Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 527-535

  Masaki, Hiroya ^a   Kurihara, Tatsuya ^b   Yamaki, Akira ^b   Inomata, Norio ^b   Nozawa, Yoshihisa ^c   Mori, Yasukiyo ^a   Murasawa, Satoshi ^a   Kizima, Kazuhisa ^a   Maruyama, Katsuya ^a   Horiuchi, Masatsugu ^d   Dzau, Victor J ^d   Takahashi, Hakuo ^a   Iwasaka, Toshiji ^a   Inada, Mitsuo ^a   Matsubara, Hiroaki ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b SUNTORY LTD   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Angiotensin II; Angiotensin receptors; Inotropic action; K+ current; Transgenic mouse

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; MYOSIN HEAVY CHAIN;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARDIOVASCULAR DISEASE; CATECHOLAMINE RELEASE; CHRONOTROPISM; DRUG EFFECT; ENZYME ACTIVITY; ISOLATED HEART; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRESSOR RESPONSE; PRIORITY JOURNAL; PROMOTER REGION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TISSUE SPECIFICITY;

EID: 0032004934     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1885     Document Type: Article

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