Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: The yeast perspective

Genes and Development

Volumn 15, Issue 4, 2001, Pages 365-379

  Gulli, M P ^a   Peter, M ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; INTEGRIN; MEMBRANE PROTEIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; T LYMPHOCYTE RECEPTOR; TYROSINE KINASE RECEPTOR; UBIQUITIN;

CELL CYCLE; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INACTIVATION; LIFE CYCLE; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

CELL CYCLE PROTEINS; CELL DIVISION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, FUNGAL; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; PROTO-ONCOGENE PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0035118704     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.876901     Document Type: Review

References (116)

1. Interferon-α signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2
2. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
3. Responding to attraction: Chemotaxis and chemotropism in Dictyostelium and yeast
4. The Rap1 GTPase functions as a regulator of morphogenesis in vivo
5. Effectors for the Rho GTPases
6. A role for the yeast actin cytoskeleton in pheromone receptor clustering and signalling
7. Cell polarity in yeast
8. N-formyl peptide receptor ligation induces Rac-dependent actin reorganization through Gβγ subunits and class Ia phosphoinositide 3-kinases
9. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1
10. Genetic analysis of C1n/Cdc28 regulation of cell morphogenesis in budding yeast
11. Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-γ1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells
12. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking cdc24p and cdc42p to actin polarization in yeast
13. Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p
14. Nuclear-specific degradation of Far1p is controlled by the localization of the F-box protein Cdc4p
15. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle regulated phosphorylation of Cdc24p
16. Phospholipid-binding protein domains
17. Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins
18. Regulatory and signaling properties of the Vav family
19. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
20. The GTPase Rap1 controls functional activation of macrophage integrin α M β 2 by LPS and other inflammatory mediators
21. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation
22. The Dbl family of oncogenes
23. Cell polarity in yeast
24. Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1
25. Recycling of the yeast a-factor receptor
26. A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains
27. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling
28. Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line
29. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
30. Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation
31. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
32. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
33. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
34. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
35. Phosphorylation and proteolysis: Partners in the regulation of cell division in budding yeast
36. Cell Polarity
37. Actin cytoskeleton organization regulated by the PAK family of protein kinases
38. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
39. Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains
40. Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils
41. Biology of the adenomatous polyposis coli tumor suppressor
42. Distinct roles for Ga and Gbg in regulating spindle position and orientation in early C. elegans embryos
43. Phosphorylation of the Cdc42p exchange factor Cdc24p by the PAK-like kinase Cla4p may regulate polarized growth in yeast
44. Rho GTPases and the actin cytoskeleton
45. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor
46. Lck regulates Vav activation of members of the Rho family of GTPases
47. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
48. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
49. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
50. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
51. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
52. Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1
53. CYK-4: A Rho family GTPase activating protein (GAP) required for central spindle formation and cytokinesis
54. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex
55. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
56. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
57. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
58. Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors
59. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
60. Asef, a link between the tumor suppressor APC and G-protein signaling
61. Functions and functional domains of the GTPase Cdc42p
62. Localized rac activation dynamics visualized in living cells
63. Budding yeast morphogenesis: Signalling, cytoskeleton and cell cycle
64. Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity
65. Pheromone signalling and polarized morphogenesis in yeast
66. Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization
67. Cell cycle control of morphogenesis in budding yeast
68. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
69. Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
70. The Nck SH2/SH3 adaptor protein: A regulator of multiple intracellular signal transduction events
71. Polarized distribution of endogenous Rac1 and RhoA at the cell surface
72. A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization
73. A GTP-exchange factor required for cell orientation
74. A Cdc24p-Far1p-Gβγ protein complex required for yeast orientation during mating
75. G proteins mediate changes in cell shape by stabilizing the axis of polarity
76. Nucleocytoplasmic shuttling of the Cdc42p exchange factor Cdc24p
77. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
78. The ins and outs of cell-polarity decisions
79. G-protein-coupled receptors function as oligomers in vivo
80. Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
81. Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site
82. Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast
83. Activation of Rac and Cdc42 by integrins mediates cell spreading
84. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
85. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
86. The small GTPase, Rap1, mediates CD31-induced integrin adhesion
87. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
88. Saccharomyces cerevisiae Cdc42p GTPase is involved in preventing the recurrence of bud emergence during the cell cycle
89. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast
90. Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein
91. The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility
92. RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): Role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae
93. ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells
94. Molecular cloning and characterization of Drosophila genes encoding small GTPases of the rab and rho families
95. A protein complex containing inscuteable and the G α-binding protein Pins orients asymmetric cell divisions in Drosophila
96. Bidirectional signaling between the cytoskeleton and integrins
97. Cell polarity: Fixing cell polarity with Pins
98. Polarization of yeast cells in spatial gradients of α mating factor
99. Nuclear sequestration of the exchange factor Cdc24p by Far1p regulates cell polarity during mating
100. The GoLoco motif: A Gai/0 binding motif and potential guanine-nucleotide exchange factor
101. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae
102. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
103. Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae
104. CH domains revisited
105. Rho family GTPases: More than simple switches
106. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
107. The guanine-nucleotide-exchange factor Cdc24p is targeted to the nucleus and polarized growth sites
108. Paxillin and focal adhesion signalling
109. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
110. Proteolysis and the cell cycle: With this RING I do thee destroy
111. Rho GTPases and signaling networks
112. Cell polarity in response to chemoattractants
113. Dbl family proteins
114. Analysis of partner of inscutable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscutable apical localization
115. Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae
116. Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae