The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain

Journal of Neurochemistry

Volumn 68, Issue 6, 1997, Pages 2530-2537

  Moeller, Ingrid ^a   Lew, Rebecca A ^b   Mendelsohn, Frederick A O ^a   Smith, A Ian ^b   Brennan, Michelle E ^a   Tetaz, Timothy J ^b   Chai, Siew Yeen ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Angiotensin (3 8); Hemoglobin; Hemorphins; Renin angiotensin system

Indexed keywords

ANGIOTENSIN II [3-8]; GLOBIN; HORMONE RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RECEPTOR AFFINITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHEEP;

EID: 0030921136     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68062530.x     Document Type: Article

References (35)

1. Allen A. M., Dampney R. A. L., and Mendelsohn F. A. O. (1988) Angiotensin receptor binding and pressor effects in cat subretrofacial nucleus. Am. J. Physiol. 255, H1011-H1017.
2. Allen A. M., Paxinos G., Song K. F., and Mendelsohn F. A. O. (1992) Localization of angiotensin receptor binding sites in the rat brain, in Handbook of Chemical Neuroanatomy, Vol. 11: Neuropeptide Receptors in the CNS (Bjorklund A., Hökfelt T., and Kuhar M. J., eds), pp. 1-37. Elsevier Science Publishers, New York.
3. Barkhudaryan N., Oberthuer W., Lottspeich F., and Galoyan A. (1992) Structure of hypothalamic coronaro-constrictory peptide factors. Neurochem. Res. 17, 1217-1221.
4. Barkhudaryan N., Kellermann J., Galoyan A., and Lottspeich F. (1993) High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the β-chain of hemoglobin. FEBS Lett. 329, 215-218.
5. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
6. Brantl V., Gramsch C., Lottspeich F., Mertz R., Jaeger K.-H., and Herz A. (1986) Novel opioid peptides derived from hemoglobin: hemorphins. Eur. J. Pharmacol. 125, 309-310.
7. Braszko J. J., Kupryszewski G., Witczuk B., and Wisniewski K. (1988) Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats. Neuroscience 27, 777-783.
8. Bunnemann B., Fuxe K., Bjelke B., and Ganten D. (1991) The brain renin-angiotensin system and its possible involvement in volume transmission, in Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission (Fuxe K. and Agnati L. F., eds). pp. 131-158. Raven Press, New York.
9. Bunnemann B., Fuxe K., Metzger R., Bjelke B., and Ganten D. (1992) The semi-quantitative distribution and cellular localization of angiotensinogen mRNA in the rat brain. J. Chem. Neuroanat. 5, 245-262.
10. Chang R. C. C., Huang W.-Y., Redding T. W., Arimura A., Coy D. H., and Schally A. V. (1980) Isolation and structure of several peptides from porcine hypothalami. Biochim. Biophys. Acta 625, 266-273.
11. de Gasparo M., Husain A., Alexander W., Catt K. J., Chiu A. T., Drew M., Goodfriend T., Harding J. W., Inagami T., and Timmermans P. B. M. W. M. (1995) Proposed update of angiotensin receptor nomenclature. Hypertension 25, 924-927.
12. Glamsta E.-L., Markland A., Hellman U., Wernstedt C., Terenius L., and Nyberg F. (1991) Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland. Regul. Pept. 34, 169-179.
13. Glamsta E.-L., Meyerson B., Silberring J., Terenius L., and Nyberg F. (1992) Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings. Biochem. Biophys. Res. Commun. 184, 1060-1066.
14. Hall K. L., Hanesworth J. M., Ball A. E., Felgenhauer G. P., Hosick H. L., and Harding J. W. (1993) Identification and characterization of a novel angiotensin binding site in cultured vascular smooth muscle cells that is specific for the hexapeptide (3-8) fragment of angiotensin II, angiotensin IV. Regul. Pept. 44, 225-232.
15. Hanesworth J. M., Sardinia M. F., Krebs L. T., Hall K. L., and Harding J.W. (1993) Elucidation of a specific binding site for angiotensin II (3-8), angiotensin IV, in mammalian heart membranes. J. Pharmacol. Exp. Ther. 266, 1036-1042.
16. Johnson A. K. and Gross P. M. (1993) Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 7, 678-686.
17. Lind R. W., Swanson L. W., and Ganten D. (1985) Organization of angiotensin II immunoreactive cells and fibres in the rat central nervous system. Neuroendocrinology 40, 2-24.
18. McKinley M. J., McAllen R. M., Mendelsohn F. A. O., Allen A. M., Chai S. Y., and Oldfield B. J. (1990) Circumventricular organs: neuroendocrine interfaces between the brain and the hemal milieu. Front. Neuroendocrinol. 11, 91-127.
19. Miller-Wing A. V., Hanesworth J. M., Sardinia M. F., Hall K. L., Wright J. W., Speth R. C., Grove K. L., and Harding J. W. (1993) Central angiotensin IV binding sites: distribution and specificity in guinea pig brain. J. Pharmacol. Exp. Ther. 266, 1718-1726.
20. Moeller I., Chai S. Y., Oldfield B. J., McKinley M. J., Casley D., and Mendelsohn F. A. O. (1995) Localization of angiotensin IV binding sites to motor and sensory neurons in the sheep spinal cord and hindbrain. Brain Res. 701, 301-306.
21. 4 receptors in the Macaca fascicularis brain. Brain Res. 712, 307-324.
22. Moeller I., Small D. H., Reed G., Harding J. W., Mendelsohn F. A. O., and Chai S. Y. (1996b) Angiotensin IV inhibits neurite outgrowth in cultured embryonic chicken sympathetic neurones. Brain Res. 725, 61-66.
23. Ohyagi Y., Yamada T., and Goto I. (1994) Hemoglobin as a novel protein developmentally regulated in neurons. Brain Res. 635, 323-327.
24. Piot J. M., Zhao Q., Guillochon D., Ricart G., and Thomas D. (1992) Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysate. Biochem. Biophys. Res. Commun. 189, 101-110.
25. Roberts K. A., Krebs L. T., Kramar E. A., Shaffer M. J., Harding J. W., and Wright J. W. (1995) Autoradiographic identification of brain angiotensin IV binding sites and differential c-Fos expression following intracerebroventricular injection of angiotensin II and IV in rats. Brain Res. 682, 13-21.
26. Sanderson K., Thornwall M., Nyberg G., Glamsta E.-L., and Nyberg F. (1994) Reversed-phase high-performance liquid chromatography for the determination of haemorphin-like immunoreactivity in human cerebrospinal fluid. J. Chromatogr. [A] 676, 155-160.
27. Sardinia M. F., Hanesworth J. M., Krebs L. T., and Harding J. W. (1993) AT4 receptor binding characteristics: D-amino acid- and glycine-substituted peptides. Peptides 14, 949-954.
28. Slemmon J. R., Hughes C. M., Campbell G. A., and Flood D. G. (1994) Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum. J. Neurosci. 14, 2225-2235.
29. Smith A. I. (1993) Peptide characterization and purification using high-performance liquid chromatography, in Methods in Neurosciences: Neuropeptide Analogs, Conjugates and Fragments (Conn P. M., ed), pp. 91-106. Academic Press, San Diego.
30. Stornetta R. L., Hawelu-Johnson C. L., Guyenet P. G., and Lynch K. R. (1988) Astrocytes synthesize angiotensinogen in brain. Science 242, 1444-1446.
31. Swanson G. N., Hanesworth J. M., Sardinia M. F., Coleman J. K. M., Wright J. W., Hall K. L., Miller-Wing A. V., Stobb J. W., Cook V. I., Harding E. C., and Harding J. W. (1992) Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul. Pept. 40, 409-419.
32. Thomas W. G. and Sernia C. (1988) Immunocytochemical localization of angiotensinogen in the rat brain. Neuroscience 25, 319-341.
33. Wang L., Eberhard M., and Erne P. (1995) Stimulation of DNA and RNA synthesis in cultured rabbit cardiac fibroblasts by angiotensin IV. Clin. Sci. 88, 557-562.
34. Wright J. W., Miller-Wing A. V., Shaffer M. J., Higginson C., Wright D. E., Hanesworth J. M., and Harding J. W. (1993) Angiotensin II (3-8) (Ang IV) hippocampal binding: potential role in the facilitation of memory. Brain Res. Brain Res. Bull. 32, 497-502.
35. Zhao Q., Sannier F., Garreau I., Guillochon D., and Piot J. M. (1994) Inhibition and inhibition kinetics of angiotensin converting enzyme activity by hemorphins, isolated from a peptic bovine hemoglobin hydrolysate. Biochem. Biophys. Res. Commun. 204, 216-223.