SIP1 (smad interacting protein 1) and δEF1 (δ-crystallin enhancer binding factor) are structurally similar transcriptional repressors. A current survey of their functions and mechanisms of action in transforming growth factor-β signalling

Journal of Bone and Joint Surgery

Volumn 83, Issue SUPPL. 1, 2001, Pages

  Van Grunsven, L A ^a   Schellens, A ^a   Huylebroeck, D ^a   Verschueren, K ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; COMPLEMENTARY DNA; CRYSTALLIN; DNA; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; ZINC FINGER PROTEIN;

ANIMAL CELL; CONFERENCE PAPER; DNA BINDING; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; XENOPUS;

EID: 0035084643     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (67)

1. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
2. Mechanism of activation of the TGF-beta receptor
3. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
4. Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors
5. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
6. TGF-beta receptors
7. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
8. Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes
9. Spemann organizer activity of Smad1O
10. Identification of two Smad4 proteins in Xenopus: Their common and distinct properties
11. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling
12. Identification of Smad7, a TGF beta-inducible antagonist of TGF-beta signalling
13. Smad6 inhibits signalling by the TGF-beta superfamily
14. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
15. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
16. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
17. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
18. Role of p300, a transcriptional coactivator, in signaling of TGF-beta
19. A Smad transcriptional corepressor
20. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
21. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes
22. Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: Implications for olfactory neuronal development
23. Identification of a common ecotropic viral integration site, Evi.1, in the DNA of AKXD murine myeloid tumors
24. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders
25. Expression of EVIl in myelodysplastics syndromes and other hematologic malignancies without 3q26 translocations
26. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling
27. Sehnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
28. The zinc finger protein scnurri acts as a smad partner in mediating the transcriptional response to decapentaplegic
29. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
30. The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
31. Schnurri interacts with Mad in a Dpp-dependent manner
32. Schnurri mediates dpp-dependent repression of brinker transcription
33. Brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes
34. The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation
35. Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer
36. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription
37. Displacement of an E-box-binding repressor by basic helix-loop-helix-proteins- implications for B-cell specificity of the immunoglobulin heavy-chain enhancer
38. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2
39. Identification of a zinc finger protein that inhibits IL-2 gene expression
40. Transcription factors positively and negatively regulating the Na,K.ATPase alpha 1 subunit gene
41. Alternative splicing gives rise to two isoforms of Zfhep, a zinc finger/homeodomain protein that binds T3-response elements
42. Prediction of the coding sequences of unidentified human genes. IX The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
43. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
44. New mode of DNA binding of multi-zinc finger transcription factors: DeltaEF1 family members bind with two hands to two target sites
45. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction
46. Impairment of T cell development in deltaEF1 mutant mice
47. DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
48. The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation
49. Independent repressor domains in ZEB regulate muscle and T-cell differentiation
50. c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB
51. Two mechanisms in the action of repressor deltaEF1: Binding site competition with an activator and active repression
52. Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6
53. Cloning and characterization of mCtBP2, a corepressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
54. ZEB represses transcription through interaction with the corepressor CtBP
55. Evidence for a function of CtBP in epithelial gene regulation and anoikis
56. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1
57. XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development
58. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
59. Neural induction
60. XSIP1, a member of two-handed zinc finger proteins, induced anterior neural markers in Xenopus laevis animal cap
61. Region-specific activation of the Xenopus brachyury promoter involves active repression in ectoderm and endoderm: A study using transgenic frog embryos
62. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
63. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
64. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
65. Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
66. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
67. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination