How WASP regulates actin polymerization

Journal of Cell Biology

Volumn 150, Issue 6, 2000, Pages

  Zigmond, S H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL PROTEIN; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN POLYMERIZATION; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; NOTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION;

EID: 0034683577     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.6.f117     Document Type: Note

References (20)

1. Identification of Itk/Tsk src homology 3 domain ligands
2. Grb2 links signalling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin-related proteins (Arp2/3) complex
3. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation
4. Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability
5. Activation of the Cdc42 effector N-WASP by the Shigella flexneria IcsA protein promotes actin nucleation by Arp2/3complex and bacterial actin-based motility
6. Identification of regions of the Wiskott-Aldrich Syndrome protein responsible for association with selected Src homology 3 domains
7. Regulation of actin polymerization by Arp2/3 complex and the WASp/Scar proteins
8. Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
9. Wiskott-Aldrich Syndrome protein induces actin clustering without direct binding to Cdc42
10. Autoinhibition and activation mechanisms of the Wiskott-Aldrich Syndrome protein
11. Scar, a WASp-related protein, activates dendritic nucleation of actin filaments by the Arp2/3 complex
12. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
13. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
14. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
15. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich Syndrome protein
16. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells
17. Mechanism of N-WASP activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate
18. Wiskott-Aldrich Syndrome protein is associated with the adaptor protein Grb2 and the epidermal growth factor receptor in living cells
19. Profilin enhances Cdc42-induced nucleation of actin polymerization
20. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex