1-[N,O-Bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle

Biochemical Journal

Volumn 339, Issue 3, 1999, Pages 533-540

  Brozinick Jr , Joseph T ^a   Reynolds, Thomas H ^a   Dean, David ^b   Cartee, Gregory ^b   Cushman, Samuel W ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Akt kinase; GLUT4; Photolabelling; PI 3 kinase

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM 45; CALCIUM BINDING PROTEIN; GLUTAMINE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; DRUG EFFECT; ENZYME ACTIVITY; FAST MUSCLE; GLUCOSE TRANSPORT; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CELL HYPOXIA; CELL MEMBRANE; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; INSULIN; INSULIN ANTAGONISTS; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033137056     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3390533     Document Type: Article

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