Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders

Cancer Research

Volumn 57, Issue 4, 1997, Pages 564-569

  Peeters, Pieter ^a   Wlodarska, Iwona ^a   Baens, Mathijs ^a   Criel, Arnold ^b   Selleslag, Dominique ^b   Hagemeijer, Anne ^a   Van den Berghe, Herman ^a   Marynen, Peter ^a,c  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b General Hospital St Jan   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; ETOPOSIDE; IDARUBICIN;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CHROMOSOME 12P; CHROMOSOME 3Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 3; FEMALE; GENE FUSION; GENE LOCATION; HUMAN; KARYOTYPING; MALE; MYELOPROLIFERATIVE DISORDER; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AMINO ACID SEQUENCE; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 3; DNA-BINDING PROTEINS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MYELOID, CHRONIC; MALE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0031053092     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Golub, T. R., Barker, G. F., Lovett, M., and Gilliland, D. G. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77: 307-316, 1994.
2. Buys, A., Sherr, S., van Baal, S., van Bezouw, S., van der Plas, D., Geurts van Kessel, A., Riegman, P., Lekanne Deprez, R., Zwarthoff, E., Hagemeijer, A., and Grosveld, G. Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of 68 the ETS-Iike TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene, 10: 1511-1519, 1995.
3. Papadopoulos, P., Ridge, S. A., Boucher, C. A., Stocking, C., and Wiedemann, L. M. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res., 55: 34-38, 1995.
4. Golub, T. R., Barker, G. F., Bohlander, S. K., Hiebert, S. W., Ward, D. C., BrayWard, P., Morgan, E., Raimondi, S. C., Rowley, J. D., and Gilliland, D. G. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA, 92: 4917-4921, 1995.
5. Romana, S. P., Mauchauffé, M., Le Coniat, M., Chumakov, I., Le Paslier, D., Berger, R., and Bernard, O. A. The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood, 85: 3662-3670, 1995.
6. Morishita, K., Parker, D. S., Mucenski, M. L., Jenkins, N. A., Copeland, N. G., and Ihile, J. N. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell, 54: 831-840, 1988.
7. Morishita, K., Parganas, E., Willman, C. L., Whittaker, M. H., Drabkin, H., Oval, J., Taetle, R., Valentine, M. B., and Ihle, J. N. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26. Proc. Natl. Acad. Sci. USA, 89: 3937-3941, 1992.
8. Mitani, K., Ogawa, S., Tanaka, T., Miyoshi, H., Kurokawa, M., Mano, H., Yazaki, Y., Ohki, M., and Hirai, H. Generation of the AML1-EVI1 fusion gene in the t(3;21)(q26; q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J., 13: 504-510, 1994.
9. Nucifora, G., Begy, C. R., Kobayashi, H., Roulston, D., Claxton, D., Pedersen- Bjergaard, J., Parganas, E., Ihle, J. N., and Rowley, J. D. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc. Natl. Acad. Sci. USA, 91: 4004-4008, 1994.
10. Fears, S., Mathieu, C., Zeleznik-Le, N., Huang, S., Rowley, J. D., and Nucifora, G. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. Proc. Natl. Acad. Sci. USA, 93: 1642-1647, 1996.
11. Raynaud, S. D., Baens, M., Grosgeorge, J., Rodgers, K., Reid, C. D. L., Dainton, M., Fuzibet, J. G., Gratecos, N., Taillan, B., Ayraud, N., and Marynen, P. Fluorescence in situ hybridization analysis of t(3;12)(q26;p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. Blood, 88: 682-689, 1996.
12. Dierlamm, J., Wlodarska, I., Michaux, L., La Starza, R., Zeller, W., Mecucci, C., and Van Den Berghe, H. Successful use of the same slide for consecutive fluorescence in situ hybridization experiments. Genes Chromosomes & Cancer, 16: 261-264, 1996.
13. Baens, M., Peeters, P., Guo, C., Aerssens, J., and Marynen, P. Genomic organization of TEL: the human ETS-variant gene 6. Genome Res., 6: 404-413, 1996.
14. Baldini A., Rocchi M., Archidiacono N., Miller, O. J., and Miller, D. A. A human α satellite DNA subset specific for chromosome 12. Am. J. Hum. Genet., 46: 784-788, 1990.
15. Sambrook, J., Fritsh, E., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
16. Altschul, S. F., Miller, W. W., Myers, E. W., and Lipman, D. J. Basic local alignment search tool. J. Mol. Biol., 215: 403-410, 1990.
17. Morishita, K., Parganas, E., Parham, D. M., Matsugi, T., and Ihle, J. N. The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes. Oncogene, 5: 1419-1423, 1990.
18. Tanaka, T., Mitani, K., Kurokawa, M., Ogawa, S., Tanaka, K., Nishida, J., Yazaki, Y., Shibata, Y., and Hirai, H. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in the t(3;21) leukemias. Mol. Cell. Biol., 15: 2383- 2392, 1995.
19. Morishita, K., Parganas, E., Matsugi, T., and Ihle, J. N. Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol. Cell. Biol., 12: 183-189, 1992.
20. Raynaud, S., Cavé, H., Baens, M., Bastard, C., Cacheux, V., Grosgeorge, J., Guidal- Giroux, C., Guo, C., Vilmer, E., Marynen, P., and Grandchamp, B. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood, 87: 2891-2899, 1996.
21. Chaffanet, M., Baens, M., Aerssens, J., Schoenmakers, E., Cassiman, J-J., and Marynen, P. Mapping of an ordered set of 14 cosmids to human chromosome 12p by two-color in situ hybridization. Cytogenet. Cell Genet., 69: 27-32, 1995.