Lifelong angiotensin-converting enzyme inhibition, pressure natriuresis, and renin-angiotensin system gene expression in transgenic (mRen-2)27 rats

Journal of the American Society of Nephrology

Volumn 7, Issue 10, 1996, Pages 2119-2129

  Lippoldt, Andrea ^a   Gross, Volkmar ^a   Bohlender, Jürgen ^a   Ganten, Ursula ^a   Luft, Friedrich C ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

Author keywords

Angiotensin converting enzyme; Experimental hypertension; Gene expression; Renal function curves; Transgenic rats

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; LISINOPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HISTOLOGY; KIDNEY DENERVATION; KIDNEY FUNCTION; NATRIURESIS; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENE;

EID: 0030377677     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Mullins JJ, Peter J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature (Lond) 1990;344:541-544.
2. Paul M, Wagner J, Hoffmann S, Urata H, Ganten D: Transgenic rats: A new experimental model for the study of candidate genes in hypertension. Annu Rev Physiol 1994;50:811-829.
3. Bachmann S, Peters J, Engler E, Ganten D, Mullins J: Transgenic rats carrying the mouse renin gene. Morphological characterization of a low-renin hypertension model. Kidney Int 1992;41:24-36.
4. Lee MA, Böhm M, Kim S, et al.: Differential gene expression of renin and angiotensinogen in the TGR(mREN2)27 transgenic rat. Hypertension (Dallas) 1995;25:570-580.
5. Böhm M, Lee MA, Kreutz R, et al.: Angiotensin II receptor blockade in TGR(mRen2)27: Effects of renin-angiotensin-system gene expression and cardiovascular functions. J Hypertens 1995;13:891-899.
6. Gross V, Roman RJ, Cowley AW Jr: Abnormal pressure-natriuresis in transgenic renin gene rats. J Hypertens 1994;12:1029-1034.
7. Gross V, Lippoldt A, Schneider M, Luft FC: Effect of captopril and AT1 receptor blockade on pressure natriuresis and diuresis in (mRen2)27 transgenic rats. Hypertension (Dallas) 1995;26:471-479.
8. Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR: Molecular cloning of rat renin cDNA and its gene. Proc Natl Acad Sci USA 1987;84:5605-5609.
9. Mullins JJ, Sigmund CD, Kane-Haas C, Gross KW: Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. EMBO (Eur Mol Biol Organ) J 1989;8:4065-4072.
10. Okhubo H, Kageyama R, Ujihara M, et al.: Cloning and sequence analysis of cDNA for rat angiotensinogen. Proc Natl Acad Sci USA 1983;80:2196-2200.
11. Kimura S, Mullins JJ, Bunnemann B, et al.: High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO (Eur Mol Biol Organ) J 1992;11: 821-827.
12. Bunnemann B, Fuxe K, Bjelke B, Ganten D: The semiquantitative distribution and cellular localization of angiotensinogen mRNA in the rat brain. J Chem Neuroanat 1992;5:245-262.
13. Auffray C, Rougeon F: Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980;107:303-314.
14. Djavidani B, Sander M, Kreutz R, et al.: Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27. J Hypertens 1995;13:637-645.
15. Zoli M, Zini I, Agnati LF, et al.: Aspects of neural plasticity in the central nervous system. I. Computer-assisted image analysis methods. Neurochem Int 1990; 16:383-418.
16. Führ J, Kaczmarczyk J, Kröttgen CD: Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearanceuntersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wochenschr 1955;33: 729-730.
17. Führ J: Clearance-Methoden zur Nierenfunktionsprüfung unter besonderer Berücksichtigung des Total-Clearance-Verfahrens. Ärzt Labor 1958;4:79-95.
18. Tokita Y, Franco-Saenz R, Mulrow PJ: Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR(mRen-2)27 by ACE inhibition. Am J Hypertens 1995;8:1031-1039.
19. Véniant M, Whitworth CE, Ménard J, et al.: Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats. Am J Hypertens 1995;8:1167-1176.
20. Roman RJ: Altered pressure-natriuresis relationship in young spontaneously hypertensive rats. Hypertension (Dallas) 1987;9[Suppl 3]:III/130-III/136.
21. Roman RJ: Abnormal renal hemodynamics and pressure-natriuresis relationship in Dahl salt-sensitive rats. Am J Physiol 1986;251:F57-F65.
22. Tokita Y, Franco-Saenz R, Reimann EM, Mulrow PJ: Hypertension in the transgenic rat TGR(mRen-2)27 may be due to enhanced kinetics of the reaction between mouse renin and rat angiotensinogen. Hypertension (Dallas) 1994;23:422-427.
23. Hall JE, Mizelle HL, Hildebrandt DA, Brands MW: Abnormal pressure natriuresis: a cause or a consequence of hypertension? Hypertension (Dallas) 1990;15:547-559.
24. Roman RJ, Cowley AW Jr: Characterization of a new model for the study of pressure-natriuresis in the rat. Am J Physiol 1985;248:F190-F198.
25. Hall JE, Granger JP, Hester RL, et al.: Mechanisms of escape from sodium retention during angiotensin II hypertension. Am J Physiol 1984;246:F627-F634.
26. Hall JE: Control of sodium excretion by angiotensin II: Intrarenal mechanisms and blood pressure regulation. Am J Physiol 1986;250:R960-R972.
27. Navar LG, Lewis L, Hymel A, Braam B, Mitchell KD: Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 1994;5:1153-1158.