staining of neurons in the somatosensory cortex of the rat. J. Physiol. 232, 67-69.
76. Huguenard, J.R., Hamill, O.P., and Prince, D.A. (1989). Sodium channels in dendrites of rat cortical pyramidal neurons. Proc. Natl. Acad. Sci. USA 86, 2473-2477.
77. Hume, R.I., and Purves, D. (1981). Geometry of neonatal neurons and the regulation of synaptic elimination. Nature 293, 469-471.
78. Hyde, I.H. (1921). A micro-electrode and unicellular stimulation. Biol. Bull. 40, 130-133.
79. Jaffe, D.B., Johnston, D., Lasser-Ross, N., Lisman, J.E., Miyakawa, H., and Ross, W.N. (1992). The spread of Na spikes determines the pattern of dendritic Ca entry into hippocampal neurons. Nature 357, 244-246.
80. Katz, L.C., and Constantine-Paton, M. (1988). Relationships between segregated afferents and postsynaptic neurons in the optic tectum of three-eyed frogs. J. Neurosci. 8, 3160-3180.
81. Kim, H.G., and Connors, B.W. (1993). Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology. J. Neurosci. 13, 5301-5311.
82. Kim, H.G., Beierlein, M., and Connors, B.W. (1995). Inhibitory control of excitable dendrites in neocortex. J. Neurophysiol. 74, 1810-1815.
83. Kisvarday, Z.F., Martin, K.A.C., Friedlander, M.J., and Somogyi, P. (1987). Evidence for interlaminar inhibitory circuits in the striate cortex of the cat. J. Comp. Neurol. 260, 1-19.
84. Koch, C., and Zador, A. (1993). The function of dendritic spines: devices subserving biochemical rather than electrical compartmentalization. J. Neurosci. 13, 413-422.
85. Koch, C., Poggio, T., and Torre, V. (1983). Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing. Proc. Natl. Acad. Sci. USA 80, 2799-2802.
86. Kogan, A., Ross, W.N., Zecevic, D., and Lasser-Ross, N. (1996). Optical recording from cerebellar Purkinje cells using intracellularly injected voltage-sensitive dyes. Brain Res., in press.
87. Kölliker A. (1889). Handbuch der Gewebelehre (Leipzig).
88. Kosaka, T. (1983). Neuronal gap junctions in the polymorph layer of the rat dentate gyrus. Brain Res. 277, 347-351.
89. Larkman, A.U. (1991). Dendritic morphology of pyramidal neurons of the visual cortex of the rat. III. Spine distributions. J. Comp. Neurol. 306, 332-343.
90. Laurent, G., and Burrows, M. (1989). Intersegmental interneurons can control the gain of reflexes in adjacent segments of the locust by their action on nonspiking local interneurons. J. Neurosci. 9, 3030-3039.
91. Levy, W.B., and Desmond, N.L. (1985). Associative potentiation/ depression in the hippocampal dentate gyrus. In Electrical Activity of the Archicortex, G. Buzsáki and C.H. Vanderwolf, eds. (Budapest: Akademiai Kiado), pp. 359-373.
92. Levy, W.B., and Steward, O. (1979). Synapses as associative memory elements in the hippocampal formation. Brain Res. 175, 233-245.
93. Ling, G., and Gerard, R.W. (1949). The normal membrane potential of frog sartorius fibers. J. Cell Comp. Physiol. 34, 383-396.
94. Lisman, J. (1989). A mechanism for the Hebb and anti-Hebb processes underlying learning and memory. Proc. Natl. Acad. Sci. USA 86, 9574-9578.
95. Llinás, R. (1988). The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242, 1654-1664.
96. Llinás, R., and Greenfield, S.A. (1987). On-line visualization of dendritic release of acetylcholinesterase from mammalian substantia nigra neurons. Proc. Natl. Acad. Sci. USA 84, 3047-3050.
97. Llinás, R., and Hess, R. (1976). Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells. Proc. Natl. Acad. Sci. USA 73, 2520-2523.
98. Llinás, R., and Nicholson, C. (1971). Electroresponsive properties of dendrites and somata in alligator Purkinje cells. J. Neurophysiol. 34, 532-551.
99. Llinás, R., and Sugimori, M. (1980). Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J. Physiol. 305, 197-213.
100. Llinás, R., and Sugimori, M. (1992). The electrophysiology of the cerebellar Purkinje cells revisited. In The Cerebellum Revisited, R. Llinás and C. Sotelo, eds. (New York: Springer-Verlag), pp. 167-181.
101. Llinás, R., and Yarom, Y. (1981). Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro. J. Physiol. (Lond.) 315, 569-584.
102. Llinás, R., Nicholson, C., Freeman, J.A., and Hillman, D.E. (1968). Dendritic spikes and their inhibition in alligator Purkinje cells. Science 160, 1132-1135.
103. Llinás, R., Baker, R., and Sotelo, C. (1974). Electrotonic coupling between neurons in cat inferior olive. J. Neurophysiol. 37, 560-571.
104. Lorente de Nó, R., and Coundouris, G.A. (1959). Decremental conduction in peripheral nerve integration of stimuli in the neuron. Proc. Natl. Acad. Sci. USA 45, 592-617.
105. Lo Turco, J.J., and Kriegstein, A.R. (1991). Clusters of coupled neuroblasts in embryonic neocortex. Science 252, 563-566.
106. MacVicar, B.A., and Dudek, F.E. (1981). Electrotonic coupling between pyramidal cells: a direct demonstration in rat hippocampal slices. Science 213, 782-785.
107. 2+ channels in apical dendrites of rat CA1 pyramidal neurons. J. Physiol. 487, 67-90.
108. Magee, J.C., and Johnston, D. (1995b). Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons. Science 268, 301-304.
109. Mainen, Z.F., and Sejnowski, T.J. (1995). Reliability of spike timing in neocortical neurons. Science 268, 1503-1506.
110. Major, G. (1993). Solutions for transients in arbitrarily branching cables. III. Voltage clamp problems. Biophys. J. 65, 469-491.
111. Major, G., Evans, J.D., and Jack, J.B. (1993). Solutions for transients in arbitrary branching cables: I. Voltage recording with a somatic shunt. Biophys. J. 65, 423-449.
112. Major, G., Larkman, A.U., Jonas, P., Sakmann, B., and Jack, J.J. (1994). Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. J. Neurosci. 14, 4613-4638.
113. Markram, H., and Sakmann, B. (1994). Calcium transients in apical dendrites evoked by single sub-threshold excitatory post-synaptic potentials via low voltage-activated calcium channels. Proc. Natl. Acad. Sci. USA 91, 5207-5211.
114. Matsumura, M., Cope, T., and Fetz, E.E. (1988). Sustained excitatory synaptic input to motor cortex neurons in awake animals revealed by intracellular recording of membrane potentials. Exp. Brain Res. 70, 463-469.
115. Mel, B.W. (1994). Information processing in dendritic trees. Neural Comp. 6, 1031-1085.
116. Michelson, H.B., and Wong, R.K.S. (1994). Synchronization of inhibitory neurons in the guinea pig hippocampus in vitro. J. Physiol. 477, 35-45.
117. Minski, M. (1961). Microscopy apparatus. US Patent 1961, 3013467.
118. Montana, V., Farkas, D.L., and Loew, L.M. (1989). Dual-wavelength ratiometric fluorescence measurements of membrane potential. Biochemistry 28, 4536-4539.
119. 2+ responses. Nature 354, 73-76.
120. Murphy, T.H., Baraban, J.M., Gil Wier, W., and Blatter, L.A. (1994). Visualization of quantal synaptic transmission by dendritic calcium imaging. Nature 263, 529-532.
