Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 12, 1997, Pages 6391-6396

  Hein, Lutz ^a,d   Stevens, Mary E ^b   Barsh, Gregory S ^c   Pratt, Richard E ^a,e   Kobilka, Brian K ^a,c   Dzau, Victor J ^a,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPERPLASIA; DISEASE ASSOCIATION; GENE EXPRESSION; HEART BLOCK; HEART ELECTROPHYSIOLOGY; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART RHYTHM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; CARDIOMEGALY; ELECTROCARDIOGRAPHY; GENETICS; HEART; HEART RATE; HISTOLOGY; LIVER; LUNG; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REFERENCE VALUE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR; CAPTOPRIL; HYBRID PROTEIN; MYOSIN HEAVY CHAIN;

ANIMALS; BODY WEIGHT; CAPTOPRIL; CARDIOMEGALY; ELECTROCARDIOGRAPHY; HEART; HEART BLOCK; HEART RATE; LIVER; LUNG; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOSIN HEAVY CHAINS; ORGAN SIZE; POLYMERASE CHAIN REACTION; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; RECOMBINANT FUSION PROTEINS; REFERENCE VALUES;

EID: 0030610246     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.12.6391     Document Type: Article

References (49)

1. Baker, K. M., Booz, G. W. & Dostal, D. E. (1992) Annu. Rev. Physiol. 54, 227-241.
2. Lindpaintner, K. & Ganten, D. (1991) Circ. Res. 68, 905-921.
3. Baker, K. M., Chemin, M. I., Wixson, S. K. & Accto, J. F. (1990) Am. J. Physiol. 259, H324-H332.
4. Dzau, V. J. & Pratt, R. E. (1993) in The Renin-Angiotensin-System, ed. Robertson, J. I. S. & Nicholls, M. G. (Gower Medical Publishing, London), pp. 42.1-42.8.
5. Sadoshima, J., Xu, Y., Slayter, H. S. & Izumo, S. (1993) Cell 75, 977-984.
6. Sadoshima, J. & Izumo, S. (1993) Circ. Res. 73, 413-423.
7. Linz, W., Scholkens, B. A. & Ganten, D. (1989) Clin. Exp. Hypertens. [A] 11, 1325-1350.
8. Pfeffer, J. M., Pfeffer, M. A., Mirsky, I. & Braunwald, E. (1982) Proc. Natl. Acad. Sci. USA 79, 3310-3314.
9. Pfeffer, M. A., Lamas, G. A., Vaughan, D. E., Parisi, A. F. & Braunwald, E. (1988) N. Engl. J. Med. 319, 80-86.
10. Gulick, J., Subramaniam, A., Neumann, J. & Robbins, J. (1991) J. Biol. Chem. 266, 9180-9185.
11. Hogan, B., Costantini, F. & Lacy, E. (1986) Manipulating the Mouse Embryo. A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
12. Overbeek, P. A., Aguilar, C. E., Hanten, G., Schaffner, D. L., Patel, P., Lebovitz, R. M. & Lieberman, M. W. (1991) Transgenic Res. 1, 31-37.
13. Sasamura, H., Hein, L., Krieger, J. E., Pratt, R. E., Kobilka, B. K. & Dzau, V. J. (1992) Biochem. Biophys. Res. Commun. 185, 253-259.
14. Anversa, P., Capasso, J. M., Olivetti, G. & Sonnenblick, E. H. (1992) Acta Paediatr. Suppl. 383, 29-31.
15. De Groot, I. J. M., Lamers, W. H. & Moorman, A. F. M. (1988) Anat. Rec. 224, 365-373.
16. Dzau, V. J., Gibbons, G. H. & Pratt, R. E. (1991) Hypertension 18, II100-II105.
17. Gibbons, G. H., Pratt, R. E. & Dzau, V. J. (1992) J. Clin. Invest. 90, 456-461.
18. Nakajima, M., Hutchinson, H. G., Fujinaga, M., Hayashida, W., Morishita, R., Zhang, L., Horiuchi, M., Pratt, R. E. & Dzau, V. J. (1995) Proc. Natl. Acad. Sci. USA 92, 10663-10667.
