TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization

Journal of Immunology

Volumn 162, Issue 3, 1999, Pages 1367-1375

  Sedwick, Caitlin E ^a   Morgan, Margaret M ^a   Jusino, Lismaida ^a   Cannon, Judy L ^a   Miller, Jim ^a   Burkhardt, Janis K ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHOSPHATIDYLINOSITOL 3 KINASE; T LYMPHOCYTE RECEPTOR; WORTMANNIN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSKELETON; MICROTUBULE; MOUSE; NONHUMAN; ORGANIZATION; POLARIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANDROSTADIENES; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD28; ANTIGENS, CD80; CELL LINE; CELL MEMBRANE; CELL POLARITY; CYTOSKELETON; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICROTUBULES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TALIN; TH1 CELLS; TRANSFECTION;

EID: 0033083257     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Lub, M., Y. van Kooyk, and C. Figdor. 1995. Ins and outs of LFA-1. Immunol. Today 16:479.
2. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259.
3. Chambers, C. A., and J. P. Allison. 1997. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:396.
4. Lollo, B. A., K. W. Chan, E. M. Hanson, V. T. Moy, and A. A. Brian. 1993. Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells. J. Biol. Chem. 268:21693.
5. Kucik, D. F., M. L. Dustin, J. M. Miller, and E. J. Brown. 1996. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J. Clin. Invest. 97:2139.
6. Dustin, M. L., S. K. Bromley, Z. Kan, D. A. Peterson, and E. R. Unanue. 1997. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl. Acad. Sci. USA 94:3909
7. Lub, M., Y. van Kooyk, S. J. van Vliet, and C. G. Figdor. 1997. Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol. Biol. Cell 8:341.
8. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T cell receptors by a few peptide-MHC complexes. Nature 375:148.
9. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. J. Exp. Med. 181:577.
10. Yannelli, J. R., J. A. Sullivan, G. L. Mandell, and V. H. Engelhard. 1986. Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography. J. Immunol. 136: 377.
11. Negulescu, P. A., T. B. Krasieva, A. Khan, H. Kerschbaum, and M. Cahalan. 1996. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4:421.
12. Ratner, S., W. S. Sherrod, and D. Lichlyter. 1997. Microtubule retraction into the uropod and its role in T cell polarization and motility. J. Immunol. 159:1063.
13. Kupfer, A., S. Singer, C. Janeway, Jr., and S. Swain. 1987. Cocluslering of CD4 (L3T4) molecule with the T cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc. Natl. Acad. Sci. USA 84: 5888.
14. Kupfer, A., S. L. Swain, and S. J. Singer. 1987. The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells. J. Exp. Med. 165:1565.
15. Kupfer, A., and S. J. Singer. 1989. The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J. Exp. Med. 170:1697.
16. Monks, C. R., H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer. 1997. Selective modulation of protein kinase C-θ during T-cell activation. Nature 385:83.
17. Ryser, J. E., E. Rungger-Brandle, C. Chaponnier, G. Gabbiani, and P. Vassalli. 1982. The area of attachment of cytotoxic T lymphocytes to their target cells shows high motility and polarization of actin, but not myosin. J. Immunol. 128: 1159.
18. Slowers, L., D. Yelon, L. J. Berg, and J. Chant. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92:5027.
19. Geiger, B., D. Rosen, and G. Berke. 1982. Spatial relationships of microtubule-organizing centers and the contact area of cylotoxic T lymphocytes and target cells. J. Cell Biol. 95:137.
20. Kupfer, A., T. R. Mosmann, and H. Kupfer. 1991. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl. Acad. Sci. USA 88:775.
21. Kupfer, A., G. Dennert, and S. J. Singer. 1985. The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. J. Mol. Cell. Immunol. 2:37.
22. Podack, E. R., and A. Kupfer. 1991. T-cell effector functions: mechanisms for delivery of cytotoxicity and help. Annu. Rev. Cell Biol. 7:479.
23. Rubbi, C. P., and D. Rickwood. 1996. A simple immunomagnetic bead-based technique for the detection of surface molecules capable of inducing T cell functional polarization. J. Immunol. Methods 192:157.
24. Lowin-Kropf, B., V. S. Shapiro, and A. Weiss. 1998. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140:861.
25. Nobes, C. D., P. Hawkins, L. Stephens, and A. Hall. 1995. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108: 225.
26. + T cells. J. Immunol. 158: 4688.
27. Zuckerman, L. A., A. J. Sant, and J. Miller. 1995. Identification of a unique costimulatory activity for murine T helper 1 T cell clones. J. Immunol. 154:4503.
28. Zuckerman, L. A., L. Pullen, and J. Miller. 1998. Functional consequences of costimulation by ICAM-1 on IL-2 gene expression and T cell activation. J. Immunol. 160:3259.
