Spemann organizer activity of Smad10

Development

Volumn 126, Issue 1, 1999, Pages 137-146

  LeSueur, James A ^a   Graff, Jonathan M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Neural induction; Signal transduction; Smads; Spemann organizer; Transforming growth factor superfamily; Xenopus laevis

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

ARTICLE; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE ISOLATION; MOLECULAR CLONING; NERVOUS TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE INDUCTION; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CLONING, MOLECULAR; EMBRYO, NONMAMMALIAN; EMBRYONIC INDUCTION; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESODERM; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NERVOUS SYSTEM; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD PROTEINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

XENOPUS LAEVIS;

EID: 0032960352     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Allen, T. (1992). Hematoxylin and Eosin. In Laboratory Methods in Histotechnology (ed. E. B. Prophet, B. Mills, J. B. Arrington, and L. H. Sobin), pp. 53-58. Washington, DC: American Registry of Pathology.
2. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E. M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
3. Bradley, L., Snape, A., Bhatt, S. and Wilkinson, D. (1993). The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest. Mech. Dev. 40, 73-84.
4. Candia, A. F., Watabe, T., Hawley, S. H. B., Onichtchouk, D., Zhng, Y., Derynck, R., Niehrs, C. and Cho, K. W. Y. (1997). Cellular interpretation ot multiple TGF-β signals: intracellular antagonism between activin/BVgl and BMP-2/4 signaling mediated by Smads. Development 124, 4467-4480.
5. Carnac, G., Kodjahachian, L., Gurdon and Lemaire, P. (1996). The homeobox gene Siamois is a target of the Wnt dorsalization pathway and trigger organizer activity in the absence of mesoderm. Development 122, 3055-3056.
6. Cho, K., Blumberg, B., Steinbeisser, H. and De Robertis, E. (1991). Molecular nature of Spemann's organizer: the role of Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.
7. Christian, J. L., McMahon, J. A., McMahon, A. P. and Moon, R. T. (1991). Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm inducing factors may play a role in ventral mesodermal patterning during embryogenesis. Development 111, 1045-1056.
8. Cox, W. and Hemmati-Brivanlou, A. (1995). Caudalization of neural fate by tissue recombination and bFGF Development 121, 4349-4358.
9. Darras, S., Marikawa, Y., Elinson, R., Lemaire, P. (1997). Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organizer. Development 124, 4275-4286.
10. Derynck, R. and Zhang, Y. (1996). Intracellular signaling: The Mad way to do it. Current Biology 6, 1226-1229.
11. Eppert, K., Scherer, S., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L. C., Bapat, B., Gallinger, S., Andrulis, I., Thomsen, G., Wrana, J. and Attisano, L. (1996). MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 88, 543-552.
12. Gawantka, V., Delius, H., Hirschfeld, K., Blumenstock, C. and Niehrs, C. (1995). Antagonizing the Spemann organizer: role of the homeobox gene Xvent. EMBO J. 14, 6268-6279.
13. Graff, J., Thies, R., Song, J., Celeste, A. and Melton, D. (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.
14. Graff, J., Bansal, A. and Melton, D. (1996). Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85, 479-487.
15. Graff, J. (1997). Embryonic patterning: To BMP or not to BMP that is the question. Cell 89, 171-174.
16. Hamburger, V. (1988). The Heritage of Experimental Embryology: Hans Spemann and the Organizer. New York: Oxford University Press.
17. Hansen, C., Marion, C., Steele, K., George, S. and Smith, W. (1997) Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3. Development 124, 483-492.
18. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B., Richardson, M., Topper, J., Gimbrone, M., Wrana, J. and Falb, D. (1997). The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89, 1165-1173.
19. Heldin, C. H., Miyazano, K. and ten Dijke. P. (1997). TGF-β signalling from cell membrane to nucleus through SMAD proteins, Nature 390, 465-471.
20. Hemmati-Brivanlou, A., Frank, D., Bolce, M. K., Brown, R. D., Sive, H. L. and Harland, R. M. (1990). Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization. Development 110, 325-330.
21. Hemmati-Brivanlou, A., de la Torre, J., Holt, C. and Harland, R. (1991). Cephalic expression and molecular characterization of Xenopus En-2. Development 111, 715-724.
22. Hemmati-Brivanlou, A. and Melton, D. A. (1992). A truncated activin receptor dominantly inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 359, 609-614.
23. Hemmati-Brivanlou, A. and Melton, D. (1994) Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell 77, 273-281.
24. Hemmati-Brivanlou, A., Kelly, O. and Melton, D. (1994) Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77, 283-295.
25. Hemmati-Brivanlou, A. and Melton, D. (1997). Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell 88, 13-17.
26. Hoodless, P., Haerry, T., Abdollah, S., Stapleton, M., O'Conner, M., Attisano, A. and Wrana, J. (1996). MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85, 489-500.
27. Hsu, D., Economides, A., Wang, X., Eimon, P. and Harland, R. M. (1998). The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Molecular Cell 1, 673-683.
28. Imamura, I., Takase, M., Nishihara, A., Oeda, E., Hanai. J., Kawabata, M. and Miyazono, K. (1997). Smad6 inhibits signaling by the TGFβ superfamily. Nature 389, 622-626.
29. Kintner, C. and Melton, D. (1987). Expression of Xenopus, N-CAM RNA in ectoderm is an early response to neural induction. Development 99, 311-325.
30. Knecht, A., Good, P., David, I. and Harland, R. (1995). Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm. Development 121, 1927-1936.
31. Kretzschmar, M., Liu, F., Hata, A., Doody, J. and Massague, J. (1997). The TGFβ family mediator Smadl is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984-995.
32. Krieg, P. and Melton, D. (1987). In vitro RNA synthesis with SP6 RNA polymerase. Methods in Enzymology 155, 397-415.
33. Krieg, P. A., Varnum, S., Wormington, M. and Melton, D. A. (1989). The mRNA encoding elongation factor 1α (EF-1α) is a major transcript at the mid blastula transition in Xenopus. Dev. Biol. 133, 93-100.
34. Lagna, G., Hata, A., Hemmati-Brivanlou, A. and Massague, J. (1996). Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways. Nature 383, 832-836.
35. Lamb, T., Knecht, A., Smith, W., Stachel, S., Economides, A., Stahl, N., Yancopolus, G. and Harland, R. (1993). Neural induction by the secreted polypeptide noggin. Science 262, 713-718.
36. Lamb, T. and Harland, R. (1995). FGF is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development 121, 3627-3636.
37. Lemaire, P. and Gurdon, J. B. (1994). A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos. Development. 120, 1191-1199.
38. Liu, F., Hata, A., Baker, J., Doody, J., Caracamo, J., Harland, R. and Massague, J. (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623.
39. Liu, F., Pouponnot, C. and Massague, J. (1997). Dual roles of Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
40. Macias-Silva, M., Abdollah, S., Hoodless, P., Pirone, R., Attisano, L. and Wrana, J. (1996). MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224.
41. Massague, J. (1996). TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85, 947-950.
42. McGrew L. L., Lai, C. J., Moon, R. T. (1995). Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin. Dev. Biol. 172, 337-342.
43. Mohun, T. J., Brennan, S., Dathan, N., Fairman, S. and Gurdon, J. B. (1984). Cell type specific activation of actin genes in the early amphibian embryo. Nature 311, 716-721.
44. Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N., Heldin, C. and Ten Dijke, P. (1997). Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signaling. Nature 389, 631-635.
45. Nieuwkoop, P. D. and Faber, J. (1967). Normal Table of Xenopus laevis (Daudin). Amsterdam: North Holland Publishing Company.
46. Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C. and Niehrs, C. (1996). The Xvent-2 homeobox gene is pan of the BMP-4 signaling pathway controlling dorsoventral patterning of the Xenopus mesoderm. Development 122, 3045-3053.
47. Piccolo, S., Sasai, Y., Lu, B. and DeRobertis, E. (1996). Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86, 589-598.
48. Re'em-Kalma, Y., Lamb, T. and Frank, D. (1995). Competition between noggin and BMP4 activities may regulate dorsalization during Xenopus development. Proc. Natl Acad. Sci. USA 92, 12141-12145.
49. Rebagliati, M. R., Weeks, D. L., Harvey, R. P. and Melton, D. A. (1985). Identification and cloning of localized maternal mRNAs from Xenopus eggs. Cell 42, 769-777.
50. Ryan, K., Garrett, N., Mitchell, A. and Gurdon, J. (1996). Eosmesodermin. a key early gene in Xenopus mesoderm differentiation. Cell 87, 989-1000.
51. Sasai, Y., Lu, B. Steinbeisser, H., Geissert, D., Gont, L. and De Robertis, E. M. (1994). Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79, 779-790.
52. Sasai, Y., Lu, B. Steinbeisser, H. and De Robertis, E. M. (1995). Regulation of neural induction by the Chd and BMP-4 antagonistic patterning signals in Xenopus. Nature 376, 333-336.
53. Sasai, Y., Lu, B., Piccolo, S. and De Robertis, E. (1996). Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J. 15, 4547-4555.
54. Sasai, Y. and De Robertis, E. (1997). Ectodermal patterning in vertebrate embryos. Dev. Biol. 182, 5-20.
55. Slack, J. M. W. (1994). Inducing factors in Xenopus early embryos. Current Biology 4, 116-126.
56. Smith, J. C. (1989). Mesoderm induction and mesoderm-inducing factors in early amphibian development. Development 105, 665-667.
57. Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D. and Herrmann, B. G. (1991). Expression of a Xenopus homolog of Brachyury (T) in an immediate-early response to mesoderm induction. Cell 67, 79-87.
58. Smith, W. C. and Harland, R. M. (1991). Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell 67, 753-765.
59. Smith, W. and Harland, R. (1992). Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70, 829-840.
60. Smith, W., Knecht, A., Wu, M. and Harland, R. M. (1993). Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature 361, 547-549.
61. Smith, W. C., McKendry, R. M., Ribisi, S. and Harland, R. M. (1995). A nodal-related gene defines a physical and functional domain within the Spemann Organizer. Cell 82, 37-46.
62. Spemann, H. (1938). Embryonic Development and Induction. New Haven, CT: Yale University Press.
63. Wilson, P. and Melton, D. (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Current Biol. 4, 676-686.
64. Wrana, J. and Attisano, L. (1996). MAD-relaled proteins in TGFβ signaling. Trends in Genetics 12, 493-496.
65. Wright, C, Morita, E., Wilkin, D. and DeRobertis, E. (1990). The Xenopus XLHbox6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. Development 109, 225-234.
66. Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T., Andries, M., Smith, J., Heldin, C. and Miyazono, K. (1995). Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J. Cell Biol. 130, 217-226.
67. Zhang, Y., Feng, X., Wu, R. and Derynck, R. (1996). Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172.
68. Zimmerman, L., De Jesus-Escobar, J. and Harland, R. (1996). The Spemann organizer signal noggin binds and inactivates BMP4. Cell 86, 599-606.