121. Núñez, A., García-Austt, E., and Buño, W. (1990). In vivo electrophysiological analysis of Lucifer Yellow-coupled hippocampal pyramids. Exp. Neurol. 108, 76-82.
122. Núñez, A., Amzica, F., and Steriade, M. (1993). Electrophysiology of cat association cortical cells in vivo: intrinsic properties and synaptic responses. J. Neurophys. 70, 418-430.
123. Palay, S.L (1956). Synapses in the central nervous system. J. Biophys. Biochem. Cytol. 2, 193-201.
124. Peinado, A., Yuste, R., and Katz, L.C. (1993). Extensive dye coupling between rat neocortical neurons during the period of circuit formation. Neuron 10, 103-114.
125. Peters, A., Palay, S.L., and Webster, H.D. (1991). The Fine Structure of the Nervous System (New York: Oxford University Press).
126. Phillips, C.G., Powel, T.P.S., and Shepherd, G.M. (1963). Responses of mitral cells to stimulation of the lateral olfactory tract in the rabbit. J. Physiol. 168, 65-88.
127. Pinsky, P.F., and Rinzel, J. (1994). Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J. Comput. Neurosci. 1, 39-60.
128. Pockberger, H. (1991). Electrophysiological and morphological properties of rat motor cortex neurons in vivo. Brain Res. 539, 181-190.
129. Pollack, G.S. (1988). Selective attention in an insect auditory neuron. J. Neurosci. 8, 2635-2639.
130. Powell, T.P.S. (1981). Certain aspects of the intrinsic organization of the cerebral cortex. In Brain Mechanisms and Perceptual Awareness, O. Pompeiano and C. Ajmone Marsan, eds. (New York: Raven Press), pp. 1-19.
131. Purpura, D.P. (1967). Comparative physiology of dendrites. In The Neurosciences: A Study Program, G.C. Quarton, T. Melnechuk, and F.O. Schmitt, eds. (New York: Rockefeller University Press), pp. 372-875.
132. Purpura, D.P., and Shofer, R.J. (1964). Cortical intracellular potentials during augmenting and recruiting responses. I. Effects on injected hyperpolarizing currents on evoked membrane potential changes. J. Neurophysiol. 27, 117-132.
133. Purves, D., and Hume, R.I. (1981). The relation of postsynaptic geometry to the number of presynaptic axons that innervate autonomic ganglion cells. J. Neurosci. 1, 441-452.
134. Rall, W. (1959). Branching dendritic trees and motoneuron membrane resistivity. Exp. Neurol. 1, 491-527.
135. Rall, W. (1964). Theoretical significance of dendritic trees for neuronal input-output relations. In Neural Theory and Modeling, R.F. Reiss, ed. (Stanford: Stanford University Press), pp. 73-97.
136. Rall, W. (1974). Dendritic spines, synaptic potency and neuronal plasticity. In Cellular Mechanisms Subserving Changes in Neuronal Activity, C.D. Woody, K.A. Brown, T.J. Crow, and J.D. Knispel, eds. (Los Angeles: Brain Information Services), pp. 13-21.
137. Rall, W. (1995). The Theoretical Foundation of Dendritic Function, I. Segev, J. Rinzel, and G.M. Shepherd, eds. (Cambridge, Massachusetts: MIT Press).
138. Rall, W., and Segev, I. (1987). Functional possibilities for synapses on dendrites and on dendritic spines. In Synaptic Function, G.E. Edelman, W.F. Gall, and W.M. Cowan, eds. (New York: Wiley), pp. 605-637.
139. Rall, W., and Shepherd, G.M. (1968). Theoretical reconstruction of field potentials and dendro-dendritic synaptic interactions in olfactory bulb. J. Neurophys. 31, 884-915.
140. Rall, W., Shepherd, G.M., Reese, T.S., and Brightman, M.W. (1966). Dendrodenritic synaptic pathways for inhibition in the olfactory bulb. Exp. Neurol. 14, 44-56.
141. Raman, I.M., and Trussell, L.O. (1992). The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus. Neuron 9, 173-186.
142. Ramón, P. (1890). Investigaciones de histología comparada en los centros ópticos de los vertebrados. PhDthesis, University of Madrid.
143. Ramón y Cajal, S. (1889). Conexión general de los elementos nerviosos. Medicina Práctica.
144. Ramón y Cajal, S. (1891 a). Significación fisiológica de las expansiones protoplásmicas y nerviosas de la sustancia gris. Rev. Ciencias Méd. 22, 23.
145. Ramón y Cajal, S. (1891b). Sur la structure de l'ecorce cerebrale de quelques mamiferes. Cellule 7.
146. Ramón y Cajal, S. (1897). Las leyes de la morfología y dinamismo de las células nerviosas. Revista Trim. Microgr. 1.
147. Ramón y Cajal, S. (1904). La Textura del Sistema Nerviosa del Hombre y los Vertebrados (Madrid: Moya).
148. Ramón y Cajal, S. (1923). Recuerdos de mi Vida: Historia de mi Labor Científica (Madrid: Alianza Editorial).
149. Rapp, M., Segev, I., and Yarom, Y. (1994). Physiology, morphology and detailed passive models of guinea-pig Purkinje cells. J. Physiol. (Lond.) 474, 101-118.
150. Regehr, W.G., and Tank, D.W. (1992). Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells. J. Neurosci. 12, 4202-4223.
151. Regehr, W.G., Connor, J.A., and Tank, D.W. (1989). Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation. Nature 341, 533-536.
152. Regehr, W.G., Konnerth, A., and Armstrong, C.M. (1992). Sodium action potentials in the dendrites of cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA 89, 5492-5496.
153. Regehr, W.G., Kehoe, J., Ascher, P., and Armstrong, C. (1993). Synaptically triggered action potentials in dendrites. Neuron 11, 145-151.
154. Renshaw, B. (1942). Effects of presynaptic volleys on spread of impulses over the soma of the motoneurons. J. Neurophysiol. 5, 235-243.
155. 2+ channels in dendrites. J. Neurosci. 13, 4609-4621.
156. Reyher, C.H.K., Lubke, J., Larsen, W.J., Hendrix, G.M., Shipley, M.T., and Baumgarten, H.G. (1991). Olfactory bulb granule cell aggregates: morphological evidence for interperikaryal electrotronic coupling via gap junctions. J. Neurosci. 11, 1485-1495.
157. Rhodes, P.A., and Gray, C.M. (1994). Simulations of intrinsically bursting neocortical pyramidal neurons. Neural Comp. 6, 1086-1110.
158. Richardson, T.L., Turner, R.W., and Miller, J.J. (1987). Action-potential discharge in hippocampal CA1 pyramidal neurons. J. Neurophys. 58, 981-996.
159. Rockland, K.S., and Virga, A. (1989). Terminal arbors of individual "feedback" axons projecting from V2 to V1 in the macaque monkey: a study using immunocytochemistry of anterogradely transported Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 285, 54-72.
160. Rose, G.J., and Call, S.J. (1993). Temporal filtering properties of midbrain neurons in an electric fish: implications for the function of dendritic spines. J. Neurosci. 13, 1178-1189.
161. Ross, W.N., and Werman, R. (1987). Mapping calcium transients in the dendrites of Purkinje cells from guinea-pig cerebellum in vitro. J. Physiol. 389, 319-336.
162. Ross, W.N., Lewenstein Stockbridge, L., and Stockbridge, N.L. (1986). Regional properties of calcium entry in barnacle neurons determined with Arsenazo III and a photodiode array. J. Neurosci. 6, 1148-1159.
163. Rubel, E.W., and Parks, T.N. (1988). Organization and development of the avian brain-stem auditory system. In Auditory Function, G.M. Edelman, W.E. Gall, and W.M. Cowan, eds. (New York: John Wiley and Sons), pp. 3-93.
164. Sakmann, B., and Neher, E. (1983). Single Channel Recording (New York: Plenum).
165. Schadlen, M.N., and Newsome, W.T. (1994). Noise, neural codes and cortical organization. Curr. Opin. Neurobiol. 4, 569-579.
166. Scharfman, H.E., and Sarvey, J.M. (1985). Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus. Brain Res. 331, 267-274.
167. Schwartzkroin, P.A., and Slawsky, M. (1977). Probable calcium spikes in hippocampus neurons. Brain Res. 135, 157-161.
168. Shelton, D.P. (1985). Membrane resistivity estimated for the Purkinje neuron by means of a passive computer model. Neuroscience 14, 111-131.
169. Shepherd, G.M., and Brayton, R.K. (1987). Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience 21, 151-165.
170. Shepherd, G.M., Brayton, R.K., Miller, J.P., Segev, I., Rinzel, J., and Rall, W. (1985). Signal enhancement in distal cortical dendrites by means of interactions between active dendritic spines. Proc. Natl. Acad. Sci. USA 82, 2192-2195.
171. Sloper, J.J. (1972). Gap junctions between dendrites in the primate neocortex. Brain Res. 44, 641-646.
172. 2+ dynamics in a cricket auditory neuron: an example of chemical computation. Science 263, 823-826.
173. Softky, W.R., and Koch, C. (1992). The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs. J. Neurosci. 13, 334-350.
174. Sotelo, C., Llinás, R., and Baker, R. (1974). Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling. J. Neurophysiol. 37, 541-559.
175. Spencer, W.A., and Kandel, E.R. (1961). Electrophysiology of hippocampal neurons: IV. Fast prepotentials. J. Neurophysiol. 24, 272-285.
176. Spruston, N., Jaffe, D.B., and Johnston, D. (1994). Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties. Trends Neurosci. 17, 161-166.
177. Spruston, N., Schiller, Y., Stuart, G., and Sakmann, B. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 286, 297-300.
178. Stafstrom, C.E., Schwindt, P.C., Chabb, M.C., and Crill, W.E. (1985). Properties of persistent sodium and calcium conductances of layer 5 neurons from cat sensory motor cortex in vivo. J. Neurophysiol. 55, 153-170.
179. Stratford, K., Mason, A., Larkman, A., Major, G., and Jack, J.J. (1989). The modelling of pyramidal neurons in the visual cortex. In The Computing Neuron, R. Durbin, C. Miall, and G. Mitchinson, eds. (Workingham, England: Addison-Wesley), pp. 296-322.
180. Stuart, G.J., and Häusser, M. (1994). Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13, 703-712.
181. Stuart, G.J., and Sakmann, B. (1994). Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367, 69-72.
182. Stuart, G.J., Dodt, H.-U., and Sakmann, B. (1993). Patch clamp recording from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflügers Arch. 423, 511-518.
183. Sugihara, I., Lang, E.J., and Llinás, R. (1993). Uniform olivocerebellar conduction time underlies Purkinje cell complex spike synchronicity in the rat cerebellum. J Physiol. (Lond.) 470, 243-271.
184. Sutor, B., and Hablitz, J.J. (1989). EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs. J. Neurophysiol. 61, 621-634.
185. Tank, D.W., Sugimori, M., Connor, J.A., and Llinás, R.R. (1988). Spatially resolved calcium dynamics of mammalian Purkinje cells in cerebellar slice. Science 242, 773-777.
186. Thompson, A.M., Girdlestone, D., and West, D.C. (1988). Voltage-dependent currents prolong single-axon postsynaptic potentials in layer III pyramidal neurons in rat neocortical slices. J. Neurophysiol. 60, 1896-1907.
187. Traub, R.D. (1996). Model of sustained population bursts in electrically coupled inerneurons containingactive dendritic conductances. J. Comput. Neurosci., in press.
188. Traub, R.D., Wong, R.K., Miles, R., and Michelson, H. (1991). A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J. Neurophysiol. 66, 635-650.
189. Tsien, R.Y. (1989). Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253.
190. Turner, R.W., Meyers, E.R., Richardson, D.L., and Barker, J.L. (1991). The site for initiation of action potential discharge over the somatosensory axis of rat hippocampal CA1 pyramidal neurons. J. Neurosci. 11, 2270-2280.
191. Vaney, D.I. (1991). Many diverse types of retinal neurons show tracer coupling when injected with biocytin or neurobiotin. Neurosci. Lett. 125, 187-190.
192. Van Gehuchten, A. (1891). La moelle epiniere et le cervelet. Cellule 7.
193. Watson, A.H.D., and Burrows, M. (1988). Distribution and morphology of synapses on nonspiking local interneurons in the thoracic nervous system of the locust. J. Comp. Neurol. 272, 605-616.
194. 2+ channnels at the base of major dendrites in hippocampal pyramidal neurons. Nature 347, 281-284.
195. Westenbroek, R.E., Hell, J.W., Warner, C., Dubel, S.J., Snutch, T.P., and Catterall, W.A. (1992). Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron 9, 1099-1115.
196. Wickens, J. (1988). Electrically coupled but chemically isolated synapses: dendritic spines and calcium in a rule for synaptic modification. Prog. Neurobiol. 31, 507-528.
197. Wilson, T., and Sheppard, C. (1984). Theory and Practice of Scanning Optical Microscopy (New York: Academic Press).
198. Wong, R.K.S., and Prince, D.A. (1978). Participation of calcium spikes during intrinsic burst firing in hippocampal neurons. Brain Res. 159, 385-390.
199. Wong, R.K.S., and Steward, M. (1992). Different firing patterns generated in dendrites and somata of CA1 pyramidal neurones in guinea-pig hippocampus. J. Physiol. 457, 675-687.
200. Wong, R.K.S., Prince, D.A., and Basbaum, A.I. (1979). Intradendritic recordings from hippocampal neurons. Proc. Natl. Acad. Sci. USA 76, 986-990.
201. 2+ channel antagonists nitrendipine, to a postsynaptic density fraction isolated from canine cerebral cortex. Mol. Brain Res. 1, 176-184.
202. Yamamoto, C. (1972). Activation of hippocampal neurons by mossy fiber stimulation in thin brain sections in vitro. Exp. Brain Res. 14, 423-435.
203. Yang, G., and Masland, R.H. (1992). Direct visualization of the dendritic and receptive fields of directionally selective retinal ganglion cells. Science 258, 1949-1952.
204. Yuste, R., and Denk, W. (1995). Dendritic spines as basic units of synaptic integration. Nature 375, 682-684.
205. Yuste, R., Peinado, A., and Katz, L.C. (1992). Neuronal domains in developing neocortex. Science 257, 665-669.
206. Yuste, R., Gutnick, M.J., Saar, D., Delaney, K.D., and Tank, D.W. (1994). Calcium accumulations in dendrites from neocortical neurons: an apical band and evidence for functional compartments. Neuron 13, 23-43.
207. Yuste, R., Nelson, D., Rubin, W., and Katz, L.C. (1995). Neuronal domains in developing neocortex: mechanisms of coactivation. Neuron 14, 7-17.
208. Zeki, S. (1993). The modularity of the brain. In A Vision of the Brain, S. Zeki, ed. (Oxford: Blackwell), pp. 197-296.
209. Zohary, E., Shadlen, M.N., and Newsome, W. T. (1994). Correlated neuronal discharge rate and its implications for psychophysical performance. Nature 370, 140-143.