19. Dostal, D. E. & Baker, K. M. (1992) Am. J. Hypertens. 5, 276-280.
20. Khairallah, P. A. & Kanabus, J. (1983) Perspect. Cardiovasc. Res. 8, 337-347.
21. Bruckschlegel, G., Holmer, S. R., Jandeleit, K., Grimm, D., Muders, F., Kromer, E. P., Riegger, G. A. & Schunkert, H. (1995) Hypertension 25, 250-259.
22. Iwai, N., Shimoike, H. & Kinoshita, M. (1995) Circulation 92, 2690-2696.
23. Zhang, X., Dostal, D. E., Reiss, K., Cheng, W., Kajstura, J., Li, P., Huang, H., Sonnenblick, E. H., Meggs, L. G. & Baker, K. M. (1995) Am. J. Physiol. 269, H1791-H1802.
24. Cook, J. L., Bhandaru, S., Giardina, J. F., Claycomb, W. C. & Re, R. N. (1995) Am. J. Physiol. 268, H1471-H1482.
25. Baker, K. M. & Aceto, J. F. (1990) Am. J. Physiol. 259, H610-H618.
26. Everett, A. D., Tufro, M. A., Fisher, A. & Gomez, R. A. (1994) Hypertension 23, 587-592.
27. Sharma, H. S., van Heugten, H., Goedbloed, M. A., Verdouw, P. D. & Lamers, J. M. (1994) Biochem. Biophys. Res. Commun. 205, 105-112.
28. Booz, G. W. & Baker, K. M. (1995) Cardiovasc. Res. 30, 537-543.
29. Lee, A. A., Dillmann, W. H., McCulloch, A. D. & Villarreal, F. J. (1995) J. Mol. Cell. Cardiol. 27, 2347-2357.
30. Ng, W. A., Grupp, I. L., Subramaniam, A. & Robbins, J. (1991) Circ. Res. 68, 1742-1750.
31. Subramaniam, A., Jones, W. K., Gulick, J., Wert, S., Neumann, J. & Robbins, J. (1991) J. Biol. Chem. 266, 24613-24620.
32. Subramaniam, A., Gulick, J., Neumann, J., Knotts, S. & Robbins, J. (1993) J. Biol. Chem. 268, 4331-4336.
33. Milano, C. A., Dolber, P. C., Rockman, H. A., Bond, R. A., Venable, M. E., Allen, L. F. & Lefkowitz, R. J. (1994) Proc. Natl. Acad. Sci. USA 91, 10109-10113.
34. Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A. & Lefkowitz, R. J. (1994) Science 264, 582-586.
35. Milano, C. A., Allen, L. F., Dolber, P. C., Johnson, T. D., Rockman, H.A., Bond, R. A. & Lefkowitz, R. J. (1995) J. Thorac. Cardiovasc. Surg. 109, 236-241.
36. Fukuda, K. & Izumo, S. (1996) Circulation 94, 1157 (abstr.).
37. Gruver, C. L., DeMayo, F., Goldstein, M. A. & Means, A. R. (1993) Endocrinology 133, 376-388.
38. Robbins, R. J. & Swain, J. L. (1992) Am. J. Physiol. 262, 590-597.
39. Jackson, T., Allard, M. F., Sreenan, C. M., Doss, L. K., Bishop, S. P. & Swain, J. L. (1990) Mol. Cell. Biol. 10, 3709-3716.
40. Katz, E. B., Steinhelper, M. E., Delcarpio, J. B., Daud, A. I., Claycomb, W. C. & Field, L. J. (1992) Am. J. Physiol. 262, H1867-H1876.
41. Kaplan, S. (1990) Drugs 39, 388-393.
42. Schneeweiss, A. (1988) Pediatr. Cardiol. 9, 109-115.
43. Scammell, A. M. & Diver, M. J. (1987) Arch. Dis. Child. 62, 1136-1138.
44. De Mello, W. C. & Altieri, P. (1992) J. Cardiovasc. Pharm. 20, 643-651.
45. De Mello, W. C. (1995) Cardiovasc. Res. 29, 730-736.
46. Allen, A. M., Yamada, H. & Mendelsohn, F. A. (1990) Int. J. Cardiol. 28, 25-33.
47. Saavedra, J. M., Viswanathan, M. & Shigematsu, K. (1993) Eur. J. Pharmacol. 235, 301-303.
48. Sechi, L. A., Griffin, C. A., Grady, E. F., Kalinyak, J. E. & Schambelan, M. (1992) Circ. Res. 71, 1482-1489.
49. Field, L. J. (1988) Science 239, 1029-1033.