Growth factor release from tissue engineering scaffolds

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 11, 2001, Pages 1427-1437

  Whitaker, M J ^a   Quirk, R A ^a   Howdle, S M ^a   Shakesheff, K M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; NERVE GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG MECHANISM; DRUG SYNTHESIS; ENCAPSULATION; EXPERT SYSTEM; HUMAN; HYDROGEL; IN VIVO STUDY; MORPHOGENESIS; PHARMACEUTICAL ENGINEERING; PROTECTION; PROTEIN SECRETION; REVIEW; TISSUE GROWTH; TISSUE REPAIR; WOUND; WOUND HEALING;

BIOARTIFICIAL ORGANS; BIOCOMPATIBLE MATERIALS; DRUG DELIVERY SYSTEMS; GROWTH SUBSTANCES; HUMANS; PROSTHESES AND IMPLANTS; REGENERATION; TISSUE ENGINEERING; TISSUE TRANSPLANTATION;

EID: 0035165289     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011777963     Document Type: Review

References (130)

1. Biodegradable PLA-PGA polymers for tissue engineering in orthopaedics
2. Intraarterial protein delivery via intimally-adherent bilayer hydrogels
3. Issues and perspectives on the biocompatability and immunotoxicity evaluation of implanted controlled release systems
4. Host response to tissue engineered devices
5. Growth factor delivery for tissue engineering
6. Materials for protein delivery in tissue engineering
7. Development of microspheres for neurological disorders: From basics to clinical applications
8. Microspheres for protein delivery prepared from amphiphilic multiblock copolymers. 1. Influence of preparation techniques on particle characteristics and protein delivery
9. Bioactive factors for bone tissue engineering
10. Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration
11. Ankle fractures treated using biodegradable internal fixation
12. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation
13. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders
14. Generation of neotendon using synthetic polymers seeded with tenocytes
15. FGF2-targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation
16. Photo-immobilization of epidermal growth factor enhances its mitogenic effect by artificial juxtacrine signaling
17. Novel injectable neutral solutions of chitosan form biodegradable gels in situ
18. Adhesion prevention with ancrod released via a tissue-adherent hydrogel
19. Tissue engineering by cell transplantation using degradable polymer substrates
20. Biodegradable polymeric microparticles for drug delivery and vaccine formulation: The surface attachment of hydrophilic species using the concept of poly(ethylene glycol) anchoring segments
21. Stability and release of bovine serum albumin encapsulated within poly(D,L-lactide-co-glycolide) microparticles
22. Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels
23. Toward development of an implantable tissue engineered liver
24. Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide-ε-caprolacton) nerve guide
25. Multifunctional poly(ethylene glycol) semi-interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting
26. Synthesis and characterization of photo-gross-linked polymers based on poly(L-lactic acid-co-L-aspartic acid)
27. In vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration
28. Controlled release of ionic compounds from poly(L-lactide) microspheres produced by precipitation with a compressed antisolvent
29. Lab-grown organs begin to take shape
30. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers
31. Biodegradable polymer scaffolds for tissue engineering
32. FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres
33. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres
34. Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold
35. Hepatocyte behavior within three-dimensional porous alginate scaffolds
36. Localized delivery of proteins in the brain: Can transport be customized?
37. Enzymatic-reactions in supercritical gases
38. Lactide-based poly(ethylene glycol) polymer networks for scaffolds in tissue engineering
39. Synthesis of polymer network scaffolds from L-lactide and poly(ethylene glycol) and their interactions with cells
40. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing
41. 2
42. Inhibition of thrombosis and intimal thickening by in-situ photopolymerization of thin hydrogel barriers
43. Poly(alpha-hydroxy acids): Carriers for bone morphogenetic proteins
44. Supercritical fluid mixing: Preparation of thermally sensitive polymer composites containing bioactive materials
45. Hydrogel systems for barriers and local drug delivery in the control of wound healing
46. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers
47. Water in carbon dioxide microemulsions: An environment for hydrophiles including proteins
48. Selective stimulation of endothelial-cell proliferation with inhibition of smooth-muscle cell-proliferation by fibroblast growth-factor-1 plus heparin delivered from fibrin glue suspensions
49. Highly porous polymer matrices as a three-dimensional culture system for hepatocytes
50. Human osteoblast response in vitro to platelet-derived growth factor and transforming growth factor-beta delivered from controlled-release polymer rods
51. Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels
52. Engineered smooth muscle tissues: Regulating cell phenotype with the scaffold
53. Development and in vitro characterization of vascular endothelial growth factor (VEGF)-loaded poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) microspheres using a solid encapsulation/single emulsion/solvent extraction technique
54. Heterotopic hepatocyte transplantation utilizing pancreatic islet cotransplantation for hepatotrophic stimulation: Morphologic and morphometric evaluation
55. Long-term differentiated function of heterotopically transplanted hepatocytes on three-dimensional polymer matrices
56. Transport and elimination of recombinant human NGF during long-term delivery to the brain
57. Combined gelatin-chondroitin sulfate hydrogels for controlled release of cationic antibacterial proteins
58. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties
59. Controlled growth factor release from synthetic extracellular matrices
60. Poly(vinyl alcohol) synthetic polymer foams as scaffolds for cell encapsulation
61. Structure property relationships in the case of the degradation of massive aliphatic poly(alpha-hydroxy acids) in aqueous-media. 1. Poly(DL-lactic acid)
62. Structure-property relationships in the case of the degradation of massive poly(alpha-hydroxy acids) in aqueous-media 3. Influence of the morphology of poly(L-lactic acid)
63. Transforming growth factor-beta 1 adsorbed to tricalciumphosphate coated implants increases peri-implant bone remodeling
64. Pretreatment with platelet derived growth factor-BB modulates the ability of costochondral resting zone chondrocytes incorporated into PLA/PGA scaffolds to form new cartilage in vivo
65. The importance of new processing techniques in tissue engineering
66. Effects of pore size in 3-D fibrous matrix on human trophoblast tissue development
67. Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition
68. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells
69. Design of macroporous biodegradable polymer scaffolds for cell transplantation
70. Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue
71. In vitro and in vivo studies on bioabsorbable ultrahigh-strength poly(L-lactide) rods
72. Matrices for tissue engineering-scaffold structure for a bioartificial liver support system
73. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel
74. Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA tri-block copolymer-type
75. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents
76. Localised delivery of epidermal growth factor improves the survival of transplanted hepatocytes
77. Stabilized polyglycolic acid fibre-based tubes for tissue engineering
78. Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro
79. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering
80. Lipase activity and stability in supercritical carbon dioxide
81. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation
82. In vitro characterization of transforming growth factor-beta 1 loaded composites of biodegradable polymer and mesenchymal cells
83. Polypeptide growth factors: Targeted delivery systems
84. Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion
85. Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration
86. Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration
87. In vitro degradation of a poly(propylene fumarate)/beta-tricalcium phosphate composite orthopaedic scaffold
88. Intracellularly biorecognizable derivatives of 5-fluorouracil - Implications for site-specific delivery in the human condition
89. Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid)
90. Enzymatic catalysis in a supercritical fluid
91. Alginate hydrogels as synthetic extracellular matrix materials
92. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: An example of designer matrices in tissue engineering
93. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix
94. Development of fibrin derivatives for controlled release of heparin-binding growth factors
95. Intracranial delivery of recombinant nerve growth factor: Release kinetics and protein distribution for three delivery systems
96. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension
97. Importance of distinct water environments in the hydrolysis of poly(DL-lactide-co-glycolide)
98. Polylactide macroporous biodegradable implants for cell transplantation. 2. Preparation of polylactide foams by liquid-liquid phase separation
99. DNA delivery from polymer matrices for tissue engineering
100. Bioadsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery
101. Modulation of vascular cell growth kinetics by local cytokine delivery from fibrin glue suspensions
102. Polymeric endoluminal gel paving: Hydrogel systems for local barrier creation and site-specific drug delivery
103. Incorporation of protein in PLG-microspheres with retention of bioactivity
104. Synthesis and characterization of a block copolymer consisting of poly(propylene fumarate) and poly(ethylene glycol)
105. Preparation and characterization of poly(propylene fumarate-co-ethylene glycol) hydrogels
106. In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels
107. Platelet adhesion on a bioresorbable poly(propylene fumarate-co-ethylene glycol) copolymer
108. Strength retention of self-reinforced poly-L-lactide screws and plates - An in vivo and in vitro study
109. De novo formation of adipose tissue by controlled release of basic fibroblast growth factor
110. Fabrication of biodegradable polymer scaffolds to engineer trabecular bone
111. Multilayer aggregrate culture of rat hepatocytes on a porous material: Three dimensional cellular organization and maintenance of hepatic functions
112. Applications of supercritical fluids in the controlled release of drugs
113. Polymeric systems for controlled drug release
114. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
115. Synthetic-polymers seeded with chondrocytes provide a template for new cartilage formation
116. Tissue engineering using synthetic biodegradable polymers. Polymers of biological biomedical significance
117. The effect of a water/organic solvent interface on the structural stability of lysozyme
118. Growth factor and matrix molecules preserve cell function on thermally responsive culture surfaces
119. Controlled-release of platelet-derived growth-factor using ethylene-vinyl acetate copolymer (evac) coated on stainless-steel wires
120. Gene transfection of multicellular speroid of hepatocytes on an artificial substrate
121. Vascular endothelial growth factor and heparin in a biologic glue promotes human aortic endothelial cell proliferation with aortic smooth muscle cell inhibition
122. Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds
123. A biodegradable polymer scaffold for delivery of osteotropic factors
124. Precipitation of proteins in supercritical carbon dioxide
125. Endothelial cell seeding of (heparinized) collagen matrices: Effects of bFGF pre-loading on proliferation (after low density seeding) and pro-coagulant factors
126. In vitro degradation of a poly(propylene fumarate)-based composite material
127. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering
128. Formation of microparticulate protein powders using a supercritical fluid antisolvent
129. Tissue engineering: A new approach in cardiovascular surgery; Seeding of human fibroblasts followed by human endothelial cells on resorbable mesh