Progressive islet graft failure occurs significantly earlier in autoantibody-positive than in autoantibody-negative IDDM recipients of intrahepatic islet allografts

Diabetes

Volumn 46, Issue 11, 1997, Pages 1907-1910

  Jaeger, Clemens ^a   Brendel, Mathias D ^a   Hering, Bernhard J ^a   Eckhard, Michael ^a   Bretzel, Reinhard G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; C PEPTIDE; CYCLOSPORIN A; GLUTAMATE DECARBOXYLASE; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; PANCREAS ISLET CELL ANTIBODY; STEROID;

ADULT; ALLOIMMUNITY; ALLOTRANSPLANTATION; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; CLINICAL ARTICLE; CLINICAL PROTOCOL; COMPLICATION; CONTROLLED STUDY; DRUG THERAPY; FEMALE; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; PANCREAS ISLET TRANSPLANTATION; PREVENTION; PRIORITY JOURNAL;

EID: 0030695038     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.11.1907     Document Type: Article

References (10)

1. Eisenbarth GS, Stegall M: Islet and pancreatic transplantation: autoimmunity and alloimmunity. N Engl J Med 335:888-889, 1996
2. Tyden G, Reinholt FP, Sundkvist G, Bolinder J: Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. JV Engl J Med 335:860-363, 1996
3. Stegall MD, Lafferty KJ, Kam I, Gill RG: Evidence of recurrent autoimmunity in human allogeneic islet transplantation. Transplantation 63:1272-1274, 1996
4. Jaeger C, Hering BJ, Dyrberg T, Federlin K, Bretzel RG: Islet cell antibodies and glutamic acid decarboxylase antibodies in patients with insulin-dependent diabetes mellitus undergoing kidney and islet-after-kidney transplantation. Transplantation 62:424-426, 1996
5. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo GF, Gale EAM, Bosi E: Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38:816-822, 1995
6. Bretzel RG, Browatzki CC, Schultz A, Brandhorst H, Klitscher D, Bollen CC, Raptis G, Friemann S, Ernst W, Rau WS, Hering BJ: Clinical islet transplantation: report of the islet transplant registry and the Giessen center experience: Diab Stoffw 2:378-390, 1993
7. Peterson JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen B, Dyrberg T: Detection of GAD 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43:459-467, 1994
8. Sibley RK, Sutherland DER, Goetz F, Michael AF: Recurrent diabetes mellitus in the pancreas iso and allograft; a light and electron microscopic and immunohisto-chemical analysis of four cases: Lab Invest 53:132-144, 1985
9. Peterson JS, Dyrberg T, Karlsen AE, Molvig J, Michelsen B, Nerup J, Mandrup-Poulsen T, and the Canadian-European Randomized Control Trial Goup: Glutamic acid decarboxylase (GAD 65) autoantibodies in prediction of β-cell function and remission in recent-onset IDDM after cyclosporin treatment Diabetes 43:1291-1296, 1994
10. Mandrup-Poulsen T, Molvig J, Andersen HU, Helqvist S, Spinas GA, Munck M, the Canadian-European Randomized Control Trial Group: Lack of predictive value of islet cell antibodies, insulin antibodies and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. Diabetes 39:204-210, 1990