29. Miller, J., and R. Germain. 1986. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. J. Exp. Med. 164:1478.
30. Kuhlman, P., V. T. Moy, B. A. Lollo, and A. A. Brian. 1991. The accessory function of murine Intercellular adhesion molecule-1 in T lymphocyte activation: contributions of adhesion and co-activation. J. Immunol. 146:1773.
31. Saito, T., A. Weiss, J. Miller, M. A. Norcross, and R. N. Germain. 1987. Specific antigen-1a activation of transfected human T cells expressing murine Ti αβ-human T3 receptor complexes. Nature 325:125.
32. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
33. Ozato, K., T. H. Hansen, and D. H. Sachs. 1980. Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J. Immunol. 125: 2473.
34. Schwartz, R. H., B. S. Fox, E. Fraga, C. Chen, and B. Singh. 1985. The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T celt clones and assessment of the contribution of each residue beyond this size to antigenic potency. J. Immunol. 135:2598.
35. Seung, L. P., S. K. Seung, and H. Schreiber. 1995. Antigenic cancer cells that escape immune destruction are stimulated by host cells. Cancer Res. 55:5094.
36. Linsley, P., E. Clark, and J. Ledbetter. 1990. T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. USA 87:5031.
37. 1-integrin adhesion involves phosphalidylinositol 3-kinase. J. Immunol. 156:883.
38. Miyamoto, S., S. K. Akiyama, and K. M. Yamada. 1995. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267:883.
39. Miyamoto, S., H. Teramoto, O. A. Coso, J. S. Gutkind, P. D. Burbelo, S. K. Akiyama, and K. M. Yamada. 1995. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131:791.
40. 1 cytoplasmic domain mutants. Mol. Biol. Cell 6:151.
41. 2-integrin subunit CD18. J. Immunol. 154:3461.
42. Moulder, G. L., M. M. Huang, R. H. Waterston, and R. J. Barstead, 1996. Talin requires beta]-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans. Mol. Biol. Cell 7:1181.
43. Pfaff, M., S. Liu, D. J. Erle, and M. H. Ginsberg. 1998. Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins. J. Biol. Chem. 273:6104.
44. Dustin, M. L., and T. A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619.
45. Ward, S. G., S. C. Ley, C. MacPhee, and D. A. Cantrell. 1992. Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens. Eur. J. Immunol. 22:45.
46. Ueda, Y., B. L. Levine, M. L. Huang, G. J. Freeman, L. M. Nadler, C. H. June, and S. G. Ward. 1995. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int. Immunol. 7:957.
47. Ward, S. G., A. Wilson, L. Turner, J. Westwick, and D. M. Sansom. 1995. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol. 25:526.
48. Ward, S. G., C. H. June, and D. Olive. 1996. PI 3-kinase: a pivotal pathway in T-cell activation? Immunol. Today 17:187.
49. Olefsky, J. M. 1996. Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. Endocrinology 137:5045.
50. Araki, N., M. T. Johnson, and J. A. Swanson. 1996. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135:1249.
51. Kobayashi, M., S. Nagata, Y. Kita, N. Nakatsu, S. Ihara, K. Kaibuchi, S. Kuroda, M. Ui, H. Iba, H. Konishi, U. Kikkawa, I. Saitoh, and Y. Fukui. 1997. Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells: use of Cre/loxP recombination system. J. Biol. Chem. 272: 16089.
52. Lakkakorpi, P. T., G. Wesolowski, Z. Zimolo, G. A. Rodan, and S. B. Rodan. 1997. Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading. Exp. Cell Res. 237: 296.
53. Ojaniemi, M., and K. Vuori. 1997. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas: involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. J. Biol. Chem. 272:25993.
54. Lange, K., U. Brandt, J. Gartzke, and J. Bergmann. 1998. Action of insulin on the surface morphology of hepatocytes: role of phosphatidylinositol 3-kinase in insulin-induced shape change of microvilli. Exp. Cell Res. 239:139.
55. Ganpule, G., R. Knorr, J. M. Miller, C. P. Carron, and M. L. Dustin. 1997. Low affinity of cell surface lymphocyte function-associated antigen-1 (LFA-1) generates selectivity for cell-cell interactions. J. Immunol. 159:2685.
56. Truitt, K. E., J. Shi, S. Gibson, L. G. Segal, G. B. Mills, and J. B. Imboden. 1995. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J. Immunol. 155:4702.
57. Lu, Y., R. Rodriguez, J. Bjorndahl, C. A. Phillips, and J. M. Trevillyan. 1996. CD28-dependenl killing by human YT cells requires phosphatidylinositol 3-kinase activation. Eur. J. Immunol. 26:1278.
58. Ni, H. T., M. J. Deeths, and M. F. Mescher. 1996. Phosphalidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells. J. Immunol. 157:2243.
59. Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and D. Brock. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosinc triphosphalases by Vav. Science 279:558.